Publications:

Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex.

Molecular Oncology

Weirich, Sara S; Kudithipudi, Srikanth S; Jeltsch, Albert A

Publication Date: 2017-04

Variant appearance in text: MLL3: R3864Q

PubMed Link: 28182322

Variant Present in the following documents:

• Main text
• MOL2-11-373.pdf

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A non-active-site SET domain surface crucial for the interaction of MLL1 and the RbBP5/Ash2L heterodimer within MLL family core complexes.

Journal Of Molecular Biology

Shinsky, Stephen A SA; Hu, Michael M; Vought, Valarie E VE; Ng, Sarah B SB; Bamshad, Michael J MJ; Shendure, Jay J; Cosgrove, Michael S MS

Publication Date: 2014-06-12

Variant appearance in text: KMT2C: R3864Q

PubMed Link: 24680668

Variant Present in the following documents:

• Main text

View BVdb publication page