Publications:

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Strategies for cystic fibrosis transmembrane conductance regulator inhibition: from molecular mechanisms to treatment for secretory diarrhoeas.

Febs Letters

de Jonge, Hugo R HR; Ardelean, Maria C MC; Bijvelds, Marcel J C MJC; Vergani, Paola P

Publication Date: 2020-12

Variant appearance in text: CFTR: F337C

PubMed Link: 33113586

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• FEB2-594-4085.pdf

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Molecular structure of the ATP-bound, phosphorylated human CFTR.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Zhang, Zhe Z; Liu, Fangyu F; Chen, Jue J

Publication Date: 2018-12-11

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PubMed Link: 30459277

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• pnas.201815287.pdf

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Structural mechanisms of CFTR function and dysfunction.

The Journal Of General Physiology

Hwang, Tzyh-Chang TC; Yeh, Jiunn-Tyng JT; Zhang, Jingyao J; Yu, Ying-Chun YC; Yeh, Han-I HI; Destefano, Samantha S

Publication Date: 2018-04-02

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PubMed Link: 29581173

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• JGP_201711946.pdf

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Long-range coupling between the extracellular gates and the intracellular ATP binding domains of multidrug resistance protein pumps and cystic fibrosis transmembrane conductance regulator channels.

Faseb Journal : Official Publication Of The Federation Of American Societies For Experimental Biology

Wei, Shipeng S; Roessler, Bryan C BC; Icyuz, Mert M; Chauvet, Sylvain S; Tao, Binli B; Hartman, John L JL; Kirk, Kevin L KL

Publication Date: 2016-03

Variant appearance in text: CFTR: F337C

PubMed Link: 26606940

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Localizing a gate in CFTR.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Gao, Xiaolong X; Hwang, Tzyh-Chang TC

Publication Date: 2015-02-24

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PubMed Link: 25675504

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Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator.

Molecular Pharmacology

Norimatsu, Yohei Y; Ivetac, Anthony A; Alexander, Christopher C; O'Donnell, Nicolette N; Frye, Leah L; Sansom, Mark S P MS; Dawson, David C DC

Publication Date: 2012-12

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PubMed Link: 22923500

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Cystic fibrosis transmembrane conductance regulator: a molecular model defines the architecture of the anion conduction path and locates a "bottleneck" in the pore.

Biochemistry

Norimatsu, Yohei Y; Ivetac, Anthony A; Alexander, Christopher C; Kirkham, John J; O'Donnell, Nicolette N; Dawson, David C DC; Sansom, Mark S P MS

Publication Date: 2012-03-20

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PubMed Link: 22352759

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Cystic fibrosis transmembrane conductance regulator: temperature-dependent cysteine reactivity suggests different stable conformers of the conduction pathway.

Biochemistry

Liu, Xuehong X; Dawson, David C DC

Publication Date: 2011-11-29

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PubMed Link: 22014307

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Alignment of transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore.

The Journal Of General Physiology

Wang, Wuyang W; El Hiani, Yassine Y; Linsdell, Paul P

Publication Date: 2011-08

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PubMed Link: 21746847

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• JGP_201110605.pdf

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Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.

The Journal Of General Physiology

Bai, Yonghong Y; Li, Min M; Hwang, Tzyh-Chang TC

Publication Date: 2010-09

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PubMed Link: 20805575

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• JGP_201010480.pdf

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Changes in accessibility of cytoplasmic substances to the pore associated with activation of the cystic fibrosis transmembrane conductance regulator chloride channel.

The Journal Of Biological Chemistry

El Hiani, Yassine Y; Linsdell, Paul P

Publication Date: 2010-10-15

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PubMed Link: 20675380

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Cystic fibrosis transmembrane conductance regulator: using differential reactivity toward channel-permeant and channel-impermeant thiol-reactive probes to test a molecular model for the pore.

Biochemistry

Alexander, Christopher C; Ivetac, Anthony A; Liu, Xuehong X; Norimatsu, Yohei Y; Serrano, Jose R JR; Landstrom, Allison A; Sansom, Mark M; Dawson, David C DC

Publication Date: 2009-10-27

Variant appearance in text: CFTR: F337C

PubMed Link: 19754156

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• bi901314c.pdf
• bi901314c_si_001.pdf

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Locating the anion-selectivity filter of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.

The Journal Of General Physiology

Cheung, M M; Akabas, M H MH

Publication Date: 1997-03

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PubMed Link: 9089437

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• 7357.pdf

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