BRAF c.1793C>T ;(p.A598V)

Variant ID: 7-140453142-G-A

NM_004333.4(BRAF):c.1793C>T;(p.A598V)

This variant was identified in 38 publications

View GRCh38 version.




Publications:


Recapitulating thyroid cancer histotypes through engineering embryonic stem cells.

Nature Communications
Veschi, Veronica V; Turdo, Alice A; Modica, Chiara C; Verona, Francesco F; Di Franco, Simone S; Gaggianesi, Miriam M; Tirrò, Elena E; Di Bella, Sebastiano S; Iacono, Melania Lo ML; Pantina, Vincenzo Davide VD; Porcelli, Gaetana G; Mangiapane, Laura Rosa LR; Bianca, Paola P; Rizzo, Aroldo A; Sciacca, Elisabetta E; Pillitteri, Irene I; Vella, Veronica V; Belfiore, Antonino A; Bongiorno, Maria Rita MR; Pistone, Giuseppe G; Memeo, Lorenzo L; Colarossi, Lorenzo L; Giuffrida, Dario D; Colarossi, Cristina C; Vigneri, Paolo P; Todaro, Matilde M; Stassi, Giorgio G
Publication Date: 2023-03-11

Variant appearance in text: BRAF: A598V
PubMed Link: 36906579
Variant Present in the following documents:
  • 41467_2023_36922_MOESM4_ESM.xls, sheet 2
View BVdb publication page



Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma.

Frontiers In Oncology
Yin, Xiang-Qian XQ; Yin, Xue-Hui XH; Yu, Ya-Qin YQ; Xu, Lang L; Zhang, Mao M
Publication Date: 2022

Variant appearance in text: BRAF: 1793C>T; A598V
PubMed Link: 35936718
Variant Present in the following documents:
  • Table_4.xlsx, sheet 2
View BVdb publication page



Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.

Nature Genetics
Kar, Siddhartha P SP; Quiros, Pedro M PM; Gu, Muxin M; Jiang, Tao T; Mitchell, Jonathan J; Langdon, Ryan R; Iyer, Vivek V; Barcena, Clea C; Vijayabaskar, M S MS; Fabre, Margarete A MA; Carter, Paul P; Petrovski, Slavé S; Burgess, Stephen S; Vassiliou, George S GS
Publication Date: 2022-08

Variant appearance in text: BRAF: A598V
PubMed Link: 35835912
Variant Present in the following documents:
  • 41588_2022_1121_MOESM3_ESM.xlsx, sheet 3
View BVdb publication page



Somatic targeted mutation profiling of colorectal cancer precursor lesions.

Bmc Medical Genomics
Dos Santos, Wellington W; Dos Reis, Mariana Bisarro MB; Porto, Jun J; de Carvalho, Ana Carolina AC; Matsushita, Marcus M; Oliveira, Gabriela G; Syrjänen, Kari K; Reis, Rui Manuel RM; Guimarães, Denise Peixoto DP
Publication Date: 2022-06-28

Variant appearance in text: BRAF: Ala598Val
PubMed Link: 35761395
Variant Present in the following documents:
  • 12920_2022_1294_MOESM5_ESM.xlsx, sheet 1
  • 12920_2022_1294_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Targeted Therapy for Melanomas Without BRAF V600 Mutations.

Current Treatment Options In Oncology
Menzer, Christian C; Hassel, Jessica C JC
Publication Date: 2022-06

Variant appearance in text: BRAF: A598V
PubMed Link: 35380338
Variant Present in the following documents:
  • Main text
  • 11864_2022_Article_946.pdf
View BVdb publication page



The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer
Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J
Publication Date: 2022-02

Variant appearance in text: BRAF: Ala598Val
PubMed Link: 35221333
Variant Present in the following documents:
  • 43018_2022_332_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: BRAF: A598V
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Distinct Somatic Alteration Features Identified by Gene Panel Sequencing in Korean Triple-Negative Breast Cancer with High Ki67 Expression.

Diagnostics (Basel, Switzerland)
Sun, Woo Young WY; Lee, Jina J; Kim, Bong Kyun BK; Kim, Jong Ok JO; Park, Joonhong J
Publication Date: 2021-03-01

Variant appearance in text: BRAF: 1793C>T; Ala598Val
PubMed Link: 33804295
Variant Present in the following documents:
  • diagnostics-11-00416-s001.pdf
View BVdb publication page



Usefulness of monitoring circulating tumor cells as a therapeutic biomarker in melanoma with BRAF mutation.

Bmc Cancer
Kiniwa, Yukiko Y; Nakamura, Kenta K; Mikoshiba, Asuka A; Ashida, Atsuko A; Akiyama, Yasuyuki Y; Morimoto, Atsushi A; Okuyama, Ryuhei R
Publication Date: 2021-03-17

Variant appearance in text: BRAF: A598V
PubMed Link: 33731038
Variant Present in the following documents:
  • Main text
  • 12885_2021_Article_8016.pdf
View BVdb publication page



Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer
Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA
Publication Date: 2021-05

Variant appearance in text: BRAF: 1793C>T; A598V
PubMed Link: 33704917
Variant Present in the following documents:
  • TCA-12-1271-s003.xls, sheet 1
View BVdb publication page



A Narrative Review of Genetic Alterations in Primary Thyroid Epithelial Cancer.

International Journal Of Molecular Sciences
Romei, Cristina C; Elisei, Rossella R
Publication Date: 2021-02-09

Variant appearance in text: BRAF: 1793C>T; A598V
PubMed Link: 33572167
Variant Present in the following documents:
  • Main text
  • ijms-22-01726.pdf
View BVdb publication page



KANK1-NTRK3 fusions define a subset of BRAF mutation negative renal metanephric adenomas.

Bmc Medical Genetics
Catic, Aida A; Kurtovic-Kozaric, Amina A; Sophian, Ardis A; Mazur, Lech L; Skenderi, Faruk F; Hes, Ondrej O; Rohan, Stephen S; Rakheja, Dinesh D; Kogan, Jillene J; Pins, Michael R MR
Publication Date: 2020-10-12

Variant appearance in text: BRAF: A598V
PubMed Link: 33046021
Variant Present in the following documents:
  • Main text
  • 12881_2020_Article_1143.pdf
View BVdb publication page



Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine
Li, Jiaping J; Jiang, Wei W; Wei, Jinwang J; Zhang, Jianwei J; Cai, Linbo L; Luo, Minjie M; Wang, Zhan Z; Sun, Wending W; Wang, Shengzhou S; Wang, Chen C; Dai, Chun C; Liu, Jun J; Wang, Guan G; Wang, Jiping J; Xu, Qiang Q; Deng, Yanhong Y
Publication Date: 2020-08-01

Variant appearance in text: BRAF: A598V
PubMed Link: 32738923
Variant Present in the following documents:
  • 12967_2020_2449_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: BRAF: A598V
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



Clinicopathologic Features of Diencephalic Neuronal and Glioneuronal Tumors.

Journal Of Neuropathology And Experimental Neurology
Ho, Cheng-Ying CY; Bornhorst, Miriam M; Almira-Suarez, M Isabel MI; Donev, Kliment K; Grafe, Marjorie M; Gordish-Dressman, Heather H; Rodriguez, Fausto J FJ
Publication Date: 2020-01-01

Variant appearance in text: BRAF: A598V
PubMed Link: 31793986
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers.

Nature Communications
Gopal, Priyanka P; Sarihan, Elif Irem EI; Chie, Eui Kyu EK; Kuzmishin, Gwendolyn G; Doken, Semihcan S; Pennell, Nathan A NA; Raymond, Daniel P DP; Murthy, Sudish C SC; Ahmad, Usman U; Raja, Siva S; Almeida, Francisco F; Sethi, Sonali S; Gildea, Thomas R TR; Peacock, Craig D CD; Adams, Drew J DJ; Abazeed, Mohamed E ME
Publication Date: 2019-11-13

Variant appearance in text: BRAF: A598V
PubMed Link: 31723142
Variant Present in the following documents:
  • 41467_2019_13161_MOESM5_ESM.xlsx, sheet 1
View BVdb publication page



Atypical BRAF and NRAS Mutations in Mucosal Melanoma.

Cancers
Dumaz, Nicolas N; Jouenne, Fanélie F; Delyon, Julie J; Mourah, Samia S; Bensussan, Armand A; Lebbé, Céleste C
Publication Date: 2019-08-08

Variant appearance in text: BRAF: A598V
PubMed Link: 31398831
Variant Present in the following documents:
  • cancers-11-01133.pdf
View BVdb publication page



Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology
Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR
Publication Date: 2019-04

Variant appearance in text: BRAF: A598V
PubMed Link: 31034466
Variant Present in the following documents:
  • pcbi.1006981.s010.xlsx, sheet 1
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: BRAF: A598V
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 1
  • pone.0196434.s001.xlsx, sheet 3
  • pone.0196434.s001.xlsx, sheet 2
View BVdb publication page



Mutations in BRAF codons 594 and 596 predict good prognosis in melanoma.

Oncology Letters
Wu, Xiaowen X; Yan, Junya J; Dai, Jie J; Ma, Meng M; Tang, Huan H; Yu, Jiayi J; Xu, Tianxiao T; Yu, Huan H; Si, Lu L; Chi, Zhihong Z; Sheng, Xinan X; Cui, Chuanliang C; Kong, Yan Y; Guo, Jun J
Publication Date: 2017-09

Variant appearance in text: BRAF: A598V
PubMed Link: 28927118
Variant Present in the following documents:
  • Main text
View BVdb publication page



Detection of BRAF, NRAS, KIT, GNAQ, GNA11 and MAP2K1/2 mutations in Russian melanoma patients using LNA PCR clamp and biochip analysis.

Oncotarget
Emelyanova, Marina M; Ghukasyan, Lilit L; Abramov, Ivan I; Ryabaya, Oxana O; Stepanova, Evgenia E; Kudryavtseva, Anna A; Sadritdinova, Asiya A; Dzhumakova, Cholpon C; Belysheva, Tatiana T; Surzhikov, Sergey S; Lyubchenko, Lyudmila L; Zasedatelev, Alexander A; Nasedkina, Tatiana T
Publication Date: 2017-08-08

Variant appearance in text: BRAF: 1793C>T; A598V
PubMed Link: 28881731
Variant Present in the following documents:
  • Main text
  • oncotarget-08-52304.pdf
View BVdb publication page



Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Nature Communications
Chen, Fengju F; Zhang, Yiqun Y; Bossé, Dominick D; Lalani, Aly-Khan A AA; Hakimi, A Ari AA; Hsieh, James J JJ; Choueiri, Toni K TK; Gibbons, Don L DL; Ittmann, Michael M; Creighton, Chad J CJ
Publication Date: 2017-08-04

Variant appearance in text: BRAF: 1793C>T; A598V
PubMed Link: 28775315
Variant Present in the following documents:
  • 41467_2017_289_MOESM7_ESM.xlsx, sheet 1
View BVdb publication page



Significant Improvement in Detecting BRAF, KRAS, and EGFR Mutations Using Next-Generation Sequencing as Compared with FDA-Cleared Kits.

Molecular Diagnosis & Therapy
Ma, Wanlong W; Brodie, Steven S; Agersborg, Sally S; Funari, Vincent A VA; Albitar, Maher M
Publication Date: 2017-10

Variant appearance in text: BRAF: 1793C>T; Ala598Val
PubMed Link: 28639239
Variant Present in the following documents:
  • Main text
  • 40291_2017_Article_290.pdf
View BVdb publication page



Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing.

Molecular Cancer
Kovaleva, Valentina V; Geissler, Anna-Lena AL; Lutz, Lisa L; Fritsch, Ralph R; Makowiec, Frank F; Wiesemann, Sebastian S; Hopt, Ulrich T UT; Passlick, Bernward B; Werner, Martin M; Lassmann, Silke S
Publication Date: 2016-10-18

Variant appearance in text: BRAF: 1793C>T; Ala598Val
PubMed Link: 27756406
Variant Present in the following documents:
  • 12943_2016_549_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



The diagnostic application of RNA sequencing in patients with thyroid cancer: an analysis of 851 variants and 133 fusions in 524 genes.

Bmc Bioinformatics
Pagan, Moraima M; Kloos, Richard T RT; Lin, Chu-Fang CF; Travers, Kevin J KJ; Matsuzaki, Hajime H; Tom, Ed Y EY; Kim, Su Yeon SY; Wong, Mei G MG; Stewart, Andrew C AC; Huang, Jing J; Walsh, P Sean PS; Monroe, Robert J RJ; Kennedy, Giulia C GC
Publication Date: 2016-01-11

Variant appearance in text: BRAF: A598V
PubMed Link: 26818556
Variant Present in the following documents:
  • 12859_2015_849_MOESM5_ESM.pdf
View BVdb publication page



Clinical detection and categorization of uncommon and concomitant mutations involving BRAF.

Bmc Cancer
Zheng, Gang G; Tseng, Li-Hui LH; Chen, Guoli G; Haley, Lisa L; Illei, Peter P; Gocke, Christopher D CD; Eshleman, James R JR; Lin, Ming-Tseh MT
Publication Date: 2015-10-24

Variant appearance in text: BRAF: A598V
PubMed Link: 26498038
Variant Present in the following documents:
  • Main text
View BVdb publication page



Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Cell
Creixell, Pau P; Schoof, Erwin M EM; Simpson, Craig D CD; Longden, James J; Miller, Chad J CJ; Lou, Hua Jane HJ; Perryman, Lara L; Cox, Thomas R TR; Zivanovic, Nevena N; Palmeri, Antonio A; Wesolowska-Andersen, Agata A; Helmer-Citterich, Manuela M; Ferkinghoff-Borg, Jesper J; Itamochi, Hiroaki H; Bodenmiller, Bernd B; Erler, Janine T JT; Turk, Benjamin E BE; Linding, Rune R
Publication Date: 2015-09-24

Variant appearance in text: BRAF: A598V
PubMed Link: 26388441
Variant Present in the following documents:
  • mmc4.xlsx, sheet 1
View BVdb publication page



Comprehensive Molecular Analysis of NSCLC; Clinicopathological Associations.

Plos One
Chatziandreou, Ilenia I; Tsioli, Panagiota P; Sakellariou, Stratigoula S; Mourkioti, Ioanna I; Giannopoulou, Ioanna I; Levidou, Georgia G; Korkolopoulou, Penelope P; Patsouris, Efstratios E; Saetta, Angelica A AA
Publication Date: 2015

Variant appearance in text: BRAF: Ala598Val
PubMed Link: 26208325
Variant Present in the following documents:
  • Main text
  • pone.0133859.pdf
View BVdb publication page



Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Publication Date: 2014-10-28

Variant appearance in text: BRAF: A598V
PubMed Link: 25348012
Variant Present in the following documents:
  • 13059_2014_484_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations.

Molecular Systems Biology
Kiel, Christina C; Serrano, Luis L
Publication Date: 2014-05-06

Variant appearance in text: BRAF: A598V
PubMed Link: 24803665
Variant Present in the following documents:
  • MSB-10-5-727-s13.xls, sheet 1
View BVdb publication page



BRAF pyrosequencing analysis aided by a lookup table.

American Journal Of Clinical Pathology
Olson, Matthew T MT; Harrington, Colleen C; Beierl, Katie K; Chen, Guoli G; Thiess, Michele M; O'Neill, Alan A; Taube, Janis M JM; Zeiger, Martha A MA; Lin, Ming-Tseh MT; Eshleman, James R JR
Publication Date: 2014-05

Variant appearance in text: BRAF: 1793C>T; A598V
PubMed Link: 24713734
Variant Present in the following documents:
  • Main text
View BVdb publication page



BRAF and NRAS mutations are heterogeneous and not mutually exclusive in nodular melanoma.

Applied Immunohistochemistry & Molecular Morphology : Aimm
Chiappetta, Caterina C; Proietti, Ilaria I; Soccodato, Valentina V; Puggioni, Chiara C; Zaralli, Roberto R; Pacini, Luca L; Porta, Natale N; Skroza, Nevena N; Petrozza, Vincenzo V; Potenza, Concetta C; Della Rocca, Carlo C; Di Cristofano, Claudio C
Publication Date: 2015-03

Variant appearance in text: BRAF: A598V
PubMed Link: 24710085
Variant Present in the following documents:
  • Main text
  • pai-23-172.pdf
View BVdb publication page



Improvement of the quality of BRAF testing in melanomas with nationwide external quality assessment, for the BRAF EQA group.

Bmc Cancer
Emile, Jean-François JF; Tisserand, Julie J; Bergougnoux, Loic L; Nowak, Frédérique F; Faucher, Gladwys G; Surel, Sylvie S; Lamy, Aude A; Lecorre, Delphine D; Helias-Rodzewicz, Zofia Z; Hofman, Paul P; Sabourin, Jean-Christophe JC; Laurent-Puig, Pierre P; ,
Publication Date: 2013-10-11

Variant appearance in text: BRAF: 1793C>T; Ala598Val
PubMed Link: 24119386
Variant Present in the following documents:
  • Main text
  • 1471-2407-13-472.pdf
View BVdb publication page



Assessment of computational methods for predicting the effects of missense mutations in human cancers.

Bmc Genomics
Gnad, Florian F; Baucom, Albion A; Mukhyala, Kiran K; Manning, Gerard G; Zhang, Zemin Z
Publication Date: 2013

Variant appearance in text: BRAF: A598V
PubMed Link: 23819521
Variant Present in the following documents:
  • 1471-2164-14-S3-S7-S1.xlsx, sheet 1
View BVdb publication page



Frequent BRAF gain in low-grade diffuse gliomas with 1p/19q loss.

Brain Pathology (Zurich, Switzerland)
Kim, Young-Ho YH; Nonoguchi, Naosuke N; Paulus, Werner W; Brokinkel, Benjamin B; Keyvani, Kathy K; Sure, Ulrich U; Wrede, Karsten K; Mariani, Luigi L; Giangaspero, Felice F; Tanaka, Yuko Y; Nakazato, Yoichi Y; Vital, Anne A; Mittelbronn, Michel M; Perry, Arie A; Ohgaki, Hiroko H
Publication Date: 2012-11

Variant appearance in text: BRAF: A598V
PubMed Link: 22568401
Variant Present in the following documents:
  • Main text
View BVdb publication page



The energy landscape analysis of cancer mutations in protein kinases.

Plos One
Dixit, Anshuman A; Verkhivker, Gennady M GM
Publication Date: 2011

Variant appearance in text: BRAF: A598V
PubMed Link: 21998754
Variant Present in the following documents:
View BVdb publication page



Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research
Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C
Publication Date: 2011-09-01

Variant appearance in text: BRAF: A598V
PubMed Link: 21727090
Variant Present in the following documents:
  • supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1
View BVdb publication page