KCNH2 c.1837_1839delinsTGT ;(p.T613C)

Variant ID: 7-150648642-CGT-ACA

NM_000238.3(KCNH2):c.1837_1839delinsTGT;(p.T613C)

This variant was identified in 4 publications

View GRCh38 version.




Publications:


Probing the binding sites and mechanisms of action of two human ether-a-go-go-related gene channel activators, 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) and 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid (PD307243).

Molecular Pharmacology
Xu, Xulin X; Recanatini, Maurizio M; Roberti, Marinella M; Tseng, Gea-Ny GN
Publication Date: 2008-06

Variant appearance in text: LQT2: T613C
PubMed Link: 18372399
Variant Present in the following documents:
  • Main text
View BVdb publication page



Probing the outer mouth structure of the HERG channel with peptide toxin footprinting and molecular modeling.

Biophysical Journal
Tseng, Gea-Ny GN; Sonawane, Kailas D KD; Korolkova, Yuliya V YV; Zhang, Mei M; Liu, Jie J; Grishin, Eugene V EV; Guy, H Robert HR
Publication Date: 2007-05-15

Variant appearance in text: HERG: T613C
PubMed Link: 17293393
Variant Present in the following documents:
  • Main text
View BVdb publication page



BeKm-1 is a HERG-specific toxin that shares the structure with ChTx but the mechanism of action with ErgTx1.

Biophysical Journal
Zhang, Mei M; Korolkova, Yuliya V YV; Liu, Jie J; Jiang, Min M; Grishin, Eugene V EV; Tseng, Gea-Ny GN
Publication Date: 2003-05

Variant appearance in text: HERG: T613C
PubMed Link: 12719233
Variant Present in the following documents:
  • Main text
View BVdb publication page



Structural and functional role of the extracellular s5-p linker in the HERG potassium channel.

The Journal Of General Physiology
Liu, Jie J; Zhang, Mei M; Jiang, Min M; Tseng, Gea-Ny GN
Publication Date: 2002-11

Variant appearance in text: HERG: T613C
PubMed Link: 12407082
Variant Present in the following documents:
  • Main text
  • 20028687.pdf
View BVdb publication page