KCNH2 c.1618_1620delinsAAG ;(p.D540K)

Variant ID: 7-150648861-ATC-CTT

NM_000238.3(KCNH2):c.1618_1620delinsAAG;(p.D540K)

This variant was identified in 21 publications

View GRCh38 version.




Publications:


Binding of RPR260243 at the intracellular side of the hERG1 channel pore domain slows closure of the helix bundle crossing gate.

Frontiers In Molecular Biosciences
Zangerl-Plessl, Eva-Maria EM; Wu, Wei W; Sanguinetti, Michael C MC; Stary-Weinzinger, Anna A
Publication Date: 2023

Variant appearance in text: KCNH2: D540K
PubMed Link: 36911523
Variant Present in the following documents:
  • Main text
  • fmolb-10-1137368.pdf
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Molecular dynamics simulations suggest possible activation and deactivation pathways in the hERG channel.

Communications Biology
Costa, Flavio F; Guardiani, Carlo C; Giacomello, Alberto A
Publication Date: 2022-02-24

Variant appearance in text: HERG: D540K
PubMed Link: 35210539
Variant Present in the following documents:
  • 42003_2022_3074_MOESM1_ESM.pdf
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Assessment of proarrhythmogenic risk for chloroquine and hydroxychloroquine using the CiPA concept.

European Journal Of Pharmacology
Thomet, Urs U; Amuzescu, Bogdan B; Knott, Thomas T; Mann, Stefan A SA; Mubagwa, Kanigula K; Radu, Beatrice Mihaela BM
Publication Date: 2021-12-15

Variant appearance in text: HERG: D540K
PubMed Link: 34785211
Variant Present in the following documents:
  • main.pdf
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Mapping Electromechanical Coupling Pathways in Voltage-Gated Ion Channels: Challenges and the Way Forward.

Journal Of Molecular Biology
Cowgill, John J; Chanda, Baron B
Publication Date: 2021-08-20

Variant appearance in text: HERG: D540K
PubMed Link: 34139217
Variant Present in the following documents:
  • nihms-1748076.pdf
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Investigating the state dependence of drug binding in hERG channels using a trapped-open channel phenotype.

Scientific Reports
Thouta, Samrat S; Lo, Garman G; Grajauskas, Lukas L; Claydon, Tom T
Publication Date: 2018-03-21

Variant appearance in text: LQT2: D540K
PubMed Link: 29563525
Variant Present in the following documents:
  • Main text
  • 41598_2018_Article_23346.pdf
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Quantitative approach for cardiac risk assessment and interpretation in tuberculosis drug development.

Journal Of Pharmacokinetics And Pharmacodynamics
Polak, Sebastian S; Romero, Klaus K; Berg, Alexander A; Patel, Nikunjkumar N; Jamei, Masoud M; Hermann, David D; Hanna, Debra D
Publication Date: 2018-06

Variant appearance in text: HERG: D540K
PubMed Link: 29520534
Variant Present in the following documents:
  • 10928_2018_9580_MOESM1_ESM.xlsx, sheet 1
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Drug trapping in hERG K+ channels: (not) a matter of drug size?

Medchemcomm
Linder, Tobias T; Bernsteiner, Harald H; Saxena, Priyanka P; Bauer, Florian F; Erker, Thomas T; Timin, Eugen E; Hering, Steffen S; Stary-Weinzinger, Anna A
Publication Date: 2016-03-01

Variant appearance in text: HERG: D540K
PubMed Link: 28337337
Variant Present in the following documents:
  • Main text
View BVdb publication page



Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.

Biophysical Journal
Thouta, Samrat S; Sokolov, Stanislav S; Abe, Yuki Y; Clark, Sheldon J SJ; Cheng, Yen M YM; Claydon, Tom W TW
Publication Date: 2014-03-04

Variant appearance in text: Kv11.1: D540K
PubMed Link: 24606930
Variant Present in the following documents:
  • Main text
View BVdb publication page



Role of the activation gate in determining the extracellular potassium dependency of block of HERG by trapped drugs.

Channels (Austin, Tex.)
Pareja, Kristeen K; Chu, Elaine E; Dodyk, Katrina K; Richter, Kristofer K; Miller, Alan A
Publication Date: 2013-01-01

Variant appearance in text: HERG: D540K
PubMed Link: 23221912
Variant Present in the following documents:
  • Main text
View BVdb publication page



A leucine zipper motif essential for gating of hyperpolarization-activated channels.

The Journal Of Biological Chemistry
Wemhöner, Konstantin K; Silbernagel, Nicole N; Marzian, Stefanie S; Netter, Michael F MF; Rinné, Susanne S; Stansfeld, Phillip J PJ; Decher, Niels N
Publication Date: 2012-11-23

Variant appearance in text: HERG: D540K
PubMed Link: 23048023
Variant Present in the following documents:
  • Main text
View BVdb publication page



Mechanism of electromechanical coupling in voltage-gated potassium channels.

Frontiers In Pharmacology
Blunck, Rikard R; Batulan, Zarah Z
Publication Date: 2012

Variant appearance in text: HERG: D540K
PubMed Link: 22988442
Variant Present in the following documents:
  • Main text
  • fphar-03-00166.pdf
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Voltage-dependent gating of HERG potassium channels.

Frontiers In Pharmacology
Cheng, Yen May YM; Claydon, Tom W TW
Publication Date: 2012

Variant appearance in text: Kv11.1: D540K
PubMed Link: 22586397
Variant Present in the following documents:
  • Main text
View BVdb publication page



Stereoselective Inhibition of the hERG1 Potassium Channel.

Frontiers In Pharmacology
Grilo, Liliana Sintra LS; Carrupt, Pierre-Alain PA; Abriel, Hugues H
Publication Date: 2010

Variant appearance in text: KCNH2: D540K
PubMed Link: 21833176
Variant Present in the following documents:
  • Main text
  • fphar-01-00137.pdf
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Trapping and dissociation of propafenone derivatives in HERG channels.

British Journal Of Pharmacology
Windisch, A A; Timin, En E; Schwarz, T T; Stork-Riedler, D D; Erker, T T; Ecker, Gf G; Hering, S S
Publication Date: 2011-04

Variant appearance in text: HERG: D540K
PubMed Link: 21175572
Variant Present in the following documents:
  • Main text
View BVdb publication page



Transfer of rolf S3-S4 linker to HERG eliminates activation gating but spares inactivation.

Biophysical Journal
Choveau, Frank S FS; El Harchi, Aziza A; Rodriguez, Nicolas N; Louérat-Oriou, Bénédicte B; Baró, Isabelle I; Demolombe, Sophie S; Charpentier, Flavien F; Loussouarn, Gildas G
Publication Date: 2009-09-02

Variant appearance in text: KCNH2: D540K
PubMed Link: 19720020
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular determinants of hERG channel block by terfenadine and cisapride.

Journal Of Pharmacological Sciences
Kamiya, Kaichiro K; Niwa, Ryoko R; Morishima, Mikio M; Honjo, Haruo H; Sanguinetti, Michael C MC
Publication Date: 2008-11

Variant appearance in text: HERG: D540K
PubMed Link: 18987434
Variant Present in the following documents:
  • Main text
View BVdb publication page



State dependent dissociation of HERG channel inhibitors.

British Journal Of Pharmacology
Stork, D D; Timin, E N EN; Berjukow, S S; Huber, C C; Hohaus, A A; Auer, M M; Hering, S S
Publication Date: 2007-08

Variant appearance in text: HERG: D540K
PubMed Link: 17592502
Variant Present in the following documents:
  • Main text
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Inhibition of the HERG potassium channel by the tricyclic antidepressant doxepin.

Biochemical Pharmacology
Duncan, R S RS; McPate, M J MJ; Ridley, J M JM; Gao, Z Z; James, A F AF; Leishman, D J DJ; Leaney, J L JL; Witchel, H J HJ; Hancox, J C JC
Publication Date: 2007-08-01

Variant appearance in text: HERG: D540K
PubMed Link: 17560554
Variant Present in the following documents:
  • Main text
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Functional interaction between extracellular sodium, potassium and inactivation gating in HERG channels.

The Journal Of Physiology
Mullins, Franklin M FM; Stepanovic, Svetlana Z SZ; Gillani, Niloufar B NB; George, Alfred L AL; Balser, Jeffrey R JR
Publication Date: 2004-08-01

Variant appearance in text: HERG: D540K
PubMed Link: 15169846
Variant Present in the following documents:
  • Main text
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The S4-S5 linker couples voltage sensing and activation of pacemaker channels.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Chen, J J; Mitcheson, J S JS; Tristani-Firouzi, M M; Lin, M M; Sanguinetti, M C MC
Publication Date: 2001-09-25

Variant appearance in text: HERG: D540K
PubMed Link: 11553787
Variant Present in the following documents:
  • Main text
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Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate.

The Journal Of General Physiology
Mitcheson, J S JS; Chen, J J; Sanguinetti, M C MC
Publication Date: 2000-03

Variant appearance in text: HERG: D540K
PubMed Link: 10694252
Variant Present in the following documents:
  • Main text
  • GP-8134.pdf
View BVdb publication page