KCNH2 c.1366_1367delinsTG ;(p.D456C)

Variant ID: 7-150649703-TC-CA

NM_000238.3(KCNH2):c.1366_1367delinsTG;(p.D456C)

This variant was identified in 4 publications

View GRCh38 version.




Publications:


External pH modulates EAG superfamily K+ channels through EAG-specific acidic residues in the voltage sensor.

The Journal Of General Physiology
Kazmierczak, Marcin M; Zhang, Xiaofei X; Chen, Bihan B; Mulkey, Daniel K DK; Shi, Yingtang Y; Wagner, Paul G PG; Pivaroff-Ward, Kendra K; Sassic, Jessica K JK; Bayliss, Douglas A DA; Jegla, Timothy T
Publication Date: 2013-06

Variant appearance in text: Kv11.1: D456C
PubMed Link: 23712551
Variant Present in the following documents:
  • Main text
  • JGP_201210938.pdf
View BVdb publication page



Modification of hERG1 channel gating by Cd2+.

The Journal Of General Physiology
Abbruzzese, Jennifer J; Sachse, Frank B FB; Tristani-Firouzi, Martin M; Sanguinetti, Michael C MC
Publication Date: 2010-08

Variant appearance in text: KCNH2: D456C
PubMed Link: 20660661
Variant Present in the following documents:
  • Main text
  • JGP_201010450.pdf
View BVdb publication page



Molecular mapping of a site for Cd2+-induced modification of human ether-à-go-go-related gene (hERG) channel activation.

The Journal Of Physiology
Fernandez, David D; Ghanta, Azad A; Kinard, Krista I KI; Sanguinetti, Michael C MC
Publication Date: 2005-09-15

Variant appearance in text: HERG: D456C
PubMed Link: 15975984
Variant Present in the following documents:
  • Main text
View BVdb publication page



Negative charges in the transmembrane domains of the HERG K channel are involved in the activation- and deactivation-gating processes.

The Journal Of General Physiology
Liu, Jie J; Zhang, Mei M; Jiang, Min M; Tseng, Gea-Ny GN
Publication Date: 2003-06

Variant appearance in text: HERG: D456C
PubMed Link: 12771194
Variant Present in the following documents:
  • Main text
  • 200308788.pdf
View BVdb publication page