Publications:

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PHLPP1 regulates CFTR activity and lumen expansion through AMPK.

Development (Cambridge, England)

Lobert, Viola H VH; Skardal, Maren L ML; Malerød, Lene L; Simensen, Julia E JE; Algra, Hermine A HA; Andersen, Aram N AN; Fleischer, Thomas T; Enserink, Hilde A HA; Liestøl, Knut K; Heath, Joan K JK; Rusten, Tor Erik TE; Stenmark, Harald A HA

Publication Date: 2022-10-15

Variant appearance in text: CFTR: S768A

PubMed Link: 35997536

Variant Present in the following documents:

• Main text
• develop-149-200955_review_history.pdf
• develop-149-200955-s1.pdf

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Protein kinase A phosphorylation potentiates cystic fibrosis transmembrane conductance regulator gating by relieving autoinhibition on the stimulatory C terminus of the regulatory domain.

The Journal Of Biological Chemistry

Chen, Jeng-Haur JH

Publication Date: 2020-04-03

Variant appearance in text: CFTR: S768A

PubMed Link: 32102849

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Synergy of cAMP and calcium signaling pathways in CFTR regulation.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Bozoky, Zoltan Z; Ahmadi, Saumel S; Milman, Tal T; Kim, Tae Hun TH; Du, Kai K; Di Paola, Michelle M; Pasyk, Stan S; Pekhletski, Roman R; Keller, Jacob P JP; Bear, Christine E CE; Forman-Kay, Julie D JD

Publication Date: 2017-03-14

Variant appearance in text: CFTR: S768A

PubMed Link: 28242698

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• Main text
• pnas.201613546.pdf

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Trafficking and function of the cystic fibrosis transmembrane conductance regulator: a complex network of posttranslational modifications.

American Journal Of Physiology. Lung Cellular And Molecular Physiology

McClure, Michelle L ML; Barnes, Stephen S; Brodsky, Jeffrey L JL; Sorscher, Eric J EJ

Publication Date: 2016-10-01

Variant appearance in text: CFTR: S768A

PubMed Link: 27474090

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Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Stevers, Loes M LM; Lam, Chan V CV; Leysen, Seppe F R SF; Meijer, Femke A FA; van Scheppingen, Daphne S DS; de Vries, Rens M J M RM; Carlile, Graeme W GW; Milroy, Lech G LG; Thomas, David Y DY; Brunsveld, Luc L; Ottmann, Christian C

Publication Date: 2016-03-01

Variant appearance in text: CFTR: S768A

PubMed Link: 26888287

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The inhibition mechanism of non-phosphorylated Ser768 in the regulatory domain of cystic fibrosis transmembrane conductance regulator.

The Journal Of Biological Chemistry

Wang, Guangyu G

Publication Date: 2011-01-21

Variant appearance in text: CFTR: S768A

PubMed Link: 21059651

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State-dependent regulation of cystic fibrosis transmembrane conductance regulator (CFTR) gating by a high affinity Fe3+ bridge between the regulatory domain and cytoplasmic loop 3.

The Journal Of Biological Chemistry

Wang, Guangyu G

Publication Date: 2010-12-24

Variant appearance in text: CFTR: S768A

PubMed Link: 20952391

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AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR.

American Journal Of Physiology. Cell Physiology

King, J Darwin JD; Fitch, Adam C AC; Lee, Jeffrey K JK; McCane, Jill E JE; Mak, Don-On Daniel DO; Foskett, J Kevin JK; Hallows, Kenneth R KR

Publication Date: 2009-07

Variant appearance in text: CFTR: S768A

PubMed Link: 19419994

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Mechanistic insight into control of CFTR by AMPK.

The Journal Of Biological Chemistry

Kongsuphol, Patthara P; Cassidy, Diane D; Hieke, Bernhard B; Treharne, Kate J KJ; Schreiber, Rainer R; Mehta, Anil A; Kunzelmann, Karl K

Publication Date: 2009-02-27

Variant appearance in text: CFTR: S768A

PubMed Link: 19095655

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• 5645.pdf

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Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.

The Journal Of General Physiology

Csanády, László L; Seto-Young, Donna D; Chan, Kim W KW; Cenciarelli, Cristina C; Angel, Benjamin B BB; Qin, Jun J; McLachlin, Derek T DT; Krutchinsky, Andrew N AN; Chait, Brian T BT; Nairn, Angus C AC; Gadsby, David C DC

Publication Date: 2005-02

Variant appearance in text: CFTR: S768A

PubMed Link: 15657296

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• 200409076.pdf

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