Efficacy and clinicogenomic correlates of response to immune checkpoint inhibitors alone or with chemotherapy in non-small cell lung cancer.
Nature Communications
Hong, Lingzhi L; Aminu, Muhammad M; Li, Shenduo S; Lu, Xuetao X; Petranovic, Milena M; Saad, Maliazurina B MB; Chen, Pingjun P; Qin, Kang K; Varghese, Susan S; Rinsurongkawong, Waree W; Rinsurongkawong, Vadeerat V; Spelman, Amy A; Elamin, Yasir Y YY; Negrao, Marcelo V MV; Skoulidis, Ferdinandos F; Gay, Carl M CM; Cascone, Tina T; Gandhi, Saumil J SJ; Lin, Steven H SH; Lee, Percy P PP; Carter, Brett W BW; Wu, Carol C CC; Antonoff, Mara B MB; Sepesi, Boris B; Lewis, Jeff J; Gibbons, Don L DL; Vaporciyan, Ara A AA; Le, Xiuning X; Jack Lee, J J; Roy-Chowdhuri, Sinchita S; Routbort, Mark J MJ; Gainor, Justin F JF; Heymach, John V JV; Lou, Yanyan Y; Wu, Jia J; Zhang, Jianjun J; Vokes, Natalie I NI
Prevalence of Molecular Alterations in a Swiss Cohort of 512 Colorectal Carcinoma Patients by Targeted Next-Generation Sequencing Analysis in Routine Diagnostics.
Pathobiology : Journal Of Immunopathology, Molecular And Cellular Biology
Haefliger, Simon S; Marston, Katharina K; Alborelli, Ilaria I; Stauffer, Edouard-Jean EJ; Gugger, Mathias M; Jermann, Philip M PM; Hoeller, Sylvia S; Tornillo, Luigi L; Terracciano, Luigi M LM; Bihl, Michel M; Matter, Matthias S MS
Development of actionable targets of multi-kinase inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cells.
Scientific Reports
Denisova, Oxana V OV; Merisaari, Joni J; Kaur, Amanpreet A; Yetukuri, Laxman L; Jumppanen, Mikael M; von Schantz-Fant, Carina C; Ohlmeyer, Michael M; Wennerberg, Krister K; Aittokallio, Tero T; Taipale, Mikko M; Westermarck, Jukka J
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.
Nature Genetics
Kar, Siddhartha P SP; Quiros, Pedro M PM; Gu, Muxin M; Jiang, Tao T; Mitchell, Jonathan J; Langdon, Ryan R; Iyer, Vivek V; Barcena, Clea C; Vijayabaskar, M S MS; Fabre, Margarete A MA; Carter, Paul P; Petrovski, Slavé S; Burgess, Stephen S; Vassiliou, George S GS
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Orthogonal MET analysis in a population-representative stage II-III colon cancer cohort: prognostic and potential therapeutic implications.
Molecular Oncology
Craig, Stephanie G SG; Mende, Svenja S; Humphries, Matthew P MP; Bingham, Victoria V; Viratham Pulsawatdi, Amélie A; Loughrey, Maurice B MB; Coleman, Helen G HG; McQuaid, Stephen S; Wilson, Richard H RH; Van Schaeybroeck, Sandra S; James, Jacqueline A JA; Salto-Tellez, Manuel M
Orthogonal MET analysis in a population-representative stage II-III colon cancer cohort: prognostic and potential therapeutic implications.
Molecular Oncology
Craig, Stephanie G SG; Mende, Svenja S; Humphries, Matthew P MP; Bingham, Victoria V; Viratham Pulsawatdi, Amélie A; Loughrey, Maurice B MB; Coleman, Helen G HG; McQuaid, Stephen S; Wilson, Richard H RH; Van Schaeybroeck, Sandra S; James, Jacqueline A JA; Salto-Tellez, Manuel M
Assessment of RAS Dependency for BRAF Alterations Using Cancer Genomic Databases.
Jama Network Open
Zhao, Yiqing Y; Yu, Hanzhong H; Ida, Cris M CM; Halling, Kevin C KC; Kipp, Benjamin R BR; Geiersbach, Katherine K; Rumilla, Kandelaria M KM; Gupta, Sounak S; Lin, Ming-Tseh MT; Zheng, Gang G
The genomic landscapes of individual melanocytes from human skin.
Nature
Tang, Jessica J; Fewings, Eleanor E; Chang, Darwin D; Zeng, Hanlin H; Liu, Shanshan S; Jorapur, Aparna A; Belote, Rachel L RL; McNeal, Andrew S AS; Tan, Tuyet M TM; Yeh, Iwei I; Arron, Sarah T ST; Judson-Torres, Robert L RL; Bastian, Boris C BC; Shain, A Hunter AH
BRAF in Lung Cancers: Analysis of Patient Cases Reveals Recurrent BRAF Mutations, Fusions, Kinase Duplications, and Concurrent Alterations.
Jco Precision Oncology
Sheikine, Yuri Y; Pavlick, Dean D; Klempner, Samuel J SJ; Trabucco, Sally E SE; Chung, Jon H JH; Rosenzweig, Mark M; Wang, Kai K; Velcheti, Vamsidhar V; Frampton, Garrett M GM; Peled, Nir N; Murray, Molly M; Chae, Young Kwang YK; Albacker, Lee A LA; Gay, Laurie L; Husain, Hatim H; Suh, James H JH; Millis, Sherri Z SZ; Reddy, Venkataprasanth P VP; Elvin, Julia A JA; Hartmaier, Ryan J RJ; Dowlati, Afshin A; Stephens, Phil P; Ross, Jeffrey S JS; Bivona, Trever G TG; Miller, Vincent A VA; Ganesan, Shridar S; Schrock, Alexa B AB; Ou, Sai-Hong Ignatius SI; Ali, Siraj M SM
The relationships between systemic cytokine profiles and inflammatory markers in colorectal cancer and the prognostic significance of these parameters.
British Journal Of Cancer
Park, Ji Won JW; Chang, Hee Jin HJ; Yeo, Hyun Yang HY; Han, Nayoung N; Kim, Byung Chang BC; Kong, Sun-Young SY; Kim, Jeongseon J; Oh, Jae Hwan JH
Pre-analytical factors affecting the establishment of a single tube assay for multiparameter liquid biopsy detection in melanoma patients.
Molecular Oncology
Schneegans, Svenja S; Lück, Lelia L; Besler, Katharina K; Bluhm, Leonie L; Stadler, Julia-Christina JC; Staub, Janina J; Greinert, Rüdiger R; Volkmer, Beate B; Kubista, Mikael M; Gebhardt, Christoffer C; Sartori, Alexander A; Irwin, Darryl D; Serkkola, Elina E; Af Hällström, Taija T; Lianidou, Evi E; Sprenger-Haussels, Markus M; Hussong, Melanie M; Mohr, Peter P; Schneider, Stefan W SW; Shaffer, Jonathan J; Pantel, Klaus K; Wikman, Harriet H
Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Development, Implementation and Assessment of Molecular Diagnostics by Next Generation Sequencing in Personalized Treatment of Cancer: Experience of a Public Reference Healthcare Hospital.
Cancers
Simarro, Javier J; Murria, Rosa R; Pérez-Simó, Gema G; Llop, Marta M; Mancheño, Nuria N; Ramos, David D; Juan, Inmaculada de I; Barragán, Eva E; Laiz, Begoña B; Cases, Enrique E; Ansótegui, Emilio E; Gómez-Codina, José J; Aparicio, Jorge J; Salvador, Carmen C; Juan, Óscar Ó; Palanca, Sarai S
Publication Date: 2019-08-16
Variant appearance in text: BRAF: 1781A>T; Asp594Val
Immune Cell Infiltration of the Primary Tumor, Not PD-L1 Status, Is Associated With Improved Response to Checkpoint Inhibition in Metastatic Melanoma.
Frontiers In Medicine
Kümpers, Christiane C; Jokic, Mladen M; Haase, Ozan O; Offermann, Anne A; Vogel, Wenzel W; Grätz, Victoria V; Langan, Ewan A EA; Perner, Sven S; Terheyden, Patrick P
Whole transcriptome targeted gene quantification provides new insights on pulmonary sarcomatoid carcinomas.
Scientific Reports
Alì, Greta G; Bruno, Rossella R; Poma, Anello Marcello AM; Affinito, Ornella O; Monticelli, Antonella A; Piaggi, Paolo P; Ricciardi, Sara S; Lucchi, Marco M; Melfi, Franca F; Chella, Antonio A; Cocozza, Sergio S; Fontanini, Gabriella G
Type II RAF inhibitor causes superior ERK pathway suppression compared to type I RAF inhibitor in cells expressing different BRAF mutant types recurrently found in lung cancer.
Oncotarget
Noeparast, Amir A; Giron, Philippe P; De Brakeleer, Sylvia S; Eggermont, Carolien C; De Ridder, Ulrike U; Teugels, Erik E; De Grève, Jacques J
Bcl-xL as a poor prognostic biomarker and predictor of response to adjuvant chemotherapy specifically in BRAF-mutant stage II and III colon cancer.
Oncotarget
Dunne, Philip D PD; Coleman, Helen G HG; Bankhead, Peter P; Alderdice, Matthew M; Gray, Ronan T RT; McQuaid, Stephen S; Bingham, Victoria V; Loughrey, Maurice B MB; James, Jacqueline A JA; McCorry, Amy M B AMB; Gilmore, Alan A; Holohan, Caitriona C; Klingbiel, Dirk D; Tejpar, Sabine S; Johnston, Patrick G PG; McArt, Darragh G DG; Di Nicolantonio, Federica F; Longley, Daniel B DB; Lawler, Mark M
Concurrent Alterations in EGFR-Mutant Lung Cancers Associated with Resistance to EGFR Kinase Inhibitors and Characterization of MTOR as a Mediator of Resistance.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Yu, Helena A HA; Suzawa, Ken K; Jordan, Emmet E; Zehir, Ahmet A; Ni, Ai A; Kim, Ryan R; Kris, Mark G MG; Hellmann, Matthew D MD; Li, Bob T BT; Somwar, Romel R; Solit, David B DB; Berger, Michael F MF; Arcila, Maria M; Riely, Gregory J GJ; Ladanyi, Marc M
Pan-urologic cancer genomic subtypes that transcend tissue of origin.
Nature Communications
Chen, Fengju F; Zhang, Yiqun Y; Bossé, Dominick D; Lalani, Aly-Khan A AA; Hakimi, A Ari AA; Hsieh, James J JJ; Choueiri, Toni K TK; Gibbons, Don L DL; Ittmann, Michael M; Creighton, Chad J CJ
Functional KRAS mutations and a potential role for PI3K/AKT activation in Wilms tumors.
Molecular Oncology
Polosukhina, Dina D; Love, Harold D HD; Correa, Hernan H; Su, Zengliu Z; Dahlman, Kimberly B KB; Pao, William W; Moses, Harold L HL; Arteaga, Carlos L CL; Lovvorn, Harold N HN; Zent, Roy R; Clark, Peter E PE
Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.
Genome Research
Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U
Prognostic Role of BRAF Mutation in Stage II/III Colorectal Cancer Receiving Curative Resection and Adjuvant Chemotherapy: A Meta-Analysis Based on Randomized Clinical Trials.
Mutational profiling of brain metastasis from breast cancer: matched pair analysis of targeted sequencing between brain metastasis and primary breast cancer.
Oncotarget
Lee, Ji Yun JY; Park, Kyunghee K; Lim, Sung Hee SH; Kim, Hae Su HS; Yoo, Kwai Han KH; Jung, Ki Sun KS; Song, Haa-Na HN; Hong, Mineui M; Do, In-Gu IG; Ahn, TaeJin T; Lee, Se Kyung SK; Bae, Soo Youn SY; Kim, Seok Won SW; Lee, Jeong Eon JE; Nam, Seok Jin SJ; Kim, Duk-Hwan DH; Jung, Hae Hyun HH; Kim, Ji-Yeon JY; Ahn, Jin Seok JS; Im, Young-Hyuck YH; Park, Yeon Hee YH
Recurrent inactivating RASA2 mutations in melanoma.
Nature Genetics
Arafeh, Rand R; Qutob, Nouar N; Emmanuel, Rafi R; Keren-Paz, Alona A; Madore, Jason J; Elkahloun, Abdel A; Wilmott, James S JS; Gartner, Jared J JJ; Di Pizio, Antonella A; Winograd-Katz, Sabina S; Sindiri, Sivasish S; Rotkopf, Ron R; Dutton-Regester, Ken K; Johansson, Peter P; Pritchard, Antonia L AL; Waddell, Nicola N; Hill, Victoria K VK; Lin, Jimmy C JC; Hevroni, Yael Y; Rosenberg, Steven A SA; Khan, Javed J; Ben-Dor, Shifra S; Niv, Masha Y MY; Ulitsky, Igor I; Mann, Graham J GJ; Scolyer, Richard A RA; Hayward, Nicholas K NK; Samuels, Yardena Y