KCNH2 c.1984_1985delinsGC ;(p.I662A)

Variant ID: 7-150648169-AT-GC

NM_000238.3(KCNH2):c.1984_1985delinsGC;(p.I662A)

This variant was identified in 5 publications

View GRCh38 version.




Publications:


Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking.

Biochemical Pharmacology
Zhang, Yihong Y; Colenso, Charlotte K CK; El Harchi, Aziza A; Cheng, Hongwei H; Witchel, Harry J HJ; Dempsey, Chris E CE; Hancox, Jules C JC
Publication Date: 2016-08-01

Variant appearance in text: HERG: I662A
PubMed Link: 27256139
Variant Present in the following documents:
  • Main text
  • main.pdf
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Mechanism of electromechanical coupling in voltage-gated potassium channels.

Frontiers In Pharmacology
Blunck, Rikard R; Batulan, Zarah Z
Publication Date: 2012

Variant appearance in text: HERG: I662A
PubMed Link: 22988442
Variant Present in the following documents:
  • Main text
  • fphar-03-00166.pdf
View BVdb publication page



Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643.

Molecular Pharmacology
Grunnet, Morten M; Abbruzzese, Jennifer J; Sachse, Frank B FB; Sanguinetti, Michael C MC
Publication Date: 2011-01

Variant appearance in text: LQT2: I662A
PubMed Link: 20876384
Variant Present in the following documents:
  • Main text
View BVdb publication page



Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Perry, Matthew M; Sachse, Frank B FB; Sanguinetti, Michael C MC
Publication Date: 2007-08-21

Variant appearance in text: KCNH2: I662A
PubMed Link: 17693551
Variant Present in the following documents:
  • Main text
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A structural basis for drug-induced long QT syndrome.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Mitcheson, J S JS; Chen, J J; Lin, M M; Culberson, C C; Sanguinetti, M C MC
Publication Date: 2000-10-24

Variant appearance in text: HERG: I662A
PubMed Link: 11005845
Variant Present in the following documents:
  • Main text
View BVdb publication page