Publications:

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Cooperativity between H3.3K27M and PDGFRA poses multiple therapeutic vulnerabilities in human iPSC-derived diffuse midline glioma avatars.

Biorxiv : The Preprint Server For Biology

Skinner, Kasey R KR; Koga, Tomoyuki T; Miki, Shunichiro S; Gruener, Robert F RF; Grigore, Florina-Nicoleta FN; Torii, Emma H EH; Seelig, Davis M DM; Suzuki, Yuta Y; Kawauchi, Daisuke D; Lin, Benjamin B; Malicki, Denise M DM; Chen, Clark C CC; Benveniste, Etty N EN; Patel, Rakesh P RP; McFarland, Braden C BC; Huang, R Stephanie RS; Jones, Chris C; Mackay, Alan A; Miller, C Ryan CR; Furnari, Frank B FB

Publication Date: 2023-02-24

Variant appearance in text: BRAF: E545K

PubMed Link: 36865329

Variant Present in the following documents:

• media-2.xlsx, sheet 3

View BVdb publication page

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Analysis of acquired resistance mechanisms to osimertinib in patients with EGFR-mutated advanced non-small cell lung cancer from the AURA3 trial.

Nature Communications

Chmielecki, Juliann J; Mok, Tony T; Wu, Yi-Long YL; Han, Ji-Youn JY; Ahn, Myung-Ju MJ; Ramalingam, Suresh S SS; John, Thomas T; Okamoto, Isamu I; Yang, James Chih-Hsin JC; Shepherd, Frances A FA; Bulusu, Krishna C KC; Laus, Gianluca G; Collins, Barbara B; Barrett, J Carl JC; Hartmaier, Ryan J RJ; Papadimitrakopoulou, Vassiliki V

Publication Date: 2023-02-27

Variant appearance in text: BRAF: E545K

PubMed Link: 36849516

Variant Present in the following documents:

• 41467_2023_Article_35962.pdf

View BVdb publication page

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Pulmonary Combined Large Cell Neuroendocrine Carcinoma.

Pathology Oncology Research : Por

Li, Meihui M; Yang, Lan L; Lu, Hongyang H

Publication Date: 2022

Variant appearance in text: BRAF: E545K

PubMed Link: 36507119

Variant Present in the following documents:

• pore-28-1610747.pdf

View BVdb publication page

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Concordance Between Recommendations From Multidisciplinary Molecular Tumor Boards and Central Consensus for Cancer Treatment in Japan.

Jama Network Open

Naito, Yoichi Y; Sunami, Kuniko K; Kage, Hidenori H; Komine, Keigo K; Amano, Toraji T; Imai, Mitsuho M; Koyama, Takafumi T; Ennishi, Daisuke D; Kanai, Masashi M; Kenmotsu, Hirotsugu H; Maeda, Takahiro T; Morita, Sachi S; Sakai, Daisuke D; Watanabe, Kousuke K; Shirota, Hidekazu H; Kinoshita, Ichiro I; Yoshioka, Masashiro M; Mamesaya, Nobuaki N; Ito, Mamoru M; Kohsaka, Shinji S; Saigusa, Yusuke Y; Yamamoto, Kouji K; Hirata, Makoto M; Tsuchihara, Katsuya K; Yoshino, Takayuki T

Publication Date: 2022-12-01

Variant appearance in text: BRAF: E545K

PubMed Link: 36469316

Variant Present in the following documents:

• Main text

View BVdb publication page

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Sensitivities and Dependencies of BRAF Mutant Colorectal Cancer Cell Lines with or without PIK3CA Mutations for Discovery of Vulnerabilities with Therapeutic Potential.

Medicina (Kaunas, Lithuania)

Voutsadakis, Ioannis A IA

Publication Date: 2022-10-21

Variant appearance in text: BRAF: E545K

PubMed Link: 36295658

Variant Present in the following documents:

• medicina-58-01498.pdf

View BVdb publication page

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Investigation of early neoplastic transformation and premalignant biology using genetically engineered organoid models.

Computational And Structural Biotechnology Journal

Zhao, Hua H; Collet, Casey C; Peng, Dongzi D; Sinha, Uttam K UK; Lin, De-Chen DC

Publication Date: 2022

Variant appearance in text: BRAF: E545K

PubMed Link: 36212534

Variant Present in the following documents:

• Main text

View BVdb publication page

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RNF43 mutations predict response to anti-BRAF/EGFR combinatory therapies in BRAF^V600E metastatic colorectal cancer.

Nature Medicine

Elez, Elena E; Ros, Javier J; Fernández, Jose J; Villacampa, Guillermo G; Moreno-Cárdenas, Ana Belén AB; Arenillas, Carlota C; Bernatowicz, Kinga K; Comas, Raquel R; Li, Shanshan S; Kodack, David Philip DP; Fasani, Roberta R; Garcia, Ariadna A; Gonzalo-Ruiz, Javier J; Piris-Gimenez, Alejandro A; Nuciforo, Paolo P; Kerr, Grainne G; Intini, Rossana R; Montagna, Aldo A; Germani, Marco Maria MM; Randon, Giovanni G; Vivancos, Ana A; Smits, Ron R; Graus, Diana D; Perez-Lopez, Raquel R; Cremolini, Chiara C; Lonardi, Sara S; Pietrantonio, Filippo F; Dienstmann, Rodrigo R; Tabernero, Josep J; Toledo, Rodrigo A RA

Publication Date: 2022-10

Variant appearance in text: BRAF: Glu545Lys

PubMed Link: 36097219

Variant Present in the following documents:

• 41591_2022_1976_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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A highly selective JAK3 inhibitor is developed for treating rheumatoid arthritis by suppressing γc cytokine-related JAK-STAT signal.

Science Advances

Chen, Chengjuan C; Yin, Yuan Y; Shi, Gaona G; Zhou, Yu Y; Shao, Shuai S; Wei, Yazi Y; Wu, Lei L; Zhang, Dayong D; Sun, Lan L; Zhang, Tiantai T

Publication Date: 2022-08-19

Variant appearance in text: BRAF: E545K

PubMed Link: 35984890

Variant Present in the following documents:

• sciadv.abo4363_sm.pdf

View BVdb publication page

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A lymphatic-absorbed multi-targeted kinase inhibitor for myelofibrosis therapy.

Nature Communications

Ross, Brian D BD; Jang, Youngsoon Y; Welton, Amanda A; Bonham, Christopher A CA; Palagama, Dilrukshika S W DSW; Heist, Kevin K; Boppisetti, Jagadish J; Imaduwage, Kasun P KP; Robison, Tanner T; King, Leah R LR; Zhang, Edward Z EZ; Amirfazli, Cyrus C; Luker, Kathryn E KE; Lee, Winston Y WY; Luker, Gary D GD; Chenevert, Thomas L TL; Van Dort, Marcian E ME

Publication Date: 2022-08-17

Variant appearance in text: BRAF: E545K

PubMed Link: 35977945

Variant Present in the following documents:

• 41467_2022_32486_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Heterogeneity in Melanoma.

Cancers

Ng, Mei Fong MF; Simmons, Jacinta L JL; Boyle, Glen M GM

Publication Date: 2022-06-20

Variant appearance in text: BRAF: E545K

PubMed Link: 35740696

Variant Present in the following documents:

• Main text

View BVdb publication page

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Altered Signaling Pathways Revealed by Comprehensive Genomic Profiling in Patients With Unknown Primary Tumors.

Frontiers In Oncology

Yang, Zhen Z; Cui, Wei W; Yu, Ruoying R; Dong, Xinhua X; Zhao, Jian J; Dai, Lu L; Ou, Qiuxiang Q; Bao, Hua H; Wu, Xue X; Wu, Chuanxin C; Lai, Jinhuo J

Publication Date: 2022

Variant appearance in text: BRAF: E545K

PubMed Link: 35402276

Variant Present in the following documents:

• fonc-12-753311.pdf

View BVdb publication page

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Covalent Proximity Scanning of a Distal Cysteine to Target PI3Kα.

Journal Of The American Chemical Society

Borsari, Chiara C; Keles, Erhan E; McPhail, Jacob A JA; Schaefer, Alexander A; Sriramaratnam, Rohitha R; Goch, Wojciech W; Schaefer, Thorsten T; De Pascale, Martina M; Bal, Wojciech W; Gstaiger, Matthias M; Burke, John E JE; Wymann, Matthias P MP

Publication Date: 2022-04-13

Variant appearance in text: BRAF: E545K

PubMed Link: 35353516

Variant Present in the following documents:

• ja1c13568_si_001.pdf

View BVdb publication page

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Identifying Actionable Variants Using Capture-Based Targeted Sequencing in 563 Patients With Non-Small Cell Lung Carcinoma.

Frontiers In Oncology

Jiang, Haiping H; Wang, Yinan Y; Xu, Hanlin H; Lei, Wei W; Yu, Xiaoyun X; Tian, Haiying H; Meng, Cong C; Wang, Xueying X; Zhao, Zicheng Z; Jin, Xiangfeng X

Publication Date: 2021

Variant appearance in text: BRAF: E545K

PubMed Link: 35186718

Variant Present in the following documents:

• fonc-11-812433.pdf

View BVdb publication page

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Real-world data analysis of patients with cancer of unknown primary.

Scientific Reports

Kang, Sora S; Jeong, Jae Ho JH; Yoon, Shinkyo S; Yoo, Changhoon C; Kim, Kyu-Pyo KP; Cho, Hyungwoo H; Ryoo, Baek-Yeol BY; Jung, Jinhong J; Kim, Jeong Eun JE

Publication Date: 2021-11-29

Variant appearance in text: BRAF: E545K

PubMed Link: 34845302

Variant Present in the following documents:

• Main text

View BVdb publication page

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Establishment and characterization of novel highly aggressive HER2‑positive and triple‑negative breast cancer cell lines.

Oncology Reports

Thongchot, Suyanee S; Jamjuntra, Pranisa P; Prasopsiri, Jaturawitt J; Thuwajit, Peti P; Sawasdee, Nunghathai N; Poungvarin, Naravat N; Warnnissorn, Malee M; Sa-Nguanraksa, Doonyapat D; O-Charoenrat, Pornchai P; Yenchitsomanus, Pa-Thai PT; Thuwajit, Chanitra C

Publication Date: 2021-12

Variant appearance in text: BRAF: 1633G>A; E545K

PubMed Link: 34651665

Variant Present in the following documents:

• or-46-06-08205.pdf

View BVdb publication page

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Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase.

Oncotarget

Okawa, Yuki Y; Ebata, Nobutaka N; Kim, Nayoung K D NKD; Fujita, Masashi M; Maejima, Kazuhiro K; Sasagawa, Shota S; Nakamura, Toru T; Park, Woong-Yang WY; Hirano, Satoshi S; Nakagawa, Hidewaki H

Publication Date: 2021-07-20

Variant appearance in text: BRAF: Glu545Lys

PubMed Link: 34316332

Variant Present in the following documents:

• oncotarget-12-1540-s001.pdf

View BVdb publication page

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Genomic Profiling Identified Novel Prognostic Biomarkers in Chinese Midline Glioma Patients.

Frontiers In Oncology

Li, Hainan H; Shan, Changguo C; Wu, Shengnan S; Cheng, Baijie B; Fan, Chongzu C; Cai, Linbo L; Chen, Yedan Y; Shi, Yuqian Y; Liu, Kaihua K; Shao, Yang Y; Zhu, Dan D; Li, Zhi Z

Publication Date: 2020

Variant appearance in text: BRAF: E545K

PubMed Link: 33747896

Variant Present in the following documents:

• fonc-10-607429.pdf

View BVdb publication page

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Impressive response to dabrafenib, trametinib, and osimertinib in a metastatic EGFR-mutant/BRAF V600E lung adenocarcinoma patient.

Npj Precision Oncology

Ribeiro, Maurício Fernando Silva Almeida MFSA; Knebel, Franciele Hinterholz FH; Bettoni, Fabiana F; Saddi, Rodrigo R; Sacardo, Karina Perez KP; Canedo, Felipe Sales Nogueira Amorim FSNA; Alessi, João Victor Machado JVM; Shimada, Andrea Kazumi AK; Marin, José Flávio Gomes JFG; Camargo, Anamaria Aranha AA; Katz, Artur A

Publication Date: 2021-02-12

Variant appearance in text: BRAF: E545K

PubMed Link: 33580193

Variant Present in the following documents:

• 41698_2021_Article_149.pdf

View BVdb publication page

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Whole-exome mutational landscape of neuroendocrine carcinomas of the gallbladder.

Signal Transduction And Targeted Therapy

Liu, Fatao F; Li, Yongsheng Y; Ying, Dongjian D; Qiu, Shimei S; He, Yong Y; Li, Maolan M; Liu, Yun Y; Zhang, Yijian Y; Zhu, Qin Q; Hu, Yunping Y; Liu, Liguo L; Li, Guoqiang G; Pan, Weihua W; Jin, Wei W; Mu, Jiasheng J; Cao, Yang Y; Liu, Yingbin Y

Publication Date: 2021-02-10

Variant appearance in text: BRAF: Glu545Lys

PubMed Link: 33563892

Variant Present in the following documents:

• 41392_2020_412_MOESM7_ESM.xlsx, sheet 1
• 41392_2020_412_MOESM19_ESM.xlsx, sheet 1

View BVdb publication page

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Distinct mutation profiles between primary bladder cancer and circulating tumor cells warrant the use of circulating tumors cells as cellular resource for mutation follow-up.

Bmc Cancer

Kim, Tae-Min TM; Yoo, Jin-Seon JS; Moon, Hyong Woo HW; Hur, Kyung Jae KJ; Choi, Jin Bong JB; Hong, Sung-Hoo SH; Lee, Ji Youl JY; Ha, U-Syn US

Publication Date: 2020-12-07

Variant appearance in text: BRAF: E545K

PubMed Link: 33287735

Variant Present in the following documents:

• 12885_2020_7684_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Molecular subtype-specific responses of colon cancer cells to the SMAC mimetic Birinapant.

Cell Death & Disease

Fichtner, Michael M; Bozkurt, Emir E; Salvucci, Manuela M; McCann, Christopher C; McAllister, Katherine A KA; Halang, Luise L; Düssmann, Heiko H; Kinsella, Sinéad S; Crawford, Nyree N; Sessler, Tamas T; Longley, Daniel B DB; Prehn, Jochen H M JHM

Publication Date: 2020-11-30

Variant appearance in text: BRAF: E545K

PubMed Link: 33257690

Variant Present in the following documents:

• Main text

View BVdb publication page

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Thyroid paraganglioma accompanied by lymph node metastasis or trachea invasion: A case report.

Oncology Letters

Yu, Xing X; Wang, Yong Y; Xie, Qiuping Q; Yan, Haichao H; Zhao, Qunzi Q; Xiang, Cheng C; Zhang, Maolin M; Li, Jin-Fan JF; Wang, Ping P

Publication Date: 2020-12

Variant appearance in text: BRAF: E545K

PubMed Link: 33123256

Variant Present in the following documents:

• Main text

View BVdb publication page

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Mass Spectrometry as a Highly Sensitive Method for Specific Circulating Tumor DNA Analysis in NSCLC: A Comparison Study.

Cancers

Lamy, Pierre-Jean PJ; van der Leest, Paul P; Lozano, Nicolas N; Becht, Catherine C; Duboeuf, Frédérique F; Groen, Harry J M HJM; Hilgers, Werner W; Pourel, Nicolas N; Rifaela, Naomi N; Schuuring, Ed E; Alix-Panabières, Catherine C

Publication Date: 2020-10-16

Variant appearance in text: BRAF: 1633G>A

PubMed Link: 33081150

Variant Present in the following documents:

• cancers-12-03002-s001.pdf

View BVdb publication page

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Genetic profiling of somatic alterations by Oncomine Focus Assay in Korean patients with advanced gastric cancer.

Oncology Letters

Park, Joonhong J; Lee, Sang-Il SI; Shin, Soyoung S; Hong, Jang Hee JH; Yoo, Han Mo HM; Kim, Jeong Goo JG

Publication Date: 2020-11

Variant appearance in text: BRAF: 1633G>A; Glu545Lys

PubMed Link: 32934698

Variant Present in the following documents:

• ol-20-05-11990.pdf

View BVdb publication page

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Clinical Application of Targeted Deep Sequencing in Metastatic Colorectal Cancer Patients: Actionable Genomic Alteration in K-MASTER Project.

Cancer Research And Treatment

Lee, Youngwoo Y; Lee, Soohyeon S; Sung, Jae Sook JS; Chung, Hee-Joon HJ; Lim, Ah-Reum AR; Kim, Ju Won JW; Choi, Yoon Ji YJ; Park, Kyong Hwa KH; Kim, Yeul Hong YH

Publication Date: 2021-01

Variant appearance in text: BRAF: E545K

PubMed Link: 32810930

Variant Present in the following documents:

• crt-2020-559-suppl3.pdf

View BVdb publication page

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Evaluation of circulating tumor DNA as a biomarker in pancreatic cancer with liver metastasis.

Plos One

Uesato, Yasunori Y; Sasahira, Naoki N; Ozaka, Masato M; Sasaki, Takashi T; Takatsuki, Mitsuhisa M; Zembutsu, Hitoshi H

Publication Date: 2020

Variant appearance in text: BRAF: E545K

PubMed Link: 32614932

Variant Present in the following documents:

• pone.0235623.s001.xlsx, sheet 1

View BVdb publication page

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A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling.

Cell Research

Qian, Junbin J; Olbrecht, Siel S; Boeckx, Bram B; Vos, Hanne H; Laoui, Damya D; Etlioglu, Emre E; Wauters, Els E; Pomella, Valentina V; Verbandt, Sara S; Busschaert, Pieter P; Bassez, Ayse A; Franken, Amelie A; Bempt, Marlies Vanden MV; Xiong, Jieyi J; Weynand, Birgit B; van Herck, Yannick Y; Antoranz, Asier A; Bosisio, Francesca Maria FM; Thienpont, Bernard B; Floris, Giuseppe G; Vergote, Ignace I; Smeets, Ann A; Tejpar, Sabine S; Lambrechts, Diether D

Publication Date: 2020-09

Variant appearance in text: BRAF: 1633G>A; E545K

PubMed Link: 32561858

Variant Present in the following documents:

• 41422_2020_355_MOESM15_ESM.xlsx, sheet 1

View BVdb publication page

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Circulating Tumor DNA as a Novel Biomarker Optimizing Chemotherapy for Colorectal Cancer.

Cancers

Osumi, Hiroki H; Shinozaki, Eiji E; Yamaguchi, Kensei K

Publication Date: 2020-06-13

Variant appearance in text: BRAF: E545K

PubMed Link: 32545750

Variant Present in the following documents:

• cancers-12-01566.pdf

View BVdb publication page

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A harmonized meta-knowledgebase of clinical interpretations of somatic genomic variants in cancer.

Nature Genetics

Wagner, Alex H AH; Walsh, Brian B; Mayfield, Georgia G; Tamborero, David D; Sonkin, Dmitriy D; Krysiak, Kilannin K; Deu-Pons, Jordi J; Duren, Ryan P RP; Gao, Jianjiong J; McMurry, Julie J; Patterson, Sara S; Del Vecchio Fitz, Catherine C; Pitel, Beth A BA; Sezerman, Ozman U OU; Ellrott, Kyle K; Warner, Jeremy L JL; Rieke, Damian T DT; Aittokallio, Tero T; Cerami, Ethan E; Ritter, Deborah I DI; Schriml, Lynn M LM; Freimuth, Robert R RR; Haendel, Melissa M; Raca, Gordana G; Madhavan, Subha S; Baudis, Michael M; Beckmann, Jacques S JS; Dienstmann, Rodrigo R; Chakravarty, Debyani D; Li, Xuan Shirley XS; Mockus, Susan S; Elemento, Olivier O; Schultz, Nikolaus N; Lopez-Bigas, Nuria N; Lawler, Mark M; Goecks, Jeremy J; Griffith, Malachi M; Griffith, Obi L OL; Margolin, Adam A AA; ,

Publication Date: 2020-04

Variant appearance in text: BRAF: E545K

PubMed Link: 32246132

Variant Present in the following documents:

• Main text
• 41588_2020_Article_603.pdf

View BVdb publication page

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Direct targeting of oncogenic RAS mutants with a tumor-specific cytosol-penetrating antibody inhibits RAS mutant-driven tumor growth.

Science Advances

Shin, Seung-Min SM; Kim, Ji-Sun JS; Park, Seong-Wook SW; Jun, Sei-Yong SY; Kweon, Hye-Jin HJ; Choi, Dong-Ki DK; Lee, Dakeun D; Cho, Yong Beom YB; Kim, Yong-Sung YS

Publication Date: 2020-01

Variant appearance in text: BRAF: E545K

PubMed Link: 31998840

Variant Present in the following documents:

• aay2174_SM.pdf

View BVdb publication page

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High Frequency of PIK3CA Mutations in Low-Grade Serous Ovarian Carcinomas of Japanese Patients.

Diagnostics (Basel, Switzerland)

Ishibashi, Tomoka T; Nakayama, Kentaro K; Razia, Sultana S; Ishikawa, Masako M; Nakamura, Kohei K; Yamashita, Hitomi H; Dey, Puja P; Iida, Koji K; Kurioka, Hiroko H; Nakayama, Satoru S; Otsuki, Yoshiro Y; Ishikawa, Noriyoshi N; Kyo, Satoru S

Publication Date: 2019-12-27

Variant appearance in text: BRAF: E545K

PubMed Link: 31892193

Variant Present in the following documents:

• Main text

View BVdb publication page

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The emerging treatment landscape of targeted therapy in non-small-cell lung cancer.

Signal Transduction And Targeted Therapy

Yuan, Min M; Huang, Li-Li LL; Chen, Jian-Hua JH; Wu, Jie J; Xu, Qing Q

Publication Date: 2019

Variant appearance in text: BRAF: E545K

PubMed Link: 31871778

Variant Present in the following documents:

• 41392_2019_Article_99.pdf

View BVdb publication page

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POT1 and Damage Response Malfunction Trigger Acquisition of Somatic Activating Mutations in the VEGF Pathway in Cardiac Angiosarcomas.

Journal Of The American Heart Association

Calvete, Oriol O; Garcia-Pavia, Pablo P; Domínguez, Fernando F; Mosteiro, Lluc L; Pérez-Cabornero, Lucía L; Cantalapiedra, Diego D; Zorio, Esther E; Ramón Y Cajal, Teresa T; Crespo-Leiro, Maria G MG; Teulé, Álex Á; Lázaro, Conxi C; Morente, Manuel M MM; Urioste, Miguel M; Benitez, Javier J

Publication Date: 2019-09-17

Variant appearance in text: BRAF: Glu545Lys

PubMed Link: 31510873

Variant Present in the following documents:

• JAH3-8-e012875.pdf

View BVdb publication page

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Systematic analysis of the intersection of disease mutations with protein modifications.

Bmc Medical Genomics

Simpson, Claire M CM; Zhang, Bin B; Hornbeck, Peter V PV; Gnad, Florian F

Publication Date: 2019-07-25

Variant appearance in text: BRAF: E545K

PubMed Link: 31345222

Variant Present in the following documents:

• Main text
• 12920_2019_Article_543.pdf

View BVdb publication page

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Signalling involving MET and FAK supports cell division independent of the activity of the cell cycle-regulating CDK4/6 kinases.

Oncogene

Zhang, Chi C; Stockwell, Simon R SR; Elbanna, May M; Ketteler, Robin R; Freeman, Jamie J; Al-Lazikani, Bissan B; Eccles, Suzanne S; De Haven Brandon, Alexis A; Raynaud, Florence F; Hayes, Angela A; Clarke, Paul A PA; Workman, Paul P; Mittnacht, Sibylle S

Publication Date: 2019-07

Variant appearance in text: BRAF: E545K

PubMed Link: 31296956

Variant Present in the following documents:

• 41388_2019_Article_850.pdf

View BVdb publication page

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Application of cell-free DNA for genomic tumor profiling: a feasibility study.

Oncotarget

Ahlborn, Lise B LB; Rohrberg, Kristoffer S KS; Gabrielaite, Migle M; Tuxen, Ida V IV; Yde, Christina W CW; Spanggaard, Iben I; Santoni-Rugiu, Eric E; Nielsen, Finn C FC; Lassen, Ulrik U; Mau-Sorensen, Morten M; Østrup, Olga O

Publication Date: 2019-02-15

Variant appearance in text: BRAF: E545K

PubMed Link: 30858924

Variant Present in the following documents:

• oncotarget-10-1388-s002.xls, sheet 5

View BVdb publication page

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Long noncoding RNA and mRNA profiling in cetuximab-resistant colorectal cancer cells by RNA sequencing analysis.

Cancer Medicine

Jing, Changwen C; Ma, Rong R; Cao, Haixia H; Wang, Zhuo Z; Liu, Siwen S; Chen, Dan D; Wu, Yang Y; Zhang, Junying J; Wu, Jianzhong J

Publication Date: 2019-04

Variant appearance in text: BRAF: 1633G>A; E545K

PubMed Link: 30848094

Variant Present in the following documents:

• Main text

View BVdb publication page

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Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas.

Cell Death & Disease

De Bessa, Tiphany Coralie TC; Pagano, Alessandra A; Moretti, Ana Iochabel Soares AIS; Oliveira, Percillia Victoria Santos PVS; Mendonça, Samir Andrade SA; Kovacic, Herve H; Laurindo, Francisco Rafael Martins FRM

Publication Date: 2019-02-13

Variant appearance in text: BRAF: E545K

PubMed Link: 30760703

Variant Present in the following documents:

• Main text
• 41419_2019_Article_1402.pdf

View BVdb publication page

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Drug Sensitivity Screening and Targeted Pathway Analysis Reveal a Multi-Driver Proliferative Mechanism and Suggest a Strategy of Combination Targeted Therapy for Colorectal Cancer Cells.

Molecules (Basel, Switzerland)

Shen, Jinyan J; Li, Li L; Yang, Tao T; Cheng, Niuliang N; Sun, Gongqin G

Publication Date: 2019-02-11

Variant appearance in text: BRAF: E545K

PubMed Link: 30754629

Variant Present in the following documents:

• Main text

View BVdb publication page

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Brain Somatic Mutations in Epileptic Disorders.

Molecules And Cells

Koh, Hyun Yong HY; Lee, Jeong Ho JH

Publication Date: 2018-10-31

Variant appearance in text: BRAF: 1633G>A

PubMed Link: 30352490

Variant Present in the following documents:

• Main text

View BVdb publication page

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Capturing colorectal cancer inter-tumor heterogeneity in patient-derived xenograft (PDX) models.

International Journal Of Cancer

Prasetyanti, Pramudita R PR; van Hooff, Sander R SR; van Herwaarden, Tessa T; de Vries, Nathalie N; Kalloe, Kieshen K; Rodermond, Hans H; van Leersum, Ronald R; de Jong, Joan H JH; Franitza, Marek M; Nürnberg, Peter P; Todaro, Matilde M; Stassi, Giorgio G; Medema, Jan Paul JP

Publication Date: 2019-01-15

Variant appearance in text: BRAF: E545K

PubMed Link: 30151914

Variant Present in the following documents:

• Main text

View BVdb publication page

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Integrative omics analyses broaden treatment targets in human cancer.

Genome Medicine

Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L

Publication Date: 2018-07-27

Variant appearance in text: BRAF: E545K

PubMed Link: 30053901

Variant Present in the following documents:

• 13073_2018_Article_564.pdf

View BVdb publication page

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Genetic characterisation of molecular targets in carcinoma of unknown primary.

Journal Of Translational Medicine

Clynick, B B; Dessauvagie, B B; Sterrett, G G; Harvey, N T NT; Allcock, R J N RJN; Saunders, C C; Erber, W W; Meehan, K K

Publication Date: 2018-07-04

Variant appearance in text: BRAF: E545K

PubMed Link: 29973234

Variant Present in the following documents:

• 12967_2018_Article_1564.pdf

View BVdb publication page

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Preclinical evaluation of novel fatty acid synthase inhibitors in primary colorectal cancer cells and a patient-derived xenograft model of colorectal cancer.

Oncotarget

Zaytseva, Yekaterina Y YY; Rychahou, Piotr G PG; Le, Anh-Thu AT; Scott, Timothy L TL; Flight, Robert M RM; Kim, Ji Tae JT; Harris, Jennifer J; Liu, Jinpeng J; Wang, Chi C; Morris, Andrew J AJ; Sivakumaran, Theru A TA; Fan, Teresa T; Moseley, Hunter H; Gao, Tianyan T; Lee, Eun Y EY; Weiss, Heidi L HL; Heuer, Timothy S TS; Kemble, George G; Evers, Mark M

Publication Date: 2018-05-15

Variant appearance in text: BRAF: 1633G>A; Glu545Lys

PubMed Link: 29872506

Variant Present in the following documents:

• oncotarget-09-24787-s001.pdf

View BVdb publication page

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Aberrant status and clinicopathologic characteristic associations of 11 target genes in 1,321 Chinese patients with lung adenocarcinoma.

Journal Of Thoracic Disease

Zhao, Mengnan M; Zhan, Cheng C; Li, Ming M; Yang, Xiaodong X; Yang, Xinyu X; Zhang, Yong Y; Lin, Miao M; Xia, Yifeng Y; Feng, Mingxiang M; Wang, Qun Q

Publication Date: 2018-01

Variant appearance in text: BRAF: E545K

PubMed Link: 29600072

Variant Present in the following documents:

• Main text

View BVdb publication page

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CSF-ctDNA SMSEQ Analysis to Tailor the Treatment of a Patient with Brain Metastases: A Case Report.

Case Reports In Oncology

Huang, Wen-Tsung WT; Lu, Na-Mi NM; Hsu, Wen-Yuan WY; Chang, Shih-En SE; Atkins, Alex A; Mei, Rui R; Javey, Manana M

Publication Date: 2018

Variant appearance in text: BRAF: 1633G>A; E545K

PubMed Link: 29515413

Variant Present in the following documents:

• Main text

View BVdb publication page

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Prognostic and histogenetic roles of gene alteration and the expression of key potentially actionable targets in salivary duct carcinomas.

Oncotarget

Shimura, Tomotaka T; Tada, Yuichiro Y; Hirai, Hideaki H; Kawakita, Daisuke D; Kano, Satoshi S; Tsukahara, Kiyoaki K; Shimizu, Akira A; Takase, Soichiro S; Imanishi, Yorihisa Y; Ozawa, Hiroyuki H; Okami, Kenji K; Sato, Yuichiro Y; Sato, Yukiko Y; Fushimi, Chihiro C; Takahashi, Hideaki H; Okada, Takuro T; Sato, Hiroki H; Otsuka, Kuninori K; Watanabe, Yoshihiro Y; Sakai, Akihiro A; Ebisumoto, Koji K; Togashi, Takafumi T; Ueki, Yushi Y; Ota, Hisayuki H; Ando, Mizuo M; Kohsaka, Shinji S; Hanazawa, Toyoyuki T; Chazono, Hideaki H; Kadokura, Yoshiyuki Y; Kobayashi, Hitome H; Nagao, Toshitaka T

Publication Date: 2018-01-05

Variant appearance in text: BRAF: 1633G>A; E545K

PubMed Link: 29416736

Variant Present in the following documents:

• oncotarget-09-1852-s001.pdf

View BVdb publication page

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Therapeutic strategies and genetic profile comparisons in small cell carcinoma and large cell neuroendocrine carcinoma of the lung using next-generation sequencing.

Oncotarget

Ito, Masaoki M; Miyata, Yoshihiro Y; Hirano, Shoko S; Kimura, Shingo S; Irisuna, Fumiko F; Ikeda, Kyoko K; Kushitani, Kei K; Tsutani, Yasuhiro Y; Ueda, Daisuke D; Tsubokawa, Norifumi N; Takeshima, Yukio Y; Okada, Morihito M

Publication Date: 2017-12-12

Variant appearance in text: BRAF: E545K

PubMed Link: 29312580

Variant Present in the following documents:

• oncotarget-08-108936-s001.pdf

View BVdb publication page

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Preoperative chemoradiation with capecitabine, irinotecan and cetuximab in rectal cancer: significance of pre-treatment and post-resection RAS mutations.

British Journal Of Cancer

Gollins, Simon S; West, Nick N; Sebag-Montefiore, David D; Myint, Arthur Sun AS; Saunders, Mark M; Susnerwala, Shabbir S; Quirke, Phil P; Essapen, Sharadah S; Samuel, Leslie L; Sizer, Bruce B; Worlding, Jane J; Southward, Katie K; Hemmings, Gemma G; Tinkler-Hundal, Emma E; Taylor, Morag M; Bottomley, Daniel D; Chambers, Philip P; Lawrie, Emma E; Lopes, Andre A; Beare, Sandy S

Publication Date: 2017-10-24

Variant appearance in text: BRAF: 1633G>A

PubMed Link: 28859058

Variant Present in the following documents:

• Main text

View BVdb publication page

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Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications

Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ

Publication Date: 2017-05-11

Variant appearance in text: BRAF: 1633G>A

PubMed Link: 28492226

Variant Present in the following documents:

• ncomms15086-s3.xlsx, sheet 1

View BVdb publication page

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Clinical sequencing using a next-generation sequencing-based multiplex gene assay in patients with advanced solid tumors.

Cancer Science

Kou, Tadayuki T; Kanai, Masashi M; Yamamoto, Yoshihiro Y; Kamada, Mayumi M; Nakatsui, Masahiko M; Sakuma, Tomohiro T; Mochizuki, Hiroaki H; Hiroshima, Akinori A; Sugiyama, Aiko A; Nakamura, Eijiro E; Miyake, Hidehiko H; Minamiguchi, Sachiko S; Takaori, Kyoichi K; Matsumoto, Shigemi S; Haga, Hironori H; Seno, Hiroshi H; Kosugi, Shinji S; Okuno, Yasushi Y; Muto, Manabu M

Publication Date: 2017-07

Variant appearance in text: BRAF: E545K

PubMed Link: 28440963

Variant Present in the following documents:

View BVdb publication page

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Significance of KRAS, NRAS, BRAF and PIK3CA mutations in metastatic colorectal cancer patients receiving Bevacizumab: a single institution experience.

Acta Medica Lituanica

Baltruškevičienė, Edita E; Mickys, Ugnius U; Žvirblis, Tadas T; Stulpinas, Rokas R; Pipirienė Želvienė, Teresė T; Aleknavičius, Eduardas E

Publication Date: 2016

Variant appearance in text: BRAF: E545K

PubMed Link: 28356789

Variant Present in the following documents:

• Main text

View BVdb publication page

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Gold Nanoparticle Based Platforms for Circulating Cancer Marker Detection.

Nanotheranostics

Huang, Xiaohua X; O'Connor, Ryan R; Kwizera, Elyahb Allie EA

Publication Date: 2017

Variant appearance in text: BRAF: E545K

PubMed Link: 28217434

Variant Present in the following documents:

• Main text

View BVdb publication page

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Mechanisms of resistance to anti-EGFR therapy in colorectal cancer.

Oncotarget

Zhao, Ben B; Wang, Lu L; Qiu, Hong H; Zhang, Mingsheng M; Sun, Li L; Peng, Ping P; Yu, Qianqian Q; Yuan, Xianglin X

Publication Date: 2017-01-17

Variant appearance in text: BRAF: E545K

PubMed Link: 28002810

Variant Present in the following documents:

• Main text
• oncotarget-08-3980.pdf

View BVdb publication page

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Combining a GSI and BCL-2 inhibitor to overcome melanoma's resistance to current treatments.

Oncotarget

Mukherjee, Nabanita N; Almeida, Adam A; Partyka, Katie A KA; Lu, Yan Y; Schwan, Josianna V JV; Lambert, Karoline K; Rogers, Madison M; Robinson, William A WA; Robinson, Steven E SE; Applegate, Allison J AJ; Amato, Carol M CM; Luo, Yuchun Y; Fujita, Mayumi M; Norris, David A DA; Shellman, Yiqun G YG

Publication Date: 2016-12-20

Variant appearance in text: BRAF: E545K

PubMed Link: 27829238

Variant Present in the following documents:

• oncotarget-07-84594-s001.pdf

View BVdb publication page

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CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network.

Oncotarget

Fertig, Elana J EJ; Ozawa, Hiroyuki H; Thakar, Manjusha M; Howard, Jason D JD; Kagohara, Luciane T LT; Krigsfeld, Gabriel G; Ranaweera, Ruchira S RS; Hughes, Robert M RM; Perez, Jimena J; Jones, Siân S; Favorov, Alexander V AV; Carey, Jacob J; Stein-O'Brien, Genevieve G; Gaykalova, Daria A DA; Ochs, Michael F MF; Chung, Christine H CH

Publication Date: 2016-11-08

Variant appearance in text: BRAF: E545K

PubMed Link: 27650546

Variant Present in the following documents:

• oncotarget-07-73845-s007.xlsx, sheet 5
• oncotarget-07-73845-s007.xlsx, sheet 4
• oncotarget-07-73845-s007.xlsx, sheet 2
• oncotarget-07-73845-s007.xlsx, sheet 6
• oncotarget-07-73845-s007.xlsx, sheet 1

View BVdb publication page

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Evaluating Cancer of the Central Nervous System Through Next-Generation Sequencing of Cerebrospinal Fluid.

Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology

Pentsova, Elena I EI; Shah, Ronak H RH; Tang, Jiabin J; Boire, Adrienne A; You, Daoqi D; Briggs, Samuel S; Omuro, Antonio A; Lin, Xuling X; Fleisher, Martin M; Grommes, Christian C; Panageas, Katherine S KS; Meng, Fanli F; Selcuklu, S Duygu SD; Ogilvie, Shahiba S; Distefano, Natalie N; Shagabayeva, Larisa L; Rosenblum, Marc M; DeAngelis, Lisa M LM; Viale, Agnes A; Mellinghoff, Ingo K IK; Berger, Michael F MF

Publication Date: 2016-07-10

Variant appearance in text: BRAF: E545K

PubMed Link: 27161972

Variant Present in the following documents:

• JCO666487.pdf

View BVdb publication page

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Plasmid-Based Materials as Multiplex Quality Controls and Calibrators for Clinical Next-Generation Sequencing Assays.

The Journal Of Molecular Diagnostics : Jmd

Sims, David J DJ; Harrington, Robin D RD; Polley, Eric C EC; Forbes, Thomas D TD; Mehaffey, Michele G MG; McGregor, Paul M PM; Camalier, Corinne E CE; Harper, Kneshay N KN; Bouk, Courtney H CH; Das, Biswajit B; Conley, Barbara A BA; Doroshow, James H JH; Williams, P Mickey PM; Lih, Chih-Jian CJ

Publication Date: 2016-05

Variant appearance in text: BRAF: 1633G>A; E545K

PubMed Link: 27105923

Variant Present in the following documents:

• Main text

View BVdb publication page

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VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research.

Nucleic Acids Research

Lai, Zhongwu Z; Markovets, Aleksandra A; Ahdesmaki, Miika M; Chapman, Brad B; Hofmann, Oliver O; McEwen, Robert R; Johnson, Justin J; Dougherty, Brian B; Barrett, J Carl JC; Dry, Jonathan R JR

Publication Date: 2016-06-20

Variant appearance in text: BRAF: 1633G>A; E545K

PubMed Link: 27060149

Variant Present in the following documents:

• supp_gkw227_nar-03544-met-k-2015-File003.xls, sheet 2

View BVdb publication page

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Human lung adenocarcinoma cell cultures derived from malignant pleural effusions as model system to predict patients chemosensitivity.

Journal Of Translational Medicine

Roscilli, Giuseppe G; De Vitis, Claudia C; Ferrara, Fabiana Fosca FF; Noto, Alessia A; Cherubini, Emanuela E; Ricci, Alberto A; Mariotta, Salvatore S; Giarnieri, Enrico E; Giovagnoli, Maria Rosaria MR; Torrisi, Maria Rosaria MR; Bergantino, Francesca F; Costantini, Susan S; Fenizia, Francesca F; Lambiase, Matilde M; Aurisicchio, Luigi L; Normanno, Nicola N; Ciliberto, Gennaro G; Mancini, Rita R

Publication Date: 2016-02-29

Variant appearance in text: BRAF: 1633G>A

PubMed Link: 26928703

Variant Present in the following documents:

• 12967_2016_Article_816.pdf

View BVdb publication page

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Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics.

Acta Neuropathologica Communications

Hoffman, Lindsey M LM; DeWire, Mariko M; Ryall, Scott S; Buczkowicz, Pawel P; Leach, James J; Miles, Lili L; Ramani, Arun A; Brudno, Michael M; Kumar, Shiva Senthil SS; Drissi, Rachid R; Dexheimer, Phillip P; Salloum, Ralph R; Chow, Lionel L; Hummel, Trent T; Stevenson, Charles C; Lu, Q Richard QR; Jones, Blaise B; Witte, David D; Aronow, Bruce B; Hawkins, Cynthia E CE; Fouladi, Maryam M

Publication Date: 2016-01-04

Variant appearance in text: BRAF: E545K

PubMed Link: 26727948

Variant Present in the following documents:

• 40478_2015_269_MOESM1_ESM.xls, sheet 1

View BVdb publication page

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Clinical detection and categorization of uncommon and concomitant mutations involving BRAF.

Bmc Cancer

Zheng, Gang G; Tseng, Li-Hui LH; Chen, Guoli G; Haley, Lisa L; Illei, Peter P; Gocke, Christopher D CD; Eshleman, James R JR; Lin, Ming-Tseh MT

Publication Date: 2015-10-24

Variant appearance in text: BRAF: 1633G>A

PubMed Link: 26498038

Variant Present in the following documents:

• Main text

View BVdb publication page

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Mitochondrial D310 mutation as clonal marker for solid tumors.

Virchows Archiv : An International Journal Of Pathology

Geurts-Giele, Willemina R R WR; Gathier, Gerard H G K GH; Atmodimedjo, Peggy N PN; Dubbink, Hendrikus J HJ; Dinjens, Winand N M WN

Publication Date: 2015-11

Variant appearance in text: BRAF: E545K

PubMed Link: 26276353

Variant Present in the following documents:

• 428_2015_1817_MOESM2_ESM.xls, sheet 1

View BVdb publication page

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Comprehensive analysis of targetable oncogenic mutations in chinese cervical cancers.

Oncotarget

Xiang, Libing L; Li, Jiajia J; Jiang, Wei W; Shen, Xuxia X; Yang, Wentao W; Wu, Xiaohua X; Yang, Huijuan H

Publication Date: 2015-03-10

Variant appearance in text: BRAF: 1633G>A; E545K

PubMed Link: 25669975

Variant Present in the following documents:

• oncotarget-06-4968-s003.xlsx, sheet 1
• oncotarget-06-4968.pdf

View BVdb publication page

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