Publications:

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Pharmacological activation of the hERG K+ channel for the management of the long QT syndrome: A review.

Journal Of Arrhythmia

El Harchi, Aziza A; Brincourt, Oriane O

Publication Date: 2022-08

Variant appearance in text: LQT2: F656T

PubMed Link: 35936037

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• JOA3-38-554.pdf

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Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant.

Cellular And Molecular Life Sciences : Cmls

Al-Moubarak, Ehab E; Shiels, Holly A HA; Zhang, Yihong Y; Du, Chunyun C; Hanington, Oliver O; Harmer, Stephen C SC; Dempsey, Christopher E CE; Hancox, Jules C JC

Publication Date: 2021-12

Variant appearance in text: KCNH2: F656T

PubMed Link: 34727194

Variant Present in the following documents:

• Main text
• 18_2021_Article_3967.pdf

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Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant.

Cellular And Molecular Life Sciences : Cmls

Al-Moubarak, Ehab E; Shiels, Holly A HA; Zhang, Yihong Y; Du, Chunyun C; Hanington, Oliver O; Harmer, Stephen C SC; Dempsey, Christopher E CE; Hancox, Jules C JC

Publication Date: 2021-12

Variant appearance in text: KCNH2: F656T

PubMed Link: 34727194

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• Main text
• 18_2021_Article_3967.pdf

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A multiscale computational modelling approach predicts mechanisms of female sex risk in the setting of arousal-induced arrhythmias.

The Journal Of Physiology

Yang, Pei-Chi PC; Perissinotti, Laura L LL; López-Redondo, Fernando F; Wang, Yibo Y; DeMarco, Kevin R KR; Jeng, Mao-Tsuen MT; Vorobyov, Igor I; Harvey, Robert D RD; Kurokawa, Junko J; Noskov, Sergei Y SY; Clancy, Colleen E CE

Publication Date: 2017-07-15

Variant appearance in text: KCNH2: F656T

PubMed Link: 28516454

Variant Present in the following documents:

• Main text
• TJP-595-4695.pdf

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Pharmacological and electrophysiological characterization of AZSMO-23, an activator of the hERG K(+) channel.

British Journal Of Pharmacology

Mannikko, R R; Bridgland-Taylor, M H MH; Pye, H H; Swallow, S S; Abi-Gerges, N N; Morton, M J MJ; Pollard, C E CE

Publication Date: 2015-06

Variant appearance in text: Kv11.1: F656T

PubMed Link: 25684549

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Marine algal toxin azaspiracid is an open-state blocker of hERG potassium channels.

Chemical Research In Toxicology

Twiner, Michael J MJ; Doucette, Gregory J GJ; Rasky, Andrew A; Huang, Xi-Ping XP; Roth, Bryan L BL; Sanguinetti, Michael C MC

Publication Date: 2012-09-17

Variant appearance in text: KCNH2: F656T

PubMed Link: 22856456

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Molecular determinants of pentamidine-induced hERG trafficking inhibition.

Molecular Pharmacology

Dennis, Adrienne T AT; Wang, Lu L; Wan, Hanlin H; Nassal, Drew D; Deschenes, Isabelle I; Ficker, Eckhard E

Publication Date: 2012-02

Variant appearance in text: HERG: F656T

PubMed Link: 22046004

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Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide.

Molecular Pharmacology

Garg, Vivek V; Stary-Weinzinger, Anna A; Sachse, Frank F; Sanguinetti, Michael C MC

Publication Date: 2011-10

Variant appearance in text: KCNH2: F656T

PubMed Link: 21743002

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PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Perry, Matthew M; Sachse, Frank B FB; Abbruzzese, Jennifer J; Sanguinetti, Michael C MC

Publication Date: 2009-11-24

Variant appearance in text: KCNH2: F656T

PubMed Link: 19892732

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The 5-HT2 antagonist ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels.

British Journal Of Pharmacology

Tang, Q Q; Li, Z-Q ZQ; Li, W W; Guo, J J; Sun, H-Y HY; Zhang, X-H XH; Lau, C-P CP; Tse, H-F HF; Zhang, S S; Li, G-R GR

Publication Date: 2008-10

Variant appearance in text: HERG: F656T

PubMed Link: 18574455

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Acute effects of oestrogen on the guinea pig and human IKr channels and drug-induced prolongation of cardiac repolarization.

The Journal Of Physiology

Kurokawa, Junko J; Tamagawa, Masaji M; Harada, Nobuhiro N; Honda, Shin-Ichiro S; Bai, Chang-Xi CX; Nakaya, Haruaki H; Furukawa, Tetsushi T

Publication Date: 2008-06-15

Variant appearance in text: HERG: F656T

PubMed Link: 18440994

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Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Perry, Matthew M; Sachse, Frank B FB; Sanguinetti, Michael C MC

Publication Date: 2007-08-21

Variant appearance in text: KCNH2: F656T

PubMed Link: 17693551

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Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin.

Biochemical Pharmacology

Duncan, R S RS; McPate, M J MJ; Ridley, J M JM; Gao, Z Z; James, A F AF; Leishman, D J DJ; Leaney, J L JL; Witchel, H J HJ; Hancox, J C JC

Publication Date: 2007-08-01

Variant appearance in text: HERG: F656T

PubMed Link: 17560554

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