BRAF c.34G>C ;(p.A12P)

Variant ID: 7-140624470-C-G

NM_004333.4(BRAF):c.34G>C;(p.A12P)

This variant was identified in 22 publications

View GRCh38 version.




Publications:


Genomic and microenvironmental heterogeneity shaping epithelial-to-mesenchymal trajectories in cancer.

Nature Communications
Malagoli Tagliazucchi, Guidantonio G; Wiecek, Anna J AJ; Withnell, Eloise E; Secrier, Maria M
Publication Date: 2023-02-11

Variant appearance in text: BRAF: A12P
PubMed Link: 36774358
Variant Present in the following documents:
  • 41467_2023_36439_MOESM8_ESM.xlsx, sheet 49
View BVdb publication page



Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications
Boström, Martin M; Larsson, Erik E
Publication Date: 2022-11-17

Variant appearance in text: BRAF: A12P
PubMed Link: 36396655
Variant Present in the following documents:
  • 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



A Cross-Sectional Study for Evaluation of KRAS and BRAF Mutations by Reverse Dot Blot, PCR-RFLP, and Allele-Specific PCR Methods Among Patients with Colorectal Cancer.

Avicenna Journal Of Medical Biotechnology
Sheikhsofla, Fatemeh F; Poopak, Behzad B; Firuzyar, Sajjad S; Roudbari, Fatemeh F; Ghadiany, Mojtaba M
Publication Date: 2021

Variant appearance in text: BRAF: 34G>C
PubMed Link: 34900144
Variant Present in the following documents:
  • Main text
  • AJMB-13-183.pdf
View BVdb publication page



A novel xenonucleic acid-mediated molecular clamping technology for early colorectal cancer screening.

Plos One
Sun, Qing Q; Pastor, Larry L; Du, Jinwei J; Powell, Michael J MJ; Zhang, Aiguo A; Bodmer, Walter W; Wu, Jianzhong J; Zheng, Shu S; Sha, Michael Y MY
Publication Date: 2021

Variant appearance in text: BRAF: 34G>C
PubMed Link: 34610014
Variant Present in the following documents:
  • pone.0244332.pdf
View BVdb publication page



Comprehensive omic characterization of breast cancer in Mexican-Hispanic women.

Nature Communications
Romero-Cordoba, Sandra L SL; Salido-Guadarrama, Ivan I; Rebollar-Vega, Rosa R; Bautista-Piña, Veronica V; Dominguez-Reyes, Carlos C; Tenorio-Torres, Alberto A; Villegas-Carlos, Felipe F; Fernández-López, Juan C JC; Uribe-Figueroa, Laura L; Alfaro-Ruiz, Luis L; Hidalgo-Miranda, Alfredo A
Publication Date: 2021-04-14

Variant appearance in text: BRAF: A12P
PubMed Link: 33854067
Variant Present in the following documents:
  • 41467_2021_22478_MOESM8_ESM.xlsx, sheet 5
View BVdb publication page



Mutation status and prognostic value of KRAS and NRAS mutations in Moroccan colon cancer patients: A first report.

Plos One
El Agy, Fatima F; El Bardai, Sanae S; El Otmani, Ihsane I; Benbrahim, Zineb Z; Karim, Ibn Majdoub Hassani MH; Mazaz, Khalid K; Benjelloun, El Bachir EB; Ousadden, Abdelmalek A; El Abkari, Mohammed M; Ibrahimi, Sidi Adil SA; Chbani, Laila L
Publication Date: 2021

Variant appearance in text: BRAF: 34G>C
PubMed Link: 33784337
Variant Present in the following documents:
  • Main text
  • pone.0248522.pdf
View BVdb publication page



Clinical feasibility of NGS liquid biopsy analysis in NSCLC patients.

Plos One
Papadopoulou, Eirini E; Tsoulos, Nikolaos N; Tsantikidi, Katerina K; Metaxa-Mariatou, Vasiliki V; Stamou, Pinelopi Eleftheria PE; Kladi-Skandali, Athina A; Kapeni, Evgenia E; Tsaousis, Georgios G; Pentheroudakis, George G; Petrakis, Dimitrios D; Lampropoulou, Dimitra Ioanna DI; Aravantinos, Gerasimos G; Varthalitis, Ioannis I; Kesisis, George G; Boukovinas, Ioannis I; Papakotoulas, Pavlos P; Katirtzoglou, Nikolaos N; Athanasiadis, Elias E; Stavridi, Flora F; Christodoulou, Christos C; Koumarianou, Anna A; Eralp, Yeşim Y; Nasioulas, George G
Publication Date: 2019

Variant appearance in text: BRAF: 34G>C
PubMed Link: 31860648
Variant Present in the following documents:
  • pone.0226853.s001.xlsx, sheet 1
View BVdb publication page



NOTCH and DNA repair pathways are more frequently targeted by genomic alterations in inflammatory than in non-inflammatory breast cancers.

Molecular Oncology
Bertucci, François F; Rypens, Charlotte C; Finetti, Pascal P; Guille, Arnaud A; Adélaïde, José J; Monneur, Audrey A; Carbuccia, Nadine N; Garnier, Séverine S; Dirix, Piet P; Gonçalves, Anthony A; Vermeulen, Peter P; Debeb, Bisrat G BG; Wang, Xiaoping X; Dirix, Luc L; Ueno, Naoto T NT; Viens, Patrice P; Cristofanilli, Massimo M; Chaffanet, Max M; Birnbaum, Daniel D; Van Laere, Steven S
Publication Date: 2020-03

Variant appearance in text: BRAF: A12P
PubMed Link: 31854063
Variant Present in the following documents:
  • MOL2-14-504-s010.xlsx, sheet 1
View BVdb publication page



Parsimonious Gene Correlation Network Analysis (PGCNA): a tool to define modular gene co-expression for refined molecular stratification in cancer.

Npj Systems Biology And Applications
Care, Matthew A MA; Westhead, David R DR; Tooze, Reuben M RM
Publication Date: 2019

Variant appearance in text: BRAF: A12P
PubMed Link: 30993001
Variant Present in the following documents:
  • 41540_2019_90_MOESM2_ESM.pdf
View BVdb publication page



The prognostic effects of somatic mutations in ER-positive breast cancer.

Nature Communications
Griffith, Obi L OL; Spies, Nicholas C NC; Anurag, Meenakshi M; Griffith, Malachi M; Luo, Jingqin J; Tu, Dongsheng D; Yeo, Belinda B; Kunisaki, Jason J; Miller, Christopher A CA; Krysiak, Kilannin K; Hundal, Jasreet J; Ainscough, Benjamin J BJ; Skidmore, Zachary L ZL; Campbell, Katie K; Kumar, Runjun R; Fronick, Catrina C; Cook, Lisa L; Snider, Jacqueline E JE; Davies, Sherri S; Kavuri, Shyam M SM; Chang, Eric C EC; Magrini, Vincent V; Larson, David E DE; Fulton, Robert S RS; Liu, Shuzhen S; Leung, Samuel S; Voduc, David D; Bose, Ron R; Dowsett, Mitch M; Wilson, Richard K RK; Nielsen, Torsten O TO; Mardis, Elaine R ER; Ellis, Matthew J MJ
Publication Date: 2018-09-04

Variant appearance in text: BRAF: A12P
PubMed Link: 30181556
Variant Present in the following documents:
  • 41467_2018_5914_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



Quality and practical aspects of pathological and molecular diagnostics in metastatic colorectal cancer (mCRC).

Contemporary Oncology (Poznan, Poland)
Tysarowski, Andrzej A; Nasierowska-Guttmejer, Anna A
Publication Date: 2018

Variant appearance in text: BRAF: 34G>C
PubMed Link: 30150883
Variant Present in the following documents:
  • WO-22-77047.pdf
View BVdb publication page



Integrative omics analyses broaden treatment targets in human cancer.

Genome Medicine
Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L
Publication Date: 2018-07-27

Variant appearance in text: BRAF: A12P
PubMed Link: 30053901
Variant Present in the following documents:
  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 8
  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 19
  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 10
  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 15
View BVdb publication page



KRAS, NRAS and BRAF mutations detected by next generation sequencing, and differential clinical outcome in metastatic colorectal cancer (MCRC) patients treated with first line FIr-B/FOx adding bevacizumab (BEV) to triplet chemotherapy.

Oncotarget
Bruera, Gemma G; Pepe, Francesco F; Malapelle, Umberto U; Pisapia, Pasquale P; Mas, Antonella Dal AD; Di Giacomo, Daniela D; Calvisi, Giuseppe G; Troncone, Giancarlo G; Ricevuto, Enrico E
Publication Date: 2018-05-29

Variant appearance in text: BRAF: 34G>C
PubMed Link: 29899858
Variant Present in the following documents:
  • Main text
View BVdb publication page



A Landscape of Pharmacogenomic Interactions in Cancer.

Cell
Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ
Publication Date: 2016-07-28

Variant appearance in text: BRAF: A12P
PubMed Link: 27397505
Variant Present in the following documents:
  • mmc3.xlsx, sheet 2
View BVdb publication page



ERBB activation modulates sensitivity to MEK1/2 inhibition in a subset of driver-negative melanoma.

Oncotarget
Hutchinson, Katherine E KE; Johnson, Douglas B DB; Johnson, Adam S AS; Sanchez, Violeta V; Kuba, Maria M; Lu, Pengcheng P; Chen, Xi X; Kelley, Mark C MC; Wang, Qingguo Q; Zhao, Zhongming Z; Kris, Mark M; Berger, Michael F MF; Sosman, Jeffrey A JA; Pao, William W
Publication Date: 2015-09-08

Variant appearance in text: BRAF: 34G>C
PubMed Link: 26084293
Variant Present in the following documents:
  • oncotarget-06-22348-s002.xlsx, sheet 1
  • oncotarget-06-22348-s002.xlsx, sheet 2
View BVdb publication page



Activating GNAS and KRAS mutations in gastric foveolar metaplasia, gastric heterotopia, and adenocarcinoma of the duodenum.

British Journal Of Cancer
Matsubara, A A; Ogawa, R R; Suzuki, H H; Oda, I I; Taniguchi, H H; Kanai, Y Y; Kushima, R R; Sekine, S S
Publication Date: 2015-04-14

Variant appearance in text: BRAF: 34G>C
PubMed Link: 25867268
Variant Present in the following documents:
  • Main text
View BVdb publication page



Splicing mutation analysis reveals previously unrecognized pathways in lymph node-invasive breast cancer.

Scientific Reports
Dorman, Stephanie N SN; Viner, Coby C; Rogan, Peter K PK
Publication Date: 2014-11-14

Variant appearance in text: BRAF: A12P
PubMed Link: 25394353
Variant Present in the following documents:
  • srep07063-s2.xls, sheet 2
View BVdb publication page



Age-related mutations associated with clonal hematopoietic expansion and malignancies.

Nature Medicine
Xie, Mingchao M; Lu, Charles C; Wang, Jiayin J; McLellan, Michael D MD; Johnson, Kimberly J KJ; Wendl, Michael C MC; McMichael, Joshua F JF; Schmidt, Heather K HK; Yellapantula, Venkata V; Miller, Christopher A CA; Ozenberger, Bradley A BA; Welch, John S JS; Link, Daniel C DC; Walter, Matthew J MJ; Mardis, Elaine R ER; Dipersio, John F JF; Chen, Feng F; Wilson, Richard K RK; Ley, Timothy J TJ; Ding, Li L
Publication Date: 2014-12

Variant appearance in text: BRAF: A12P
PubMed Link: 25326804
Variant Present in the following documents:
  • NIHMS630249-supplement-5.xlsx, sheet 1
View BVdb publication page



Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review.

Molecular Cancer
Imamura, Yu Y; Lochhead, Paul P; Yamauchi, Mai M; Kuchiba, Aya A; Qian, Zhi Rong ZR; Liao, Xiaoyun X; Nishihara, Reiko R; Jung, Seungyoun S; Wu, Kana K; Nosho, Katsuhiko K; Wang, Yaoyu E YE; Peng, Shouyong S; Bass, Adam J AJ; Haigis, Kevin M KM; Meyerhardt, Jeffrey A JA; Chan, Andrew T AT; Fuchs, Charles S CS; Ogino, Shuji S
Publication Date: 2014-05-31

Variant appearance in text: BRAF: 34G>C
PubMed Link: 24885062
Variant Present in the following documents:
  • 1476-4598-13-135.pdf
View BVdb publication page



KRAS codon 12 and 13 mutations in relation to disease-free survival in BRAF-wild-type stage III colon cancers from an adjuvant chemotherapy trial (N0147 alliance).

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Yoon, Harry H HH; Tougeron, David D; Shi, Qian Q; Alberts, Steven R SR; Mahoney, Michelle R MR; Nelson, Garth D GD; Nair, Suresh G SG; Thibodeau, Stephen N SN; Goldberg, Richard M RM; Sargent, Daniel J DJ; Sinicrope, Frank A FA; ,
Publication Date: 2014-06-01

Variant appearance in text: BRAF: 34G>C
PubMed Link: 24687927
Variant Present in the following documents:
  • Main text
View BVdb publication page



Chromosome 3 anomalies investigated by genome wide SNP analysis of benign, low malignant potential and low grade ovarian serous tumours.

Plos One
Birch, Ashley H AH; Arcand, Suzanna L SL; Oros, Kathleen K KK; Rahimi, Kurosh K; Watters, A Kevin AK; Provencher, Diane D; Greenwood, Celia M CM; Mes-Masson, Anne-Marie AM; Tonin, Patricia N PN
Publication Date: 2011

Variant appearance in text: BRAF: 34G>C
PubMed Link: 22163003
Variant Present in the following documents:
  • Main text
View BVdb publication page



A multiplex SNaPshot assay as a rapid method for detecting KRAS and BRAF mutations in advanced colorectal cancers.

The Journal Of Molecular Diagnostics : Jmd
Magnin, Sandrine S; Viel, Erika E; Baraquin, Alice A; Valmary-Degano, Severine S; Kantelip, Bernadette B; Pretet, Jean-Luc JL; Mougin, Christiane C; Bigand, Marthe M; Girardo, Benoît B; Borg, Christophe C; Ferrand, Christophe C
Publication Date: 2011-09

Variant appearance in text: BRAF: 34G>C
PubMed Link: 21742054
Variant Present in the following documents:
  • Main text
View BVdb publication page