Publications:

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Spatial positioning of CFTR's pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathway.

The Journal Of General Physiology

Gao, Xiaolong X; Hwang, Tzyh-Chang TC

Publication Date: 2016-05

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PubMed Link: 27114613

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Functional Architecture of the Cytoplasmic Entrance to the Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Pore.

The Journal Of Biological Chemistry

El Hiani, Yassine Y; Linsdell, Paul P

Publication Date: 2015-06-19

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PubMed Link: 25944907

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Metal bridges illuminate transmembrane domain movements during gating of the cystic fibrosis transmembrane conductance regulator chloride channel.

The Journal Of Biological Chemistry

El Hiani, Yassine Y; Linsdell, Paul P

Publication Date: 2014-10-10

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PubMed Link: 25143385

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Two salt bridges differentially contribute to the maintenance of cystic fibrosis transmembrane conductance regulator (CFTR) channel function.

The Journal Of Biological Chemistry

Cui, Guiying G; Freeman, Cody S CS; Knotts, Taylor T; Prince, Chengyu Z CZ; Kuang, Christopher C; McCarty, Nael A NA

Publication Date: 2013-07-12

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PubMed Link: 23709221

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Regulation of activation and processing of the cystic fibrosis transmembrane conductance regulator (CFTR) by a complex electrostatic interaction between the regulatory domain and cytoplasmic loop 3.

The Journal Of Biological Chemistry

Wang, Guangyu G; Duan, Dayue Darrel DD

Publication Date: 2012-11-23

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PubMed Link: 23060444

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Relative movements of transmembrane regions at the outer mouth of the cystic fibrosis transmembrane conductance regulator channel pore during channel gating.

The Journal Of Biological Chemistry

Wang, Wuyang W; Linsdell, Paul P

Publication Date: 2012-09-14

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PubMed Link: 22843683

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Role of the juxtamembrane region of cytoplasmic loop 3 in the gating and conductance of the cystic fibrosis transmembrane conductance regulator chloride channel.

Biochemistry

El Hiani, Yassine Y; Linsdell, Paul P

Publication Date: 2012-05-15

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PubMed Link: 22545782

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Alternating access to the transmembrane domain of the ATP-binding cassette protein cystic fibrosis transmembrane conductance regulator (ABCC7).

The Journal Of Biological Chemistry

Wang, Wuyang W; Linsdell, Paul P

Publication Date: 2012-03-23

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PubMed Link: 22303012

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Alignment of transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore.

The Journal Of General Physiology

Wang, Wuyang W; El Hiani, Yassine Y; Linsdell, Paul P

Publication Date: 2011-08

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PubMed Link: 21746847

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The inhibition mechanism of non-phosphorylated Ser768 in the regulatory domain of cystic fibrosis transmembrane conductance regulator.

The Journal Of Biological Chemistry

Wang, Guangyu G

Publication Date: 2011-01-21

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PubMed Link: 21059651

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State-dependent regulation of cystic fibrosis transmembrane conductance regulator (CFTR) gating by a high affinity Fe3+ bridge between the regulatory domain and cytoplasmic loop 3.

The Journal Of Biological Chemistry

Wang, Guangyu G

Publication Date: 2010-12-24

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PubMed Link: 20952391

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Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.

The Journal Of General Physiology

Bai, Yonghong Y; Li, Min M; Hwang, Tzyh-Chang TC

Publication Date: 2010-09

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PubMed Link: 20805575

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Changes in accessibility of cytoplasmic substances to the pore associated with activation of the cystic fibrosis transmembrane conductance regulator chloride channel.

The Journal Of Biological Chemistry

El Hiani, Yassine Y; Linsdell, Paul P

Publication Date: 2010-10-15

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PubMed Link: 20675380

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Regulation of conductance by the number of fixed positive charges in the intracellular vestibule of the CFTR chloride channel pore.

The Journal Of General Physiology

Zhou, Jing-Jun JJ; Li, Man-Song MS; Qi, Jiansong J; Linsdell, Paul P

Publication Date: 2010-03

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PubMed Link: 20142516

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ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Wang, Wei W; Wu, Jianping J; Bernard, Karen K; Li, Ge G; Wang, Guangyu G; Bevensee, Mark O MO; Kirk, Kevin L KL

Publication Date: 2010-02-23

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PubMed Link: 20133716

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Cysteine-independent inhibition of the CFTR chloride channel by the cysteine-reactive reagent sodium (2-sulphonatoethyl) methanethiosulphonate.

British Journal Of Pharmacology

Li, M-S MS; Demsey, A F A AF; Qi, J J; Linsdell, P P

Publication Date: 2009-07

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PubMed Link: 19466983

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Processing mutations disrupt interactions between the nucleotide binding and transmembrane domains of P-glycoprotein and the cystic fibrosis transmembrane conductance regulator (CFTR).

The Journal Of Biological Chemistry

Loo, Tip W TW; Bartlett, M Claire MC; Clarke, David M DM

Publication Date: 2008-10-17

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PubMed Link: 18708637

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