Blood tumor mutational burden and dynamic changes in circulating tumor DNA predict response to pembrolizumab treatment in advanced non-small cell lung cancer.
Translational Lung Cancer Research
Stensgaard, Simone S; Thomsen, Astrid A; Helstrup, Sofie S; Meldgaard, Peter P; Sorensen, Boe S BS
Publication Date: 2023-05-31
Variant appearance in text: BRAF: 1415A>G; Tyr472Cys
Network expansion of genetic associations defines a pleiotropy map of human cell biology.
Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23
Variant appearance in text: BRAF: 1415A>G; Tyr472Cys
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Mayrhofer, Johanna E JE; Enzler, Florian F; Feichtner, Andreas A; Röck, Ruth R; Fleischmann, Jakob J; Raffeiner, Andrea A; Tschaikner, Philipp P; Ogris, Egon E; Huber, Roland G RG; Hartl, Markus M; Schneider, Rainer R; Troppmair, Jakob J; Torres-Quesada, Omar O; Stefan, Eduard E
Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Clinical validation of coexisting driver mutations in colorectal cancers.
Human Pathology
Zheng, Gang G; Tseng, Li-Hui LH; Haley, Lisa L; Ibrahim, Junaid J; Bynum, Jennifer J; Xian, Rena R; Gocke, Christopher D CD; Eshleman, James R JR; Lin, Ming-Tseh MT
Integrative omics analyses broaden treatment targets in human cancer.
Genome Medicine
Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L
Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.
Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
From somatic variants towards precision oncology: Evidence-driven reporting of treatment options in molecular tumor boards.
Genome Medicine
Perera-Bel, Júlia J; Hutter, Barbara B; Heining, Christoph C; Bleckmann, Annalen A; Fröhlich, Martina M; Fröhling, Stefan S; Glimm, Hanno H; Brors, Benedikt B; Beißbarth, Tim T
Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets.
Nature Communications
Chen, Ying-Bei YB; Xu, Jianing J; Skanderup, Anders Jacobsen AJ; Dong, Yiyu Y; Brannon, A Rose AR; Wang, Lu L; Won, Helen H HH; Wang, Patricia I PI; Nanjangud, Gouri J GJ; Jungbluth, Achim A AA; Li, Wei W; Ojeda, Virginia V; Hakimi, A Ari AA; Voss, Martin H MH; Schultz, Nikolaus N; Motzer, Robert J RJ; Russo, Paul P; Cheng, Emily H EH; Giancotti, Filippo G FG; Lee, William W; Berger, Michael F MF; Tickoo, Satish K SK; Reuter, Victor E VE; Hsieh, James J JJ
Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma.
Cell Reports
Giannakis, Marios M; Mu, Xinmeng Jasmine XJ; Shukla, Sachet A SA; Qian, Zhi Rong ZR; Cohen, Ofir O; Nishihara, Reiko R; Bahl, Samira S; Cao, Yin Y; Amin-Mansour, Ali A; Yamauchi, Mai M; Sukawa, Yasutaka Y; Stewart, Chip C; Rosenberg, Mara M; Mima, Kosuke K; Inamura, Kentaro K; Nosho, Katsuhiko K; Nowak, Jonathan A JA; Lawrence, Michael S MS; Giovannucci, Edward L EL; Chan, Andrew T AT; Ng, Kimmie K; Meyerhardt, Jeffrey A JA; Van Allen, Eliezer M EM; Getz, Gad G; Gabriel, Stacey B SB; Lander, Eric S ES; Wu, Catherine J CJ; Fuchs, Charles S CS; Ogino, Shuji S; Garraway, Levi A LA
Prognostic Role of BRAF Mutation in Stage II/III Colorectal Cancer Receiving Curative Resection and Adjuvant Chemotherapy: A Meta-Analysis Based on Randomized Clinical Trials.
Integrated digital error suppression for improved detection of circulating tumor DNA.
Nature Biotechnology
Newman, Aaron M AM; Lovejoy, Alexander F AF; Klass, Daniel M DM; Kurtz, David M DM; Chabon, Jacob J JJ; Scherer, Florian F; Stehr, Henning H; Liu, Chih Long CL; Bratman, Scott V SV; Say, Carmen C; Zhou, Li L; Carter, Justin N JN; West, Robert B RB; Sledge, George W GW; Shrager, Joseph B JB; Loo, Billy W BW; Neal, Joel W JW; Wakelee, Heather A HA; Diehn, Maximilian M; Alizadeh, Ash A AA
Dasatinib induces DNA damage and activates DNA repair pathways leading to senescence in non-small cell lung cancer cell lines with kinase-inactivating BRAF mutations.
Oncotarget
Peng, Shaohua S; Sen, Banibrata B; Mazumdar, Tuhina T; Byers, Lauren A LA; Diao, Lixia L; Wang, Jing J; Tong, Pan P; Giri, Uma U; Heymach, John V JV; Kadara, Humam N HN; Johnson, Faye M FM
Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.
Cell
Creixell, Pau P; Schoof, Erwin M EM; Simpson, Craig D CD; Longden, James J; Miller, Chad J CJ; Lou, Hua Jane HJ; Perryman, Lara L; Cox, Thomas R TR; Zivanovic, Nevena N; Palmeri, Antonio A; Wesolowska-Andersen, Agata A; Helmer-Citterich, Manuela M; Ferkinghoff-Borg, Jesper J; Itamochi, Hiroaki H; Bodenmiller, Bernd B; Erler, Janine T JT; Turk, Benjamin E BE; Linding, Rune R
Performance characteristics of next-generation sequencing in clinical mutation detection of colorectal cancers.
Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc
Haley, Lisa L; Tseng, Li-Hui LH; Zheng, Gang G; Dudley, Jonathan J; Anderson, Derek A DA; Azad, Nilofer S NS; Gocke, Christopher D CD; Eshleman, James R JR; Lin, Ming-Tseh MT
Molecularly targeted therapies in non-small-cell lung cancer annual update 2014.
Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer
Morgensztern, Daniel D; Campo, Meghan J MJ; Dahlberg, Suzanne E SE; Doebele, Robert C RC; Garon, Edward E; Gerber, David E DE; Goldberg, Sarah B SB; Hammerman, Peter S PS; Heist, Rebecca S RS; Hensing, Thomas T; Horn, Leora L; Ramalingam, Suresh S SS; Rudin, Charles M CM; Salgia, Ravi R; Sequist, Lecia V LV; Shaw, Alice T AT; Simon, George R GR; Somaiah, Neeta N; Spigel, David R DR; Wrangle, John J; Johnson, David D; Herbst, Roy S RS; Bunn, Paul P; Govindan, Ramaswamy R
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Beyond histology: translating tumor genotypes into clinically effective targeted therapies.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Meador, Catherine B CB; Micheel, Christine M CM; Levy, Mia A MA; Lovly, Christine M CM; Horn, Leora L; Warner, Jeremy L JL; Johnson, Douglas B DB; Zhao, Zhongming Z; Anderson, Ingrid A IA; Sosman, Jeffrey A JA; Vnencak-Jones, Cindy L CL; Dahlman, Kimberly B KB; Pao, William W