Publications:

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Identification of a novel pathogenic variant in KCNH2 in an Iranian family with long QT syndrome 2 by whole-exome sequencing.

Journal Of Arrhythmia

Fazelifar, Amir Farjam AF; Pourirahim, Maryam M; Masoumi, Tannaz T; Biglari, Alireza A; Maleki, Majid M; Kalayinia, Samira S

Publication Date: 2023-06

Variant appearance in text: KCNH2: F656C; rs199472977

PubMed Link: 37324772

Variant Present in the following documents:

• Main text
• JOA3-39-430.pdf

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Evolutionary coupling analysis guides identification of mistrafficking-sensitive variants in cardiac K+ channels: Validation with hERG.

Frontiers In Pharmacology

Zhang, Yihong Y; Grimwood, Amy L AL; Hancox, Jules C JC; Harmer, Stephen C SC; Dempsey, Christopher E CE

Publication Date: 2022

Variant appearance in text: KCNH2: F656C

PubMed Link: 36339618

Variant Present in the following documents:

• fphar-13-1010119.pdf

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Research Progress on Natural Products' Therapeutic Effects on Atrial Fibrillation by Regulating Ion Channels.

Cardiovascular Therapeutics

He, Jinshan J; Li, Sicong S; Ding, Yumeng Y; Tong, Yujia Y; Li, Xuebin X

Publication Date: 2022

Variant appearance in text: HERG: F656C

PubMed Link: 35387267

Variant Present in the following documents:

• CDTP2022-4559809.pdf

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Molecular Insights Into the Gating Kinetics of the Cardiac hERG Channel, Illuminated by Structure and Molecular Dynamics.

Frontiers In Pharmacology

Zequn, Zheng Z; Jiangfang, Lian L

Publication Date: 2021

Variant appearance in text: Kv11.1: F656C

PubMed Link: 34168566

Variant Present in the following documents:

• Main text
• fphar-12-687007.pdf

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Lipid regulation of hERG1 channel function.

Nature Communications

Miranda, Williams E WE; Guo, Jiqing J; Mesa-Galloso, Haydee H; Corradi, Valentina V; Lees-Miller, James P JP; Tieleman, D Peter DP; Duff, Henry J HJ; Noskov, Sergei Yu SY

Publication Date: 2021-03-03

Variant appearance in text: HERG: F656C

PubMed Link: 33658490

Variant Present in the following documents:

• 41467_2021_Article_21681.pdf
• 41467_2021_21681_MOESM2_ESM.pdf

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Allosteric Coupling Between Drug Binding and the Aromatic Cassette in the Pore Domain of the hERG1 Channel: Implications for a State-Dependent Blockade.

Frontiers In Pharmacology

Kudaibergenova, Meruyert M; Guo, Jiqing J; Khan, Hanif M HM; Zahid, Farhan F; Lees-Miller, James J; Noskov, Sergei Yu SY; Duff, Henry J HJ

Publication Date: 2020

Variant appearance in text: HERG: F656C

PubMed Link: 32694995

Variant Present in the following documents:

• fphar-11-00914.pdf

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Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome.

Frontiers In Pharmacology

Brewer, Kathryn R KR; Kuenze, Georg G; Vanoye, Carlos G CG; George, Alfred L AL; Meiler, Jens J; Sanders, Charles R CR

Publication Date: 2020

Variant appearance in text: LQT2: F656C

PubMed Link: 32431610

Variant Present in the following documents:

• Main text

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Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome.

Journal Of Molecular And Cellular Cardiology

Cheng, Hongwei H; Du, Chunyun C; Zhang, Yihong Y; James, Andrew F AF; Dempsey, Christopher E CE; Abdala, Ana P AP; Hancox, Jules C JC

Publication Date: 2019-10

Variant appearance in text: KCNH2: F656C

PubMed Link: 31362019

Variant Present in the following documents:

• Main text

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The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.

Molecular Pharmacology

Perissinotti, Laura L; Guo, Jiqing J; Kudaibergenova, Meruyert M; Lees-Miller, James J; Ol'khovich, Marina M; Sharapova, Angelica A; Perlovich, German L GL; Muruve, Daniel A DA; Gerull, Brenda B; Noskov, Sergei Yu SY; Duff, Henry J HJ

Publication Date: 2019-08

Variant appearance in text: Kv11.1: F656C

PubMed Link: 31182542

Variant Present in the following documents:

• Main text

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An in Vitro Assay of hERG K Channel Potency for a New EGFR Inhibitor FHND004.

Frontiers In Pharmacology

Jin, Tao T; Hu, Bingxue B; Chen, Shanshan S; Wang, Qiang Q; Dong, Xue X; Zhang, Yin Y; Zhu, Yongqiang Y; Zhang, Zhao Z

Publication Date: 2018

Variant appearance in text: KCNH2: F656C

PubMed Link: 29904349

Variant Present in the following documents:

• Main text
• fphar-09-00577.pdf

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Pore size matters for potassium channel conductance.

The Journal Of General Physiology

Naranjo, David D; Moldenhauer, Hans H; Pincuntureo, Matías M; Díaz-Franulic, Ignacio I

Publication Date: 2016-10

Variant appearance in text: KCNH2: F656C

PubMed Link: 27619418

Variant Present in the following documents:

• Main text
• JGP_201611625.pdf

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Large-scale mutational analysis of Kv11.1 reveals molecular insights into type 2 long QT syndrome.

Nature Communications

Anderson, Corey L CL; Kuzmicki, Catherine E CE; Childs, Ryan R RR; Hintz, Caleb J CJ; Delisle, Brian P BP; January, Craig T CT

Publication Date: 2014-11-24

Variant appearance in text: LQT2: F656C

PubMed Link: 25417810

Variant Present in the following documents:

• Main text
• nihms634670.pdf

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Molecular determinants of pentamidine-induced hERG trafficking inhibition.

Molecular Pharmacology

Dennis, Adrienne T AT; Wang, Lu L; Wan, Hanlin H; Nassal, Drew D; Deschenes, Isabelle I; Ficker, Eckhard E

Publication Date: 2012-02

Variant appearance in text: HERG: F656C

PubMed Link: 22046004

Variant Present in the following documents:

• Main text

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Rescue of mutated cardiac ion channels in inherited arrhythmia syndromes.

Journal Of Cardiovascular Pharmacology

Balijepalli, Sadguna Y SY; Anderson, Corey L CL; Lin, Eric C EC; January, Craig T CT

Publication Date: 2010-08

Variant appearance in text: LQT2: F656C

PubMed Link: 20224422

Variant Present in the following documents:

• Main text

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hERG gating microdomains defined by S6 mutagenesis and molecular modeling.

The Journal Of General Physiology

Wynia-Smith, Sarah L SL; Gillian-Daniel, Anne Lynn AL; Satyshur, Kenneth A KA; Robertson, Gail A GA

Publication Date: 2008-11

Variant appearance in text: KCNH2: F656C

PubMed Link: 18955593

Variant Present in the following documents:

• jgp1320507.pdf

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Doxazosin induces apoptosis of cells expressing hERG K+ channels.

European Journal Of Pharmacology

Thomas, Dierk D; Bloehs, Ramona R; Koschny, Ronald R; Ficker, Eckhard E; Sykora, Jaromir J; Kiehn, Johann J; Schlömer, Kathrin K; Gierten, Jakob J; Kathöfer, Sven S; Zitron, Edgar E; Scholz, Eberhard P EP; Kiesecker, Claudia C; Katus, Hugo A HA; Karle, Christoph A CA

Publication Date: 2008-01-28

Variant appearance in text: HERG: F656C

PubMed Link: 18054910

Variant Present in the following documents:

• Main text

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Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome.

British Journal Of Pharmacology

Takemasa, H H; Nagatomo, T T; Abe, H H; Kawakami, K K; Igarashi, T T; Tsurugi, T T; Kabashima, N N; Tamura, M M; Okazaki, M M; Delisle, B P BP; January, C T CT; Otsuji, Y Y

Publication Date: 2008-02

Variant appearance in text: KCNH2: F656C

PubMed Link: 17965736

Variant Present in the following documents:

• Main text

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Drug-induced long QT syndrome: hERG K+ channel block and disruption of protein trafficking by fluoxetine and norfluoxetine.

British Journal Of Pharmacology

Rajamani, S S; Eckhardt, L L LL; Valdivia, C R CR; Klemens, C A CA; Gillman, B M BM; Anderson, C L CL; Holzem, K M KM; Delisle, B P BP; Anson, B D BD; Makielski, J C JC; January, C T CT

Publication Date: 2006-11

Variant appearance in text: LQT2: F656C

PubMed Link: 16967046

Variant Present in the following documents:

• Main text

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Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy.

British Journal Of Pharmacology

Kawakami, Kazunobu K; Nagatomo, Toshihisa T; Abe, Haruhiko H; Kikuchi, Kan K; Takemasa, Hiroko H; Anson, Blake D BD; Delisle, Brian P BP; January, Craig T CT; Nakashima, Yasuhide Y

Publication Date: 2006-03

Variant appearance in text: HERG: F656C

PubMed Link: 16314852

Variant Present in the following documents:

• Main text

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Blockade of HERG cardiac K+ current by antifungal drug miconazole.

British Journal Of Pharmacology

Kikuchi, Kan K; Nagatomo, Toshihisa T; Abe, Haruhiko H; Kawakami, Kazunobu K; Duff, Henry J HJ; Makielski, Jonathan C JC; January, Craig T CT; Nakashima, Yasuhide Y

Publication Date: 2005-03

Variant appearance in text: HERG: F656C

PubMed Link: 15778703

Variant Present in the following documents:

• Main text

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