Publications:

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Association of BRAF Variants With Disease Characteristics, Prognosis, and Targeted Therapy Response in Intrahepatic Cholangiocarcinoma.

Jama Network Open

Xin, Hao-Yang HY; Sun, Rong-Qi RQ; Zou, Ji-Xue JX; Wang, Peng-Cheng PC; Wang, Jia-Yin JY; Ye, Yu-Hang YH; Liu, Kai-Xuan KX; Hu, Zhi-Qiang ZQ; Zhou, Zheng-Jun ZJ; Fan, Jia J; Zhou, Jian J; Zhou, Shao-Lai SL

Publication Date: 2023-03-01

Variant appearance in text: BRAF: L597P

PubMed Link: 36867406

Variant Present in the following documents:

• Main text
• jamanetwopen-e231476-s001.pdf

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Mutually exclusive genetic interactions and gene essentiality shape the genomic landscape of primary melanoma.

The Journal Of Pathology

Birkeälv, Sofia S; Harland, Mark M; Matsuyama, Larissa Satiko Alcantara Sekimoto LSAS; Rashid, Mamun M; Mehta, Ishan I; Laye, Jonathan P JP; Haase, Kerstin K; Mell, Tracey T; Iyer, Vivek V; Robles-Espinoza, Carla Daniela CD; McDermott, Ultan U; van Loo, Peter P; Kuijjer, Marieke L ML; Possik, Patricia A PA; Maria Engler, Silvya Stuchi SS; Bishop, D Timothy DT; Newton-Bishop, Julia J; Adams, David J DJ

Publication Date: 2022-10-11

Variant appearance in text: BRAF: L597P

PubMed Link: 36219477

Variant Present in the following documents:

• PATH-259-56-s004.xlsx, sheet 2
• PATH-259-56-s006.xlsx, sheet 2

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Targeted Therapy for Melanomas Without BRAF V600 Mutations.

Current Treatment Options In Oncology

Menzer, Christian C; Hassel, Jessica C JC

Publication Date: 2022-06

Variant appearance in text: BRAF: L597P

PubMed Link: 35380338

Variant Present in the following documents:

• Main text
• 11864_2022_Article_946.pdf

View BVdb publication page

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UGT1A1 Polymorphism for Irinotecan Dose Escalation in Patients with BRAF-Mutated Metastatic Colorectal Cancer Treated with First-Line Bevacizumab and FOLFIRI.

Journal Of Oncology

Hsieh, Yi-Chien YC; Chang, Tsung-Kun TK; Su, Wei-Chih WC; Huang, Ching-Wen CW; Tsai, Hsiang-Lin HL; Chen, Yen-Cheng YC; Li, Ching-Chun CC; Chen, Po-Jung PJ; Yin, Tzu-Chieh TC; Ma, Cheng-Jen CJ; Wang, Jaw-Yuan JY

Publication Date: 2021

Variant appearance in text: BRAF: L597P

PubMed Link: 33777142

Variant Present in the following documents:

• Main text
• JO2021-6686517.pdf

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Molecular and Immune Biomarkers for Cutaneous Melanoma: Current Status and Future Prospects.

Cancers

Pilla, Lorenzo L; Alberti, Andrea A; Di Mauro, Pierluigi P; Gemelli, Maria M; Cogliati, Viola V; Cazzaniga, Marina Elena ME; Bidoli, Paolo P; Maccalli, Cristina C

Publication Date: 2020-11-20

Variant appearance in text: BRAF: L597P

PubMed Link: 33233603

Variant Present in the following documents:

• Main text
• cancers-12-03456.pdf

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Optimal treatment strategy for metastatic melanoma patients harboring BRAF-V600 mutations.

Therapeutic Advances In Medical Oncology

Giunta, Emilio Francesco EF; De Falco, Vincenzo V; Napolitano, Stefania S; Argenziano, Giuseppe G; Brancaccio, Gabriella G; Moscarella, Elvira E; Ciardiello, Davide D; Ciardiello, Fortunato F; Troiani, Teresa T

Publication Date: 2020

Variant appearance in text: BRAF: L597P

PubMed Link: 32612709

Variant Present in the following documents:

• Main text
• 10.1177_1758835920925219.pdf

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Tumor Location Is Associated With the Prevalence of Braf And Pik3ca Mutations in Patients with Wild-Type Ras Colorectal Cancer: A Prospective Multi-Center Cohort Study in Japan.

Translational Oncology

Taniguchi, Hiroya H; Uehara, Keisuke K; Nakayama, Goro G; Nakayama, Hiroshi H; Aiba, Toshisada T; Hattori, Norifumi N; Kataoka, Masato M; Nakano, Yasuyuki Y; Kawase, Yoshihisa Y; Okochi, Osamu O; Matsuoka, Hiroshi H; Utsunomiya, Setsuo S; Sakamoto, Eiji E; Mori, Yoshinori Y; Umeda, Shinichi S; Shikano, Toshio T; Komori, Koji K; Tajika, Masahiro M; Kadowaki, Shigenori S; Muro, Kei K; Yatabe, Yasushi Y

Publication Date: 2020-07

Variant appearance in text: BRAF: L597P

PubMed Link: 32428838

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Long-Term Outcomes in BRAF-Mutated Melanoma Treated with Combined Targeted Therapy or Immune Checkpoint Blockade: Are We Approaching a True Cure?

American Journal Of Clinical Dermatology

Schummer, Patrick P; Schilling, Bastian B; Gesierich, Anja A

Publication Date: 2020-08

Variant appearance in text: BRAF: L597P

PubMed Link: 32124332

Variant Present in the following documents:

• Main text
• 40257_2020_Article_509.pdf

View BVdb publication page

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Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm.

Oncogene

Raimondi, Francesco F; Inoue, Asuka A; Kadji, Francois M N FMN; Shuai, Ni N; Gonzalez, Juan-Carlos JC; Singh, Gurdeep G; de la Vega, Alicia Alonso AA; Sotillo, Rocio R; Fischer, Bernd B; Aoki, Junken J; Gutkind, J Silvio JS; Russell, Robert B RB

Publication Date: 2019-09

Variant appearance in text: BRAF: L597P

PubMed Link: 31337866

Variant Present in the following documents:

• 41388_2019_895_MOESM2_ESM.xlsx, sheet 8

View BVdb publication page

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Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One

Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS

Publication Date: 2018

Variant appearance in text: BRAF: L597P

PubMed Link: 29698444

Variant Present in the following documents:

• pone.0196434.s001.xlsx, sheet 2
• pone.0196434.s001.xlsx, sheet 3
• pone.0196434.s001.xlsx, sheet 1

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Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research

Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U

Publication Date: 2017-04

Variant appearance in text: BRAF: 1790T>C; L597P

PubMed Link: 28179366

Variant Present in the following documents:

• supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1

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A Landscape of Pharmacogenomic Interactions in Cancer.

Cell

Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ

Publication Date: 2016-07-28

Variant appearance in text: BRAF: 1790T>C; L597P

PubMed Link: 27397505

Variant Present in the following documents:

• mmc3.xlsx, sheet 2

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NRAS (Q61R), BRAF (V600E) immunohistochemistry: a concomitant tool for mutation screening in melanomas.

Diagnostic Pathology

Uguen, Arnaud A; Talagas, Matthieu M; Costa, Sebastian S; Samaison, Laura L; Paule, Laure L; Alavi, Zarrin Z; De Braekeleer, Marc M; Le Marechal, Cédric C; Marcorelles, Pascale P

Publication Date: 2015-07-25

Variant appearance in text: BRAF: L597P

PubMed Link: 26204954

Variant Present in the following documents:

• Main text

View BVdb publication page

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Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations.

Molecular Systems Biology

Kiel, Christina C; Serrano, Luis L

Publication Date: 2014-05-06

Variant appearance in text: BRAF: L597P

PubMed Link: 24803665

Variant Present in the following documents:

• MSB-10-5-727-s13.xls, sheet 1

View BVdb publication page

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Correlation of somatic mutations and clinical outcome in melanoma patients treated with Carboplatin, Paclitaxel, and sorafenib.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Wilson, Melissa A MA; Zhao, Fengmin F; Letrero, Richard R; D'Andrea, Kurt K; Rimm, David L DL; Kirkwood, John M JM; Kluger, Harriet M HM; Lee, Sandra J SJ; Schuchter, Lynn M LM; Flaherty, Keith T KT; Nathanson, Katherine L KL

Publication Date: 2014-06-15

Variant appearance in text: BRAF: L597P

PubMed Link: 24714776

Variant Present in the following documents:

• Main text

View BVdb publication page

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