Publications:

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Recognition of BRAF by CDC37 and Re-Evaluation of the Activation Mechanism for the Class 2 BRAF-L597R Mutant.

Biomolecules

Bjorklund, Dennis M DM; Morgan, R Marc L RML; Oberoi, Jasmeen J; Day, Katie L I M KLIM; Galliou, Panagiota A PA; Prodromou, Chrisostomos C

Publication Date: 2022-06-28

Variant appearance in text: BRAF: T599E

PubMed Link: 35883461

Variant Present in the following documents:

• Main text
• biomolecules-12-00905.pdf

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BRAFV600E expression in neural progenitors results in a hyperexcitable phenotype in neocortical pyramidal neurons.

Journal Of Neurophysiology

Goz, Roman U RU; Akgül, Gülcan G; LoTurco, Joseph J JJ

Publication Date: 2020-06-01

Variant appearance in text: BRAF: T599E

PubMed Link: 32401131

Variant Present in the following documents:

• Main text

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BRaf signaling principles unveiled by large-scale human mutation analysis with a rapid lentivirus-based gene replacement method.

Genes & Development

Lim, Chae-Seok CS; Kang, Xi X; Mirabella, Vincent V; Zhang, Huaye H; Bu, Qian Q; Araki, Yoichi Y; Hoang, Elizabeth T ET; Wang, Shiqiang S; Shen, Ying Y; Choi, Sukwoo S; Kaang, Bong-Kiun BK; Chang, Qiang Q; Pang, Zhiping P ZP; Huganir, Richard L RL; Zhu, J Julius JJ

Publication Date: 2017-03-15

Variant appearance in text: BRAF: T599E

PubMed Link: 28404629

Variant Present in the following documents:

• 537.pdf

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An Integrated Model of RAF Inhibitor Action Predicts Inhibitor Activity against Oncogenic BRAF Signaling.

Cancer Cell

Karoulia, Zoi Z; Wu, Yang Y; Ahmed, Tamer A TA; Xin, Qisheng Q; Bollard, Julien J; Krepler, Clemens C; Wu, Xuewei X; Zhang, Chao C; Bollag, Gideon G; Herlyn, Meenhard M; Fagin, James A JA; Lujambio, Amaia A; Gavathiotis, Evripidis E; Poulikakos, Poulikos I PI

Publication Date: 2016-09-12

Variant appearance in text: BRAF: T599E

PubMed Link: 27523909

Variant Present in the following documents:

• Main text

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Clinical detection and categorization of uncommon and concomitant mutations involving BRAF.

Bmc Cancer

Zheng, Gang G; Tseng, Li-Hui LH; Chen, Guoli G; Haley, Lisa L; Illei, Peter P; Gocke, Christopher D CD; Eshleman, James R JR; Lin, Ming-Tseh MT

Publication Date: 2015-10-24

Variant appearance in text: BRAF: T599E

PubMed Link: 26498038

Variant Present in the following documents:

• Main text

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Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling.

Scientific Reports

An, Lei L; Jia, Wei W; Yu, Yang Y; Zou, Ning N; Liang, Li L; Zhao, Yanling Y; Fan, Yihui Y; Cheng, Jin J; Shi, Zhongcheng Z; Xu, Gufeng G; Li, Grace G; Yang, Jianhua J; Zhang, Hong H

Publication Date: 2013

Variant appearance in text: BRAF: T599E

PubMed Link: 23907581

Variant Present in the following documents:

• Main text
• srep02344.pdf

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Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors.

Human Molecular Genetics

Anastasaki, Corina C; Estep, Anne L AL; Marais, Richard R; Rauen, Katherine A KA; Patton, E Elizabeth EE

Publication Date: 2009-07-15

Variant appearance in text: BRAF: T599E

PubMed Link: 19376813

Variant Present in the following documents:

• Main text

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Differential regulation of B-raf isoforms by phosphorylation and autoinhibitory mechanisms.

Molecular And Cellular Biology

Hmitou, Isabelle I; Druillennec, Sabine S; Valluet, Agathe A; Peyssonnaux, Carole C; Eychène, Alain A

Publication Date: 2007-01

Variant appearance in text: BRAF: T599E

PubMed Link: 17074813

Variant Present in the following documents:

• Main text

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