Publications:

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Extracellular phosphate enhances the function of F508del-CFTR rescued by CFTR correctors.

Journal Of Cystic Fibrosis : Official Journal Of The European Cystic Fibrosis Society

Saint-Criq, Vinciane V; Wang, Yiting Y; Delpiano, Livia L; Lin, JinHeng J; Sheppard, David N DN; Gray, Michael A MA

Publication Date: 2021-09

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PubMed Link: 34020896

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Protein kinase A phosphorylation potentiates cystic fibrosis transmembrane conductance regulator gating by relieving autoinhibition on the stimulatory C terminus of the regulatory domain.

The Journal Of Biological Chemistry

Chen, Jeng-Haur JH

Publication Date: 2020-04-03

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PubMed Link: 32102849

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Regulation of activation and processing of the cystic fibrosis transmembrane conductance regulator (CFTR) by a complex electrostatic interaction between the regulatory domain and cytoplasmic loop 3.

The Journal Of Biological Chemistry

Wang, Guangyu G; Duan, Dayue Darrel DD

Publication Date: 2012-11-23

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PubMed Link: 23060444

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Multiple residues in the distal C terminus of the α-subunit have roles in modulating human epithelial sodium channel activity.

American Journal Of Physiology. Renal Physiology

Mueller, Gunhild M GM; Yan, Wusheng W; Copelovitch, Lawrence L; Jarman, Susan S; Wang, Zhijian Z; Kinlough, Carol L CL; Tolino, Michael A MA; Hughey, Rebecca P RP; Kleyman, Thomas R TR; Rubenstein, Ronald C RC

Publication Date: 2012-07-15

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PubMed Link: 22573385

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The inhibition mechanism of non-phosphorylated Ser768 in the regulatory domain of cystic fibrosis transmembrane conductance regulator.

The Journal Of Biological Chemistry

Wang, Guangyu G

Publication Date: 2011-01-21

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PubMed Link: 21059651

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State-dependent regulation of cystic fibrosis transmembrane conductance regulator (CFTR) gating by a high affinity Fe3+ bridge between the regulatory domain and cytoplasmic loop 3.

The Journal Of Biological Chemistry

Wang, Guangyu G

Publication Date: 2010-12-24

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PubMed Link: 20952391

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ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Wang, Wei W; Wu, Jianping J; Bernard, Karen K; Li, Ge G; Wang, Guangyu G; Bevensee, Mark O MO; Kirk, Kevin L KL

Publication Date: 2010-02-23

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PubMed Link: 20133716

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Direct sensing of intracellular pH by the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel.

The Journal Of Biological Chemistry

Chen, Jeng-Haur JH; Cai, Zhiwei Z; Sheppard, David N DN

Publication Date: 2009-12-18

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PubMed Link: 19837660

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CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices.

Nature Structural & Molecular Biology

Baker, Jennifer M R JM; Hudson, Rhea P RP; Kanelis, Voula V; Choy, Wing-Yiu WY; Thibodeau, Patrick H PH; Thomas, Philip J PJ; Forman-Kay, Julie D JD

Publication Date: 2007-08

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PubMed Link: 17660831

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Reversible silencing of CFTR chloride channels by glutathionylation.

The Journal Of General Physiology

Wang, Wei W; Oliva, Claudia C; Li, Ge G; Holmgren, Arne A; Lillig, Christopher Horst CH; Kirk, Kevin L KL

Publication Date: 2005-02

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PubMed Link: 15657297

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Functional roles of nonconserved structural segments in CFTR's NH2-terminal nucleotide binding domain.

The Journal Of General Physiology

Csanády, László L; Chan, Kim W KW; Nairn, Angus C AC; Gadsby, David C DC

Publication Date: 2005-01

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PubMed Link: 15596536

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A macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Naren, Anjaparavanda P AP; Cobb, Bryan B; Li, Chunying C; Roy, Koushik K; Nelson, David D; Heda, Ghanshyam D GD; Liao, Jie J; Kirk, Kevin L KL; Sorscher, Eric J EJ; Hanrahan, John J; Clancy, John P JP

Publication Date: 2003-01-07

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PubMed Link: 12502786

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Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domains.

The Journal Of General Physiology

Csanády, L L; Chan, K W KW; Seto-Young, D D; Kopsco, D C DC; Nairn, A C AC; Gadsby, D C DC

Publication Date: 2000-09

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PubMed Link: 10962022

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Regulation of CFTR Cl- channel gating by ATP binding and hydrolysis.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Ikuma, M M; Welsh, M J MJ

Publication Date: 2000-07-18

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PubMed Link: 10880569

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A functional R domain from cystic fibrosis transmembrane conductance regulator is predominantly unstructured in solution.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Ostedgaard, L S LS; Baldursson, O O; Vermeer, D W DW; Welsh, M J MJ; Robertson, A D AD

Publication Date: 2000-05-09

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PubMed Link: 10792060

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