Publications:

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Animal Models and Their Role in Imaging-Assisted Co-Clinical Trials.

Tomography (Ann Arbor, Mich.)

Peehl, Donna M DM; Badea, Cristian T CT; Chenevert, Thomas L TL; Daldrup-Link, Heike E HE; Ding, Li L; Dobrolecki, Lacey E LE; Houghton, A McGarry AM; Kinahan, Paul E PE; Kurhanewicz, John J; Lewis, Michael T MT; Li, Shunqiang S; Luker, Gary D GD; Ma, Cynthia X CX; Manning, H Charles HC; Mowery, Yvonne M YM; O'Dwyer, Peter J PJ; Pautler, Robia G RG; Rosen, Mark A MA; Roudi, Raheleh R; Ross, Brian D BD; Shoghi, Kooresh I KI; Sriram, Renuka R; Talpaz, Moshe M; Wahl, Richard L RL; Zhou, Rong R

Publication Date: 2023-03-16

Variant appearance in text: BRAF: R172H

PubMed Link: 36961012

Variant Present in the following documents:

• Main text

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Glycolysis regulates KRAS plasma membrane localization and function through defined glycosphingolipids.

Nature Communications

Liu, Junchen J; van der Hoeven, Ransome R; Kattan, Walaa E WE; Chang, Jeffrey T JT; Montufar-Solis, Dina D; Chen, Wei W; Wong, Maurice M; Zhou, Yong Y; Lebrilla, Carlito B CB; Hancock, John F JF

Publication Date: 2023-01-28

Variant appearance in text: BRAF: R172H

PubMed Link: 36709325

Variant Present in the following documents:

• Main text

View BVdb publication page

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Drugs Targeting p53 Mutations with FDA Approval and in Clinical Trials.

Cancers

Nishikawa, Shigeto S; Iwakuma, Tomoo T

Publication Date: 2023-01-09

Variant appearance in text: BRAF: R172H

PubMed Link: 36672377

Variant Present in the following documents:

• cancers-15-00429.pdf

View BVdb publication page

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The connection between innervation and metabolic rearrangements in pancreatic cancer through serine.

Frontiers In Oncology

Dong, Mengmeng M; Cao, Lidong L; Cui, Ranji R; Xie, Yingjun Y

Publication Date: 2022

Variant appearance in text: BRAF: R172H

PubMed Link: 36582785

Variant Present in the following documents:

• fonc-12-992927.pdf

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Antibody-drug conjugates: beyond current approvals and potential future strategies.

Exploration Of Targeted Anti-Tumor Therapy

Menon, Siddharth S; Parakh, Sagun S; Scott, Andrew M AM; Gan, Hui K HK

Publication Date: 2022

Variant appearance in text: BRAF: R172H

PubMed Link: 36046842

Variant Present in the following documents:

• Main text

View BVdb publication page

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Sensitivity towards HDAC inhibition is associated with RTK/MAPK pathway activation in gastric cancer.

Embo Molecular Medicine

Seidlitz, Therese T; Schmäche, Tim T; Garcίa, Fernando F; Lee, Joon Ho JH; Qin, Nan N; Kochall, Susan S; Fohgrub, Juliane J; Pauck, David D; Rothe, Alexander A; Koo, Bon-Kyoung BK; Weitz, Jürgen J; Remke, Marc M; Muñoz, Javier J; Stange, Daniel E DE

Publication Date: 2022-10-10

Variant appearance in text: BRAF: R172H

PubMed Link: 35993110

Variant Present in the following documents:

• EMMM-14-e15705.pdf
• EMMM-14-e15705-s008.pdf

View BVdb publication page

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Isatuximab plus atezolizumab in patients with advanced solid tumors: results from a phase I/II, open-label, multicenter study.

Esmo Open

Simonelli, M M; Garralda, E E; Eskens, F F; Gil-Martin, M M; Yen, C-J CJ; Obermannova, R R; Chao, Y Y; Lonardi, S S; Melichar, B B; Moreno, V V; Yu, M-L ML; Bongiovanni, A A; Calvo, E E; Rottey, S S; Machiels, J-P JP; Gonzalez-Martin, A A; Paz-Ares, L L; Chang, C-L CL; Mason, W W; Lin, C-C CC; Reardon, D A DA; Vieito, M M; Santoro, A A; Meng, R R; Abbadessa, G G; Menas, F F; Lee, H H; Liu, Q Q; Combeau, C C; Ternes, N N; Ziti-Ljajic, S S; Massard, C C

Publication Date: 2022-10

Variant appearance in text: BRAF: R172H

PubMed Link: 35987165

Variant Present in the following documents:

• Main text

View BVdb publication page

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Mutant p53, the Mevalonate Pathway and the Tumor Microenvironment Regulate Tumor Response to Statin Therapy.

Cancers

Pereira, Madison M; Matuszewska, Kathy K; Glogova, Alice A; Petrik, Jim J

Publication Date: 2022-07-19

Variant appearance in text: BRAF: R172H

PubMed Link: 35884561

Variant Present in the following documents:

• Main text
• cancers-14-03500.pdf

View BVdb publication page

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RAS-mediated tumor stress adaptation and the targeting opportunities it presents.

Disease Models & Mechanisms

Redding, Alexandra A; Aplin, Andrew E AE; Grabocka, Elda E

Publication Date: 2022-02-01

Variant appearance in text: BRAF: R172H

PubMed Link: 35147163

Variant Present in the following documents:

• Main text

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RAS-mediated tumor stress adaptation and the targeting opportunities it presents.

Disease Models & Mechanisms

Redding, Alexandra A; Aplin, Andrew E AE; Grabocka, Elda E

Publication Date: 2022-02-01

Variant appearance in text: BRAF: R172H

PubMed Link: 35147163

Variant Present in the following documents:

• Main text

View BVdb publication page

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Translational Advances in Cancer Prevention Agent Development (TACPAD) Virtual Workshop on Immunomodulatory Agents: Report.

Journal Of Cancer Prevention

Mohammed, Altaf A; Dashwood, Roderick H RH; Dickinson, Sally S; Disis, Mary L ML; Jaffee, Elizabeth M EM; Johnson, Bryon D BD; Khleif, Samir N SN; Pollak, Michael N MN; Schlom, Jeffrey J; Shoemaker, Robert H RH; Stanton, Sasha E SE; Wondrak, Georg T GT; You, Ming M; Zhu, Hao H; Miller, Mark Steven MS

Publication Date: 2021-12-30

Variant appearance in text: BRAF: R172H

PubMed Link: 35047458

Variant Present in the following documents:

• Main text

View BVdb publication page

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Characterization of RNF43 frameshift mutations that drive Wnt ligand- and R-spondin-dependent colon cancer.

The Journal Of Pathology

Yamamoto, Daisuke D; Oshima, Hiroko H; Wang, Dong D; Takeda, Haruna H; Kita, Kenji K; Lei, Xuelian X; Nakayama, Mizuho M; Murakami, Kazuhiro K; Ohama, Takashi T; Takemura, Hirofumi H; Toyota, Mutsumi M; Suzuki, Hiromu H; Inaki, Noriyuki N; Oshima, Masanobu M

Publication Date: 2022-05

Variant appearance in text: BRAF: R172H

PubMed Link: 35040131

Variant Present in the following documents:

• PATH-257-39.pdf

View BVdb publication page

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PDAC as an Immune Evasive Disease: Can 3D Model Systems Aid to Tackle This Clinical Problem?

Frontiers In Cell And Developmental Biology

Narayanan, Shruthi S; Vicent, Silve S; Ponz-Sarvisé, Mariano M

Publication Date: 2021

Variant appearance in text: BRAF: R172H

PubMed Link: 34957115

Variant Present in the following documents:

• fcell-09-787249.pdf

View BVdb publication page

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Microbiota Alterations and Their Association with Oncogenomic Changes in Pancreatic Cancer Patients.

International Journal Of Molecular Sciences

Sammallahti, Heidelinde H; Kokkola, Arto A; Rezasoltani, Sama S; Ghanbari, Reza R; Asadzadeh Aghdaei, Hamid H; Knuutila, Sakari S; Puolakkainen, Pauli P; Sarhadi, Virinder Kaur VK

Publication Date: 2021-11-30

Variant appearance in text: BRAF: R172H

PubMed Link: 34884776

Variant Present in the following documents:

• Main text

View BVdb publication page

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Oncogenic KRAS-Induced Feedback Inflammatory Signaling in Pancreatic Cancer: An Overview and New Therapeutic Opportunities.

Cancers

Bansod, Sapana S; Dodhiawala, Paarth B PB; Lim, Kian-Huat KH

Publication Date: 2021-10-31

Variant appearance in text: BRAF: R172H

PubMed Link: 34771644

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genetic Characterization, Current Model Systems and Prognostic Stratification in PAX Fusion-Negative vs. PAX Fusion-Positive Rhabdomyosarcoma.

Genes

Dehner, Carina A CA; Armstrong, Amy E AE; Yohe, Marielle M; Shern, Jack F JF; Hirbe, Angela C AC

Publication Date: 2021-09-25

Variant appearance in text: BRAF: R172H

PubMed Link: 34680895

Variant Present in the following documents:

• Main text

View BVdb publication page

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Overcoming Immunotherapy Resistance by Targeting the Tumor-Intrinsic NLRP3-HSP70 Signaling Axis.

Cancers

Theivanthiran, Balamayooran B; Haykal, Tarek T; Cao, Linda L; Holtzhausen, Alisha A; Plebanek, Michael M; DeVito, Nicholas C NC; Hanks, Brent A BA

Publication Date: 2021-09-23

Variant appearance in text: BRAF: R172H

PubMed Link: 34638239

Variant Present in the following documents:

• Main text

View BVdb publication page

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Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels.

Science Advances

Kurth, Isabel I; Yamaguchi, Norihiro N; Andreu-Agullo, Celia C; Tian, Helen S HS; Sridhar, Subhasree S; Takeda, Shugaku S; Gonsalves, Foster C FC; Loo, Jia Min JM; Barlas, Afsar A; Manova-Todorova, Katia K; Busby, Robert R; Bendell, Johanna C JC; Strauss, James J; Fakih, Marwan M; McRee, Autumn J AJ; Hendifar, Andrew E AE; Rosen, Lee S LS; Cercek, Andrea A; Wasserman, Robert R; Szarek, Michael M; Spector, Scott L SL; Raza, Syed S; Tavazoie, Masoud F MF; Tavazoie, Sohail F SF

Publication Date: 2021-10-08

Variant appearance in text: BRAF: R172H

PubMed Link: 34613776

Variant Present in the following documents:

• Main text

View BVdb publication page

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The Role of p53 in Progression of Cutaneous Squamous Cell Carcinoma.

Cancers

Piipponen, Minna M; Riihilä, Pilvi P; Nissinen, Liisa L; Kähäri, Veli-Matti VM

Publication Date: 2021-09-07

Variant appearance in text: BRAF: R172H

PubMed Link: 34572732

Variant Present in the following documents:

• cancers-13-04507.pdf

View BVdb publication page

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Therapeutic Strategies Targeting Tumor Suppressor Genes in Pancreatic Cancer.

Cancers

Kuo, Kung-Kai KK; Hsiao, Pi-Jung PJ; Chang, Wen-Tsan WT; Chuang, Shih-Chang SC; Yang, Ya-Han YH; Wuputra, Kenly K; Ku, Chia-Chen CC; Pan, Jia-Bin JB; Li, Chia-Pei CP; Kato, Kohsuke K; Liu, Chung-Jung CJ; Wu, Deng-Chyang DC; Yokoyama, Kazunari K KK

Publication Date: 2021-08-03

Variant appearance in text: BRAF: R172H

PubMed Link: 34359820

Variant Present in the following documents:

• Main text

View BVdb publication page

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Targeting CDK4 overcomes EMT-mediated tumor heterogeneity and therapeutic resistance in KRAS-mutant lung cancer.

Jci Insight

Padhye, Aparna A; Konen, Jessica M JM; Rodriguez, B Leticia BL; Fradette, Jared J JJ; Ochieng, Joshua K JK; Diao, Lixia L; Wang, Jing J; Lu, Wei W; Solis, Luisa S LS; Batra, Harsh H; Raso, Maria G MG; Peoples, Michael D MD; Minelli, Rosalba R; Carugo, Alessandro A; Bristow, Christopher A CA; Gibbons, Don L DL

Publication Date: 2021-09-08

Variant appearance in text: BRAF: R172H

PubMed Link: 34309585

Variant Present in the following documents:

• Main text

View BVdb publication page

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Single-cell analysis defines a pancreatic fibroblast lineage that supports anti-tumor immunity.

Cancer Cell

Hutton, Colin C; Heider, Felix F; Blanco-Gomez, Adrian A; Banyard, Antonia A; Kononov, Alexander A; Zhang, Xiaohong X; Karim, Saadia S; Paulus-Hock, Viola V; Watt, Dale D; Steele, Nina N; Kemp, Samantha S; Hogg, Elizabeth K J EKJ; Kelly, Joanna J; Jackstadt, Rene-Filip RF; Lopes, Filipa F; Menotti, Matteo M; Chisholm, Luke L; Lamarca, Angela A; Valle, Juan J; Sansom, Owen J OJ; Springer, Caroline C; Malliri, Angeliki A; Marais, Richard R; Pasca di Magliano, Marina M; Zelenay, Santiago S; Morton, Jennifer P JP; Jørgensen, Claus C

Publication Date: 2021-09-13

Variant appearance in text: BRAF: R172H

PubMed Link: 34297917

Variant Present in the following documents:

• Main text

View BVdb publication page

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Therapeutic Potential of Targeting Stromal Crosstalk-Mediated Immune Suppression in Pancreatic Cancer.

Frontiers In Oncology

Du, Wenting W; Pasca di Magliano, Marina M; Zhang, Yaqing Y

Publication Date: 2021

Variant appearance in text: BRAF: R172H

PubMed Link: 34290984

Variant Present in the following documents:

• Main text

View BVdb publication page

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Mebendazole disrupts stromal desmoplasia and tumorigenesis in two models of pancreatic cancer.

Oncotarget

Williamson, Tara T; de Abreu, Michelle Carvalho MC; Trembath, Dimitri G DG; Brayton, Cory C; Kang, Byunghak B; Mendes, Thais Biude TB; de Assumpção, Paulo Pimentel PP; Cerutti, Janete M JM; Riggins, Gregory J GJ

Publication Date: 2021-07-06

Variant appearance in text: BRAF: R172H

PubMed Link: 34262644

Variant Present in the following documents:

• Main text

View BVdb publication page

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Drugging the Undruggable: Advances on RAS Targeting in Cancer.

Genes

Molina-Arcas, Miriam M; Samani, Amit A; Downward, Julian J

Publication Date: 2021-06-10

Variant appearance in text: BRAF: R172H

PubMed Link: 34200676

Variant Present in the following documents:

• Main text

View BVdb publication page

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Highly metastatic claudin-low mammary cancers can originate from luminal epithelial cells.

Nature Communications

Rädler, Patrick D PD; Wehde, Barbara L BL; Triplett, Aleata A AA; Shrestha, Hridaya H; Shepherd, Jonathan H JH; Pfefferle, Adam D AD; Rui, Hallgeir H; Cardiff, Robert D RD; Perou, Charles M CM; Wagner, Kay-Uwe KU

Publication Date: 2021-06-18

Variant appearance in text: BRAF: R172H

PubMed Link: 34145248

Variant Present in the following documents:

• Main text

View BVdb publication page

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The Role of p53 Dysfunction in Colorectal Cancer and Its Implication for Therapy.

Cancers

Michel, Maurice M; Kaps, Leonard L; Maderer, Annett A; Galle, Peter R PR; Moehler, Markus M

Publication Date: 2021-05-11

Variant appearance in text: BRAF: R172H

PubMed Link: 34064974

Variant Present in the following documents:

• Main text
• cancers-13-02296.pdf

View BVdb publication page

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Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer.

Elife

Sacchetti, Andrea A; Teeuwssen, Miriam M; Verhagen, Mathijs M; Joosten, Rosalie R; Xu, Tong T; Stabile, Roberto R; van der Steen, Berdine B; Watson, Martin M MM; Gusinac, Alem A; Kim, Won Kyu WK; Ubink, Inge I; Van de Werken, Harmen Jg HJ; Fumagalli, Arianna A; Paauwe, Madelon M; Van Rheenen, Jacco J; Sansom, Owen J OJ; Kranenburg, Onno O; Fodde, Riccardo R

Publication Date: 2021-05-26

Variant appearance in text: BRAF: R172H

PubMed Link: 34036938

Variant Present in the following documents:

• Main text

View BVdb publication page

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Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Cheng, Derek K DK; Oni, Tobiloba E TE; Thalappillil, Jennifer S JS; Park, Youngkyu Y; Ting, Hsiu-Chi HC; Alagesan, Brinda B; Prasad, Nadia V NV; Addison, Kenneth K; Rivera, Keith D KD; Pappin, Darryl J DJ; Van Aelst, Linda L; Tuveson, David A DA

Publication Date: 2021-05-25

Variant appearance in text: BRAF: R172H

PubMed Link: 34021083

Variant Present in the following documents:

• Main text

View BVdb publication page

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Sensitivity and Resistance of Oncogenic RAS-Driven Tumors to Dual MEK and ERK Inhibition.

Cancers

Catalano, Antonella A; Adlesic, Mojca M; Kaltenbacher, Thorsten T; Klar, Rhena F U RFU; Albers, Joachim J; Seidel, Philipp P; Brandt, Laura P LP; Hejhal, Tomas T; Busenhart, Philipp P; Röhner, Niklas N; Zodel, Kyra K; Fritsch, Kornelia K; Wild, Peter J PJ; Duyster, Justus J; Fritsch, Ralph R; Brummer, Tilman T; Frew, Ian J IJ

Publication Date: 2021-04-13

Variant appearance in text: BRAF: R172H

PubMed Link: 33924486

Variant Present in the following documents:

• Main text

View BVdb publication page

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Identification of cancer driver genes using Sleeping Beauty transposon mutagenesis.

Cancer Science

Takeda, Haruna H; Jenkins, Nancy A NA; Copeland, Neal G NG

Publication Date: 2021-06

Variant appearance in text: BRAF: R172H

PubMed Link: 33783919

Variant Present in the following documents:

• Main text
• CAS-112-2089.pdf

View BVdb publication page

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KRAS drives immune evasion in a genetic model of pancreatic cancer.

Nature Communications

Ischenko, Irene I; D'Amico, Stephen S; Rao, Manisha M; Li, Jinyu J; Hayman, Michael J MJ; Powers, Scott S; Petrenko, Oleksi O; Reich, Nancy C NC

Publication Date: 2021-03-05

Variant appearance in text: BRAF: R172H

PubMed Link: 33674596

Variant Present in the following documents:

• Main text

View BVdb publication page

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Subversion of Niche-Signalling Pathways in Colorectal Cancer: What Makes and Breaks the Intestinal Stem Cell.

Cancers

Sphyris, Nathalie N; Hodder, Michael C MC; Sansom, Owen J OJ

Publication Date: 2021-02-27

Variant appearance in text: BRAF: R172H

PubMed Link: 33673710

Variant Present in the following documents:

• Main text

View BVdb publication page

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Targeted Therapies for Pancreatic Cancer: Overview of Current Treatments and New Opportunities for Personalized Oncology.

Cancers

Leroux, Cédric C; Konstantinidou, Georgia G

Publication Date: 2021-02-14

Variant appearance in text: BRAF: R172H

PubMed Link: 33672917

Variant Present in the following documents:

• Main text
• cancers-13-00799.pdf

View BVdb publication page

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Differential Effects of Trp53 Alterations in Murine Colorectal Cancer.

Cancers

Betzler, Alexander M AM; Nanduri, Lahiri K LK; Hissa, Barbara B; Blickensdörfer, Linda L; Muders, Michael H MH; Roy, Janine J; Jesinghaus, Moritz M; Steiger, Katja K; Weichert, Wilko W; Kloor, Matthias M; Klink, Barbara B; Schroeder, Michael M; Mazzone, Massimiliano M; Weitz, Jürgen J; Reissfelder, Christoph C; Rahbari, Nuh N NN; Schölch, Sebastian S

Publication Date: 2021-02-15

Variant appearance in text: BRAF: R172H

PubMed Link: 33671932

Variant Present in the following documents:

• Main text

View BVdb publication page

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Promoterless Transposon Mutagenesis Drives Solid Cancers via Tumor Suppressor Inactivation.

Cancers

Aiderus, Aziz A; Contreras-Sandoval, Ana M AM; Meshey, Amanda L AL; Newberg, Justin Y JY; Ward, Jerrold M JM; Swing, Deborah A DA; Copeland, Neal G NG; Jenkins, Nancy A NA; Mann, Karen M KM; Mann, Michael B MB

Publication Date: 2021-01-09

Variant appearance in text: BRAF: R172H

PubMed Link: 33435458

Variant Present in the following documents:

• Main text
• cancers-13-00225.pdf

View BVdb publication page

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Mutant p53 in Cancer Progression and Targeted Therapies.

Frontiers In Oncology

Zhu, Gaoyang G; Pan, Chaoyun C; Bei, Jin-Xin JX; Li, Bo B; Liang, Chen C; Xu, Yang Y; Fu, Xuemei X

Publication Date: 2020

Variant appearance in text: BRAF: R172H

PubMed Link: 33240819

Variant Present in the following documents:

• Main text

View BVdb publication page

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Unbiased in vivo preclinical evaluation of anticancer drugs identifies effective therapy for the treatment of pancreatic adenocarcinoma.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Grbovic-Huezo, Olivera O; Pitter, Kenneth L KL; Lecomte, Nicolas N; Saglimbeni, Joseph J; Askan, Gokce G; Holm, Matilda M; Melchor, Jerry P JP; Chandwani, Rohit R; Joshi, Suhasini S; Haglund, Caj C; Iacobuzio-Donahue, Christine A CA; Chiosis, Gabriela G; Tammela, Tuomas T; Leach, Steven D SD

Publication Date: 2020-12-01

Variant appearance in text: BRAF: R172H

PubMed Link: 33199632

Variant Present in the following documents:

• pnas.201920240.pdf

View BVdb publication page

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Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients.

Journal Of Experimental & Clinical Cancer Research : Cr

Terlizzi, Michela M; Colarusso, Chiara C; De Rosa, Ilaria I; Somma, Pasquale P; Curcio, Carlo C; Aquino, Rita P RP; Panico, Luigi L; Salvi, Rosario R; Zito Marino, Federica F; Botti, Gerardo G; Pinto, Aldo A; Sorrentino, Rosalinda R

Publication Date: 2020-11-13

Variant appearance in text: BRAF: R172H

PubMed Link: 33187551

Variant Present in the following documents:

• Main text

View BVdb publication page

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AXL Inhibition Induces DNA Damage and Replication Stress in Non-Small Cell Lung Cancer Cells and Promotes Sensitivity to ATR Inhibitors.

Molecular Cancer Research : Mcr

Ramkumar, Kavya K; Stewart, C Allison CA; Cargill, Kasey R KR; Della Corte, Carminia M CM; Wang, Qi Q; Shen, Li L; Diao, Lixia L; Cardnell, Robert J RJ; Peng, David H DH; Rodriguez, B Leticia BL; Fan, You-Hong YH; Heymach, John V JV; Wang, Jing J; Gay, Carl M CM; Gibbons, Don L DL; Byers, Lauren A LA

Publication Date: 2021-03

Variant appearance in text: BRAF: R172H

PubMed Link: 33172976

Variant Present in the following documents:

• Main text

View BVdb publication page

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SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling.

The Journal Of Experimental Medicine

Fedele, Carmine C; Li, Shuai S; Teng, Kai Wen KW; Foster, Connor J R CJR; Peng, David D; Ran, Hao H; Mita, Paolo P; Geer, Mitchell J MJ; Hattori, Takamitsu T; Koide, Akiko A; Wang, Yubao Y; Tang, Kwan Ho KH; Leinwand, Joshua J; Wang, Wei W; Diskin, Brian B; Deng, Jiehui J; Chen, Ting T; Dolgalev, Igor I; Ozerdem, Ugur U; Miller, George G; Koide, Shohei S; Wong, Kwok-Kin KK; Neel, Benjamin G BG

Publication Date: 2021-01-04

Variant appearance in text: BRAF: R172H

PubMed Link: 33045063

Variant Present in the following documents:

• Main text

View BVdb publication page

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Emerging role of tumor cell plasticity in modifying therapeutic response.

Signal Transduction And Targeted Therapy

Qin, Siyuan S; Jiang, Jingwen J; Lu, Yi Y; Nice, Edouard C EC; Huang, Canhua C; Zhang, Jian J; He, Weifeng W

Publication Date: 2020-10-07

Variant appearance in text: BRAF: R172H

PubMed Link: 33028808

Variant Present in the following documents:

• Main text

View BVdb publication page

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Cancer-Associated Fibroblasts: Versatile Players in the Tumor Microenvironment.

Cancers

Ganguly, Debolina D; Chandra, Raghav R; Karalis, John J; Teke, Martha M; Aguilera, Todd T; Maddipati, Ravikanth R; Wachsmann, Megan B MB; Ghersi, Dario D; Siravegna, Giulia G; Zeh, Herbert J HJ; Brekken, Rolf R; Ting, David T DT; Ligorio, Matteo M

Publication Date: 2020-09-17

Variant appearance in text: BRAF: R172H

PubMed Link: 32957515

Variant Present in the following documents:

• Main text

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A protumorigenic secretory pathway activated by p53 deficiency in lung adenocarcinoma.

The Journal Of Clinical Investigation

Tan, Xiaochao X; Shi, Lei L; Banerjee, Priyam P; Liu, Xin X; Guo, Hou-Fu HF; Yu, Jiang J; Bota-Rabassedas, Neus N; Rodriguez, B Leticia BL; Gibbons, Don L DL; Russell, William K WK; Creighton, Chad J CJ; Kurie, Jonathan M JM

Publication Date: 2021-01-04

Variant appearance in text: BRAF: R172H

PubMed Link: 32931483

Variant Present in the following documents:

• Main text

View BVdb publication page

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Current methods in translational cancer research.

Cancer Metastasis Reviews

Lee, Michael W MW; Miljanic, Mihailo M; Triplett, Todd T; Ramirez, Craig C; Aung, Kyaw L KL; Eckhardt, S Gail SG; Capasso, Anna A

Publication Date: 2021-03

Variant appearance in text: BRAF: R172H

PubMed Link: 32929562

Variant Present in the following documents:

• Main text

View BVdb publication page

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Autophagy as a therapeutic target in pancreatic cancer.

British Journal Of Cancer

Piffoux, Max M; Eriau, Erwan E; Cassier, Philippe A PA

Publication Date: 2021-01

Variant appearance in text: BRAF: R172H

PubMed Link: 32929194

Variant Present in the following documents:

• Main text

View BVdb publication page

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Re-education of the Tumor Microenvironment With Targeted Therapies and Immunotherapies.

Frontiers In Immunology

Ngiow, Shin Foong SF; Young, Arabella A

Publication Date: 2020

Variant appearance in text: BRAF: R172H

PubMed Link: 32849557

Variant Present in the following documents:

• Main text

View BVdb publication page

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BRAFV600E drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation.

Oncogene

Reischmann, Nadine N; Andrieux, Geoffroy G; Griffin, Ricarda R; Reinheckel, Thomas T; Boerries, Melanie M; Brummer, Tilman T

Publication Date: 2020-09

Variant appearance in text: BRAF: R172H

PubMed Link: 32792685

Variant Present in the following documents:

• Main text

View BVdb publication page

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Combining BRAF inhibition with oncolytic herpes simplex virus enhances the immune-mediated antitumor therapy of BRAF-mutant thyroid cancer.

Journal For Immunotherapy Of Cancer

Crespo-Rodriguez, Eva E; Bergerhoff, Katharina K; Bozhanova, Galabina G; Foo, Shane S; Patin, Emmanuel C EC; Whittock, Harriet H; Buus, Richard R; Haider, Syed S; Muirhead, Gareth G; Thway, Khin K; Newbold, Kate K; Coffin, Robert S RS; Vile, Richard G RG; Kim, Dae D; McLaughlin, Martin M; Melcher, Alan A AA; Harrington, Kevin J KJ; Pedersen, Malin M

Publication Date: 2020-08

Variant appearance in text: BRAF: R172H

PubMed Link: 32759235

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Dendritic cell vaccination and CD40-agonist combination therapy licenses T cell-dependent antitumor immunity in a pancreatic carcinoma murine model.

Journal For Immunotherapy Of Cancer

Lau, Sai Ping SP; van Montfoort, Nadine N; Kinderman, Priscilla P; Lukkes, Melanie M; Klaase, Larissa L; van Nimwegen, Menno M; van Gulijk, Mandy M; Dumas, Jasper J; Mustafa, Dana A M DAM; Lievense, Sanne L A SLA; Groeneveldt, Christianne C; Stadhouders, Ralph R; Li, Yunlei Y; Stubbs, Andrew A; Marijt, Koen A KA; Vroman, Heleen H; van der Burg, Sjoerd H SH; Aerts, Joachim J; van Hall, Thorbald T; Dammeijer, Floris F; van Eijck, Casper H J CHJ

Publication Date: 2020-07

Variant appearance in text: BRAF: R172H

PubMed Link: 32690771

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• jitc-2020-000772.pdf

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Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer.

Molecular Therapy Oncolytics

Koujima, Takeshi T; Tazawa, Hiroshi H; Ieda, Takeshi T; Araki, Hiroyuki H; Fushimi, Takuro T; Shoji, Ryohei R; Kuroda, Shinji S; Kikuchi, Satoru S; Yoshida, Ryuichi R; Umeda, Yuzo Y; Teraishi, Fuminori F; Urata, Yasuo Y; Mizuguchi, Hiroyuki H; Fujiwara, Toshiyoshi T

Publication Date: 2020-06-26

Variant appearance in text: BRAF: R172H

PubMed Link: 32322667

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Discovery of a selective inhibitor of doublecortin like kinase 1.

Nature Chemical Biology

Ferguson, Fleur M FM; Nabet, Behnam B; Raghavan, Srivatsan S; Liu, Yan Y; Leggett, Alan L AL; Kuljanin, Miljan M; Kalekar, Radha L RL; Yang, Annan A; He, Shuning S; Wang, Jinhua J; Ng, Raymond W S RWS; Sulahian, Rita R; Li, Lianbo L; Poulin, Emily J EJ; Huang, Ling L; Koren, Jost J; Dieguez-Martinez, Nora N; Espinosa, Sergio S; Zeng, Zhiyang Z; Corona, Cesear R CR; Vasta, James D JD; Ohi, Ryoma R; Sim, Taebo T; Kim, Nam Doo ND; Harshbarger, Wayne W; Lizcano, Jose M JM; Robers, Matthew B MB; Muthaswamy, Senthil S; Lin, Charles Y CY; Look, A Thomas AT; Haigis, Kevin M KM; Mancias, Joseph D JD; Wolpin, Brian M BM; Aguirre, Andrew J AJ; Hahn, William C WC; Westover, Kenneth D KD; Gray, Nathanael S NS

Publication Date: 2020-06

Variant appearance in text: BRAF: R172H

PubMed Link: 32251410

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• nihms-1566234.pdf

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Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.

Cell

Ruscetti, Marcus M; Morris, John P JP; Mezzadra, Riccardo R; Russell, James J; Leibold, Josef J; Romesser, Paul B PB; Simon, Janelle J; Kulick, Amanda A; Ho, Yu-Jui YJ; Fennell, Myles M; Li, Jinyang J; Norgard, Robert J RJ; Wilkinson, John E JE; Alonso-Curbelo, Direna D; Sridharan, Ramya R; Heller, Daniel A DA; de Stanchina, Elisa E; Stanger, Ben Z BZ; Sherr, Charles J CJ; Lowe, Scott W SW

Publication Date: 2020-04-16

Variant appearance in text: BRAF: R172H

PubMed Link: 32234521

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The stressful tumour environment drives plasticity of cell migration programmes, contributing to metastasis.

The Journal Of Pathology

Nikolaou, Savvas S; Machesky, Laura M LM

Publication Date: 2020-04

Variant appearance in text: BRAF: R172H

PubMed Link: 32057095

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Preclinical murine tumor models: a structural and functional perspective.

Elife

Guerin, Marion V MV; Finisguerra, Veronica V; Van den Eynde, Benoit J BJ; Bercovici, Nadege N; Trautmann, Alain A

Publication Date: 2020-01-28

Variant appearance in text: BRAF: R172H

PubMed Link: 31990272

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Metastasis in Pancreatic Ductal Adenocarcinoma: Current Standing and Methodologies.

Genes

Ayres Pereira, Marina M; Chio, Iok In Christine IIC

Publication Date: 2019-12-19

Variant appearance in text: BRAF: R172H

PubMed Link: 31861620

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Translational reprogramming marks adaptation to asparagine restriction in cancer.

Nature Cell Biology

Pathria, Gaurav G; Lee, Joo Sang JS; Hasnis, Erez E; Tandoc, Kristofferson K; Scott, David A DA; Verma, Sachin S; Feng, Yongmei Y; Larue, Lionel L; Sahu, Avinash D AD; Topisirovic, Ivan I; Ruppin, Eytan E; Ronai, Ze'ev A ZA

Publication Date: 2019-12

Variant appearance in text: BRAF: R172H

PubMed Link: 31740775

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eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma.

Nature Communications

Chan, Karina K; Robert, Francis F; Oertlin, Christian C; Kapeller-Libermann, Dana D; Avizonis, Daina D; Gutierrez, Johana J; Handly-Santana, Abram A; Doubrovin, Mikhail M; Park, Julia J; Schoepfer, Christina C; Da Silva, Brandon B; Yao, Melissa M; Gorton, Faith F; Shi, Junwei J; Thomas, Craig J CJ; Brown, Lauren E LE; Porco, John A JA; Pollak, Michael M; Larsson, Ola O; Pelletier, Jerry J; Chio, Iok In Christine IIC

Publication Date: 2019-11-13

Variant appearance in text: BRAF: R172H

PubMed Link: 31723131

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• 41467_2019_Article_13086.pdf

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34th Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2019): part 2 : National Harbor, MD, USA. 10 November 2019.

Journal For Immunotherapy Of Cancer

Publication Date: 2019-11-06

Variant appearance in text: BRAF: R172H

PubMed Link: 31694708

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Conceptual Development of Immunotherapeutic Approaches to Gastrointestinal Cancer.

International Journal Of Molecular Sciences

Abolarinwa, Bilikis Aderonke BA; Ibrahim, Ridwan Babatunde RB; Huang, Yen-Hua YH

Publication Date: 2019-09-18

Variant appearance in text: BRAF: R172H

PubMed Link: 31540435

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Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis.

Cancer Cell

Jackstadt, Rene R; van Hooff, Sander R SR; Leach, Joshua D JD; Cortes-Lavaud, Xabier X; Lohuis, Jeroen O JO; Ridgway, Rachel A RA; Wouters, Valérie M VM; Roper, Jatin J; Kendall, Timothy J TJ; Roxburgh, Campbell S CS; Horgan, Paul G PG; Nixon, Colin C; Nourse, Craig C; Gunzer, Matthias M; Clark, William W; Hedley, Ann A; Yilmaz, Omer H OH; Rashid, Mamunur M; Bailey, Peter P; Biankin, Andrew V AV; Campbell, Andrew D AD; Adams, David J DJ; Barry, Simon T ST; Steele, Colin W CW; Medema, Jan Paul JP; Sansom, Owen J OJ

Publication Date: 2019-09-16

Variant appearance in text: BRAF: R172H

PubMed Link: 31526760

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Targeting c-MYC through Interference with NAMPT and SIRT1 and Their Association to Oncogenic Drivers in Murine Serrated Intestinal Tumorigenesis.

Neoplasia (New York, N.Y.)

Brandl, Lydia L; Zhang, Yina Y; Kirstein, Nina N; Sendelhofert, Andrea A; Boos, Sophie Luise SL; Jung, Peter P; Greten, Florian F; Rad, Roland R; Menssen, Antje A

Publication Date: 2019-10

Variant appearance in text: BRAF: R172H

PubMed Link: 31442917

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A more physiological approach to lipid metabolism alterations in cancer: CRC-like organoids assessment.

Plos One

Cruz-Gil, Silvia S; Sánchez-Martínez, Ruth R; Wagner-Reguero, Sonia S; Stange, Daniel D; Schölch, Sebastian S; Pape, Kristin K; Ramírez de Molina, Ana A

Publication Date: 2019

Variant appearance in text: BRAF: R172H

PubMed Link: 31339921

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• Main text
• pone.0219944.pdf

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Targeted Therapy Against the Cell of Origin in Cutaneous Squamous Cell Carcinoma.

International Journal Of Molecular Sciences

Goldie, Stephen J SJ; Chincarini, Ginevra G; Darido, Charbel C

Publication Date: 2019-05-05

Variant appearance in text: BRAF: R172H

PubMed Link: 31060263

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