Publications:

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An Update on the Structure of hERG.

Frontiers In Pharmacology

Butler, Andrew A; Helliwell, Matthew V MV; Zhang, Yihong Y; Hancox, Jules C JC; Dempsey, Christopher E CE

Publication Date: 2019

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PubMed Link: 32038248

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• fphar-10-01572.pdf

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Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker.

The Journal Of Biological Chemistry

Helliwell, Matthew V MV; Zhang, Yihong Y; El Harchi, Aziza A; Du, Chunyun C; Hancox, Jules C JC; Dempsey, Christopher E CE

Publication Date: 2018-05-04

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PubMed Link: 29545312

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• zbc7040.pdf

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Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking.

Biochemical Pharmacology

Zhang, Yihong Y; Colenso, Charlotte K CK; El Harchi, Aziza A; Cheng, Hongwei H; Witchel, Harry J HJ; Dempsey, Chris E CE; Hancox, Jules C JC

Publication Date: 2016-08-01

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PubMed Link: 27256139

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Stereoselective Inhibition of the hERG1 Potassium Channel.

Frontiers In Pharmacology

Grilo, Liliana Sintra LS; Carrupt, Pierre-Alain PA; Abriel, Hugues H

Publication Date: 2010

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PubMed Link: 21833176

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• fphar-01-00137.pdf

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Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide.

Molecular Pharmacology

Garg, Vivek V; Stary-Weinzinger, Anna A; Sachse, Frank F; Sanguinetti, Michael C MC

Publication Date: 2011-10

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PubMed Link: 21743002

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Molecular determinants of hERG channel block by terfenadine and cisapride.

Journal Of Pharmacological Sciences

Kamiya, Kaichiro K; Niwa, Ryoko R; Morishima, Mikio M; Honjo, Haruo H; Sanguinetti, Michael C MC

Publication Date: 2008-11

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PubMed Link: 18987434

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hERG gating microdomains defined by S6 mutagenesis and molecular modeling.

The Journal Of General Physiology

Wynia-Smith, Sarah L SL; Gillian-Daniel, Anne Lynn AL; Satyshur, Kenneth A KA; Robertson, Gail A GA

Publication Date: 2008-11

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PubMed Link: 18955593

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• jgp1320507.pdf

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Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Perry, Matthew M; Sachse, Frank B FB; Sanguinetti, Michael C MC

Publication Date: 2007-08-21

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PubMed Link: 17693551

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A structural basis for drug-induced long QT syndrome.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Mitcheson, J S JS; Chen, J J; Lin, M M; Culberson, C C; Sanguinetti, M C MC

Publication Date: 2000-10-24

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PubMed Link: 11005845

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