BRAF c.1798G>T ;(p.V600L)

Variant ID: 7-140453137-C-A

NM_004333.4(BRAF):c.1798G>T;(p.V600L)

This variant was identified in 63 publications

View GRCh38 version.




Publications:


The Genomic Landscape of Melanoma and Its Therapeutic Implications.

Genes
Yang, Ting-Ting TT; Yu, Sebastian S; Ke, Chiao-Li Khale CK; Cheng, Shih-Tsung ST
Publication Date: 2023-04-29

Variant appearance in text: BRAF: V600L
PubMed Link: 37239381
Variant Present in the following documents:
  • Main text
  • genes-14-01021.pdf
View BVdb publication page



Recapitulating thyroid cancer histotypes through engineering embryonic stem cells.

Nature Communications
Veschi, Veronica V; Turdo, Alice A; Modica, Chiara C; Verona, Francesco F; Di Franco, Simone S; Gaggianesi, Miriam M; Tirrò, Elena E; Di Bella, Sebastiano S; Iacono, Melania Lo ML; Pantina, Vincenzo Davide VD; Porcelli, Gaetana G; Mangiapane, Laura Rosa LR; Bianca, Paola P; Rizzo, Aroldo A; Sciacca, Elisabetta E; Pillitteri, Irene I; Vella, Veronica V; Belfiore, Antonino A; Bongiorno, Maria Rita MR; Pistone, Giuseppe G; Memeo, Lorenzo L; Colarossi, Lorenzo L; Giuffrida, Dario D; Colarossi, Cristina C; Vigneri, Paolo P; Todaro, Matilde M; Stassi, Giorgio G
Publication Date: 2023-03-11

Variant appearance in text: BRAF: V600L
PubMed Link: 36906579
Variant Present in the following documents:
  • 41467_2023_36922_MOESM4_ESM.xls, sheet 2
View BVdb publication page



Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23

Variant appearance in text: BRAF: 1798G>T; Val600Leu
PubMed Link: 36823319
Variant Present in the following documents:
  • 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Whole-genome characterization of myoepithelial carcinomas of the soft tissue.

Cold Spring Harbor Molecular Case Studies
Cyrta, Joanna J; Rosiene, Joel J; Bareja, Rohan R; Kudman, Sarah S; Al Zoughbi, Wael W; Motanagh, Samaneh S; Wilkes, David C DC; Eng, Kenneth K; Zhang, Tuo T; Sticca, Evan E; Mathew, Susan S; Rubin, Mark A MA; Sboner, Andrea A; Elemento, Olivier O; Rubin, Brian P BP; Imielinski, Marcin M; Mosquera, Juan Miguel JM
Publication Date: 2022-12

Variant appearance in text: BRAF: V600L
PubMed Link: 36577525
Variant Present in the following documents:
  • supp_mcs.a006227_Supplemental_Table_1.xlsx, sheet 2
View BVdb publication page



Improvements in Quality Control and Library Preparation for Targeted Sequencing Allowed Detection of Potentially Pathogenic Alterations in Circulating Cell-Free DNA Derived from Plasma of Brain Tumor Patients.

Cancers
Szadkowska, Paulina P; Roura, Adria-Jaume AJ; Wojtas, Bartosz B; Wojnicki, Kamil K; Licholai, Sabina S; Waller, Tomasz T; Gubala, Tomasz T; Zukowski, Kacper K; Karpeta, Michal M; Wilkus, Kinga K; Kaspera, Wojciech W; Nawrocki, Sergiusz S; Kaminska, Bozena B
Publication Date: 2022-08-12

Variant appearance in text: rs121913378
PubMed Link: 36010895
Variant Present in the following documents:
  • cancers-14-03902.pdf
View BVdb publication page



Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.

Nature Genetics
Kar, Siddhartha P SP; Quiros, Pedro M PM; Gu, Muxin M; Jiang, Tao T; Mitchell, Jonathan J; Langdon, Ryan R; Iyer, Vivek V; Barcena, Clea C; Vijayabaskar, M S MS; Fabre, Margarete A MA; Carter, Paul P; Petrovski, Slavé S; Burgess, Stephen S; Vassiliou, George S GS
Publication Date: 2022-08

Variant appearance in text: BRAF: V600L
PubMed Link: 35835912
Variant Present in the following documents:
  • 41588_2022_1121_MOESM3_ESM.xlsx, sheet 3
View BVdb publication page



Altered Signaling Pathways Revealed by Comprehensive Genomic Profiling in Patients With Unknown Primary Tumors.

Frontiers In Oncology
Yang, Zhen Z; Cui, Wei W; Yu, Ruoying R; Dong, Xinhua X; Zhao, Jian J; Dai, Lu L; Ou, Qiuxiang Q; Bao, Hua H; Wu, Xue X; Wu, Chuanxin C; Lai, Jinhuo J
Publication Date: 2022

Variant appearance in text: BRAF: V600L
PubMed Link: 35402276
Variant Present in the following documents:
  • Main text
  • fonc-12-753311.pdf
View BVdb publication page



Targeted Therapy for Melanomas Without BRAF V600 Mutations.

Current Treatment Options In Oncology
Menzer, Christian C; Hassel, Jessica C JC
Publication Date: 2022-06

Variant appearance in text: BRAF: V600L
PubMed Link: 35380338
Variant Present in the following documents:
  • Main text
  • 11864_2022_Article_946.pdf
View BVdb publication page



Systematic review and meta-analysis of genomic alterations in acral melanoma.

Pigment Cell & Melanoma Research
Broit, Natasa N; Johansson, Peter A PA; Rodgers, Chloe B CB; Walpole, Sebastian T ST; Hayward, Nicholas K NK; Pritchard, Antonia L AL
Publication Date: 2022-05

Variant appearance in text: BRAF: V600L
PubMed Link: 35229492
Variant Present in the following documents:
  • PCMR-35-369-s002.pdf
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: BRAF: V600L
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Orthogonal MET analysis in a population-representative stage II-III colon cancer cohort: prognostic and potential therapeutic implications.

Molecular Oncology
Craig, Stephanie G SG; Mende, Svenja S; Humphries, Matthew P MP; Bingham, Victoria V; Viratham Pulsawatdi, Amélie A; Loughrey, Maurice B MB; Coleman, Helen G HG; McQuaid, Stephen S; Wilson, Richard H RH; Van Schaeybroeck, Sandra S; James, Jacqueline A JA; Salto-Tellez, Manuel M
Publication Date: 2021-12

Variant appearance in text: BRAF: V600L
PubMed Link: 34428346
Variant Present in the following documents:
  • Main text
  • MOL2-15-3317.pdf
View BVdb publication page



Orthogonal MET analysis in a population-representative stage II-III colon cancer cohort: prognostic and potential therapeutic implications.

Molecular Oncology
Craig, Stephanie G SG; Mende, Svenja S; Humphries, Matthew P MP; Bingham, Victoria V; Viratham Pulsawatdi, Amélie A; Loughrey, Maurice B MB; Coleman, Helen G HG; McQuaid, Stephen S; Wilson, Richard H RH; Van Schaeybroeck, Sandra S; James, Jacqueline A JA; Salto-Tellez, Manuel M
Publication Date: 2021-12

Variant appearance in text: BRAF: V600L
PubMed Link: 34428346
Variant Present in the following documents:
  • Main text
  • MOL2-15-3317.pdf
View BVdb publication page



The tumor genetics of acral melanoma: What should a dermatologist know?

Jaad International
Tod, Bianca M BM; Schneider, Johann W JW; Bowcock, Anne M AM; Visser, Willem I WI; Kotze, Maritha J MJ
Publication Date: 2020-12

Variant appearance in text: BRAF: V600L
PubMed Link: 34355205
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer
Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA
Publication Date: 2021-05

Variant appearance in text: BRAF: 1798G>T; V600L
PubMed Link: 33704917
Variant Present in the following documents:
  • TCA-12-1271-s003.xls, sheet 1
View BVdb publication page



Precision Approaches in the Management of Colorectal Cancer: Current Evidence and Latest Advancements Towards Individualizing the Treatment.

Cancers
Shuford, Rebecca A RA; Cairns, Ashley L AL; Moaven, Omeed O
Publication Date: 2020-11-23

Variant appearance in text: BRAF: V600L
PubMed Link: 33238500
Variant Present in the following documents:
  • Main text
  • cancers-12-03481.pdf
View BVdb publication page



Integrated molecular drivers coordinate biological and clinical states in melanoma.

Nature Genetics
Conway, Jake R JR; Dietlein, Felix F; Taylor-Weiner, Amaro A; AlDubayan, Saud S; Vokes, Natalie N; Keenan, Tanya T; Reardon, Brendan B; He, Meng Xiao MX; Margolis, Claire A CA; Weirather, Jason L JL; Haq, Rizwan R; Schilling, Bastian B; Stephen Hodi, F F; Schadendorf, Dirk D; Liu, David D; Van Allen, Eliezer M EM
Publication Date: 2020-12

Variant appearance in text: rs121913378
PubMed Link: 33230298
Variant Present in the following documents:
  • NIHMS1637640-supplement-SuppData1.xlsx, sheet 1
View BVdb publication page



Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports
Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O
Publication Date: 2020-10-13

Variant appearance in text: rs121913378
PubMed Link: 33051506
Variant Present in the following documents:
  • 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



The relationships between systemic cytokine profiles and inflammatory markers in colorectal cancer and the prognostic significance of these parameters.

British Journal Of Cancer
Park, Ji Won JW; Chang, Hee Jin HJ; Yeo, Hyun Yang HY; Han, Nayoung N; Kim, Byung Chang BC; Kong, Sun-Young SY; Kim, Jeongseon J; Oh, Jae Hwan JH
Publication Date: 2020-08

Variant appearance in text: BRAF: V600L
PubMed Link: 32488137
Variant Present in the following documents:
  • 41416_2020_924_MOESM1_ESM.pdf
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: BRAF: V600L
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



The association between BRAF mutation class and clinical features in BRAF-mutant Chinese non-small cell lung cancer patients.

Journal Of Translational Medicine
Lin, Quan Q; Zhang, Haoran H; Ding, Huaxin H; Qian, Jun J; Lizaso, Analyn A; Lin, Jing J; Han-Zhang, Han H; Xiang, Jianxing J; Li, Yuping Y; Zhu, Hong H
Publication Date: 2019-08-30

Variant appearance in text: BRAF: V600L
PubMed Link: 31470866
Variant Present in the following documents:
  • Main text
  • 12967_2019_Article_2036.pdf
View BVdb publication page



Mutational concordance between primary and metastatic melanoma: a next-generation sequencing approach.

Journal Of Translational Medicine
Manca, Antonella A; Paliogiannis, Panagiotis P; Colombino, Maria M; Casula, Milena M; Lissia, Amelia A; Botti, Gerardo G; Caracò, Corrado C; Ascierto, Paolo A PA; Sini, Maria Cristina MC; Palomba, Grazia G; Pisano, Marina M; , ; , ; Doneddu, Valentina V; Cossu, Antonio A; Palmieri, Giuseppe G; ,
Publication Date: 2019-08-28

Variant appearance in text: rs121913378
PubMed Link: 31455347
Variant Present in the following documents:
  • 12967_2019_2039_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



Atypical BRAF and NRAS Mutations in Mucosal Melanoma.

Cancers
Dumaz, Nicolas N; Jouenne, Fanélie F; Delyon, Julie J; Mourah, Samia S; Bensussan, Armand A; Lebbé, Céleste C
Publication Date: 2019-08-08

Variant appearance in text: BRAF: V600L
PubMed Link: 31398831
Variant Present in the following documents:
  • cancers-11-01133.pdf
View BVdb publication page



RAS Mutation in Mucinous Carcinoma of the Ovary

Asian Pacific Journal Of Cancer Prevention : Apjcp
Panyavaranant, Pinyada P; Teerapakpinyo, Chinachote C; Pohthipornthawat, Natkrita N; Oranratanaphan, Shina S; Shuangshoti, Shanop S; Triratanachat, Surang S
Publication Date: 2019-04-29

Variant appearance in text: BRAF: V600L
PubMed Link: 31030485
Variant Present in the following documents:
  • Main text
  • APJCP-20-1127.pdf
View BVdb publication page



Distinct Molecular Profiles and Immunotherapy Treatment Outcomes of V600E and V600K BRAF-Mutant Melanoma.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Pires da Silva, Inês I; Wang, Kevin Y X KYX; Wilmott, James S JS; Holst, Jeff J; Carlino, Matteo S MS; Park, John J JJ; Quek, Camelia C; Wongchenko, Matthew M; Yan, Yibing Y; Mann, Graham G; Johnson, Douglas B DB; McQuade, Jennifer L JL; Rai, Rajat R; Kefford, Richard F RF; Rizos, Helen H; Scolyer, Richard A RA; Yang, Jean Y H JYH; Long, Georgina V GV; Menzies, Alexander M AM
Publication Date: 2019-02-15

Variant appearance in text: BRAF: V600L
PubMed Link: 30630828
Variant Present in the following documents:
  • Main text
View BVdb publication page



Fibroblast growth factor receptor 3 (FGFR3) aberrations in muscle-invasive urothelial carcinoma.

Bmc Urology
Kim, Young Saing YS; Kim, Kyung K; Kwon, Ghee-Young GY; Lee, Su Jin SJ; Park, Se Hoon SH
Publication Date: 2018-07-31

Variant appearance in text: BRAF: 1798G>T; V600L
PubMed Link: 30064409
Variant Present in the following documents:
  • 12894_2018_380_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



KIT, NRAS, BRAF and FMNL2 mutations in oral mucosal melanoma and a systematic review of the literature.

Oncology Letters
Chen, Feng F; Zhang, Qian Q; Wang, Yanjin Y; Wang, Siwen S; Feng, Shawein S; Qi, Liyuan L; Li, Xuefen X; Ding, Chong C
Publication Date: 2018-06

Variant appearance in text: BRAF: V600L
PubMed Link: 29805686
Variant Present in the following documents:
  • Main text
  • ol-15-06-9786.pdf
View BVdb publication page



Feasibility study of cancer genome alterations identified by next generation sequencing: ABC study.

Japanese Journal Of Clinical Oncology
Naito, Yoichi Y; Takahashi, Hideaki H; Shitara, Kohei K; Okamoto, Wataru W; Bando, Hideaki H; Kuwata, Takeshi T; Kuboki, Yasutoshi Y; Matsumoto, Shingo S; Miki, Izumi I; Yamanaka, Takeharu T; Watanabe, Atsushi A; Kojima, Motohiro M
Publication Date: 2018-06-01

Variant appearance in text: BRAF: 1798G>T; V600L
PubMed Link: 29659903
Variant Present in the following documents:
  • hyy052supplementaltable1ionver1.xls, sheet 1
View BVdb publication page



Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer.

Oncotarget
Dunne, Philip D PD; Coleman, Helen G HG; Bankhead, Peter P; Alderdice, Matthew M; Gray, Ronan T RT; McQuaid, Stephen S; Bingham, Victoria V; Loughrey, Maurice B MB; James, Jacqueline A JA; McCorry, Amy M B AMB; Gilmore, Alan A; Holohan, Caitriona C; Klingbiel, Dirk D; Tejpar, Sabine S; Johnston, Patrick G PG; McArt, Darragh G DG; Di Nicolantonio, Federica F; Longley, Daniel B DB; Lawler, Mark M
Publication Date: 2018-03-02

Variant appearance in text: BRAF: V600L
PubMed Link: 29568398
Variant Present in the following documents:
  • Main text
  • oncotarget-09-13834.pdf
View BVdb publication page



Bystro: rapid online variant annotation and natural-language filtering at whole-genome scale.

Genome Biology
Kotlar, Alex V AV; Trevino, Cristina E CE; Zwick, Michael E ME; Cutler, David J DJ; Wingo, Thomas S TS
Publication Date: 2018-02-06

Variant appearance in text: rs121913378
PubMed Link: 29409527
Variant Present in the following documents:
  • 13059_2018_1387_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



Molecular Characterization of Urothelial Carcinoma of the Bladder and Upper Urinary Tract.

Translational Oncology
Lee, Ji Yun JY; Kim, Kyung K; Sung, Hyun Hwan HH; Jeon, Hwang Gyun HG; Jeong, Byong Chang BC; Seo, Seong Il SI; Jeon, Seong Soo SS; Lee, Hyun Moo HM; Choi, Han-Yong HY; Kwon, Ghee-Young GY; Kim, Kyoung-Mee KM; Lee, Jeeyun J; Lim, Ho Yeong HY; Park, Se Hoon SH
Publication Date: 2018-02

Variant appearance in text: BRAF: 1798G>T; V600L
PubMed Link: 29161613
Variant Present in the following documents:
  • mmc1.xlsx, sheet 1
View BVdb publication page



Characterizing temporal genomic heterogeneity in pediatric high-grade gliomas.

Acta Neuropathologica Communications
Salloum, Ralph R; McConechy, Melissa K MK; Mikael, Leonie G LG; Fuller, Christine C; Drissi, Rachid R; DeWire, Mariko M; Nikbakht, Hamid H; De Jay, Nicolas N; Yang, Xiaodan X; Boue, Daniel D; Chow, Lionel M L LML; Finlay, Jonathan L JL; Gayden, Tenzin T; Karamchandani, Jason J; Hummel, Trent R TR; Olshefski, Randal R; Osorio, Diana S DS; Stevenson, Charles C; Kleinman, Claudia L CL; Majewski, Jacek J; Fouladi, Maryam M; Jabado, Nada N
Publication Date: 2017-10-30

Variant appearance in text: BRAF: V600L
PubMed Link: 29084603
Variant Present in the following documents:
  • 40478_2017_479_MOESM2_ESM.xlsx, sheet 12
  • 40478_2017_479_MOESM2_ESM.xlsx, sheet 13
View BVdb publication page



Intracardiac Metastases Detected by 18F-FSPG PET/CT.

Clinical Nuclear Medicine
Magarik, Meaghan A MA; Walker, Ronald C RC; Gilbert, Jill J; Manning, H Charles HC; Massion, Pierre P PP
Publication Date: 2018-01

Variant appearance in text: BRAF: V600L
PubMed Link: 29076915
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mutation of NRAS is a rare genetic event in ovarian low-grade serous carcinoma.

Human Pathology
Xing, Deyin D; Suryo Rahmanto, Yohan Y; Zeppernick, Felix F; Hannibal, Charlotte G CG; Kjaer, Susanne K SK; Vang, Russell R; Shih, Ie-Ming IM; Wang, Tian-Li TL
Publication Date: 2017-10

Variant appearance in text: BRAF: V600L
PubMed Link: 28873354
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular profiling of signet ring cell colorectal cancer provides a strong rationale for genomic targeted and immune checkpoint inhibitor therapies.

British Journal Of Cancer
Alvi, Muhammad A MA; Loughrey, Maurice B MB; Dunne, Philip P; McQuaid, Stephen S; Turkington, Richard R; Fuchs, Marc-Aurel MA; McGready, Claire C; Bingham, Victoria V; Pang, Brendan B; Moore, Wendy W; Maxwell, Perry P; Lawler, Mark M; James, Jacqueline A JA; Murray, Graeme I GI; Wilson, Richard H RH; Salto-Tellez, Manuel M
Publication Date: 2017-07-11

Variant appearance in text: rs121913378
PubMed Link: 28595259
Variant Present in the following documents:
  • bjc2017168x11.xlsx, sheet 1
View BVdb publication page



Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications
Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2017-05-11

Variant appearance in text: BRAF: V600L; rs121913378
PubMed Link: 28492226
Variant Present in the following documents:
  • ncomms15086-s3.xlsx, sheet 1
View BVdb publication page



Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research
Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U
Publication Date: 2017-04

Variant appearance in text: BRAF: 1798G>T; V600L
PubMed Link: 28179366
Variant Present in the following documents:
  • supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1
View BVdb publication page



Targeted Next Generation Sequencing as a Reliable Diagnostic Assay for the Detection of Somatic Mutations in Tumours Using Minimal DNA Amounts from Formalin Fixed Paraffin Embedded Material.

Plos One
de Leng, Wendy W J WW; Gadellaa-van Hooijdonk, Christa G CG; Barendregt-Smouter, Françoise A S FA; Koudijs, Marco J MJ; Nijman, Ies I; Hinrichs, John W J JW; Cuppen, Edwin E; van Lieshout, Stef S; Loberg, Robert D RD; de Jonge, Maja M; Voest, Emile E EE; de Weger, Roel A RA; Steeghs, Neeltje N; Langenberg, Marlies H G MH; Sleijfer, Stefan S; Willems, Stefan M SM; Lolkema, Martijn P MP
Publication Date: 2016

Variant appearance in text: BRAF: V600L
PubMed Link: 26919633
Variant Present in the following documents:
  • pone.0149405.s010.xlsx, sheet 2
View BVdb publication page



Overexpression of wildtype EGFR is tumorigenic and denotes a therapeutic target in non-small cell lung cancer.

Oncotarget
Xu, Naiqing N; Fang, Wenfeng W; Mu, Libing L; Tang, Yanna Y; Gao, Lei L; Ren, Shengxiang S; Cao, Dengfeng D; Zhou, Lixin L; Zhang, Aiqun A; Liu, Deruo D; Zhou, Caicun C; Wong, Kwok-Kin KK; Yu, Lei L; Zhang, Li L; Chen, Liang L
Publication Date: 2016-01-26

Variant appearance in text: BRAF: V600L
PubMed Link: 26646697
Variant Present in the following documents:
  • oncotarget-07-3884-s001.pdf
View BVdb publication page



Mutational profiling of brain metastasis from breast cancer: matched pair analysis of targeted sequencing between brain metastasis and primary breast cancer.

Oncotarget
Lee, Ji Yun JY; Park, Kyunghee K; Lim, Sung Hee SH; Kim, Hae Su HS; Yoo, Kwai Han KH; Jung, Ki Sun KS; Song, Haa-Na HN; Hong, Mineui M; Do, In-Gu IG; Ahn, TaeJin T; Lee, Se Kyung SK; Bae, Soo Youn SY; Kim, Seok Won SW; Lee, Jeong Eon JE; Nam, Seok Jin SJ; Kim, Duk-Hwan DH; Jung, Hae Hyun HH; Kim, Ji-Yeon JY; Ahn, Jin Seok JS; Im, Young-Hyuck YH; Park, Yeon Hee YH
Publication Date: 2015-12-22

Variant appearance in text: BRAF: 1798G>T; V600L
PubMed Link: 26527317
Variant Present in the following documents:
  • oncotarget-06-43731-s002.xlsx, sheet 1
View BVdb publication page



Recurrent inactivating RASA2 mutations in melanoma.

Nature Genetics
Arafeh, Rand R; Qutob, Nouar N; Emmanuel, Rafi R; Keren-Paz, Alona A; Madore, Jason J; Elkahloun, Abdel A; Wilmott, James S JS; Gartner, Jared J JJ; Di Pizio, Antonella A; Winograd-Katz, Sabina S; Sindiri, Sivasish S; Rotkopf, Ron R; Dutton-Regester, Ken K; Johansson, Peter P; Pritchard, Antonia L AL; Waddell, Nicola N; Hill, Victoria K VK; Lin, Jimmy C JC; Hevroni, Yael Y; Rosenberg, Steven A SA; Khan, Javed J; Ben-Dor, Shifra S; Niv, Masha Y MY; Ulitsky, Igor I; Mann, Graham J GJ; Scolyer, Richard A RA; Hayward, Nicholas K NK; Samuels, Yardena Y
Publication Date: 2015-12

Variant appearance in text: BRAF: V600L; rs121913378
PubMed Link: 26502337
Variant Present in the following documents:
  • NIHMS65345-supplement-Supplementary_table_3.xlsx, sheet 1
  • NIHMS65345-supplement-Supplementary_table_3.xlsx, sheet 2
View BVdb publication page



Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Cell
Creixell, Pau P; Schoof, Erwin M EM; Simpson, Craig D CD; Longden, James J; Miller, Chad J CJ; Lou, Hua Jane HJ; Perryman, Lara L; Cox, Thomas R TR; Zivanovic, Nevena N; Palmeri, Antonio A; Wesolowska-Andersen, Agata A; Helmer-Citterich, Manuela M; Ferkinghoff-Borg, Jesper J; Itamochi, Hiroaki H; Bodenmiller, Bernd B; Erler, Janine T JT; Turk, Benjamin E BE; Linding, Rune R
Publication Date: 2015-09-24

Variant appearance in text: BRAF: V600L
PubMed Link: 26388441
Variant Present in the following documents:
  • mmc4.xlsx, sheet 1
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Patient-derived cell models as preclinical tools for genome-directed targeted therapy.

Oncotarget
Lee, Ji Yun JY; Kim, Sun Young SY; Park, Charny C; Kim, Nayoung K D NK; Jang, Jiryeon J; Park, Kyunghee K; Yi, Jun Ho JH; Hong, Mineui M; Ahn, Taejin T; Rath, Oliver O; Schueler, Julia J; Kim, Seung Tae ST; Do, In-Gu IG; Lee, Sujin S; Park, Se Hoon SH; Ji, Yong Ick YI; Kim, Dukwhan D; Park, Joon Oh JO; Park, Young Suk YS; Kang, Won Ki WK; Kim, Kyoung-Mee KM; Park, Woong-Yang WY; Lim, Ho Yeong HY; Lee, Jeeyun J
Publication Date: 2015-09-22

Variant appearance in text: BRAF: 1798G>T; V600L
PubMed Link: 26296973
Variant Present in the following documents:
  • oncotarget-06-25619-s003.xls, sheet 1
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The Clinicopathological Features of BRAF Mutated Papillary Thyroid Cancers in Chinese Patients.

International Journal Of Endocrinology
Yang, Li-Bo LB; Sun, Lin-Yong LY; Jiang, Yong Y; Tang, Ying Y; Li, Zhi-Hui ZH; Zhang, Hong-Ying HY; Bu, Hong H; Ye, Feng F
Publication Date: 2015

Variant appearance in text: BRAF: V600L
PubMed Link: 26273300
Variant Present in the following documents:
  • Main text
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Detection of KRAS, NRAS and BRAF by mass spectrometry - a sensitive, reliable, fast and cost-effective technique.

Diagnostic Pathology
Kriegsmann, Mark M; Arens, Norbert N; Endris, Volker V; Weichert, Wilko W; Kriegsmann, Jörg J
Publication Date: 2015-07-30

Variant appearance in text: BRAF: V600L
PubMed Link: 26220423
Variant Present in the following documents:
  • Main text
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Molecular characterization of patients with pathologic complete response or early failure after neoadjuvant chemotherapy for locally advanced breast cancer using next generation sequencing and nCounter assay.

Oncotarget
Park, Kyunghee K; Choi, Moon Ki MK; Jung, Hae Hyun HH; Do, In-Gu IG; Lee, Kwang Hee KH; Ahn, TaeJin T; Kil, Won Ho WH; Kim, Seok Won SW; Lee, Jeong Eon JE; Nam, Seok Jin SJ; Kim, Duk-Hwan DH; Ahn, Jin Seok JS; Im, Young-Hyuck YH; Park, Yeon Hee YH
Publication Date: 2015-09-15

Variant appearance in text: BRAF: 1798G>T; V600L
PubMed Link: 26009992
Variant Present in the following documents:
  • oncotarget-06-24499-s002.xlsx, sheet 1
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Extended RAS and BRAF Mutation Analysis Using Next-Generation Sequencing.

Plos One
Sakai, Kazuko K; Tsurutani, Junji J; Yamanaka, Takeharu T; Yoneshige, Azusa A; Ito, Akihiko A; Togashi, Yosuke Y; De Velasco, Marco A MA; Terashima, Masato M; Fujita, Yoshihiko Y; Tomida, Shuta S; Tamura, Takao T; Nakagawa, Kazuhiko K; Nishio, Kazuto K
Publication Date: 2015

Variant appearance in text: BRAF: 1798G>T
PubMed Link: 25954997
Variant Present in the following documents:
  • Main text
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BRAF and RAS mutations as prognostic factors in metastatic colorectal cancer patients undergoing liver resection.

British Journal Of Cancer
Schirripa, M M; Bergamo, F F; Cremolini, C C; Casagrande, M M; Lonardi, S S; Aprile, G G; Yang, D D; Marmorino, F F; Pasquini, G G; Sensi, E E; Lupi, C C; De Maglio, G G; Borrelli, N N; Pizzolitto, S S; Fasola, G G; Bertorelle, R R; Rugge, M M; Fontanini, G G; Zagonel, V V; Loupakis, F F; Falcone, A A
Publication Date: 2015-06-09

Variant appearance in text: BRAF: V600L
PubMed Link: 25942399
Variant Present in the following documents:
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High-throughput sequencing and copy number variation detection using formalin fixed embedded tissue in metastatic gastric cancer.

Plos One
Kim, Seokhwi S; Lee, Jeeyun J; Hong, Min Eui ME; Do, In-Gu IG; Kang, So Young SY; Ha, Sang Yun SY; Kim, Seung Tae ST; Park, Se Hoon SH; Kang, Won Ki WK; Choi, Min-Gew MG; Lee, Jun Ho JH; Sohn, Tae Sung TS; Bae, Jae Moon JM; Kim, Sung S; Kim, Duk-Hwan DH; Kim, Kyoung-Mee KM
Publication Date: 2014

Variant appearance in text: BRAF: 1798G>T; V600L
PubMed Link: 25372287
Variant Present in the following documents:
  • pone.0111693.s003.xls, sheet 1
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Absence of 19 known hotspot oncogenic mutations in soft tissue clear cell sarcoma: two cases report with review of the literature.

International Journal Of Clinical And Experimental Pathology
Liu, Chunxia C; Ren, Yan Y; Li, Xiaoying X; Cao, Yuwen Y; Chen, Yunzhao Y; Cui, Xiaobin X; Li, Li L; Li, Feng F
Publication Date: 2014

Variant appearance in text: BRAF: V600L
PubMed Link: 25197404
Variant Present in the following documents:
  • Main text
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Prospective enterprise-level molecular genotyping of a cohort of cancer patients.

The Journal Of Molecular Diagnostics : Jmd
MacConaill, Laura E LE; Garcia, Elizabeth E; Shivdasani, Priyanka P; Ducar, Matthew M; Adusumilli, Ravali R; Breneiser, Marc M; Byrne, Mark M; Chung, Lawrence L; Conneely, Jodie J; Crosby, Lauren L; Garraway, Levi A LA; Gong, Xin X; Hahn, William C WC; Hatton, Charlie C; Kantoff, Philip W PW; Kluk, Michael M; Kuo, Frank F; Jia, Yonghui Y; Joshi, Ruchi R; Longtine, Janina J; Manning, Allison A; Palescandolo, Emanuele E; Sharaf, Nematullah N; Sholl, Lynette L; van Hummelen, Paul P; Wade, Jacqueline J; Wollinson, Bruce M BM; Zepf, Dimity D; Rollins, Barrett J BJ; Lindeman, Neal I NI
Publication Date: 2014-11

Variant appearance in text: BRAF: V600L
PubMed Link: 25157968
Variant Present in the following documents:
  • Main text
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Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine.

Nature Medicine
Van Allen, Eliezer M EM; Wagle, Nikhil N; Stojanov, Petar P; Perrin, Danielle L DL; Cibulskis, Kristian K; Marlow, Sara S; Jane-Valbuena, Judit J; Friedrich, Dennis C DC; Kryukov, Gregory G; Carter, Scott L SL; McKenna, Aaron A; Sivachenko, Andrey A; Rosenberg, Mara M; Kiezun, Adam A; Voet, Douglas D; Lawrence, Michael M; Lichtenstein, Lee T LT; Gentry, Jeff G JG; Huang, Franklin W FW; Fostel, Jennifer J; Farlow, Deborah D; Barbie, David D; Gandhi, Leena L; Lander, Eric S ES; Gray, Stacy W SW; Joffe, Steven S; Janne, Pasi P; Garber, Judy J; MacConaill, Laura L; Lindeman, Neal N; Rollins, Barrett B; Kantoff, Philip P; Fisher, Sheila A SA; Gabriel, Stacey S; Getz, Gad G; Garraway, Levi A LA
Publication Date: 2014-06

Variant appearance in text: BRAF: V600L
PubMed Link: 24836576
Variant Present in the following documents:
  • NIHMS531666-supplement-10.xlsx, sheet 1
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Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations.

Molecular Systems Biology
Kiel, Christina C; Serrano, Luis L
Publication Date: 2014-05-06

Variant appearance in text: BRAF: V600L
PubMed Link: 24803665
Variant Present in the following documents:
  • MSB-10-5-727-s13.xls, sheet 1
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Oncogene mutational profile in nasopharyngeal carcinoma.

Oncotargets And Therapy
Zhang, Zi-Chen ZC; Fu, Sha S; Wang, Fang F; Wang, Hai-Yun HY; Zeng, Yi-Xin YX; Shao, Jian-Yong JY
Publication Date: 2014

Variant appearance in text: BRAF: V600L
PubMed Link: 24672248
Variant Present in the following documents:
  • Main text
  • ott-7-457.pdf
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Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas.

Nature Genetics
Brastianos, Priscilla K PK; Taylor-Weiner, Amaro A; Manley, Peter E PE; Jones, Robert T RT; Dias-Santagata, Dora D; Thorner, Aaron R AR; Lawrence, Michael S MS; Rodriguez, Fausto J FJ; Bernardo, Lindsay A LA; Schubert, Laura L; Sunkavalli, Ashwini A; Shillingford, Nick N; Calicchio, Monica L ML; Lidov, Hart G W HG; Taha, Hala H; Martinez-Lage, Maria M; Santi, Mariarita M; Storm, Phillip B PB; Lee, John Y K JY; Palmer, James N JN; Adappa, Nithin D ND; Scott, R Michael RM; Dunn, Ian F IF; Laws, Edward R ER; Stewart, Chip C; Ligon, Keith L KL; Hoang, Mai P MP; Van Hummelen, Paul P; Hahn, William C WC; Louis, David N DN; Resnick, Adam C AC; Kieran, Mark W MW; Getz, Gad G; Santagata, Sandro S
Publication Date: 2014-02

Variant appearance in text: BRAF: V600L
PubMed Link: 24413733
Variant Present in the following documents:
  • NIHMS547859-supplement-1.xlsx, sheet 3
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Clinical, pathologic, and biologic features associated with BRAF mutations in non-small cell lung cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Cardarella, Stephanie S; Ogino, Atsuko A; Nishino, Mizuki M; Butaney, Mohit M; Shen, Jeanne J; Lydon, Christine C; Yeap, Beow Y BY; Sholl, Lynette M LM; Johnson, Bruce E BE; Jänne, Pasi A PA
Publication Date: 2013-08-15

Variant appearance in text: BRAF: V600L
PubMed Link: 23833300
Variant Present in the following documents:
  • Main text
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Assessment of computational methods for predicting the effects of missense mutations in human cancers.

Bmc Genomics
Gnad, Florian F; Baucom, Albion A; Mukhyala, Kiran K; Manning, Gerard G; Zhang, Zemin Z
Publication Date: 2013

Variant appearance in text: BRAF: V600L
PubMed Link: 23819521
Variant Present in the following documents:
  • 1471-2164-14-S3-S7-S1.xlsx, sheet 1
  • 1471-2164-14-S3-S7-S1.xlsx, sheet 2
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Network quantification of EGFR signaling unveils potential for targeted combination therapy.

Molecular Systems Biology
Klinger, Bertram B; Sieber, Anja A; Fritsche-Guenther, Raphaela R; Witzel, Franziska F; Berry, Leanne L; Schumacher, Dirk D; Yan, Yibing Y; Durek, Pawel P; Merchant, Mark M; Schäfer, Reinhold R; Sers, Christine C; Blüthgen, Nils N
Publication Date: 2013

Variant appearance in text: rs121913378
PubMed Link: 23752269
Variant Present in the following documents:
  • msb201329-s3.xls, sheet 1
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Loss of expression and promoter methylation of SLIT2 are associated with sessile serrated adenoma formation.

Plos Genetics
Beggs, Andrew D AD; Jones, Angela A; Shepherd, Neil N; Arnaout, Abed A; Finlayson, Caroline C; Abulafi, A Muti AM; Morton, Dion G DG; Matthews, Glenn M GM; Hodgson, Shirley V SV; Tomlinson, Ian P M IP
Publication Date: 2013-05

Variant appearance in text: BRAF: V600L
PubMed Link: 23671423
Variant Present in the following documents:
  • Main text
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Automated universal BRAF state detection within the activation segment in skin metastases by pyrosequencing-based assay U-BRAF(V600).

Plos One
Skorokhod, Alexander A; Helmbold, Peter P; Brors, Benedikt B; Schirmacher, Peter P; Enk, Alexander A; Penzel, Roland R
Publication Date: 2013

Variant appearance in text: BRAF: V600L
PubMed Link: 23555633
Variant Present in the following documents:
  • Main text
  • pone.0059221.s002.pdf
  • pone.0059221.pdf
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Genotyping and genomic profiling of non-small-cell lung cancer: implications for current and future therapies.

Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology
Li, Tianhong T; Kung, Hsing-Jien HJ; Mack, Philip C PC; Gandara, David R DR
Publication Date: 2013-03-10

Variant appearance in text: BRAF: V600L
PubMed Link: 23401433
Variant Present in the following documents:
  • Main text
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KRAS, BRAF and PIK3CA mutations and the loss of PTEN expression in Chinese patients with colorectal cancer.

Plos One
Mao, Chen C; Zhou, Junhua J; Yang, Zuyao Z; Huang, Yafang Y; Wu, Xinyin X; Shen, Hong H; Tang, Jinling J; Chen, Qing Q
Publication Date: 2012

Variant appearance in text: BRAF: V600L
PubMed Link: 22586484
Variant Present in the following documents:
  • Main text
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Oncogene Mutation Survey in MPNST Cell Lines Enhances the Dominant Role of Hyperactive Ras in NF1 Associated Pro-Survival and Malignancy.

Translational Oncogenomics
Sun, Daochun D; Tainsky, Michael A MA; Haddad, Ramsi R
Publication Date: 2012

Variant appearance in text: BRAF: V600L
PubMed Link: 22346343
Variant Present in the following documents:
  • Main text
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Fresh surgical specimens yield breast stem/progenitor cells and reveal their oncogenic abnormalities.

Annals Of Surgical Oncology
Pommier, Suellen J SJ; Hernandez, Ariel A; Han, Esther E; Massimino, Kristen K; Muller, Patrick P; Diggs, Brian B; Chamberlain, Erin E; Murphy, Jennifer J; Hansen, Juliana J; Naik, Arpana A; Vetto, John J; Pommier, Rodney F RF
Publication Date: 2012-02

Variant appearance in text: BRAF: V600L
PubMed Link: 21748247
Variant Present in the following documents:
  • 10434_2011_1892_MOESM2_ESM.pdf
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