Publications:

Interactions between amiodarone and the hERG potassium channel pore determined with mutagenesis and in silico docking.

Biochemical Pharmacology

Zhang, Yihong Y; Colenso, Charlotte K CK; El Harchi, Aziza A; Cheng, Hongwei H; Witchel, Harry J HJ; Dempsey, Chris E CE; Hancox, Jules C JC

Publication Date: 2016-08-01

Variant appearance in text: HERG: L622A

PubMed Link: 27256139

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

PD-118057 contacts the pore helix of hERG1 channels to attenuate inactivation and enhance K+ conductance.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Perry, Matthew M; Sachse, Frank B FB; Abbruzzese, Jennifer J; Sanguinetti, Michael C MC

Publication Date: 2009-11-24

Variant appearance in text: KCNH2: L622A

PubMed Link: 19892732

Variant Present in the following documents:

• Main text

View BVdb publication page