BRAF c.1741A>T ;(p.N581Y)

Variant ID: 7-140453987-T-A

NM_004333.4(BRAF):c.1741A>T;(p.N581Y)

This variant was identified in 28 publications

View GRCh38 version.




Publications:


An integrated model for predicting KRAS dependency.

Plos Computational Biology
Tsai, Yihsuan S YS; Chareddy, Yogitha S YS; Price, Brandon A BA; Parker, Joel S JS; Pecot, Chad V CV
Publication Date: 2023-05-04

Variant appearance in text: BRAF: N581Y
PubMed Link: 37141389
Variant Present in the following documents:
  • Main text
  • pcbi.1011095.pdf
View BVdb publication page



An EGFR L858R mutation identified in 1862 Chinese NSCLC patients can be a promising neoantigen vaccine therapeutic strategy.

Frontiers In Immunology
Lin, Jing J; Liu, Jun J; Hao, Shi-Guang SG; Lan, Bin B; Zheng, Xiao-Bin XB; Xiong, Jia-Ni JN; Zhang, Ying-Qian YQ; Gao, Xuan X; Chen, Chuan-Ben CB; Chen, Ling L; Huang, Yu-Fang YF; Luo, Hong H; Yi, Yu-Ting YT; Yi, Xin X; Lu, Jian-Ping JP; Zheng, Xiong-Wei XW; Chen, Gang G; Wang, Xue-Feng XF; Chen, Yu Y
Publication Date: 2022

Variant appearance in text: BRAF: 1741A>T; N581Y
PubMed Link: 36505399
Variant Present in the following documents:
  • Table_2.xlsx, sheet 3
  • Table_2.xlsx, sheet 2
View BVdb publication page



Decoding molecular programs in melanoma brain metastases.

Nature Communications
Radke, Josefine J; Schumann, Elisa E; Onken, Julia J; Koll, Randi R; Acker, Güliz G; Bodnar, Bohdan B; Senger, Carolin C; Tierling, Sascha S; Möbs, Markus M; Vajkoczy, Peter P; Vidal, Anna A; Högler, Sandra S; Kodajova, Petra P; Westphal, Dana D; Meier, Friedegund F; Heppner, Frank F; Kreuzer-Redmer, Susanne S; Grebien, Florian F; Jürchott, Karsten K; Redmer, Torben T
Publication Date: 2022-11-26

Variant appearance in text: BRAF: N581Y
PubMed Link: 36435874
Variant Present in the following documents:
  • Main text
  • 41467_2022_34899_MOESM1_ESM.pdf
View BVdb publication page



Sensitivities and Dependencies of BRAF Mutant Colorectal Cancer Cell Lines with or without PIK3CA Mutations for Discovery of Vulnerabilities with Therapeutic Potential.

Medicina (Kaunas, Lithuania)
Voutsadakis, Ioannis A IA
Publication Date: 2022-10-21

Variant appearance in text: BRAF: N581Y
PubMed Link: 36295658
Variant Present in the following documents:
  • Main text
  • medicina-58-01498.pdf
View BVdb publication page



Clinical associations and genetic interactions of oncogenic BRAF alleles.

Peerj
Wagner, Sebastian A SA
Publication Date: 2022

Variant appearance in text: BRAF: N581Y
PubMed Link: 36275468
Variant Present in the following documents:
  • peerj-10-14126.pdf
View BVdb publication page



Predictive mutation signature of immunotherapy benefits in NSCLC based on machine learning algorithms.

Frontiers In Immunology
Liu, Zhichao Z; Lin, Guo G; Yan, Zeping Z; Li, Linduo L; Wu, Xingchen X; Shi, Jingrong J; He, Jianxing J; Zhao, Lei L; Liang, Hengrui H; Wang, Wei W
Publication Date: 2022

Variant appearance in text: BRAF: 1741A>T; N581Y
PubMed Link: 36238300
Variant Present in the following documents:
  • Table_1.xlsx, sheet 4
View BVdb publication page



EPHA5 mutation was associated with adverse outcome of atezolizumab treatment in late-stage non-small cell lung cancers.

Bmc Pulmonary Medicine
Li, Zhenxiang Z; Zhou, Qing Q; Wang, Qi Q; Wang, Haiyong H; Yue, Weiming W
Publication Date: 2022-09-19

Variant appearance in text: BRAF: 1741A>T; N581Y
PubMed Link: 36123678
Variant Present in the following documents:
  • 12890_2022_2161_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Comprehensive germline and somatic genomic profiles of Chinese patients with biliary tract cancer.

Frontiers In Oncology
Yu, Haipeng H; Xu, Yan Y; Gao, Wei W; Li, Mei M; He, Ji'an J; Deng, Xiaoqian X; Xing, Wenge W
Publication Date: 2022

Variant appearance in text: BRAF: N581Y
PubMed Link: 36072793
Variant Present in the following documents:
  • Table_3.xlsx, sheet 1
View BVdb publication page



The genetic heterogeneity and drug resistance mechanisms of relapsed refractory multiple myeloma.

Nature Communications
Vo, Josh N JN; Wu, Yi-Mi YM; Mishler, Jeanmarie J; Hall, Sarah S; Mannan, Rahul R; Wang, Lisha L; Ning, Yu Y; Zhou, Jin J; Hopkins, Alexander C AC; Estill, James C JC; Chan, Wallace K B WKB; Yesil, Jennifer J; Cao, Xuhong X; Rao, Arvind A; Tsodikov, Alexander A; Talpaz, Moshe M; Cole, Craig E CE; Ye, Jing C JC; , ; Bergsagel, P Leif PL; Auclair, Daniel D; Cho, Hearn Jay HJ; Robinson, Dan R DR; Chinnaiyan, Arul M AM
Publication Date: 2022-06-29

Variant appearance in text: BRAF: 1741A>T; Asn581Tyr
PubMed Link: 35768438
Variant Present in the following documents:
  • 41467_2022_31430_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: BRAF: N581Y
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Exosomes from Plasma of Neuroblastoma Patients Contain Doublestranded DNA Reflecting the Mutational Status of Parental Tumor Cells.

International Journal Of Molecular Sciences
Degli Esposti, Chiara C; Iadarola, Barbara B; Maestri, Simone S; Beltrami, Cristina C; Lavezzari, Denise D; Morini, Martina M; De Marco, Patrizia P; Erminio, Giovanni G; Garaventa, Alberto A; Zara, Federico F; Delledonne, Massimo M; Ognibene, Marzia M; Pezzolo, Annalisa A
Publication Date: 2021-04-01

Variant appearance in text: BRAF: 1741A>T
PubMed Link: 33915956
Variant Present in the following documents:
  • Main text
View BVdb publication page



Discovery of a new molecule inducing melanoma cell death: dual AMPK/MELK targeting for novel melanoma therapies.

Cell Death & Disease
Jaune, Emilie E; Cavazza, Elisa E; Ronco, Cyril C; Grytsai, Oleksandr O; Abbe, Patricia P; Tekaya, Nedra N; Zerhouni, Marwa M; Beranger, Guillaume G; Kaminski, Lisa L; Bost, Frédéric F; Gesson, Maeva M; Tulic, Meri M; Hofman, Paul P; Ballotti, Robert R; Passeron, Thierry T; Botton, Thomas T; Benhida, Rachid R; Rocchi, Stéphane S
Publication Date: 2021-01-11

Variant appearance in text: BRAF: N581Y
PubMed Link: 33431809
Variant Present in the following documents:
  • 41419_2020_Article_3344.pdf
View BVdb publication page



Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications
Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q
Publication Date: 2021-01-04

Variant appearance in text: BRAF: 1741A>T; N581Y
PubMed Link: 33397889
Variant Present in the following documents:
  • 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Comparison of three commercial decision support platforms for matching of next-generation sequencing results with therapies in patients with cancer.

Esmo Open
Perakis, Samantha O SO; Weber, Sabrina S; Zhou, Qing Q; Graf, Ricarda R; Hojas, Sabine S; Riedl, Jakob M JM; Gerger, Armin A; Dandachi, Nadia N; Balic, Marija M; Hoefler, Gerald G; Schuuring, Ed E; Groen, Harry J M HJM; Geigl, Jochen B JB; Heitzer, Ellen E; Speicher, Michael R MR
Publication Date: 2020-09

Variant appearance in text: BRAF: 1741A>T; N581Y
PubMed Link: 32967919
Variant Present in the following documents:
  • esmoopen-2020-000872supp001.pdf
View BVdb publication page



Molecular Landscape of BRAF-Mutant NSCLC Reveals an Association Between Clonality and Driver Mutations and Identifies Targetable Non-V600 Driver Mutations.

Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer
Negrao, Marcelo V MV; Raymond, Victoria M VM; Lanman, Richard B RB; Robichaux, Jacqulyne P JP; He, Junqin J; Nilsson, Monique B MB; Ng, Patrick K S PKS; Amador, Bianca E BE; Roarty, Emily B EB; Nagy, Rebecca J RJ; Banks, Kimberly C KC; Zhu, Viola W VW; Ng, Chun C; Chae, Young Kwang YK; Clarke, Jeffrey M JM; Crawford, Jeffrey A JA; Meric-Bernstam, Funda F; Ignatius Ou, Sai-Hong SH; Gandara, David R DR; Heymach, John V JV; Bivona, Trever G TG; McCoach, Caroline E CE
Publication Date: 2020-10

Variant appearance in text: BRAF: N581Y
PubMed Link: 32540409
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: BRAF: N581Y
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



Evolving neoantigen profiles in colorectal cancers with DNA repair defects.

Genome Medicine
Rospo, Giuseppe G; Lorenzato, Annalisa A; Amirouchene-Angelozzi, Nabil N; Magrì, Alessandro A; Cancelliere, Carlotta C; Corti, Giorgio G; Negrino, Carola C; Amodio, Vito V; Montone, Monica M; Bartolini, Alice A; Barault, Ludovic L; Novara, Luca L; Isella, Claudio C; Medico, Enzo E; Bertotti, Andrea A; Trusolino, Livio L; Germano, Giovanni G; Di Nicolantonio, Federica F; Bardelli, Alberto A
Publication Date: 2019-06-28

Variant appearance in text: BRAF: N581Y
PubMed Link: 31253177
Variant Present in the following documents:
  • 13073_2019_654_MOESM2_ESM.xlsx, sheet 35
View BVdb publication page



Integrative omics analyses broaden treatment targets in human cancer.

Genome Medicine
Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L
Publication Date: 2018-07-27

Variant appearance in text: BRAF: N581Y
PubMed Link: 30053901
Variant Present in the following documents:
  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 3
View BVdb publication page



Germline SAMD9 and SAMD9L mutations are associated with extensive genetic evolution and diverse hematologic outcomes.

Jci Insight
Wong, Jasmine C JC; Bryant, Victoria V; Lamprecht, Tamara T; Ma, Jing J; Walsh, Michael M; Schwartz, Jason J; Del Pilar Alzamora, Maria M; Mullighan, Charles G CG; Loh, Mignon L ML; Ribeiro, Raul R; Downing, James R JR; Carroll, William L WL; Davis, Jeffrey J; Gold, Stuart S; Rogers, Paul C PC; Israels, Sara S; Yanofsky, Rochelle R; Shannon, Kevin K; Klco, Jeffery M JM
Publication Date: 2018-07-26

Variant appearance in text: BRAF: N581Y
PubMed Link: 30046003
Variant Present in the following documents:
  • Main text
View BVdb publication page



Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas.

Cell Reports
Way, Gregory P GP; Sanchez-Vega, Francisco F; La, Konnor K; Armenia, Joshua J; Chatila, Walid K WK; Luna, Augustin A; Sander, Chris C; Cherniack, Andrew D AD; Mina, Marco M; Ciriello, Giovanni G; Schultz, Nikolaus N; , ; Sanchez, Yolanda Y; Greene, Casey S CS
Publication Date: 2018-04-03

Variant appearance in text: BRAF: 1741A>T
PubMed Link: 29617658
Variant Present in the following documents:
  • NIHMS958974-supplement-5.xlsx, sheet 1
  • NIHMS958974-supplement-6.xlsx, sheet 1
View BVdb publication page



Comprehensive genomic sequencing detects important genetic differences between right-sided and left-sided colorectal cancer.

Oncotarget
Shimada, Yoshifumi Y; Kameyama, Hitoshi H; Nagahashi, Masayuki M; Ichikawa, Hiroshi H; Muneoka, Yusuke Y; Yagi, Ryoma R; Tajima, Yosuke Y; Okamura, Takuma T; Nakano, Masato M; Sakata, Jun J; Kobayashi, Takashi T; Nogami, Hitoshi H; Maruyama, Satoshi S; Takii, Yasumasa Y; Hayashida, Tetsu T; Takaishi, Hiromasa H; Kitagawa, Yuko Y; Oki, Eiji E; Konishi, Tsuyoshi T; Ishida, Fumio F; Kudo, Shin-Ei SE; Ring, Jennifer E JE; Protopopov, Alexei A; Lyle, Stephen S; Ling, Yiwei Y; Okuda, Shujiro S; Ishikawa, Takashi T; Akazawa, Kohei K; Takabe, Kazuaki K; Wakai, Toshifumi T
Publication Date: 2017-11-07

Variant appearance in text: BRAF: N581Y
PubMed Link: 29212173
Variant Present in the following documents:
  • oncotarget-08-93567-s003.xlsx, sheet 1
View BVdb publication page



Genetic and Genomic Characterization of 462 Melanoma Patient-Derived Xenografts, Tumor Biopsies, and Cell Lines.

Cell Reports
Garman, Bradley B; Anastopoulos, Ioannis N IN; Krepler, Clemens C; Brafford, Patricia P; Sproesser, Katrin K; Jiang, Yuchao Y; Wubbenhorst, Bradley B; Amaravadi, Ravi R; Bennett, Joseph J; Beqiri, Marilda M; Elder, David D; Flaherty, Keith T KT; Frederick, Dennie T DT; Gangadhar, Tara C TC; Guarino, Michael M; Hoon, David D; Karakousis, Giorgos G; Liu, Qin Q; Mitra, Nandita N; Petrelli, Nicholas J NJ; Schuchter, Lynn L; Shannan, Batool B; Shields, Carol L CL; Wargo, Jennifer J; Wenz, Brandon B; Wilson, Melissa A MA; Xiao, Min M; Xu, Wei W; Xu, Xaiowei X; Yin, Xiangfan X; Zhang, Nancy R NR; Davies, Michael A MA; Herlyn, Meenhard M; Nathanson, Katherine L KL
Publication Date: 2017-11-14

Variant appearance in text: BRAF: N581Y
PubMed Link: 29141224
Variant Present in the following documents:
  • Main text
View BVdb publication page



Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications
Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2017-05-11

Variant appearance in text: BRAF: 1741A>T
PubMed Link: 28492226
Variant Present in the following documents:
  • ncomms15086-s3.xlsx, sheet 1
View BVdb publication page



A Landscape of Pharmacogenomic Interactions in Cancer.

Cell
Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ
Publication Date: 2016-07-28

Variant appearance in text: BRAF: 1741A>T; N581Y
PubMed Link: 27397505
Variant Present in the following documents:
  • mmc3.xlsx, sheet 3
View BVdb publication page



Recurrent inactivating RASA2 mutations in melanoma.

Nature Genetics
Arafeh, Rand R; Qutob, Nouar N; Emmanuel, Rafi R; Keren-Paz, Alona A; Madore, Jason J; Elkahloun, Abdel A; Wilmott, James S JS; Gartner, Jared J JJ; Di Pizio, Antonella A; Winograd-Katz, Sabina S; Sindiri, Sivasish S; Rotkopf, Ron R; Dutton-Regester, Ken K; Johansson, Peter P; Pritchard, Antonia L AL; Waddell, Nicola N; Hill, Victoria K VK; Lin, Jimmy C JC; Hevroni, Yael Y; Rosenberg, Steven A SA; Khan, Javed J; Ben-Dor, Shifra S; Niv, Masha Y MY; Ulitsky, Igor I; Mann, Graham J GJ; Scolyer, Richard A RA; Hayward, Nicholas K NK; Samuels, Yardena Y
Publication Date: 2015-12

Variant appearance in text: BRAF: N581Y
PubMed Link: 26502337
Variant Present in the following documents:
  • NIHMS65345-supplement-Supplementary_table_3.xlsx, sheet 2
View BVdb publication page



ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma.

Oncotarget
Hutchinson, Katherine E KE; Johnson, Douglas B DB; Johnson, Adam S AS; Sanchez, Violeta V; Kuba, Maria M; Lu, Pengcheng P; Chen, Xi X; Kelley, Mark C MC; Wang, Qingguo Q; Zhao, Zhongming Z; Kris, Mark M; Berger, Michael F MF; Sosman, Jeffrey A JA; Pao, William W
Publication Date: 2015-09-08

Variant appearance in text: BRAF: N581Y
PubMed Link: 26084293
Variant Present in the following documents:
  • Main text
  • oncotarget-06-22348.pdf
  • oncotarget-06-22348-s003.xlsx, sheet 1
View BVdb publication page



Assessment of computational methods for predicting the effects of missense mutations in human cancers.

Bmc Genomics
Gnad, Florian F; Baucom, Albion A; Mukhyala, Kiran K; Manning, Gerard G; Zhang, Zemin Z
Publication Date: 2013

Variant appearance in text: BRAF: N581Y
PubMed Link: 23819521
Variant Present in the following documents:
  • 1471-2164-14-S3-S7-S1.xlsx, sheet 1
View BVdb publication page