Publications:

Inhibition of RAF dimers: it takes two to tango.

Biochemical Society Transactions

Cook, Frazer A FA; Cook, Simon J SJ

Publication Date: 2021-02-26

Variant appearance in text: BRAF: T529M

PubMed Link: 33367512

Variant Present in the following documents:

• Main text

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BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS.

Science Advances

Röck, Ruth R; Mayrhofer, Johanna E JE; Torres-Quesada, Omar O; Enzler, Florian F; Raffeiner, Andrea A; Raffeiner, Philipp P; Feichtner, Andreas A; Huber, Roland G RG; Koide, Shohei S; Taylor, Susan S SS; Troppmair, Jakob J; Stefan, Eduard E

Publication Date: 2019-08

Variant appearance in text: BRAF: T529M

PubMed Link: 31453322

Variant Present in the following documents:

• Main text
• aav8463.pdf
• aav8463_SM.pdf

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RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition.

Nature Communications

Jin, Ting T; Lavoie, Hugo H; Sahmi, Malha M; David, Maud M; Hilt, Christine C; Hammell, Amy A; Therrien, Marc M

Publication Date: 2017-10-31

Variant appearance in text: BRAF: T529M

PubMed Link: 29084939

Variant Present in the following documents:

• Main text
• 41467_2017_1274_MOESM1_ESM.pdf
• 41467_2017_Article_1274.pdf

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Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.

Nature

Yao, Zhan Z; Yaeger, Rona R; Rodrik-Outmezguine, Vanessa S VS; Tao, Anthony A; Torres, Neilawattie M NM; Chang, Matthew T MT; Drosten, Matthias M; Zhao, Huiyong H; Cecchi, Fabiola F; Hembrough, Todd T; Michels, Judith J; Baumert, Hervé H; Miles, Linde L; Campbell, Naomi M NM; de Stanchina, Elisa E; Solit, David B DB; Barbacid, Mariano M; Taylor, Barry S BS; Rosen, Neal N

Publication Date: 2017-08-10

Variant appearance in text: BRAF: T529M

PubMed Link: 28783719

Variant Present in the following documents:

• Main text

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Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization.

Nature Chemical Biology

Lavoie, Hugo H; Thevakumaran, Neroshan N; Gavory, Gwenaëlle G; Li, John J JJ; Padeganeh, Abbas A; Guiral, Sébastien S; Duchaine, Jean J; Mao, Daniel Y L DY; Bouvier, Michel M; Sicheri, Frank F; Therrien, Marc M

Publication Date: 2013-07

Variant appearance in text: BRAF: T529M

PubMed Link: 23685672

Variant Present in the following documents:

• Main text
• nihms3965.pdf

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