Mechanistic basis for type 2 long QT syndrome caused by KCNH2 mutations that disrupt conserved arginine residues in the voltage sensor.
The Journal Of Membrane Biology
McBride, Christie M CM; Smith, Ashley M AM; Smith, Jennifer L JL; Reloj, Allison R AR; Velasco, Ellyn J EJ; Powell, Jonathan J; Elayi, Claude S CS; Bartos, Daniel C DC; Burgess, Don E DE; Delisle, Brian P BP
Transfer of rolf S3-S4 linker to HERG eliminates activation gating but spares inactivation.
Biophysical Journal
Choveau, Frank S FS; El Harchi, Aziza A; Rodriguez, Nicolas N; Louérat-Oriou, Bénédicte B; Baró, Isabelle I; Demolombe, Sophie S; Charpentier, Flavien F; Loussouarn, Gildas G