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KCNH2 c.1984_1985delinsGC ;(p.I662A)
Variant ID: 7-150648169-AT-GC
NM_000238.3(
KCNH2
):c.1984_1985delinsGC;(p.I662A)
This variant was identified in 5 publications
View GRCh38 version.
Variant-Specific Resource Links:
gnomAD v2.1.1
Mutalizer Name Checker
Google
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dbSNP
Publications:
Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking.
Biochemical Pharmacology
Zhang, Yihong Y; Colenso, Charlotte K CK; El Harchi, Aziza A; Cheng, Hongwei H; Witchel, Harry J HJ; Dempsey, Chris E CE; Hancox, Jules C JC
Publication Date: 2016-08-01
Variant appearance in text: HERG: I662A
PubMed Link:
27256139
Variant Present in the following documents:
Main text
main.pdf
View BVdb publication page
Mechanism of electromechanical coupling in voltage-gated potassium channels.
Frontiers In Pharmacology
Blunck, Rikard R; Batulan, Zarah Z
Publication Date: 2012
Variant appearance in text: HERG: I662A
PubMed Link:
22988442
Variant Present in the following documents:
Main text
fphar-03-00166.pdf
View BVdb publication page
Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643.
Molecular Pharmacology
Grunnet, Morten M; Abbruzzese, Jennifer J; Sachse, Frank B FB; Sanguinetti, Michael C MC
Publication Date: 2011-01
Variant appearance in text: LQT2: I662A
PubMed Link:
20876384
Variant Present in the following documents:
Main text
View BVdb publication page
Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Perry, Matthew M; Sachse, Frank B FB; Sanguinetti, Michael C MC
Publication Date: 2007-08-21
Variant appearance in text: KCNH2: I662A
PubMed Link:
17693551
Variant Present in the following documents:
Main text
View BVdb publication page
A structural basis for drug-induced long QT syndrome.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Mitcheson, J S JS; Chen, J J; Lin, M M; Culberson, C C; Sanguinetti, M C MC
Publication Date: 2000-10-24
Variant appearance in text: HERG: I662A
PubMed Link:
11005845
Variant Present in the following documents:
Main text
View BVdb publication page