Publications:

Molecular dynamics simulations suggest possible activation and deactivation pathways in the hERG channel.

Communications Biology

Costa, Flavio F; Guardiani, Carlo C; Giacomello, Alberto A

Publication Date: 2022-02-24

Variant appearance in text: HERG: L666C

PubMed Link: 35210539

Variant Present in the following documents:

• 42003_2022_3074_MOESM1_ESM.pdf

View BVdb publication page

An Update on the Structure of hERG.

Frontiers In Pharmacology

Butler, Andrew A; Helliwell, Matthew V MV; Zhang, Yihong Y; Hancox, Jules C JC; Dempsey, Christopher E CE

Publication Date: 2019

Variant appearance in text: KCNH2: L666C

PubMed Link: 32038248

Variant Present in the following documents:

• Main text
• fphar-10-01572.pdf

View BVdb publication page

hERG S4-S5 linker acts as a voltage-dependent ligand that binds to the activation gate and locks it in a closed state.

Scientific Reports

Malak, Olfat A OA; Es-Salah-Lamoureux, Zeineb Z; Loussouarn, Gildas G

Publication Date: 2017-03-02

Variant appearance in text: KCNH2: L666C

PubMed Link: 28273916

Variant Present in the following documents:

• 41598_2017_155_MOESM1_ESM.pdf
• 41598_2017_Article_155.pdf

View BVdb publication page

Direct interaction of eag domains and cyclic nucleotide-binding homology domains regulate deactivation gating in hERG channels.

The Journal Of General Physiology

Gianulis, Elena C EC; Liu, Qiangni Q; Trudeau, Matthew C MC

Publication Date: 2013-10

Variant appearance in text: HERG: L666C

PubMed Link: 24043860

Variant Present in the following documents:

• JGP_201310995.pdf

View BVdb publication page

hERG gating microdomains defined by S6 mutagenesis and molecular modeling.

The Journal Of General Physiology

Wynia-Smith, Sarah L SL; Gillian-Daniel, Anne Lynn AL; Satyshur, Kenneth A KA; Robertson, Gail A GA

Publication Date: 2008-11

Variant appearance in text: KCNH2: L666C

PubMed Link: 18955593

Variant Present in the following documents:

• jgp1320507.pdf

View BVdb publication page