Publications:

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Sensitivities and Dependencies of BRAF Mutant Colorectal Cancer Cell Lines with or without PIK3CA Mutations for Discovery of Vulnerabilities with Therapeutic Potential.

Medicina (Kaunas, Lithuania)

Voutsadakis, Ioannis A IA

Publication Date: 2022-10-21

Variant appearance in text: BRAF: T119S

PubMed Link: 36295658

Variant Present in the following documents:

• medicina-58-01498.pdf

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Chemically modified MIR143-3p exhibited anti-cancer effects by impairing the KRAS network in colorectal cancer cells.

Molecular Therapy. Nucleic Acids

Sugito, Nobuhiko N; Heishima, Kazuki K; Akao, Yukihiro Y

Publication Date: 2022-12-13

Variant appearance in text: BRAF: T119S

PubMed Link: 36189421

Variant Present in the following documents:

• Main text
• mmc2.pdf
• main.pdf

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In PD-1+ human colon cancer cells NIVOLUMAB promotes survival and could protect tumor cells from conventional therapies.

Journal For Immunotherapy Of Cancer

Ieranò, Caterina C; Righelli, Dario D; D'Alterio, Crescenzo C; Napolitano, Maria M; Portella, Luigi L; Rea, Giuseppina G; Auletta, Federica F; Santagata, Sara S; Trotta, Anna Maria AM; Guardascione, Giuseppe G; Liotti, Federica F; Prevete, Nella N; Maiolino, Piera P; Luciano, Antonio A; Barbieri, Antonio A; Di Mauro, Annabella A; Roma, Cristin C; Esposito Abate, Riziero R; Tatangelo, Fabiana F; Pacelli, Roberto R; Normanno, Nicola N; Melillo, Rosa Marina RM; Scala, Stefania S

Publication Date: 2022-03

Variant appearance in text: BRAF: T119S

PubMed Link: 35246475

Variant Present in the following documents:

• jitc-2021-004032supp001.pdf

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Preclinical evaluation of AFM24, a novel CD16A-specific innate immune cell engager targeting EGFR-positive tumors.

Mabs

Wingert, Susanne S; Reusch, Uwe U; Knackmuss, Stefan S; Kluge, Michael M; Damrat, Michael M; Pahl, Jens J; Schniegler-Mattox, Ute U; Mueller, Thomas T; Fucek, Ivica I; Ellwanger, Kristina K; Tesar, Michael M; Haneke, Torsten T; Koch, Joachim J; Treder, Martin M; Fischer, Wolfgang W; Rajkovic, Erich E

Publication Date: 2021

Variant appearance in text: BRAF: T119S

PubMed Link: 34325617

Variant Present in the following documents:

• Main text
• KMAB_13_1950264.pdf

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Biphasic Mathematical Model of Cell-Drug Interaction That Separates Target-Specific and Off-Target Inhibition and Suggests Potent Targeted Drug Combinations for Multi-Driver Colorectal Cancer Cells.

Cancers

Shen, Jinyan J; Li, Li L; Yang, Tao T; Cohen, Paul S PS; Sun, Gongqin G

Publication Date: 2020-02-13

Variant appearance in text: BRAF: T119S

PubMed Link: 32069833

Variant Present in the following documents:

• Main text
• cancers-12-00436.pdf

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Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors.

Nature Communications

Sale, Matthew J MJ; Minihane, Emma E; Monks, Noel R NR; Gilley, Rebecca R; Richards, Frances M FM; Schifferli, Kevin P KP; Andersen, Courtney L CL; Davies, Emma J EJ; Vicente, Mario Aladren MA; Ozono, Eiko E; Markovets, Aleksandra A; Dry, Jonathan R JR; Drew, Lisa L; Flemington, Vikki V; Proia, Theresa T; Jodrell, Duncan I DI; Smith, Paul D PD; Cook, Simon J SJ

Publication Date: 2019-11-14

Variant appearance in text: BRAF: T119S

PubMed Link: 31727888

Variant Present in the following documents:

• 41467_2019_12409_MOESM1_ESM.pdf

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Evolving neoantigen profiles in colorectal cancers with DNA repair defects.

Genome Medicine

Rospo, Giuseppe G; Lorenzato, Annalisa A; Amirouchene-Angelozzi, Nabil N; Magrì, Alessandro A; Cancelliere, Carlotta C; Corti, Giorgio G; Negrino, Carola C; Amodio, Vito V; Montone, Monica M; Bartolini, Alice A; Barault, Ludovic L; Novara, Luca L; Isella, Claudio C; Medico, Enzo E; Bertotti, Andrea A; Trusolino, Livio L; Germano, Giovanni G; Di Nicolantonio, Federica F; Bardelli, Alberto A

Publication Date: 2019-06-28

Variant appearance in text: BRAF: T119S

PubMed Link: 31253177

Variant Present in the following documents:

• 13073_2019_654_MOESM2_ESM.xlsx, sheet 64
• 13073_2019_654_MOESM2_ESM.xlsx, sheet 34

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Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen.

Nature Communications

Menden, Michael P MP; Wang, Dennis D; Mason, Mike J MJ; Szalai, Bence B; Bulusu, Krishna C KC; Guan, Yuanfang Y; Yu, Thomas T; Kang, Jaewoo J; Jeon, Minji M; Wolfinger, Russ R; Nguyen, Tin T; Zaslavskiy, Mikhail M; , ; Jang, In Sock IS; Ghazoui, Zara Z; Ahsen, Mehmet Eren ME; Vogel, Robert R; Neto, Elias Chaibub EC; Norman, Thea T; Tang, Eric K Y EKY; Garnett, Mathew J MJ; Veroli, Giovanni Y Di GYD; Fawell, Stephen S; Stolovitzky, Gustavo G; Guinney, Justin J; Dry, Jonathan R JR; Saez-Rodriguez, Julio J

Publication Date: 2019-06-17

Variant appearance in text: BRAF: T119S

PubMed Link: 31209238

Variant Present in the following documents:

• 41467_2019_9799_MOESM5_ESM.xlsx, sheet 1

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MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAFV600E amplification whereas KRASG13D amplification promotes EMT-chemoresistance.

Nature Communications

Sale, Matthew J MJ; Balmanno, Kathryn K; Saxena, Jayeta J; Ozono, Eiko E; Wojdyla, Katarzyna K; McIntyre, Rebecca E RE; Gilley, Rebecca R; Woroniuk, Anna A; Howarth, Karen D KD; Hughes, Gareth G; Dry, Jonathan R JR; Arends, Mark J MJ; Caro, Pilar P; Oxley, David D; Ashton, Susan S; Adams, David J DJ; Saez-Rodriguez, Julio J; Smith, Paul D PD; Cook, Simon J SJ

Publication Date: 2019-05-02

Variant appearance in text: BRAF: T119S

PubMed Link: 31048689

Variant Present in the following documents:

• 41467_2019_9438_MOESM1_ESM.pdf

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Enhancing the Radiation Response in KRAS Mutant Colorectal Cancers Using the c-Met Inhibitor Crizotinib.

Translational Oncology

Cuneo, Kyle C KC; Mehta, Ranjit K RK; Kurapati, Himabindu H; Thomas, Dafydd G DG; Lawrence, Theodore S TS; Nyati, Mukesh K MK

Publication Date: 2019-02

Variant appearance in text: BRAF: T119S

PubMed Link: 30412912

Variant Present in the following documents:

• Main text
• main.pdf

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Macrophage migration inhibitory factor promotes resistance to MEK blockade in KRAS mutant colorectal cancer cells.

Molecular Oncology

Cheon, Seul-Ki SK; Kim, Hwang-Phill HP; Park, Ye-Lim YL; Jang, Jee-Eun JE; Lim, Yoojoo Y; Song, Sang-Hyun SH; Han, Sae-Won SW; Kim, Tae-You TY

Publication Date: 2018-08

Variant appearance in text: BRAF: T119S

PubMed Link: 29896883

Variant Present in the following documents:

• MOL2-12-1398-s001.pdf

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MEK inhibitors overcome resistance to BET inhibition across a number of solid and hematologic cancers.

Oncogenesis

Wyce, Anastasia A; Matteo, Jeanne J JJ; Foley, Shawn W SW; Felitsky, Daniel J DJ; Rajapurkar, Satyajit R SR; Zhang, Xi-Ping XP; Musso, Melissa C MC; Korenchuk, Susan S; Karpinich, Natalie O NO; Keenan, Kathryn M KM; Stern, Melissa M; Mathew, Lijoy K LK; McHugh, Charles F CF; McCabe, Michael T MT; Tummino, Peter J PJ; Kruger, Ryan G RG; Carpenter, Christopher C; Barbash, Olena O

Publication Date: 2018-04-20

Variant appearance in text: BRAF: T119S

PubMed Link: 29674704

Variant Present in the following documents:

• 41389_2018_43_MOESM5_ESM.pdf

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Development of a personalized therapeutic strategy for ERBB-gene-mutated cancers.

Therapeutic Advances In Medical Oncology

Milewska, Malgorzata M; Cremona, Mattia M; Morgan, Clare C; O'Shea, John J; Carr, Aoife A; Vellanki, Sri H SH; Hopkins, Ann M AM; Toomey, Sinead S; Madden, Stephen F SF; Hennessy, Bryan T BT; Eustace, Alex J AJ

Publication Date: 2018

Variant appearance in text: BRAF: T119S

PubMed Link: 29383036

Variant Present in the following documents:

• Main text
• 10.1177_1758834017746040.pdf

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Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies.

Molecular Cancer

Berg, Kaja C G KCG; Eide, Peter W PW; Eilertsen, Ina A IA; Johannessen, Bjarne B; Bruun, Jarle J; Danielsen, Stine A SA; Bjørnslett, Merete M; Meza-Zepeda, Leonardo A LA; Eknæs, Mette M; Lind, Guro E GE; Myklebost, Ola O; Skotheim, Rolf I RI; Sveen, Anita A; Lothe, Ragnhild A RA

Publication Date: 2017-07-06

Variant appearance in text: BRAF: T119S

PubMed Link: 28683746

Variant Present in the following documents:

• Main text
• 12943_2017_Article_691.pdf
• 12943_2017_691_MOESM1_ESM.xlsx, sheet 5

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Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications

Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ

Publication Date: 2017-05-11

Variant appearance in text: BRAF: 355A>T

PubMed Link: 28492226

Variant Present in the following documents:

• ncomms15086-s3.xlsx, sheet 1

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CoGAPS matrix factorization algorithm identifies transcriptional changes in AP-2alpha target genes in feedback from therapeutic inhibition of the EGFR network.

Oncotarget

Fertig, Elana J EJ; Ozawa, Hiroyuki H; Thakar, Manjusha M; Howard, Jason D JD; Kagohara, Luciane T LT; Krigsfeld, Gabriel G; Ranaweera, Ruchira S RS; Hughes, Robert M RM; Perez, Jimena J; Jones, Siân S; Favorov, Alexander V AV; Carey, Jacob J; Stein-O'Brien, Genevieve G; Gaykalova, Daria A DA; Ochs, Michael F MF; Chung, Christine H CH

Publication Date: 2016-11-08

Variant appearance in text: BRAF: T119S

PubMed Link: 27650546

Variant Present in the following documents:

• oncotarget-07-73845-s001.pdf

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Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor.

Plos One

Dumble, Melissa M; Crouthamel, Ming-Chih MC; Zhang, Shu-Yun SY; Schaber, Michael M; Levy, Dana D; Robell, Kimberly K; Liu, Qi Q; Figueroa, David J DJ; Minthorn, Elisabeth A EA; Seefeld, Mark A MA; Rouse, Meagan B MB; Rabindran, Sridhar K SK; Heerding, Dirk A DA; Kumar, Rakesh R

Publication Date: 2014

Variant appearance in text: BRAF: T119S

PubMed Link: 24978597

Variant Present in the following documents:

• pone.0100880.s006.xlsx, sheet 1

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