Publications:

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Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant.

Cellular And Molecular Life Sciences : Cmls

Al-Moubarak, Ehab E; Shiels, Holly A HA; Zhang, Yihong Y; Du, Chunyun C; Hanington, Oliver O; Harmer, Stephen C SC; Dempsey, Christopher E CE; Hancox, Jules C JC

Publication Date: 2021-12

Variant appearance in text: Kv11.1: F557L

PubMed Link: 34727194

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• Main text
• 18_2021_Article_3967.pdf

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Inhibition of the hERG potassium channel by phenanthrene: a polycyclic aromatic hydrocarbon pollutant.

Cellular And Molecular Life Sciences : Cmls

Al-Moubarak, Ehab E; Shiels, Holly A HA; Zhang, Yihong Y; Du, Chunyun C; Hanington, Oliver O; Harmer, Stephen C SC; Dempsey, Christopher E CE; Hancox, Jules C JC

Publication Date: 2021-12

Variant appearance in text: Kv11.1: F557L

PubMed Link: 34727194

Variant Present in the following documents:

• Main text
• 18_2021_Article_3967.pdf

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Genetic and Molecular Aspects of Drug-Induced QT Interval Prolongation.

International Journal Of Molecular Sciences

Baracaldo-Santamaría, Daniela D; Llinás-Caballero, Kevin K; Corso-Ramirez, Julián Miguel JM; Restrepo, Carlos Martín CM; Dominguez-Dominguez, Camilo Alberto CA; Fonseca-Mendoza, Dora Janeth DJ; Calderon-Ospina, Carlos Alberto CA

Publication Date: 2021-07-28

Variant appearance in text: KCNH2: Phe557Leu

PubMed Link: 34360853

Variant Present in the following documents:

• Main text
• ijms-22-08090.pdf

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Lipid regulation of hERG1 channel function.

Nature Communications

Miranda, Williams E WE; Guo, Jiqing J; Mesa-Galloso, Haydee H; Corradi, Valentina V; Lees-Miller, James P JP; Tieleman, D Peter DP; Duff, Henry J HJ; Noskov, Sergei Yu SY

Publication Date: 2021-03-03

Variant appearance in text: HERG: F557L

PubMed Link: 33658490

Variant Present in the following documents:

• 41467_2021_21681_MOESM2_ESM.pdf
• 41467_2021_Article_21681.pdf

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Hydrophobic Drug/Toxin Binding Sites in Voltage-Dependent K+ and Na+ Channels.

Frontiers In Pharmacology

Van Theemsche, Kenny M KM; Van de Sande, Dieter V DV; Snyders, Dirk J DJ; Labro, Alain J AJ

Publication Date: 2020

Variant appearance in text: Kv11.1: F557L

PubMed Link: 32499709

Variant Present in the following documents:

• Main text
• fphar-11-00735.pdf

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An Update on the Structure of hERG.

Frontiers In Pharmacology

Butler, Andrew A; Helliwell, Matthew V MV; Zhang, Yihong Y; Hancox, Jules C JC; Dempsey, Christopher E CE

Publication Date: 2019

Variant appearance in text: KCNH2: F557L

PubMed Link: 32038248

Variant Present in the following documents:

• Main text
• fphar-10-01572.pdf

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Potent hERG channel inhibition by sarizotan, an investigative treatment for Rett Syndrome.

Journal Of Molecular And Cellular Cardiology

Cheng, Hongwei H; Du, Chunyun C; Zhang, Yihong Y; James, Andrew F AF; Dempsey, Christopher E CE; Abdala, Ana P AP; Hancox, Jules C JC

Publication Date: 2019-10

Variant appearance in text: KCNH2: F557L

PubMed Link: 31362019

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The Pore-Lipid Interface: Role of Amino-Acid Determinants of Lipophilic Access by Ivabradine to the hERG1 Pore Domain.

Molecular Pharmacology

Perissinotti, Laura L; Guo, Jiqing J; Kudaibergenova, Meruyert M; Lees-Miller, James J; Ol'khovich, Marina M; Sharapova, Angelica A; Perlovich, German L GL; Muruve, Daniel A DA; Gerull, Brenda B; Noskov, Sergei Yu SY; Duff, Henry J HJ

Publication Date: 2019-08

Variant appearance in text: Kv11.1: F557L

PubMed Link: 31182542

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An in Vitro Assay of hERG K Channel Potency for a New EGFR Inhibitor FHND004.

Frontiers In Pharmacology

Jin, Tao T; Hu, Bingxue B; Chen, Shanshan S; Wang, Qiang Q; Dong, Xue X; Zhang, Yin Y; Zhu, Yongqiang Y; Zhang, Zhao Z

Publication Date: 2018

Variant appearance in text: KCNH2: F557L

PubMed Link: 29904349

Variant Present in the following documents:

• Main text
• fphar-09-00577.pdf

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Structural implications of hERG K+ channel block by a high-affinity minimally structured blocker.

The Journal Of Biological Chemistry

Helliwell, Matthew V MV; Zhang, Yihong Y; El Harchi, Aziza A; Du, Chunyun C; Hancox, Jules C JC; Dempsey, Christopher E CE

Publication Date: 2018-05-04

Variant appearance in text: HERG: F557L

PubMed Link: 29545312

Variant Present in the following documents:

• zbc7040.pdf

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Molecular Basis of Altered hERG1 Channel Gating Induced by Ginsenoside Rg3.

Molecular Pharmacology

Gardner, Alison A; Wu, Wei W; Thomson, Steven S; Zangerl-Plessl, Eva-Maria EM; Stary-Weinzinger, Anna A; Sanguinetti, Michael C MC

Publication Date: 2017-10

Variant appearance in text: KCNH2: F557L

PubMed Link: 28705808

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New potential binding determinant for hERG channel inhibitors.

Scientific Reports

Saxena, P P; Zangerl-Plessl, E-M EM; Linder, T T; Windisch, A A; Hohaus, A A; Timin, E E; Hering, S S; Stary-Weinzinger, A A

Publication Date: 2016-04-12

Variant appearance in text: HERG: F557L

PubMed Link: 27067805

Variant Present in the following documents:

• srep24182.pdf

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HERG1 channel agonists and cardiac arrhythmia.

Current Opinion In Pharmacology

Sanguinetti, Michael C MC

Publication Date: 2014-04

Variant appearance in text: KCNH2: F557L

PubMed Link: 24721650

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Stoichiometry of altered hERG1 channel gating by small molecule activators.

The Journal Of General Physiology

Wu, Wei W; Sachse, Frank B FB; Gardner, Alison A; Sanguinetti, Michael C MC

Publication Date: 2014-04

Variant appearance in text: KCNH2: F557L

PubMed Link: 24638994

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• Main text
• JGP_201311038.pdf

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ICA-105574 interacts with a common binding site to elicit opposite effects on inactivation gating of EAG and ERG potassium channels.

Molecular Pharmacology

Garg, Vivek V; Stary-Weinzinger, Anna A; Sanguinetti, Michael C MC

Publication Date: 2013-04

Variant appearance in text: KCNH2: F557L

PubMed Link: 23319419

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Tuning of EAG K(+) channel inactivation: molecular determinants of amplification by mutations and a small molecule.

The Journal Of General Physiology

Garg, Vivek V; Sachse, Frank B FB; Sanguinetti, Michael C MC

Publication Date: 2012-09

Variant appearance in text: erg1: F557L

PubMed Link: 22930803

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• JGP_201210826.pdf

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Molecular determinants for activation of human ether-à-go-go-related gene 1 potassium channels by 3-nitro-n-(4-phenoxyphenyl) benzamide.

Molecular Pharmacology

Garg, Vivek V; Stary-Weinzinger, Anna A; Sachse, Frank F; Sanguinetti, Michael C MC

Publication Date: 2011-10

Variant appearance in text: KCNH2: F557L

PubMed Link: 21743002

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Structural basis of action for a human ether-a-go-go-related gene 1 potassium channel activator.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Perry, Matthew M; Sachse, Frank B FB; Sanguinetti, Michael C MC

Publication Date: 2007-08-21

Variant appearance in text: KCNH2: F557L

PubMed Link: 17693551

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