BRAF c.1415A>G ;(p.Y472C)

Variant ID: 7-140481393-T-C

NM_004333.4(BRAF):c.1415A>G;(p.Y472C)

This variant was identified in 43 publications

View GRCh38 version.




Publications:


Blood tumor mutational burden and dynamic changes in circulating tumor DNA predict response to pembrolizumab treatment in advanced non-small cell lung cancer.

Translational Lung Cancer Research
Stensgaard, Simone S; Thomsen, Astrid A; Helstrup, Sofie S; Meldgaard, Peter P; Sorensen, Boe S BS
Publication Date: 2023-05-31

Variant appearance in text: BRAF: 1415A>G; Tyr472Cys
PubMed Link: 37323168
Variant Present in the following documents:
  • tlcr-12-05-971-supplementary.pdf
View BVdb publication page



Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23

Variant appearance in text: BRAF: 1415A>G; Tyr472Cys
PubMed Link: 36823319
Variant Present in the following documents:
  • 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Rosai-Dorfman Disease between Proliferation and Neoplasia.

Cancers
Elbaz Younes, Ismail I; Sokol, Lubomir L; Zhang, Ling L
Publication Date: 2022-10-27

Variant appearance in text: BRAF: Y472C
PubMed Link: 36358690
Variant Present in the following documents:
  • Main text
  • cancers-14-05271.pdf
View BVdb publication page



Systematic review and meta-analysis of genomic alterations in acral melanoma.

Pigment Cell & Melanoma Research
Broit, Natasa N; Johansson, Peter A PA; Rodgers, Chloe B CB; Walpole, Sebastian T ST; Hayward, Nicholas K NK; Pritchard, Antonia L AL
Publication Date: 2022-05

Variant appearance in text: BRAF: Y472C
PubMed Link: 35229492
Variant Present in the following documents:
  • PCMR-35-369-s003.xlsx, sheet 12
View BVdb publication page



The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer
Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J
Publication Date: 2022-02

Variant appearance in text: BRAF: Tyr472Cys
PubMed Link: 35221333
Variant Present in the following documents:
  • 43018_2022_332_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: BRAF: Y472C
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications
Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q
Publication Date: 2021-01-04

Variant appearance in text: BRAF: 1415A>G; Y472C
PubMed Link: 33397889
Variant Present in the following documents:
  • 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Mayrhofer, Johanna E JE; Enzler, Florian F; Feichtner, Andreas A; Röck, Ruth R; Fleischmann, Jakob J; Raffeiner, Andrea A; Tschaikner, Philipp P; Ogris, Egon E; Huber, Roland G RG; Hartl, Markus M; Schneider, Rainer R; Troppmair, Jakob J; Torres-Quesada, Omar O; Stefan, Eduard E
Publication Date: 2020-12-08

Variant appearance in text: BRAF: Y472C
PubMed Link: 33229534
Variant Present in the following documents:
  • Main text
  • pnas.202012150.pdf
  • pnas.2012150117.sapp.pdf
View BVdb publication page



Usefulness of a novel device to divide core needle biopsy specimens in a spatially matched fashion.

Scientific Reports
Shiraishi, Takumi T; Inui, Shogo S; Inoue, Yuta Y; Saito, Yumiko Y; Taga, Hideto H; Kaneko, Masatomo M; Tsuji, Keisuke K; Ueda, Saya S; Ueda, Takashi T; Matsugasumi, Toru T; Taniguchi, Hidefumi H; Ueno, Akihisa A; Yamada, Takeshi T; Yamada, Yasuhiro Y; Iwata, Tsuyoshi T; Fujihara, Atsuko A; Hongo, Fumiya F; Ukimura, Osamu O
Publication Date: 2020-10-13

Variant appearance in text: rs1057519719
PubMed Link: 33051506
Variant Present in the following documents:
  • 41598_2020_74136_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports
Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA
Publication Date: 2020-09-21

Variant appearance in text: BRAF: Y472C
PubMed Link: 32958805
Variant Present in the following documents:
  • 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2
View BVdb publication page



Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects.

Science Advances
Lee, Sangsin S; Ding, Ning N; Sun, Yidi Y; Yuan, Tanglong T; Li, Jing J; Yuan, Qichen Q; Liu, Lizhong L; Yang, Jie J; Wang, Qian Q; Kolomeisky, Anatoly B AB; Hilton, Isaac B IB; Zuo, Erwei E; Gao, Xue X
Publication Date: 2020-07

Variant appearance in text: BRAF: 1415A>G; Tyr472Cys
PubMed Link: 32832622
Variant Present in the following documents:
  • aba1773_Data_file_S1.xlsx, sheet 2
View BVdb publication page



PDX models of human lung squamous cell carcinoma: consideration of factors in preclinical and co-clinical applications.

Journal Of Translational Medicine
Jung, Hae-Yun HY; Kim, Tae Ho TH; Lee, Jong-Eun JE; Kim, Hong Kwan HK; Cho, Jong Ho JH; Choi, Yong Soo YS; Shin, Sumin S; Lee, Se-Hoon SH; Rhee, Hwanseok H; Lee, Hee Kyung HK; Choi, Hyun Jung HJ; Jang, Hye Yoon HY; Lee, Seungjae S; Kang, Jung Hee JH; Choi, Young Ae YA; Lee, Sanghyuk S; Lee, Jinseon J; Choi, Yoon La Y; Kim, Jhingook J
Publication Date: 2020-08-06

Variant appearance in text: BRAF: Y472C
PubMed Link: 32762722
Variant Present in the following documents:
  • 12967_2020_2473_MOESM4_ESM.pdf
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: BRAF: Y472C
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 11
View BVdb publication page



Clonal selection confers distinct evolutionary trajectories in BRAF-driven cancers.

Nature Communications
Gopal, Priyanka P; Sarihan, Elif Irem EI; Chie, Eui Kyu EK; Kuzmishin, Gwendolyn G; Doken, Semihcan S; Pennell, Nathan A NA; Raymond, Daniel P DP; Murthy, Sudish C SC; Ahmad, Usman U; Raja, Siva S; Almeida, Francisco F; Sethi, Sonali S; Gildea, Thomas R TR; Peacock, Craig D CD; Adams, Drew J DJ; Abazeed, Mohamed E ME
Publication Date: 2019-11-13

Variant appearance in text: BRAF: Y472C
PubMed Link: 31723142
Variant Present in the following documents:
  • 41467_2019_13161_MOESM5_ESM.xlsx, sheet 1
View BVdb publication page



Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology
Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR
Publication Date: 2019-04

Variant appearance in text: BRAF: Y472C
PubMed Link: 31034466
Variant Present in the following documents:
  • pcbi.1006981.s010.xlsx, sheet 1
View BVdb publication page



Agents to treat BRAF-mutant lung cancer.

Drugs In Context
Alvarez, Jean G Bustamante JGB; Otterson, Gregory A GA
Publication Date: 2019

Variant appearance in text: BRAF: Y472C
PubMed Link: 30899313
Variant Present in the following documents:
  • Main text
  • dic-8-212566.pdf
View BVdb publication page



Analysis on GENIE reveals novel recurrent variants that affect molecular diagnosis of sizable number of cancer patients.

Bmc Cancer
Koyama, Takahiko T; Rhrissorrakrai, Kahn K; Parida, Laxmi L
Publication Date: 2019-02-01

Variant appearance in text: BRAF: 1415A>G; Y472C
PubMed Link: 30709382
Variant Present in the following documents:
  • 12885_2019_5313_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Epidermal growth factor receptor (EGFR), KRAS, and BRAF mutations in lung adenocarcinomas: A study from India.

Current Problems In Cancer
Singh, Varsha V; Guleria, Prerna P; Malik, Prabhat Singh PS; Mohan, Anant A; Thulkar, Sanjay S; Pandey, R M RM; Luthra, Kalpana K; Arava, Sudheer S; Ray, Ruma R; Jain, Deepali D
Publication Date: 2019-10

Variant appearance in text: BRAF: Y472C
PubMed Link: 30591192
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinical validation of coexisting driver mutations in colorectal cancers.

Human Pathology
Zheng, Gang G; Tseng, Li-Hui LH; Haley, Lisa L; Ibrahim, Junaid J; Bynum, Jennifer J; Xian, Rena R; Gocke, Christopher D CD; Eshleman, James R JR; Lin, Ming-Tseh MT
Publication Date: 2019-04

Variant appearance in text: BRAF: Y472C
PubMed Link: 30481508
Variant Present in the following documents:
  • Main text
View BVdb publication page



Integrative omics analyses broaden treatment targets in human cancer.

Genome Medicine
Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L
Publication Date: 2018-07-27

Variant appearance in text: BRAF: Y472C
PubMed Link: 30053901
Variant Present in the following documents:
  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 3
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: BRAF: Y472C
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 1
View BVdb publication page



From somatic variants towards precision oncology: Evidence-driven reporting of treatment options in molecular tumor boards.

Genome Medicine
Perera-Bel, Júlia J; Hutter, Barbara B; Heining, Christoph C; Bleckmann, Annalen A; Fröhlich, Martina M; Fröhling, Stefan S; Glimm, Hanno H; Brors, Benedikt B; Beißbarth, Tim T
Publication Date: 2018-03-15

Variant appearance in text: BRAF: Y472C
PubMed Link: 29544535
Variant Present in the following documents:
  • 13073_2018_529_MOESM5_ESM.pdf
View BVdb publication page



Prevalence and detection of low-allele-fraction variants in clinical cancer samples.

Nature Communications
Shin, Hyun-Tae HT; Choi, Yoon-La YL; Yun, Jae Won JW; Kim, Nayoung K D NKD; Kim, Sook-Young SY; Jeon, Hyo Jeong HJ; Nam, Jae-Yong JY; Lee, Chung C; Ryu, Daeun D; Kim, Sang Cheol SC; Park, Kyunghee K; Lee, Eunjin E; Bae, Joon Seol JS; Son, Dae Soon DS; Joung, Je-Gun JG; Lee, Jeeyun J; Kim, Seung Tae ST; Ahn, Myung-Ju MJ; Lee, Se-Hoon SH; Ahn, Jin Seok JS; Lee, Woo Yong WY; Oh, Bo Young BY; Park, Yeon Hee YH; Lee, Jeong Eon JE; Lee, Kwang Hyuk KH; Kim, Hee Cheol HC; Kim, Kyoung-Mee KM; Im, Young-Hyuck YH; Park, Keunchil K; Park, Peter J PJ; Park, Woong-Yang WY
Publication Date: 2017-11-09

Variant appearance in text: BRAF: Y472C
PubMed Link: 29123093
Variant Present in the following documents:
  • 41467_2017_1470_MOESM11_ESM.xlsx, sheet 1
View BVdb publication page



Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer.

Oncotarget
Ashktorab, Hassan H; Mokarram, Pooneh P; Azimi, Hamed H; Olumi, Hasti H; Varma, Sudhir S; Nickerson, Michael L ML; Brim, Hassan H
Publication Date: 2017-01-31

Variant appearance in text: BRAF: Y472C
PubMed Link: 28002797
Variant Present in the following documents:
  • oncotarget-08-7852-s002.xlsx, sheet 15
View BVdb publication page



Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets.

Nature Communications
Chen, Ying-Bei YB; Xu, Jianing J; Skanderup, Anders Jacobsen AJ; Dong, Yiyu Y; Brannon, A Rose AR; Wang, Lu L; Won, Helen H HH; Wang, Patricia I PI; Nanjangud, Gouri J GJ; Jungbluth, Achim A AA; Li, Wei W; Ojeda, Virginia V; Hakimi, A Ari AA; Voss, Martin H MH; Schultz, Nikolaus N; Motzer, Robert J RJ; Russo, Paul P; Cheng, Emily H EH; Giancotti, Filippo G FG; Lee, William W; Berger, Michael F MF; Tickoo, Satish K SK; Reuter, Victor E VE; Hsieh, James J JJ
Publication Date: 2016-10-07

Variant appearance in text: BRAF: Y472C
PubMed Link: 27713405
Variant Present in the following documents:
  • Main text
  • ncomms13131-s3.xlsx, sheet 2
  • ncomms13131.pdf
View BVdb publication page



Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma.

Cell Reports
Giannakis, Marios M; Mu, Xinmeng Jasmine XJ; Shukla, Sachet A SA; Qian, Zhi Rong ZR; Cohen, Ofir O; Nishihara, Reiko R; Bahl, Samira S; Cao, Yin Y; Amin-Mansour, Ali A; Yamauchi, Mai M; Sukawa, Yasutaka Y; Stewart, Chip C; Rosenberg, Mara M; Mima, Kosuke K; Inamura, Kentaro K; Nosho, Katsuhiko K; Nowak, Jonathan A JA; Lawrence, Michael S MS; Giovannucci, Edward L EL; Chan, Andrew T AT; Ng, Kimmie K; Meyerhardt, Jeffrey A JA; Van Allen, Eliezer M EM; Getz, Gad G; Gabriel, Stacey B SB; Lander, Eric S ES; Wu, Catherine J CJ; Fuchs, Charles S CS; Ogino, Shuji S; Garraway, Levi A LA
Publication Date: 2016-04-26

Variant appearance in text: BRAF: Y472C
PubMed Link: 27149842
Variant Present in the following documents:
  • mmc2.xlsx, sheet 4
View BVdb publication page



Alterations in genes other than EGFR/ALK/ROS1 in non-small cell lung cancer: trials and treatment options.

Cancer Biology & Medicine
Desai, Arpita A; Menon, Smitha P SP; Dy, Grace K GK
Publication Date: 2016-03

Variant appearance in text: BRAF: Y472C
PubMed Link: 27144064
Variant Present in the following documents:
  • Main text
View BVdb publication page



Prognostic Role of BRAF Mutation in Stage II/III Colorectal Cancer Receiving Curative Resection and Adjuvant Chemotherapy: A Meta-Analysis Based on Randomized Clinical Trials.

Plos One
Zhu, Lizhen L; Dong, Caixia C; Cao, Ying Y; Fang, Xuefeng X; Zhong, Chenhan C; Li, Dan D; Yuan, Ying Y
Publication Date: 2016

Variant appearance in text: BRAF: Y472C
PubMed Link: 27138801
Variant Present in the following documents:
  • Main text
  • pone.0154795.pdf
View BVdb publication page



Integrated digital error suppression for improved detection of circulating tumor DNA.

Nature Biotechnology
Newman, Aaron M AM; Lovejoy, Alexander F AF; Klass, Daniel M DM; Kurtz, David M DM; Chabon, Jacob J JJ; Scherer, Florian F; Stehr, Henning H; Liu, Chih Long CL; Bratman, Scott V SV; Say, Carmen C; Zhou, Li L; Carter, Justin N JN; West, Robert B RB; Sledge, George W GW; Shrager, Joseph B JB; Loo, Billy W BW; Neal, Joel W JW; Wakelee, Heather A HA; Diehn, Maximilian M; Alizadeh, Ash A AA
Publication Date: 2016-05

Variant appearance in text: BRAF: 1415A>G; Y472C
PubMed Link: 27018799
Variant Present in the following documents:
  • NIHMS764326-supplement-6.xlsx, sheet 1
View BVdb publication page



Dasatinib induces DNA damage and activates DNA repair pathways leading to senescence in non-small cell lung cancer cell lines with kinase-inactivating BRAF mutations.

Oncotarget
Peng, Shaohua S; Sen, Banibrata B; Mazumdar, Tuhina T; Byers, Lauren A LA; Diao, Lixia L; Wang, Jing J; Tong, Pan P; Giri, Uma U; Heymach, John V JV; Kadara, Humam N HN; Johnson, Faye M FM
Publication Date: 2016-01-05

Variant appearance in text: BRAF: Y472C
PubMed Link: 26623721
Variant Present in the following documents:
  • Main text
  • oncotarget-07-0565.pdf
View BVdb publication page



Clinical detection and categorization of uncommon and concomitant mutations involving BRAF.

Bmc Cancer
Zheng, Gang G; Tseng, Li-Hui LH; Chen, Guoli G; Haley, Lisa L; Illei, Peter P; Gocke, Christopher D CD; Eshleman, James R JR; Lin, Ming-Tseh MT
Publication Date: 2015-10-24

Variant appearance in text: BRAF: 1415A>G; Y472C
PubMed Link: 26498038
Variant Present in the following documents:
  • Main text
View BVdb publication page



Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Cell
Creixell, Pau P; Schoof, Erwin M EM; Simpson, Craig D CD; Longden, James J; Miller, Chad J CJ; Lou, Hua Jane HJ; Perryman, Lara L; Cox, Thomas R TR; Zivanovic, Nevena N; Palmeri, Antonio A; Wesolowska-Andersen, Agata A; Helmer-Citterich, Manuela M; Ferkinghoff-Borg, Jesper J; Itamochi, Hiroaki H; Bodenmiller, Bernd B; Erler, Janine T JT; Turk, Benjamin E BE; Linding, Rune R
Publication Date: 2015-09-24

Variant appearance in text: BRAF: Y472C
PubMed Link: 26388441
Variant Present in the following documents:
  • mmc4.xlsx, sheet 1
View BVdb publication page



Performance characteristics of next-generation sequencing in clinical mutation detection of colorectal cancers.

Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc
Haley, Lisa L; Tseng, Li-Hui LH; Zheng, Gang G; Dudley, Jonathan J; Anderson, Derek A DA; Azad, Nilofer S NS; Gocke, Christopher D CD; Eshleman, James R JR; Lin, Ming-Tseh MT
Publication Date: 2015-10

Variant appearance in text: BRAF: Y472C
PubMed Link: 26226847
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genomics driven-oncology: challenges and perspectives.

Bmc Cancer
Normanno, Nicola N; Cree, Ian A IA
Publication Date: 2015-03-23

Variant appearance in text: BRAF: Y472C
PubMed Link: 25884512
Variant Present in the following documents:
  • Main text
  • 12885_2015_Article_1147.pdf
View BVdb publication page



Optimal drug prediction from personal genomics profiles.

Ieee Journal Of Biomedical And Health Informatics
Sheng, Jianting J; Li, Fuhai F; Wong, Stephen T C ST
Publication Date: 2015-07

Variant appearance in text: BRAF: Y472C
PubMed Link: 25781964
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genotyping of cutaneous melanoma.

Chinese Clinical Oncology
Glitza, Isabella C IC; Davies, Michael A MA
Publication Date: 2014-09

Variant appearance in text: BRAF: Y472C
PubMed Link: 25632386
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecularly targeted therapies in non-small-cell lung cancer annual update 2014.

Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer
Morgensztern, Daniel D; Campo, Meghan J MJ; Dahlberg, Suzanne E SE; Doebele, Robert C RC; Garon, Edward E; Gerber, David E DE; Goldberg, Sarah B SB; Hammerman, Peter S PS; Heist, Rebecca S RS; Hensing, Thomas T; Horn, Leora L; Ramalingam, Suresh S SS; Rudin, Charles M CM; Salgia, Ravi R; Sequist, Lecia V LV; Shaw, Alice T AT; Simon, George R GR; Somaiah, Neeta N; Spigel, David R DR; Wrangle, John J; Johnson, David D; Herbst, Roy S RS; Bunn, Paul P; Govindan, Ramaswamy R
Publication Date: 2015-01

Variant appearance in text: BRAF: Y472C
PubMed Link: 25535693
Variant Present in the following documents:
  • Main text
View BVdb publication page



Recent advances in personalized lung cancer medicine.

Personalized Medicine
Okimoto, Ross A RA; Bivona, Trever G TG
Publication Date: 2014

Variant appearance in text: BRAF: Y472C
PubMed Link: 25506379
Variant Present in the following documents:
  • Main text
View BVdb publication page



Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Publication Date: 2014-10-28

Variant appearance in text: BRAF: Y472C
PubMed Link: 25348012
Variant Present in the following documents:
  • 13059_2014_484_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Standardized decision support in next generation sequencing reports of somatic cancer variants.

Molecular Oncology
Dienstmann, Rodrigo R; Dong, Fei F; Borger, Darrell D; Dias-Santagata, Dora D; Ellisen, Leif W LW; Le, Long P LP; Iafrate, A John AJ
Publication Date: 2014-07

Variant appearance in text: BRAF: Y472C
PubMed Link: 24768039
Variant Present in the following documents:
  • Main text
View BVdb publication page



Beyond histology: translating tumor genotypes into clinically effective targeted therapies.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Meador, Catherine B CB; Micheel, Christine M CM; Levy, Mia A MA; Lovly, Christine M CM; Horn, Leora L; Warner, Jeremy L JL; Johnson, Douglas B DB; Zhao, Zhongming Z; Anderson, Ingrid A IA; Sosman, Jeffrey A JA; Vnencak-Jones, Cindy L CL; Dahlman, Kimberly B KB; Pao, William W
Publication Date: 2014-05-01

Variant appearance in text: BRAF: Y472C
PubMed Link: 24599935
Variant Present in the following documents:
  • Main text
View BVdb publication page



Kinase-impaired BRAF mutations in lung cancer confer sensitivity to dasatinib.

Science Translational Medicine
Sen, Banibrata B; Peng, Shaohua S; Tang, Ximing X; Erickson, Heidi S HS; Galindo, Hector H; Mazumdar, Tuhina T; Stewart, David J DJ; Wistuba, Ignacio I; Johnson, Faye M FM
Publication Date: 2012-05-30

Variant appearance in text: BRAF: Y472C
PubMed Link: 22649091
Variant Present in the following documents:
  • Main text
View BVdb publication page