Publications:

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Extracellular protons accelerate hERG channel deactivation by destabilizing voltage sensor relaxation.

The Journal Of General Physiology

Shi, Yu Patrick YP; Thouta, Samrat S; Cheng, Yen May YM; Claydon, Tom W TW

Publication Date: 2019-02-04

Variant appearance in text: HERG: L520C

PubMed Link: 30530765

Variant Present in the following documents:

• JGP_201812137.pdf

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Sequence of gating charge movement and pore gating in HERG activation and deactivation pathways.

Biophysical Journal

Goodchild, Samuel J SJ; Macdonald, Logan C LC; Fedida, David D

Publication Date: 2015-03-24

Variant appearance in text: LQT2: L520C

PubMed Link: 25809256

Variant Present in the following documents:

• Main text

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Proline scan of the HERG channel S6 helix reveals the location of the intracellular pore gate.

Biophysical Journal

Thouta, Samrat S; Sokolov, Stanislav S; Abe, Yuki Y; Clark, Sheldon J SJ; Cheng, Yen M YM; Claydon, Tom W TW

Publication Date: 2014-03-04

Variant appearance in text: Kv11.1: L520C

PubMed Link: 24606930

Variant Present in the following documents:

• Main text

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Voltage-sensing domain mode shift is coupled to the activation gate by the N-terminal tail of hERG channels.

The Journal Of General Physiology

Tan, Peter S PS; Perry, Matthew D MD; Ng, Chai Ann CA; Vandenberg, Jamie I JI; Hill, Adam P AP

Publication Date: 2012-09

Variant appearance in text: HERG: L520C

PubMed Link: 22891279

Variant Present in the following documents:

• JGP_201110761.pdf
• supp_jgp.201110761_JGP_201110761_sm.pdf

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Voltage-dependent gating of HERG potassium channels.

Frontiers In Pharmacology

Cheng, Yen May YM; Claydon, Tom W TW

Publication Date: 2012

Variant appearance in text: Kv11.1: L520C

PubMed Link: 22586397

Variant Present in the following documents:

• Main text
• fphar-03-00083.pdf

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Fluorescence-tracking of activation gating in human ERG channels reveals rapid S4 movement and slow pore opening.

Plos One

Es-Salah-Lamoureux, Zeineb Z; Fougere, Robert R; Xiong, Ping Yu PY; Robertson, Gail A GA; Fedida, David D

Publication Date: 2010-05-28

Variant appearance in text: HERG: L520C

PubMed Link: 20526358

Variant Present in the following documents:

• pone.0010876.pdf

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Transfer of rolf S3-S4 linker to HERG eliminates activation gating but spares inactivation.

Biophysical Journal

Choveau, Frank S FS; El Harchi, Aziza A; Rodriguez, Nicolas N; Louérat-Oriou, Bénédicte B; Baró, Isabelle I; Demolombe, Sophie S; Charpentier, Flavien F; Loussouarn, Gildas G

Publication Date: 2009-09-02

Variant appearance in text: KCNH2: L520C

PubMed Link: 19720020

Variant Present in the following documents:

• Main text

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Fast and slow voltage sensor movements in HERG potassium channels.

The Journal Of General Physiology

Smith, Paula L PL; Yellen, Gary G

Publication Date: 2002-03

Variant appearance in text: HERG: L520C

PubMed Link: 11865022

Variant Present in the following documents:

• Main text
• 8534.pdf

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