Publications:

Design and Synthesis of Type-IV Inhibitors of BRAF Kinase That Block Dimerization and Overcome Paradoxical MEK/ERK Activation.

Journal Of Medicinal Chemistry

Beneker, Chad M CM; Rovoli, Magdalini M; Kontopidis, George G; Röring, Michael M; Galda, Simeon S; Braun, Sandra S; Brummer, Tilman T; McInnes, Campbell C

Publication Date: 2019-04-25

Variant appearance in text: BRAF: F516A

PubMed Link: 30977659

Variant Present in the following documents:

• Main text

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Phosphorylation of RAF Kinase Dimers Drives Conformational Changes that Facilitate Transactivation.

Angewandte Chemie (International Ed. In English)

Jambrina, Pablo G PG; Rauch, Nora N; Pilkington, Ruth R; Rybakova, Katja K; Nguyen, Lan K LK; Kholodenko, Boris N BN; Buchete, Nicolae-Viorel NV; Kolch, Walter W; Rosta, Edina E

Publication Date: 2016-01-18

Variant appearance in text: BRAF: F516A

PubMed Link: 26644280

Variant Present in the following documents:

• Main text
• ANIE-55-983-s001.pdf
• ANIE-55-983.pdf

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