Genetic and Clinical Characteristics of ARID1A Mutated Melanoma Reveal High Tumor Mutational Load without Implications on Patient Survival.
Cancers
Thielmann, Carl Maximilian CM; Matull, Johanna J; Roth, Sebastian S; Placke, Jan-Malte JM; Chorti, Eleftheria E; Zaremba, Anne A; Lodde, Georg G; Jansen, Philipp P; Krefting, Frederik F; Kretz, Julia J; Möller, Inga I; Sucker, Antje A; Paschen, Annette A; Livingstone, Elisabeth E; Zimmer, Lisa L; Ugurel, Selma S; Schadendorf, Dirk D; Hadaschik, Eva E; Griewank, Klaus G KG
The Role of Treatment Sequencing with Immune-Checkpoint Inhibitors and BRAF/MEK Inhibitors for Response and Survival of Patients with BRAFV600-Mutant Metastatic Melanoma-A Retrospective, Real-World Cohort Study.
Cancers
Haist, Maximilian M; Stege, Henner H; Ebner, Ronja R; Fleischer, Maria Isabel MI; Loquai, Carmen C; Grabbe, Stephan S
The Experiences of Patients With Adjuvant and Metastatic Melanoma Using Disease-Specific Social Media Communities in the Advent of Novel Therapies (Excite Project): Social Media Listening Study.
Jmir Cancer
Faust, Guy G; Booth, Alison A; Merinopoulou, Evie E; Halhol, Sonia S; Tosar, Heena H; Nawaz, Amir A; Szlachetka, Magdalena M; Chiu, Gavin G
The "Great Debate" at Melanoma Bridge 2021, December 2nd-4th, 2021.
Journal Of Translational Medicine
Ascierto, Paolo A PA; Warner, Allison Betof AB; Blank, Christian C; Caracò, Corrado C; Demaria, Sandra S; Gershenwald, Jeffrey E JE; Khushalani, Nikhil I NI; Long, Georgina V GV; Luke, Jason J JJ; Mehnert, Janice M JM; Robert, Caroline C; Rutkowski, Piotr P; Tawbi, Hussein A HA; Osman, Iman I; Puzanov, Igor I
Rehman, Asad Ur AU; Khan, Parvez P; Maurya, Shailendra Kumar SK; Siddiqui, Jawed A JA; Santamaria-Barria, Juan A JA; Batra, Surinder K SK; Nasser, Mohd Wasim MW
Pediatric metanephric adenoma with Fanconi-Bickel syndrome: a case report and review of literature.
Surgical Case Reports
Sarhan, Osama M OM; Al Farhan, Ahmed A; Abdallah, Salma S; Al Ghwanmah, Hamzah H; Boqari, Deena D; Omar, Helmy H; Al Faddagh, Abdulmohsin A; Al Kanani, Hanan H; Al Kawai, Fouad F
Perspectives for Combining Viral Oncolysis With Additional Immunotherapies for the Treatment of Melanoma.
Frontiers In Molecular Biosciences
Cerqueira, Otto Luiz Dutra OLD; Antunes, Fernanda F; Assis, Nadine G NG; Cardoso, Elaine C EC; Clavijo-Salomón, Maria A MA; Domingues, Ana C AC; Tessarollo, Nayara G NG; Strauss, Bryan E BE
Anchored Multiplex PCR Custom Melanoma Next Generation Sequencing Panel for Analysis of Circulating Tumor DNA.
Frontiers In Oncology
Diefenbach, Russell J RJ; Lee, Jenny H JH; Stewart, Ashleigh A; Menzies, Alexander M AM; Carlino, Matteo S MS; Saw, Robyn P M RPM; Stretch, Jonathan R JR; Long, Georgina V GV; Scolyer, Richard A RA; Rizos, Helen H
Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy.
Science Advances
Ng, Thomas S C TSC; Hu, Huiyu H; Kronister, Stefan S; Lee, Chanseo C; Li, Ran R; Gerosa, Luca L; Stopka, Sylwia A SA; Burgenske, Danielle M DM; Khurana, Ishaan I; Regan, Michael S MS; Vallabhaneni, Sreeram S; Putta, Niharika N; Scott, Ella E; Matvey, Dylan D; Giobbie-Hurder, Anita A; Kohler, Rainer H RH; Sarkaria, Jann N JN; Parangi, Sareh S; Sorger, Peter K PK; Agar, Nathalie Y R NYR; Jacene, Heather A HA; Sullivan, Ryan J RJ; Buchbinder, Elizabeth E; Mikula, Hannes H; Weissleder, Ralph R; Miller, Miles A MA
In Vivo miRNA Decoy Screen Reveals miR-124a as a Suppressor of Melanoma Metastasis.
Frontiers In Oncology
Moubarak, Rana S RS; Koetz-Ploch, Lisa L; Mullokandov, Gavriel G; Gaziel, Avital A; de Pablos-Aragoneses, Ana A; Argibay, Diana D; Kleffman, Kevin K; Sokolova, Elena E; Berwick, Marianne M; Thomas, Nancy E NE; Osman, Iman I; Brown, Brian D BD; Hernando, Eva E
Case Report: Delayed Onset Multi-Organ Toxicities in a Melanoma Patient Achieving Complete Response to BRAF/MEK Inhibition.
Frontiers In Oncology
Knochelmann, Hannah M HM; Ware, Michael Brandon MB; Rali, Aditya A; Linderman, Susanne S; Shantha, Jessica G JG; Lawson, David H DH; Yushak, Melinda M; Swerlick, Robert R; Paulos, Chrystal M CM; Yeh, Steven S; Kudchadkar, Ragini R
Phase I study of [131I] ICF01012, a targeted radionuclide therapy, in metastatic melanoma: MELRIV-1 protocol.
Bmc Cancer
Thivat, Emilie E; Rouanet, Jacques J; Auzeloux, Philippe P; Sas, Nicolas N; Jouberton, Elodie E; Levesque, Sophie S; Billoux, Tommy T; Mansard, Sandrine S; Molnar, Ioana I; Chanchou, Marion M; Fois, Giovanna G; Maigne, Lydia L; Chezal, Jean-Michel JM; Miot-Noirault, Elisabeth E; D'Incan, Michel M; Durando, Xavier X; Cachin, Florent F
Characterization of the treatment-naive immune microenvironment in melanoma with BRAF mutation.
Journal For Immunotherapy Of Cancer
Wang, Minyu M; Zadeh, Soroor S; Pizzolla, Angela A; Thia, Kevin K; Gyorki, David E DE; McArthur, Grant A GA; Scolyer, Richard A RA; Long, Georgina G; Wilmott, James S JS; Andrews, Miles C MC; Au-Yeung, George G; Weppler, Ali A; Sandhu, Shahneen S; Trapani, Joseph A JA; Davis, Melissa J MJ; Neeson, Paul Joseph PJ
A Case of Non-Irradiated Balloon Cell Melanoma of the Choroid: Expanding the Morphological Spectrum of Primary Uveal Melanomas.
Diagnostics (Basel, Switzerland)
Failla, Maria M; Caltabiano, Rosario R; Longo, Antonio A; Russo, Andrea A; Reibaldi, Michele M; Avitabile, Teresio T; Piombino, Eliana E; Colarossi, Cristina C; Colarossi, Lorenzo L; Tirrò, Elena E; Vigneri, Paolo P; Foti, Pietro Valerio PV; Broggi, Giuseppe G
Point of Care Molecular Testing: Community-Based Rapid Next-Generation Sequencing to Support Cancer Care.
Current Oncology (Toronto, Ont.)
Sheffield, Brandon S BS; Beharry, Andrea A; Diep, Joanne J; Perdrizet, Kirstin K; Iafolla, Marco A J MAJ; Raskin, William W; Dudani, Shaan S; Brett, Mary Anne MA; Starova, Blerta B; Olsen, Brian B; Cheema, Parneet K PK
Improving Brain Metastases Outcomes Through Therapeutic Synergy Between Stereotactic Radiosurgery and Targeted Cancer Therapies.
Frontiers In Oncology
Rubino, Sebastian S; Oliver, Daniel E DE; Tran, Nam D ND; Vogelbaum, Michael A MA; Forsyth, Peter A PA; Yu, Hsiang-Hsuan Michael HM; Ahmed, Kamran K; Etame, Arnold B AB
Clinical and analytical validation of FoundationOne®CDx, a comprehensive genomic profiling assay for solid tumors.
Plos One
Milbury, Coren A CA; Creeden, James J; Yip, Wai-Ki WK; Smith, David L DL; Pattani, Varun V; Maxwell, Kristi K; Sawchyn, Bethany B; Gjoerup, Ole O; Meng, Wei W; Skoletsky, Joel J; Concepcion, Alvin D AD; Tang, Yanhua Y; Bai, Xiaobo X; Dewal, Ninad N; Ma, Pei P; Bailey, Shannon T ST; Thornton, James J; Pavlick, Dean C DC; Frampton, Garrett M GM; Lieber, Daniel D; White, Jared J; Burns, Christine C; Vietz, Christine C
Anaplastic thyroid cancer: genome-based search for new targeted therapy options.
Endocrine Connections
Hescheler, Daniel Alexander DA; Hartmann, Milan Janis Michael MJM; Riemann, Burkhard B; Michel, Maximilian M; Bruns, Christiane Josephine CJ; Alakus, Hakan H; Chiapponi, Costanza C
An integrative gene expression signature analysis identifies CMS4 KRAS-mutated colorectal cancers sensitive to combined MEK and SRC targeted therapy.
Bmc Cancer
Yang, Mingli M; Davis, Thomas B TB; Pflieger, Lance L; Nebozhyn, Michael V MV; Loboda, Andrey A; Wang, Heiman H; Schell, Michael J MJ; Thota, Ramya R; Pledger, W Jack WJ; Yeatman, Timothy J TJ
T Cells and CDDO-Me Attenuate Immunosuppressive Activation of Human Melanoma-Conditioned Macrophages.
Frontiers In Immunology
Torres, Gretel M GM; Yang, Heetaek H; Park, Chanhyuk C; Spezza, Paul A PA; Khatwani, Nikhil N; Bhandari, Rajan R; Liby, Karen T KT; Pioli, Patricia A PA
Portable real-time colorimetric LAMP-device for rapid quantitative detection of nucleic acids in crude samples.
Scientific Reports
Papadakis, G G; Pantazis, A K AK; Fikas, N N; Chatziioannidou, S S; Tsiakalou, V V; Michaelidou, K K; Pogka, V V; Megariti, M M; Vardaki, M M; Giarentis, K K; Heaney, J J; Nastouli, E E; Karamitros, T T; Mentis, A A; Zafiropoulos, A A; Sourvinos, G G; Agelaki, S S; Gizeli, E E
SEOM-GEINO clinical guideline of systemic therapy and management of brain central nervous system metastases (2021).
Clinical & Translational Oncology : Official Publication Of The Federation Of Spanish Oncology Societies And Of The National Cancer Institute Of Mexico
Martínez-García, María M; Servitja Tormo, Sonia S; Vilariño Quintela, Noelia N; Arance Fernández, Ana A; Berrocal Jaime, Alfonso A; Cantos Sánchez de Ibargüen, Blanca B; Del Barco Berrón, Sonia S; García Campelo, Rosario R; Gironés Sarrió, Regina R; Manuel Sepúlveda-Sánchez, Juan J
Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma.
Nature Communications
Smith, Lorey K LK; Parmenter, Tiffany T; Kleinschmidt, Margarete M; Kusnadi, Eric P EP; Kang, Jian J; Martin, Claire A CA; Lau, Peter P; Patel, Riyaben R; Lorent, Julie J; Papadopoli, David D; Trigos, Anna A; Ward, Teresa T; Rao, Aparna D AD; Lelliott, Emily J EJ; Sheppard, Karen E KE; Goode, David D; Hicks, Rodney J RJ; Tiganis, Tony T; Simpson, Kaylene J KJ; Larsson, Ola O; Blythe, Benjamin B; Cullinane, Carleen C; Wickramasinghe, Vihandha O VO; Pearson, Richard B RB; McArthur, Grant A GA
Correlation between treatment effects on response rate and progression-free survival and overall survival in trials of targeted therapies in molecularly enriched populations.
Esmo Open
Solomon, B J BJ; Loong, H H HH; Summers, Y Y; Thomas, Z M ZM; French, P P; Lin, B K BK; Sashegyi, A A; Wolf, J J; Yang, J C-H JC; Drilon, A A
New Therapeutic Approaches for Conjunctival Melanoma-What We Know So Far and Where Therapy Is Potentially Heading: Focus on Lymphatic Vessels and Dendritic Cells.
International Journal Of Molecular Sciences
Peil, Jennifer J; Bock, Felix F; Kiefer, Friedemann F; Schmidt, Rebecca R; Heindl, Ludwig M LM; Cursiefen, Claus C; Schlereth, Simona L SL
The Use of ctDNA for BRAF Mutation Testing in Routine Clinical Practice in Patients with Advanced Melanoma.
Cancers
Sobczuk, Paweł P; Kozak, Katarzyna K; Kopeć, Sylwia S; Rogala, Paweł P; Świtaj, Tomasz T; Koseła-Paterczyk, Hanna H; Gos, Aleksandra A; Tysarowski, Andrzej A; Rutkowski, Piotr P
Dramatic Therapeutic Response to Dabrafenib Plus Trametinib in BRAF V600E Mutated Papillary Craniopharyngiomas: A Case Report and Literature Review.
Frontiers In Medicine
Fasano, Morena M; Della Corte, Carminia Maria CM; Caterino, Marianna M; Pirozzi, Mario M; Rauso, Raffaele R; Troiani, Teresa T; Martini, Giulia G; Napolitano, Stefania S; Morgillo, Floriana F; Ciardiello, Fortunato F
Vemurafenib Combined With Trametinib Significantly Benefits the Survival of a Patient With Stage IV Pancreatic Ductal Adenocarcinoma With BRAF V600E Mutation: A Case Report.
Frontiers In Oncology
Wang, Ziyao Z; He, Du D; Chen, Chen C; Liu, Xubao X; Ke, Nengwen N
Phase I pharmacokinetic study of single agent trametinib in patients with advanced cancer and hepatic dysfunction.
Journal Of Experimental & Clinical Cancer Research : Cr
Voon, Pei Jye PJ; Chen, Eric X EX; Chen, Helen X HX; Lockhart, Albert C AC; Sahebjam, Solmaz S; Kelly, Karen K; Vaishampayan, Ulka N UN; Subbiah, Vivek V; Razak, Albiruni R AR; Renouf, Daniel J DJ; Hotte, Sebastien J SJ; Singh, Arti A; Bedard, Philippe L PL; Hansen, Aaron R AR; Ivy, S Percy SP; Wang, Lisa L; Stayner, Lee-Anne LA; Siu, Lillian L LL; Spreafico, Anna A
Trametinib versus standard of care in patients with recurrent low-grade serous ovarian cancer (GOG 281/LOGS): an international, randomised, open-label, multicentre, phase 2/3 trial.
Lancet (London, England)
Gershenson, David M DM; Miller, Austin A; Brady, William E WE; Paul, James J; Carty, Karen K; Rodgers, William W; Millan, David D; Coleman, Robert L RL; Moore, Kathleen N KN; Banerjee, Susana S; Connolly, Kate K; Secord, Angeles Alvarez AA; O'Malley, David M DM; Dorigo, Oliver O; Gaillard, Stephanie S; Gabra, Hani H; Slomovitz, Brian B; Hanjani, Parviz P; Farley, John J; Churchman, Michael M; Ewing, Ailith A; Hollis, Robert L RL; Herrington, C Simon CS; Huang, Helen Q HQ; Wenzel, Lari L; Gourley, Charlie C
Nuclear Localization of BRAFV600E Is Associated with HMOX-1 Upregulation and Aggressive Behavior of Melanoma Cells.
Cancers
Zerfaoui, Mourad M; Toraih, Eman E; Ruiz, Emmanuelle E; Errami, Youssef Y; Attia, Abdallah S AS; Krzysztof, Moroz M; Abd Elmageed, Zakaria Y ZY; Kandil, Emad E
Randomized Phase III Trial Evaluating Spartalizumab Plus Dabrafenib and Trametinib for BRAF V600-Mutant Unresectable or Metastatic Melanoma.
Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
Dummer, Reinhard R; Long, Georgina V GV; Robert, Caroline C; Tawbi, Hussein A HA; Flaherty, Keith T KT; Ascierto, Paolo A PA; Nathan, Paul D PD; Rutkowski, Piotr P; Leonov, Oleg O; Dutriaux, Caroline C; Mandalà, Mario M; Lorigan, Paul P; Ferrucci, Pier Francesco PF; Grob, Jean Jacques JJ; Meyer, Nicolas N; Gogas, Helen H; Stroyakovskiy, Daniil D; Arance, Ana A; Brase, Jan C JC; Green, Steven S; Haas, Tomas T; Masood, Aisha A; Gasal, Eduard E; Ribas, Antoni A; Schadendorf, Dirk D