BRAF c.1847C>T ;(p.S616F)

Variant ID: 7-140453088-G-A

NM_004333.4(BRAF):c.1847C>T;(p.S616F)

This variant was identified in 21 publications

View GRCh38 version.




Publications:


Mutually exclusive genetic interactions and gene essentiality shape the genomic landscape of primary melanoma.

The Journal Of Pathology
Birkeälv, Sofia S; Harland, Mark M; Matsuyama, Larissa Satiko Alcantara Sekimoto LSAS; Rashid, Mamun M; Mehta, Ishan I; Laye, Jonathan P JP; Haase, Kerstin K; Mell, Tracey T; Iyer, Vivek V; Robles-Espinoza, Carla Daniela CD; McDermott, Ultan U; van Loo, Peter P; Kuijjer, Marieke L ML; Possik, Patricia A PA; Maria Engler, Silvya Stuchi SS; Bishop, D Timothy DT; Newton-Bishop, Julia J; Adams, David J DJ
Publication Date: 2022-10-11

Variant appearance in text: BRAF: S616F
PubMed Link: 36219477
Variant Present in the following documents:
  • PATH-259-56-s004.xlsx, sheet 2
  • PATH-259-56-s006.xlsx, sheet 2
View BVdb publication page



Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma.

Frontiers In Oncology
Yin, Xiang-Qian XQ; Yin, Xue-Hui XH; Yu, Ya-Qin YQ; Xu, Lang L; Zhang, Mao M
Publication Date: 2022

Variant appearance in text: BRAF: 1847C>T; S616F
PubMed Link: 35936718
Variant Present in the following documents:
  • Table_4.xlsx, sheet 2
View BVdb publication page



Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.

Nature Genetics
Kar, Siddhartha P SP; Quiros, Pedro M PM; Gu, Muxin M; Jiang, Tao T; Mitchell, Jonathan J; Langdon, Ryan R; Iyer, Vivek V; Barcena, Clea C; Vijayabaskar, M S MS; Fabre, Margarete A MA; Carter, Paul P; Petrovski, Slavé S; Burgess, Stephen S; Vassiliou, George S GS
Publication Date: 2022-08

Variant appearance in text: BRAF: S616F
PubMed Link: 35835912
Variant Present in the following documents:
  • 41588_2022_1121_MOESM3_ESM.xlsx, sheet 3
View BVdb publication page



A full-proteome, interaction-specific characterization of mutational hotspots across human cancers.

Genome Research
Chen, Siwei S; Liu, Yuan Y; Zhang, Yingying Y; Wierbowski, Shayne D SD; Lipkin, Steven M SM; Wei, Xiaomu X; Yu, Haiyuan H
Publication Date: 2022-01

Variant appearance in text: BRAF: S616F
PubMed Link: 34963661
Variant Present in the following documents:
  • supp_gr.275437.121_Supplementary_Table_1.xlsx, sheet 3
View BVdb publication page



Integrated molecular drivers coordinate biological and clinical states in melanoma.

Nature Genetics
Conway, Jake R JR; Dietlein, Felix F; Taylor-Weiner, Amaro A; AlDubayan, Saud S; Vokes, Natalie N; Keenan, Tanya T; Reardon, Brendan B; He, Meng Xiao MX; Margolis, Claire A CA; Weirather, Jason L JL; Haq, Rizwan R; Schilling, Bastian B; Stephen Hodi, F F; Schadendorf, Dirk D; Liu, David D; Van Allen, Eliezer M EM
Publication Date: 2020-12

Variant appearance in text: BRAF: 1847C>T; S616F
PubMed Link: 33230298
Variant Present in the following documents:
  • NIHMS1637640-supplement-SuppData1.xlsx, sheet 1
View BVdb publication page



Mutations in BRAF codons 594 and 596 predict good prognosis in melanoma.

Oncology Letters
Wu, Xiaowen X; Yan, Junya J; Dai, Jie J; Ma, Meng M; Tang, Huan H; Yu, Jiayi J; Xu, Tianxiao T; Yu, Huan H; Si, Lu L; Chi, Zhihong Z; Sheng, Xinan X; Cui, Chuanliang C; Kong, Yan Y; Guo, Jun J
Publication Date: 2017-09

Variant appearance in text: BRAF: S616F
PubMed Link: 28927118
Variant Present in the following documents:
  • Main text
  • ol-14-03-3601.pdf
View BVdb publication page



Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications
Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2017-05-11

Variant appearance in text: BRAF: 1847C>T
PubMed Link: 28492226
Variant Present in the following documents:
  • ncomms15086-s3.xlsx, sheet 1
View BVdb publication page



Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth.

Cell Metabolism
Xia, Siyuan S; Lin, Ruiting R; Jin, Lingtao L; Zhao, Liang L; Kang, Hee-Bum HB; Pan, Yaozhu Y; Liu, Shuangping S; Qian, Guoqing G; Qian, Zhiyu Z; Konstantakou, Evmorfia E; Zhang, Baotong B; Dong, Jin-Tang JT; Chung, Young Rock YR; Abdel-Wahab, Omar O; Merghoub, Taha T; Zhou, Lu L; Kudchadkar, Ragini R RR; Lawson, David H DH; Khoury, Hanna J HJ; Khuri, Fadlo R FR; Boise, Lawrence H LH; Lonial, Sagar S; Lee, Benjamin H BH; Pollack, Brian P BP; Arbiser, Jack L JL; Fan, Jun J; Lei, Qun-Ying QY; Chen, Jing J
Publication Date: 2017-02-07

Variant appearance in text: BRAF: S616F
PubMed Link: 28089569
Variant Present in the following documents:
  • Main text
View BVdb publication page



A Landscape of Pharmacogenomic Interactions in Cancer.

Cell
Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ
Publication Date: 2016-07-28

Variant appearance in text: BRAF: 1847C>T; S616F
PubMed Link: 27397505
Variant Present in the following documents:
  • mmc3.xlsx, sheet 2
View BVdb publication page



Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.

Oncotarget
Eisenhardt, Anja E AE; Sprenger, Adrian A; Röring, Michael M; Herr, Ricarda R; Weinberg, Florian F; Köhler, Martin M; Braun, Sandra S; Orth, Joachim J; Diedrich, Britta B; Lanner, Ulrike U; Tscherwinski, Natalja N; Schuster, Simon S; Dumaz, Nicolas N; Schmidt, Enrico E; Baumeister, Ralf R; Schlosser, Andreas A; Dengjel, Jörn J; Brummer, Tilman T
Publication Date: 2016-05-03

Variant appearance in text: BRAF: S616F
PubMed Link: 27034005
Variant Present in the following documents:
  • oncotarget-07-26628-s007.pdf
View BVdb publication page



Clinical Validation and Implementation of a Targeted Next-Generation Sequencing Assay to Detect Somatic Variants in Non-Small Cell Lung, Melanoma, and Gastrointestinal Malignancies.

The Journal Of Molecular Diagnostics : Jmd
Fisher, Kevin E KE; Zhang, Linsheng L; Wang, Jason J; Smith, Geoffrey H GH; Newman, Scott S; Schneider, Thomas M TM; Pillai, Rathi N RN; Kudchadkar, Ragini R RR; Owonikoko, Taofeek K TK; Ramalingam, Suresh S SS; Lawson, David H DH; Delman, Keith A KA; El-Rayes, Bassel F BF; Wilson, Malania M MM; Sullivan, H Clifford HC; Morrison, Annie S AS; Balci, Serdar S; Adsay, N Volkan NV; Gal, Anthony A AA; Sica, Gabriel L GL; Saxe, Debra F DF; Mann, Karen P KP; Hill, Charles E CE; Khuri, Fadlo R FR; Rossi, Michael R MR
Publication Date: 2016-03

Variant appearance in text: BRAF: S616F
PubMed Link: 26801070
Variant Present in the following documents:
  • Main text
View BVdb publication page



Prediction of response to anti-EGFR antibody-based therapies by multigene sequencing in colorectal cancer patients.

Bmc Cancer
Lupini, Laura L; Bassi, Cristian C; Mlcochova, Jitka J; Musa, Gentian G; Russo, Marta M; Vychytilova-Faltejskova, Petra P; Svoboda, Marek M; Sabbioni, Silvia S; Nemecek, Radim R; Slaby, Ondrej O; Negrini, Massimo M
Publication Date: 2015-10-27

Variant appearance in text: BRAF: S616F
PubMed Link: 26508446
Variant Present in the following documents:
  • Main text
  • 12885_2015_1752_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Recurrent inactivating RASA2 mutations in melanoma.

Nature Genetics
Arafeh, Rand R; Qutob, Nouar N; Emmanuel, Rafi R; Keren-Paz, Alona A; Madore, Jason J; Elkahloun, Abdel A; Wilmott, James S JS; Gartner, Jared J JJ; Di Pizio, Antonella A; Winograd-Katz, Sabina S; Sindiri, Sivasish S; Rotkopf, Ron R; Dutton-Regester, Ken K; Johansson, Peter P; Pritchard, Antonia L AL; Waddell, Nicola N; Hill, Victoria K VK; Lin, Jimmy C JC; Hevroni, Yael Y; Rosenberg, Steven A SA; Khan, Javed J; Ben-Dor, Shifra S; Niv, Masha Y MY; Ulitsky, Igor I; Mann, Graham J GJ; Scolyer, Richard A RA; Hayward, Nicholas K NK; Samuels, Yardena Y
Publication Date: 2015-12

Variant appearance in text: BRAF: 1847C>T; S616F
PubMed Link: 26502337
Variant Present in the following documents:
  • NIHMS65345-supplement-Supplementary_table_1.xlsx, sheet 1
  • NIHMS65345-supplement-Supplementary_table_3.xlsx, sheet 2
View BVdb publication page



BRAF gene: From human cancers to developmental syndromes.

Saudi Journal Of Biological Sciences
Hussain, Muhammad Ramzan Manwar MR; Baig, Mukhtiar M; Mohamoud, Hussein Sheik Ali HS; Ulhaq, Zaheer Z; Hoessli, Daniel C DC; Khogeer, Ghaidaa Siraj GS; Al-Sayed, Ranem Radwan RR; Al-Aama, Jumana Yousuf JY
Publication Date: 2015-07

Variant appearance in text: BRAF: S616F
PubMed Link: 26150740
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Protein domain-level landscape of cancer-type-specific somatic mutations.

Plos Computational Biology
Yang, Fan F; Petsalaki, Evangelia E; Rolland, Thomas T; Hill, David E DE; Vidal, Marc M; Roth, Frederick P FP
Publication Date: 2015-03

Variant appearance in text: BRAF: S616F
PubMed Link: 25794154
Variant Present in the following documents:
  • pcbi.1004147.s001.xlsx, sheet 1
View BVdb publication page



Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors.

Nature Communications
Marusiak, Anna A AA; Edwards, Zoe C ZC; Hugo, Willy W; Trotter, Eleanor W EW; Girotti, Maria R MR; Stephenson, Natalie L NL; Kong, Xiangju X; Gartside, Michael G MG; Fawdar, Shameem S; Hudson, Andrew A; Breitwieser, Wolfgang W; Hayward, Nicholas K NK; Marais, Richard R; Lo, Roger S RS; Brognard, John J
Publication Date: 2014-05-22

Variant appearance in text: BRAF: S616F
PubMed Link: 24849047
Variant Present in the following documents:
  • ncomms4901.pdf
View BVdb publication page



Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations.

Molecular Systems Biology
Kiel, Christina C; Serrano, Luis L
Publication Date: 2014-05-06

Variant appearance in text: BRAF: S616F
PubMed Link: 24803665
Variant Present in the following documents:
  • MSB-10-5-727-s13.xls, sheet 1
View BVdb publication page



Assessment of computational methods for predicting the effects of missense mutations in human cancers.

Bmc Genomics
Gnad, Florian F; Baucom, Albion A; Mukhyala, Kiran K; Manning, Gerard G; Zhang, Zemin Z
Publication Date: 2013

Variant appearance in text: BRAF: S616F
PubMed Link: 23819521
Variant Present in the following documents:
  • 1471-2164-14-S3-S7-S1.xlsx, sheet 1
View BVdb publication page



Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research
Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C
Publication Date: 2011-09-01

Variant appearance in text: BRAF: S616F
PubMed Link: 21727090
Variant Present in the following documents:
  • supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1
View BVdb publication page



PIK3CA, KRAS, and BRAF mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/C) of the pancreas.

Langenbeck'S Archives Of Surgery
Schönleben, Frank F; Qiu, Wanglong W; Remotti, Helen E HE; Hohenberger, Werner W; Su, Gloria H GH
Publication Date: 2008-05

Variant appearance in text: BRAF: S616F
PubMed Link: 18343945
Variant Present in the following documents:
  • Main text
View BVdb publication page