Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator.
The Journal Of Biological Chemistry
Wang, Chi C; Aleksandrov, Andrei A AA; Yang, Zhengrong Z; Forouhar, Farhad F; Proctor, Elizabeth A EA; Kota, Pradeep P; An, Jianli J; Kaplan, Anna A; Khazanov, Netaly N; Boël, Grégory G; Stockwell, Brent R BR; Senderowitz, Hanoch H; Dokholyan, Nikolay V NV; Riordan, John R JR; Brouillette, Christie G CG; Hunt, John F JF