Publications:

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Pro-arrhythmic effects of gain-of-function potassium channel mutations in the short QT syndrome.

Philosophical Transactions Of The Royal Society Of London. Series B, Biological Sciences

Hancox, J C JC; Du, C Y CY; Butler, A A; Zhang, Y Y; Dempsey, C E CE; Harmer, S C SC; Zhang, H H

Publication Date: 2023-06-19

Variant appearance in text: KCNH2: S631A

PubMed Link: 37122211

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• rstb.2022.0165.pdf

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Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel.

Nature Communications

Zhang, Mingfeng M; Shan, Yuanyue Y; Pei, Duanqing D

Publication Date: 2023-03-16

Variant appearance in text: HERG: S631A

PubMed Link: 36928654

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• 41467_2023_37204_MOESM2_ESM.pdf

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Pharmacological activation of the hERG K+ channel for the management of the long QT syndrome: A review.

Journal Of Arrhythmia

El Harchi, Aziza A; Brincourt, Oriane O

Publication Date: 2022-08

Variant appearance in text: KCNH2: S631A

PubMed Link: 35936037

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• JOA3-38-554.pdf

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Identification through action potential clamp of proarrhythmic consequences of the short QT syndrome T618I hERG 'hotspot' mutation.

Biochemical And Biophysical Research Communications

Du, Chunyun C; Zhang, Henggui H; Harmer, Stephen C SC; Hancox, Jules C JC

Publication Date: 2022-03-12

Variant appearance in text: HERG: S631A

PubMed Link: 35114584

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• main.pdf

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Structural Modelling of KCNQ1 and KCNH2 Double Mutant Proteins, Identified in Two Severe Long QT Syndrome Cases, Reveals New Insights into Cardiac Channelopathies.

International Journal Of Molecular Sciences

Agudelo, William A WA; Gil-Quiñones, Sebastian Ramiro SR; Fonseca, Alejandra A; Arenas, Alvaro A; Castro, Laura L; Sierra-Díaz, Diana Carolina DC; Patarroyo, Manuel A MA; Laissue, Paul P; Suárez, Carlos F CF; Cabrera, Rodrigo R

Publication Date: 2021-11-28

Variant appearance in text: KCNH2: Ser631Ala

PubMed Link: 34884666

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Structural Modelling of KCNQ1 and KCNH2 Double Mutant Proteins, Identified in Two Severe Long QT Syndrome Cases, Reveals New Insights into Cardiac Channelopathies.

International Journal Of Molecular Sciences

Agudelo, William A WA; Gil-Quiñones, Sebastian Ramiro SR; Fonseca, Alejandra A; Arenas, Alvaro A; Castro, Laura L; Sierra-Díaz, Diana Carolina DC; Patarroyo, Manuel A MA; Laissue, Paul P; Suárez, Carlos F CF; Cabrera, Rodrigo R

Publication Date: 2021-11-28

Variant appearance in text: KCNH2: Ser631Ala

PubMed Link: 34884666

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Investigation of PAS and CNBH domain interactions in hERG channels and effects of long-QT syndrome-causing mutations with surface plasmon resonance.

The Journal Of Biological Chemistry

Soohoo, Stephanie M SM; Tiwari, Purushottam B PB; Suzuki, Yuichiro J YJ; Brelidze, Tinatin I TI

Publication Date: 2022-01

Variant appearance in text: LQT2: S631A

PubMed Link: 34801551

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• main.pdf

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Investigation of PAS and CNBH domain interactions in hERG channels and effects of long-QT syndrome-causing mutations with surface plasmon resonance.

The Journal Of Biological Chemistry

Soohoo, Stephanie M SM; Tiwari, Purushottam B PB; Suzuki, Yuichiro J YJ; Brelidze, Tinatin I TI

Publication Date: 2021-11-18

Variant appearance in text: LQT2: S631A

PubMed Link: 34801551

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• main.pdf

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Genetic and Molecular Aspects of Drug-Induced QT Interval Prolongation.

International Journal Of Molecular Sciences

Baracaldo-Santamaría, Daniela D; Llinás-Caballero, Kevin K; Corso-Ramirez, Julián Miguel JM; Restrepo, Carlos Martín CM; Dominguez-Dominguez, Camilo Alberto CA; Fonseca-Mendoza, Dora Janeth DJ; Calderon-Ospina, Carlos Alberto CA

Publication Date: 2021-07-28

Variant appearance in text: KCNH2: Ser631Ala

PubMed Link: 34360853

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• ijms-22-08090.pdf

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Aborted Cardiac Arrest in LQT2 Related to Novel KCNH2 (hERG) Variant Identified in One Lithuanian Family.

Medicina (Kaunas, Lithuania)

Bileišienė, Neringa N; Barysienė, Jūratė J; Mikštienė, Violeta V; Preikšaitienė, Eglė E; Marinskis, Germanas G; Keževičiūtė, Monika M; Utkus, Algirdas A; Aidietis, Audrius A

Publication Date: 2021-07-16

Variant appearance in text: KCNH2: Ser631Ala; rs199472959

PubMed Link: 34357002

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• Main text

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Molecular Insights Into the Gating Kinetics of the Cardiac hERG Channel, Illuminated by Structure and Molecular Dynamics.

Frontiers In Pharmacology

Zequn, Zheng Z; Jiangfang, Lian L

Publication Date: 2021

Variant appearance in text: KCNH2: S631A

PubMed Link: 34168566

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• Main text
• fphar-12-687007.pdf

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Shaker-IR K+ channel gating in heavy water: Role of structural water molecules in inactivation.

The Journal Of General Physiology

Szanto, Tibor G TG; Gaal, Szabolcs S; Karbat, Izhar I; Varga, Zoltan Z; Reuveny, Eitan E; Panyi, Gyorgy G

Publication Date: 2021-06-07

Variant appearance in text: Kv11.1: S631A

PubMed Link: 34014250

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• JGP_202012742.pdf

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Electrophysiological characterization of the modified hERGT potassium channel used to obtain the first cryo-EM hERG structure.

Physiological Reports

Zhang, Yihong Y; Dempsey, Christopher E CE; Hancox, Jules C JC

Publication Date: 2020-10

Variant appearance in text: LQT2: S631A

PubMed Link: 33091232

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• Main text
• PHY2-8-e14568.pdf

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Structures Illuminate Cardiac Ion Channel Functions in Health and in Long QT Syndrome.

Frontiers In Pharmacology

Brewer, Kathryn R KR; Kuenze, Georg G; Vanoye, Carlos G CG; George, Alfred L AL; Meiler, Jens J; Sanders, Charles R CR

Publication Date: 2020

Variant appearance in text: LQT2: S631A

PubMed Link: 32431610

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• Main text
• fphar-11-00550.pdf

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Modulation of hERG K+ Channel Deactivation by Voltage Sensor Relaxation.

Frontiers In Pharmacology

Shi, Yu Patrick YP; Thouta, Samrat S; Claydon, Thomas W TW

Publication Date: 2020

Variant appearance in text: Kv11.1: S631A

PubMed Link: 32184724

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An Update on the Structure of hERG.

Frontiers In Pharmacology

Butler, Andrew A; Helliwell, Matthew V MV; Zhang, Yihong Y; Hancox, Jules C JC; Dempsey, Christopher E CE

Publication Date: 2019

Variant appearance in text: HERG: S631A

PubMed Link: 32038248

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• Main text
• fphar-10-01572.pdf

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Identification of a proton sensor that regulates conductance and open time of single hERG channels.

Scientific Reports

Wilson, Stacey L SL; Dempsey, Christopher E CE; Hancox, Jules C JC; Marrion, Neil V NV

Publication Date: 2019-12-27

Variant appearance in text: KCNH2: S631A

PubMed Link: 31882846

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Atomistic basis of opening and conduction in mammalian inward rectifier potassium (Kir2.2) channels.

The Journal Of General Physiology

Zangerl-Plessl, Eva-Maria EM; Lee, Sun-Joo SJ; Maksaev, Grigory G; Bernsteiner, Harald H; Ren, Feifei F; Yuan, Peng P; Stary-Weinzinger, Anna A; Nichols, Colin G CG

Publication Date: 2020-01-06

Variant appearance in text: Kv11.1: S631A

PubMed Link: 31744859

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• JGP_201912422.pdf

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hERG Function in Light of Structure.

Biophysical Journal

Robertson, Gail A GA; Morais-Cabral, João H JH

Publication Date: 2020-02-25

Variant appearance in text: KCNH2: S631A

PubMed Link: 31669064

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Pore-modulating toxins exploit inherent slow inactivation to block K+ channels.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Karbat, Izhar I; Altman-Gueta, Hagit H; Fine, Shachar S; Szanto, Tibor T; Hamer-Rogotner, Shelly S; Dym, Orly O; Frolow, Felix F; Gordon, Dalia D; Panyi, Gyorgy G; Gurevitz, Michael M; Reuveny, Eitan E

Publication Date: 2019-09-10

Variant appearance in text: HERG: S631A

PubMed Link: 31444298

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Impact of Antiarrhythmic Drugs on the Outcome of Short QT Syndrome.

Frontiers In Pharmacology

El-Battrawy, Ibrahim I; Besler, Johanna J; Li, Xin X; Lan, Huan H; Zhao, Zhihan Z; Liebe, Volker V; Schimpf, Rainer R; Lang, Siegfried S; Wolpert, Christian C; Zhou, Xiaobo X; Akin, Ibrahim I; Borggrefe, Martin M

Publication Date: 2019

Variant appearance in text: HERG: S631A

PubMed Link: 31427960

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• Main text
• fphar-10-00771.pdf

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Short QT Syndrome: A Comprehensive Genetic Interpretation and Clinical Translation of Rare Variants.

Journal Of Clinical Medicine

Campuzano, Oscar O; Fernandez-Falgueras, Anna A; Lemus, Ximena X; Sarquella-Brugada, Georgia G; Cesar, Sergi S; Coll, Monica M; Mates, Jesus J; Arbelo, Elena E; Jordà, Paloma P; Perez-Serra, Alexandra A; Del Olmo, Bernat B; Ferrer-Costa, Carles C; Iglesias, Anna A; Fiol, Victoria V; Puigmulé, Marta M; Lopez, Laura L; Pico, Ferran F; Brugada, Josep J; Brugada, Ramon R

Publication Date: 2019-07-16

Variant appearance in text: KCNH2: Ser631Ala

PubMed Link: 31315195

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Functional and pharmacological characterization of an S5 domain hERG mutation associated with short QT syndrome.

Heliyon

Butler, Andrew A; Zhang, Yihong Y; Stuart, A Graham AG; Dempsey, Christopher E CE; Hancox, Jules C JC

Publication Date: 2019-04

Variant appearance in text: LQT2: S631A

PubMed Link: 31049424

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• Main text
• main.pdf

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Action potential clamp characterization of the S631A hERG mutation associated with short QT syndrome.

Physiological Reports

Butler, Andrew A; Zhang, Yihong Y; Stuart, Alan G AG; Dempsey, Christopher E CE; Hancox, Jules C JC

Publication Date: 2018-09

Variant appearance in text: KCNH2: S631A

PubMed Link: 30175559

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• Main text
• PHY2-6-e13845.pdf

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Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype.

Scientific Reports

Thouta, Samrat S; Lo, Garman G; Grajauskas, Lukas L; Claydon, Tom T

Publication Date: 2018-03-21

Variant appearance in text: LQT2: S631A

PubMed Link: 29563525

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Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker.

The Journal Of Biological Chemistry

Helliwell, Matthew V MV; Zhang, Yihong Y; El Harchi, Aziza A; Du, Chunyun C; Hancox, Jules C JC; Dempsey, Christopher E CE

Publication Date: 2018-05-04

Variant appearance in text: HERG: S631A

PubMed Link: 29545312

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• zbc7040.pdf

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Probing the molecular basis of hERG drug block with unnatural amino acids.

Scientific Reports

Macdonald, Logan C LC; Kim, Robin Y RY; Kurata, Harley T HT; Fedida, David D

Publication Date: 2018-01-10

Variant appearance in text: LQT2: S631A

PubMed Link: 29321549

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In Vitro and In Silico Risk Assessment in Acquired Long QT Syndrome: The Devil Is in the Details.

Frontiers In Physiology

Lee, William W; Windley, Monique J MJ; Vandenberg, Jamie I JI; Hill, Adam P AP

Publication Date: 2017

Variant appearance in text: Kv11.1: S631A

PubMed Link: 29201009

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• Main text
• fphys-08-00934.pdf

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Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3.

Molecular Pharmacology

Gardner, Alison A; Wu, Wei W; Thomson, Steven S; Zangerl-Plessl, Eva-Maria EM; Stary-Weinzinger, Anna A; Sanguinetti, Michael C MC

Publication Date: 2017-10

Variant appearance in text: KCNH2: S631A

PubMed Link: 28705808

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Modulation of Kv 11.1 (hERG) channels by 5-(((1H-indazol-5-yl)oxy)methyl)-N-(4-(trifluoromethoxy)phenyl)pyrimidin-2-amine (ITP-2), a novel small molecule activator.

British Journal Of Pharmacology

Sale, Harinath H; Roy, Samrat S; Warrier, Jayakumar J; Thangathirupathy, Srinivasan S; Vadari, Yoganand Y; Gopal, Shruthi K SK; Krishnamurthy, Prasad P; Ramarao, Manjunath M

Publication Date: 2017-08

Variant appearance in text: LQT2: S631A

PubMed Link: 28500657

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Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG.

Cell

Wang, Weiwei W; MacKinnon, Roderick R

Publication Date: 2017-04-20

Variant appearance in text: KCNH2: S631A

PubMed Link: 28431243

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Clemizole hydrochloride blocks cardiac potassium currents stably expressed in HEK 293 cells.

British Journal Of Pharmacology

Jie, Ling-Jun LJ; Wu, Wei-Yin WY; Li, Gang G; Xiao, Guo-Sheng GS; Zhang, Shetuan S; Li, Gui-Rong GR; Wang, Yan Y

Publication Date: 2017-02

Variant appearance in text: KCNH2: S631A

PubMed Link: 27886373

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Molecular Basis of Cardiac Delayed Rectifier Potassium Channel Function and Pharmacology.

Cardiac Electrophysiology Clinics

Wu, Wei W; Sanguinetti, Michael C MC

Publication Date: 2016-06

Variant appearance in text: KCNH2: S631A

PubMed Link: 27261821

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Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking.

Biochemical Pharmacology

Zhang, Yihong Y; Colenso, Charlotte K CK; El Harchi, Aziza A; Cheng, Hongwei H; Witchel, Harry J HJ; Dempsey, Chris E CE; Hancox, Jules C JC

Publication Date: 2016-08-01

Variant appearance in text: HERG: S631A

PubMed Link: 27256139

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Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide.

Journal Of Molecular And Cellular Cardiology

Melgari, Dario D; Zhang, Yihong Y; El Harchi, Aziza A; Dempsey, Christopher E CE; Hancox, Jules C JC

Publication Date: 2015-09

Variant appearance in text: HERG: S631A

PubMed Link: 26159617

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The Link between Inactivation and High-Affinity Block of hERG1 Channels.

Molecular Pharmacology

Wu, Wei W; Gardner, Alison A; Sanguinetti, Michael C MC

Publication Date: 2015-06

Variant appearance in text: KCNH2: S631A

PubMed Link: 25855787

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Bayesian models for syndrome- and gene-specific probabilities of novel variant pathogenicity.

Genome Medicine

Ruklisa, Dace D; Ware, James S JS; Walsh, Roddy R; Balding, David J DJ; Cook, Stuart A SA

Publication Date: 2015

Variant appearance in text: KCNH2: 1891T>G

PubMed Link: 25649125

Variant Present in the following documents:

• 13073_2014_120_MOESM1_ESM.pdf

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Translational toxicology and rescue strategies of the hERG channel dysfunction: biochemical and molecular mechanistic aspects.

Acta Pharmacologica Sinica

Zhang, Kai-ping KP; Yang, Bao-feng BF; Li, Bao-xin BX

Publication Date: 2014-12

Variant appearance in text: HERG: S631A

PubMed Link: 25418379

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Cooperative subunit interactions mediate fast C-type inactivation of hERG1 K+ channels.

The Journal Of Physiology

Wu, Wei W; Gardner, Alison A; Sanguinetti, Michael C MC

Publication Date: 2014-10-15

Variant appearance in text: KCNH2: Ser631Ala

PubMed Link: 25063820

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Open conformation of hERG channel turrets revealed by a specific scorpion toxin BmKKx2.

Cell & Bioscience

Hu, You-Tian YT; Hu, Jun J; Li, Tian T; Wei, Jing-Jing JJ; Feng, Jing J; Du, Yi-Mei YM; Cao, Zhi-Jian ZJ; Li, Wen-Xin WX; Wu, Ying-Liang YL

Publication Date: 2014

Variant appearance in text: HERG: S631A

PubMed Link: 24725272

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• 2045-3701-4-18.pdf

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Stoichiometry of altered hERG1 channel gating by small molecule activators.

The Journal Of General Physiology

Wu, Wei W; Sachse, Frank B FB; Gardner, Alison A; Sanguinetti, Michael C MC

Publication Date: 2014-04

Variant appearance in text: KCNH2: S631A

PubMed Link: 24638994

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Assessing hERG pore models as templates for drug docking using published experimental constraints: the inactivated state in the context of drug block.

Journal Of Chemical Information And Modeling

Dempsey, Christopher E CE; Wright, Dominic D; Colenso, Charlotte K CK; Sessions, Richard B RB; Hancox, Jules C JC

Publication Date: 2014-02-24

Variant appearance in text: HERG: S631A

PubMed Link: 24471705

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• ci400707h.pdf

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Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule.

The Journal Of General Physiology

Garg, Vivek V; Sachse, Frank B FB; Sanguinetti, Michael C MC

Publication Date: 2012-09

Variant appearance in text: erg1: S631A

PubMed Link: 22930803

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Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels.

The Journal Of General Physiology

Tan, Peter S PS; Perry, Matthew D MD; Ng, Chai Ann CA; Vandenberg, Jamie I JI; Hill, Adam P AP

Publication Date: 2012-09

Variant appearance in text: HERG: S631A

PubMed Link: 22891279

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• JGP_201110761.pdf

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Molecular determinants of pentamidine-induced hERG trafficking inhibition.

Molecular Pharmacology

Dennis, Adrienne T AT; Wang, Lu L; Wan, Hanlin H; Nassal, Drew D; Deschenes, Isabelle I; Ficker, Eckhard E

Publication Date: 2012-02

Variant appearance in text: HERG: S631A

PubMed Link: 22046004

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Molecular coupling in the human ether-a-go-go-related gene-1 (hERG1) K+ channel inactivation pathway.

The Journal Of Biological Chemistry

Ferrer, Tania T; Cordero-Morales, Julio F JF; Arias, Marcelo M; Ficker, Eckhard E; Medovoy, David D; Perozo, Eduardo E; Tristani-Firouzi, Martin M

Publication Date: 2011-11-11

Variant appearance in text: KCNH2: S631A

PubMed Link: 21908602

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Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide.

Molecular Pharmacology

Garg, Vivek V; Stary-Weinzinger, Anna A; Sachse, Frank F; Sanguinetti, Michael C MC

Publication Date: 2011-10

Variant appearance in text: KCNH2: S631A

PubMed Link: 21743002

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Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules.

Acta Pharmacologica Sinica

Zhou, Ping-zheng PZ; Babcock, Joseph J; Liu, Lian-qing LQ; Li, Min M; Gao, Zhao-bing ZB

Publication Date: 2011-06

Variant appearance in text: LQT2: S631A

PubMed Link: 21623390

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Trapping and dissociation of propafenone derivatives in HERG channels.

British Journal Of Pharmacology

Windisch, A A; Timin, En E; Schwarz, T T; Stork-Riedler, D D; Erker, T T; Ecker, Gf G; Hering, S S

Publication Date: 2011-04

Variant appearance in text: HERG: S631A

PubMed Link: 21175572

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Molecular determinants of human ether-à-go-go-related gene 1 (hERG1) K+ channel activation by NS1643.

Molecular Pharmacology

Grunnet, Morten M; Abbruzzese, Jennifer J; Sachse, Frank B FB; Sanguinetti, Michael C MC

Publication Date: 2011-01

Variant appearance in text: LQT2: S631A

PubMed Link: 20876384

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Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore opening.

Plos One

Es-Salah-Lamoureux, Zeineb Z; Fougere, Robert R; Xiong, Ping Yu PY; Robertson, Gail A GA; Fedida, David D

Publication Date: 2010-05-28

Variant appearance in text: HERG: S631A

PubMed Link: 20526358

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• pone.0010876.pdf

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Absence of direct cyclic nucleotide modulation of mEAG1 and hERG1 channels revealed with fluorescence and electrophysiological methods.

The Journal Of Biological Chemistry

Brelidze, Tinatin I TI; Carlson, Anne E AE; Zagotta, William N WN

Publication Date: 2009-10-09

Variant appearance in text: KCNH2: S631A

PubMed Link: 19671703

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Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum.

Molecular Pharmacology

Wang, Lu L; Dennis, Adrienne T AT; Trieu, Phan P; Charron, Francois F; Ethier, Natalie N; Hebert, Terence E TE; Wan, Xiaoping X; Ficker, Eckhard E

Publication Date: 2009-04

Variant appearance in text: HERG: S631A

PubMed Link: 19139152

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S4-based voltage sensors have three major conformations.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Villalba-Galea, Carlos A CA; Sandtner, Walter W; Starace, Dorine M DM; Bezanilla, Francisco F

Publication Date: 2008-11-18

Variant appearance in text: HERG: S631A

PubMed Link: 18818307

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Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs.

British Journal Of Pharmacology

McPate, M J MJ; Duncan, R S RS; Hancox, J C JC; Witchel, H J HJ

Publication Date: 2008-11

Variant appearance in text: KCNH2: S631A

PubMed Link: 18724381

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The 5-HT2 antagonist ketanserin is an open channel blocker of human cardiac ether-à-go-go-related gene (hERG) potassium channels.

British Journal Of Pharmacology

Tang, Q Q; Li, Z-Q ZQ; Li, W W; Guo, J J; Sun, H-Y HY; Zhang, X-H XH; Lau, C-P CP; Tse, H-F HF; Zhang, S S; Li, G-R GR

Publication Date: 2008-10

Variant appearance in text: HERG: S631A

PubMed Link: 18574455

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Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243).

Molecular Pharmacology

Xu, Xulin X; Recanatini, Maurizio M; Roberti, Marinella M; Tseng, Gea-Ny GN

Publication Date: 2008-06

Variant appearance in text: LQT2: S631A

PubMed Link: 18372399

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Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Perry, Matthew M; Sachse, Frank B FB; Sanguinetti, Michael C MC

Publication Date: 2007-08-21

Variant appearance in text: KCNH2: S631A

PubMed Link: 17693551

Variant Present in the following documents:

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Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin.

Biochemical Pharmacology

Duncan, R S RS; McPate, M J MJ; Ridley, J M JM; Gao, Z Z; James, A F AF; Leishman, D J DJ; Leaney, J L JL; Witchel, H J HJ; Hancox, J C JC

Publication Date: 2007-08-01

Variant appearance in text: HERG: S631A

PubMed Link: 17560554

Variant Present in the following documents:

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