Publications:

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Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer.

Biology Direct

Nardella, Caterina C; Visconti, Lorenzo L; Malagrinò, Francesca F; Pagano, Livia L; Bufano, Marianna M; Nalli, Marianna M; Coluccia, Antonio A; La Regina, Giuseppe G; Silvestri, Romano R; Gianni, Stefano S; Toto, Angelo A

Publication Date: 2021-10-12

Variant appearance in text: CFTR: F508A

PubMed Link: 34641953

Variant Present in the following documents:

• Main text
• 13062_2021_Article_303.pdf

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Targeting PDZ domains as potential treatment for viral infections, neurodegeneration and cancer.

Biology Direct

Nardella, Caterina C; Visconti, Lorenzo L; Malagrinò, Francesca F; Pagano, Livia L; Bufano, Marianna M; Nalli, Marianna M; Coluccia, Antonio A; La Regina, Giuseppe G; Silvestri, Romano R; Gianni, Stefano S; Toto, Angelo A

Publication Date: 2021-10-12

Variant appearance in text: CFTR: F508A

PubMed Link: 34641953

Variant Present in the following documents:

• Main text
• 13062_2021_Article_303.pdf

View BVdb publication page

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Cystic fibrosis lung environment and Pseudomonas aeruginosa infection.

Bmc Pulmonary Medicine

Bhagirath, Anjali Y AY; Li, Yanqi Y; Somayajula, Deepti D; Dadashi, Maryam M; Badr, Sara S; Duan, Kangmin K

Publication Date: 2016-12-05

Variant appearance in text: CFTR: F508A

PubMed Link: 27919253

Variant Present in the following documents:

• Main text

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Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening.

Journal Of Computer-Aided Molecular Design

Kalid, Ori O; Mense, Martin M; Fischman, Sharon S; Shitrit, Alina A; Bihler, Hermann H; Ben-Zeev, Efrat E; Schutz, Nili N; Pedemonte, Nicoletta N; Thomas, Philip J PJ; Bridges, Robert J RJ; Wetmore, Diana R DR; Marantz, Yael Y; Senderowitz, Hanoch H

Publication Date: 2010-12

Variant appearance in text: CFTR: F508A

PubMed Link: 20976528

Variant Present in the following documents:

• Main text

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The cystic fibrosis-causing mutation deltaF508 affects multiple steps in cystic fibrosis transmembrane conductance regulator biogenesis.

The Journal Of Biological Chemistry

Thibodeau, Patrick H PH; Richardson, John M JM; Wang, Wei W; Millen, Linda L; Watson, Jarod J; Mendoza, Juan L JL; Du, Kai K; Fischman, Sharon S; Senderowitz, Hanoch H; Lukacs, Gergely L GL; Kirk, Kevin K; Thomas, Philip J PJ

Publication Date: 2010-11-12

Variant appearance in text: CFTR: F508A

PubMed Link: 20667826

Variant Present in the following documents:

• Main text

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NMR evidence for differential phosphorylation-dependent interactions in WT and DeltaF508 CFTR.

The Embo Journal

Kanelis, Voula V; Hudson, Rhea P RP; Thibodeau, Patrick H PH; Thomas, Philip J PJ; Forman-Kay, Julie D JD

Publication Date: 2010-01-06

Variant appearance in text: CFTR: F508A

PubMed Link: 19927121

Variant Present in the following documents:

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Diminished self-chaperoning activity of the DeltaF508 mutant of CFTR results in protein misfolding.

Plos Computational Biology

Serohijos, Adrian W R AW; Hegedus, Tamás T; Riordan, John R JR; Dokholyan, Nikolay V NV

Publication Date: 2008-02-29

Variant appearance in text: CFTR: F508A

PubMed Link: 18463704

Variant Present in the following documents:

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In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer.

The Embo Journal

Mense, Martin M; Vergani, Paola P; White, Dennis M DM; Altberg, Gal G; Nairn, Angus C AC; Gadsby, David C DC

Publication Date: 2006-10-18

Variant appearance in text: CFTR: F508A

PubMed Link: 17036051

Variant Present in the following documents:

• Main text

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The two ATP binding sites of cystic fibrosis transmembrane conductance regulator (CFTR) play distinct roles in gating kinetics and energetics.

The Journal Of General Physiology

Zhou, Zhen Z; Wang, Xiaohui X; Liu, Hao-Yang HY; Zou, Xiaoqin X; Li, Min M; Hwang, Tzyh-Chang TC

Publication Date: 2006-10

Variant appearance in text: CFTR: F508A

PubMed Link: 16966475

Variant Present in the following documents:

• Main text
• jgp1280413.pdf

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The ABC protein turned chloride channel whose failure causes cystic fibrosis.

Nature

Gadsby, David C DC; Vergani, Paola P; Csanády, László L

Publication Date: 2006-03-23

Variant appearance in text: CFTR: F508A

PubMed Link: 16554808

Variant Present in the following documents:

• Main text

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Side chain and backbone contributions of Phe508 to CFTR folding.

Nature Structural & Molecular Biology

Thibodeau, Patrick H PH; Brautigam, Chad A CA; Machius, Mischa M; Thomas, Philip J PJ

Publication Date: 2005-01

Variant appearance in text: CFTR: F508A

PubMed Link: 15619636

Variant Present in the following documents:

• Main text

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