Publications:

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Structural modeling of the hERG potassium channel and associated drug interactions.

Frontiers In Pharmacology

Maly, Jan J; Emigh, Aiyana M AM; DeMarco, Kevin R KR; Furutani, Kazuharu K; Sack, Jon T JT; Clancy, Colleen E CE; Vorobyov, Igor I; Yarov-Yarovoy, Vladimir V

Publication Date: 2022

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PubMed Link: 36188564

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Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant.

Cellular And Molecular Life Sciences : Cmls

Al-Moubarak, Ehab E; Shiels, Holly A HA; Zhang, Yihong Y; Du, Chunyun C; Hanington, Oliver O; Harmer, Stephen C SC; Dempsey, Christopher E CE; Hancox, Jules C JC

Publication Date: 2021-12

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PubMed Link: 34727194

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Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant.

Cellular And Molecular Life Sciences : Cmls

Al-Moubarak, Ehab E; Shiels, Holly A HA; Zhang, Yihong Y; Du, Chunyun C; Hanington, Oliver O; Harmer, Stephen C SC; Dempsey, Christopher E CE; Hancox, Jules C JC

Publication Date: 2021-12

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PubMed Link: 34727194

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Effects of Antiarrhythmic Drugs on hERG Gating in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1.

Frontiers In Pharmacology

Huang, Mengying M; Liao, Zhenxing Z; Li, Xin X; Yang, Zhen Z; Fan, Xuehui X; Li, Yingrui Y; Zhao, Zhihan Z; Lang, Siegfried S; Cyganek, Lukas L; Zhou, Xiaobo X; Akin, Ibrahim I; Borggrefe, Martin M; El-Battrawy, Ibrahim I

Publication Date: 2021

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PubMed Link: 34025432

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A structure-based computational workflow to predict liability and binding modes of small molecules to hERG.

Scientific Reports

Kalyaanamoorthy, Subha S; Lamothe, Shawn M SM; Hou, Xiaoqing X; Moon, Tae Chul TC; Kurata, Harley T HT; Houghton, Michael M; Barakat, Khaled H KH

Publication Date: 2020-10-01

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PubMed Link: 33004839

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• 41598_2020_Article_72889.pdf

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An Update on the Structure of hERG.

Frontiers In Pharmacology

Butler, Andrew A; Helliwell, Matthew V MV; Zhang, Yihong Y; Hancox, Jules C JC; Dempsey, Christopher E CE

Publication Date: 2019

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PubMed Link: 32038248

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• fphar-10-01572.pdf

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Cardiac toxicity of Triptergium wilfordii Hook F. may correlate with its inhibition to hERG channel.

Heliyon

Zhao, Wei W; Xiao, Liping L; Pan, Lanying L; Ke, Xianfu X; Zhang, Yanting Y; Zhong, Dian D; Xu, Jianwei J; Cao, Fumin F; Wu, Liren L; Chen, Yuan Y

Publication Date: 2019-10

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PubMed Link: 31667381

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The molecular determinants of R-roscovitine block of hERG channels.

Plos One

Cernuda, Bryan B; Fernandes, Christopher Thomas CT; Allam, Salma Mohamed SM; Orzillo, Matthew M; Suppa, Gabrielle G; Chia Chang, Zuleen Z; Athanasopoulos, Demosthenes D; Buraei, Zafir Z

Publication Date: 2019

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PubMed Link: 31479461

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Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome.

Journal Of Molecular And Cellular Cardiology

Cheng, Hongwei H; Du, Chunyun C; Zhang, Yihong Y; James, Andrew F AF; Dempsey, Christopher E CE; Abdala, Ana P AP; Hancox, Jules C JC

Publication Date: 2019-10

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PubMed Link: 31362019

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An in Vitro Assay of hERG K Channel Potency for a New EGFR Inhibitor FHND004.

Frontiers In Pharmacology

Jin, Tao T; Hu, Bingxue B; Chen, Shanshan S; Wang, Qiang Q; Dong, Xue X; Zhang, Yin Y; Zhu, Yongqiang Y; Zhang, Zhao Z

Publication Date: 2018

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PubMed Link: 29904349

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• fphar-09-00577.pdf

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Electrophysiological mechanisms of vandetanib-induced cardiotoxicity: Comparison of action potentials in rabbit Purkinje fibers and pluripotent stem cell-derived cardiomyocytes.

Plos One

Lee, Hyang-Ae HA; Hyun, Sung-Ae SA; Byun, Byungjin B; Chae, Jong-Hak JH; Kim, Ki-Suk KS

Publication Date: 2018

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PubMed Link: 29630634

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• pone.0195577.pdf

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Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker.

The Journal Of Biological Chemistry

Helliwell, Matthew V MV; Zhang, Yihong Y; El Harchi, Aziza A; Du, Chunyun C; Hancox, Jules C JC; Dempsey, Christopher E CE

Publication Date: 2018-05-04

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PubMed Link: 29545312

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• zbc7040.pdf

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The Basis for Low-affinity hERG Potassium Channel Block by Sotalol.

Journal Of Pharmacology & Pharmacotherapeutics

Zhang, Yi Hong YH; Dempsey, Christopher E CE; Hancox, Jules C JC

Publication Date: 2017

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PubMed Link: 29081622

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• JPP-8-130.pdf

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Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking.

Biochemical Pharmacology

Zhang, Yihong Y; Colenso, Charlotte K CK; El Harchi, Aziza A; Cheng, Hongwei H; Witchel, Harry J HJ; Dempsey, Chris E CE; Hancox, Jules C JC

Publication Date: 2016-08-01

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PubMed Link: 27256139

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Molecular basis of hERG potassium channel blockade by the class Ic antiarrhythmic flecainide.

Journal Of Molecular And Cellular Cardiology

Melgari, Dario D; Zhang, Yihong Y; El Harchi, Aziza A; Dempsey, Christopher E CE; Hancox, Jules C JC

Publication Date: 2015-09

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PubMed Link: 26159617

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hERG potassium channel blockade by the HCN channel inhibitor bradycardic agent ivabradine.

Journal Of The American Heart Association

Melgari, Dario D; Brack, Kieran E KE; Zhang, Chuan C; Zhang, Yihong Y; El Harchi, Aziza A; Mitcheson, John S JS; Dempsey, Christopher E CE; Ng, G André GA; Hancox, Jules C JC

Publication Date: 2015-04-24

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PubMed Link: 25911606

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Suppression of the hERG potassium channel response to premature stimulation by reduction in extracellular potassium concentration.

Physiological Reports

Melgari, Dario D; Du, Chunyun C; El Harchi, Aziza A; Zhang, Yihong Y; Hancox, Jules C JC

Publication Date: 2014-10-01

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PubMed Link: 25318749

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Ranolazine inhibition of hERG potassium channels: drug-pore interactions and reduced potency against inactivation mutants.

Journal Of Molecular And Cellular Cardiology

Du, Chunyun C; Zhang, Yihong Y; El Harchi, Aziza A; Dempsey, Christopher E CE; Hancox, Jules C JC

Publication Date: 2014-09

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PubMed Link: 24877995

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• mmc1.pdf

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Assessing hERG pore models as templates for drug docking using published experimental constraints: the inactivated state in the context of drug block.

Journal Of Chemical Information And Modeling

Dempsey, Christopher E CE; Wright, Dominic D; Colenso, Charlotte K CK; Sessions, Richard B RB; Hancox, Jules C JC

Publication Date: 2014-02-24

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PubMed Link: 24471705

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Molecular determinants of pentamidine-induced hERG trafficking inhibition.

Molecular Pharmacology

Dennis, Adrienne T AT; Wang, Lu L; Wan, Hanlin H; Nassal, Drew D; Deschenes, Isabelle I; Ficker, Eckhard E

Publication Date: 2012-02

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PubMed Link: 22046004

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High potency inhibition of hERG potassium channels by the sodium-calcium exchange inhibitor KB-R7943.

British Journal Of Pharmacology

Cheng, Hongwei H; Zhang, Yihong Y; Du, Chunyun C; Dempsey, Christopher E CE; Hancox, Jules C JC

Publication Date: 2012-04

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PubMed Link: 21950687

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Stereoselective Inhibition of the hERG1 Potassium Channel.

Frontiers In Pharmacology

Grilo, Liliana Sintra LS; Carrupt, Pierre-Alain PA; Abriel, Hugues H

Publication Date: 2010

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PubMed Link: 21833176

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Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide.

Molecular Pharmacology

Garg, Vivek V; Stary-Weinzinger, Anna A; Sachse, Frank F; Sanguinetti, Michael C MC

Publication Date: 2011-10

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PubMed Link: 21743002

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Role of voltage-gated sodium, potassium and calcium channels in the development of cocaine-associated cardiac arrhythmias.

British Journal Of Clinical Pharmacology

O'Leary, Michael E ME; Hancox, Jules C JC

Publication Date: 2010-05

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PubMed Link: 20573078

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Intracellular potassium stabilizes human ether-à-go-go-related gene channels for export from endoplasmic reticulum.

Molecular Pharmacology

Wang, Lu L; Dennis, Adrienne T AT; Trieu, Phan P; Charron, Francois F; Ethier, Natalie N; Hebert, Terence E TE; Wan, Xiaoping X; Ficker, Eckhard E

Publication Date: 2009-04

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PubMed Link: 19139152

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Molecular determinants of hERG channel block by terfenadine and cisapride.

Journal Of Pharmacological Sciences

Kamiya, Kaichiro K; Niwa, Ryoko R; Morishima, Mikio M; Honjo, Haruo H; Sanguinetti, Michael C MC

Publication Date: 2008-11

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PubMed Link: 18987434

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Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243).

Molecular Pharmacology

Xu, Xulin X; Recanatini, Maurizio M; Roberti, Marinella M; Tseng, Gea-Ny GN

Publication Date: 2008-06

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PubMed Link: 18372399

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Na+ permeation and block of hERG potassium channels.

The Journal Of General Physiology

Gang, Hongying H; Zhang, Shetuan S

Publication Date: 2006-07

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PubMed Link: 16769794

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Functional interaction between extracellular sodium, potassium and inactivation gating in HERG channels.

The Journal Of Physiology

Mullins, Franklin M FM; Stepanovic, Svetlana Z SZ; Gillani, Niloufar B NB; George, Alfred L AL; Balser, Jeffrey R JR

Publication Date: 2004-08-01

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PubMed Link: 15169846

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Extracellular sodium interacts with the HERG channel at an outer pore site.

The Journal Of General Physiology

Mullins, Franklin M FM; Stepanovic, Svetlana Z SZ; Desai, Reshma R RR; George, Alfred L AL; Balser, Jeffrey R JR

Publication Date: 2002-10

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PubMed Link: 12356854

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A structural basis for drug-induced long QT syndrome.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Mitcheson, J S JS; Chen, J J; Lin, M M; Culberson, C C; Sanguinetti, M C MC

Publication Date: 2000-10-24

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PubMed Link: 11005845

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