Publications:

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Efficacy of erlotinib in NSCLC harboring rare EGFR extracellular domain mutation (T263P) and common mutations: Case report and literature review.

Frontiers In Oncology

Wang, Qian Q; Wang, Yong Y; Zhang, Xinwei X; Fang, Chen C; Qian, Xiaoying X; Li, Yong Y

Publication Date: 2022

Variant appearance in text: EGFR: M277E

PubMed Link: 36212397

Variant Present in the following documents:

• Main text
• fonc-12-954026.pdf

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The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer

Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J

Publication Date: 2022-02

Variant appearance in text: EGFR: Met277Glu

PubMed Link: 35221333

Variant Present in the following documents:

• 43018_2022_332_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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A full-proteome, interaction-specific characterization of mutational hotspots across human cancers.

Genome Research

Chen, Siwei S; Liu, Yuan Y; Zhang, Yingying Y; Wierbowski, Shayne D SD; Lipkin, Steven M SM; Wei, Xiaomu X; Yu, Haiyuan H

Publication Date: 2022-01

Variant appearance in text: EGFR: M277E

PubMed Link: 34963661

Variant Present in the following documents:

• supp_gr.275437.121_Supplementary_Table_1.xlsx, sheet 3

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Receptor Tyrosine Kinases and Their Signaling Pathways as Therapeutic Targets of Curcumin in Cancer.

Frontiers In Pharmacology

Sudhesh Dev, Sareshma S; Zainal Abidin, Syafiq Asnawi SA; Farghadani, Reyhaneh R; Othman, Iekhsan I; Naidu, Rakesh R

Publication Date: 2021

Variant appearance in text: EGFR: M277E

PubMed Link: 34867402

Variant Present in the following documents:

• fphar-12-772510.pdf

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Correlation of genetic alterations by whole-exome sequencing with clinical outcomes of glioblastoma patients from the Lebanese population.

Plos One

Saadeh, Fadi S FS; Morsi, Rami Z RZ; El-Kurdi, Abdallah A; Nemer, Georges G; Mahfouz, Rami R; Charafeddine, Maya M; Khoury, Jessica J; Najjar, Marwan W MW; Khoueiry, Pierre P; Assi, Hazem I HI

Publication Date: 2020

Variant appearance in text: EGFR: M277E

PubMed Link: 33237934

Variant Present in the following documents:

• pone.0242793.s003.xlsx, sheet 1

View BVdb publication page

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Validation and clinical application of a targeted next-generation sequencing gene panel for solid and hematologic malignancies.

Peerj

Prieto-Potin, Iván I; Carvajal, Nerea N; Plaza-Sánchez, Jenifer J; Manso, Rebeca R; Aúz-Alexandre, Carmen Laura CL; Chamizo, Cristina C; Zazo, Sandra S; López-Sánchez, Almudena A; Rodríguez-Pinilla, Socorro María SM; Camacho, Laura L; Longarón, Raquel R; Bellosillo, Beatriz B; Somoza, Rosa R; Hernández-Losa, Javier J; Fernández-Soria, Víctor Manuel VM; Ramos-Ruiz, Ricardo R; Cristóbal, Ion I; García-Foncillas, Jesús J; Rojo, Federico F

Publication Date: 2020

Variant appearance in text: EGFR: 829_830delinsGA; M277E

PubMed Link: 33083132

Variant Present in the following documents:

• peerj-08-10069-s011.xlsx, sheet 1

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Novel EGFR ectodomain mutations associated with ligand-independent activation and cetuximab resistance in head and neck cancer.

Plos One

Nair, Sindhu S; Trummell, Hoa Q HQ; Rajbhandari, Rajani R; Thudi, Nanda K NK; Nozell, Susan E SE; Warram, Jason M JM; Willey, Christopher D CD; Yang, Eddy S ES; Placzek, William J WJ; Bonner, James A JA; Bredel, Markus M

Publication Date: 2020

Variant appearance in text: EGFR: M277E

PubMed Link: 32069320

Variant Present in the following documents:

• pone.0229077.pdf

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Potential mechanism of primary resistance to icotinib in patients with advanced non-small cell lung cancer harboring uncommon mutant epidermal growth factor receptor: A multi-center study.

Cancer Science

Lei, Lei L; Wang, Wen-Xian WX; Zhu, You-Cai YC; Li, Jin-Luan JL; Fang, Yong Y; Wang, Hong H; Zhuang, Wu W; Zhang, Yin-Bin YB; Wang, Li-Ping LP; Fang, Mei-Yu MY; Xu, Chun-Wei CW; Wang, Xiao-Jia XJ; Lv, Tang-Feng TF; Song, Yong Y

Publication Date: 2020-02

Variant appearance in text: EGFR: M277E

PubMed Link: 31828849

Variant Present in the following documents:

• Main text
• CAS-111-679.pdf

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Molecular dynamics simulation-guided drug sensitivity prediction for lung cancer with rare EGFR mutations.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Ikemura, Shinnosuke S; Yasuda, Hiroyuki H; Matsumoto, Shingo S; Kamada, Mayumi M; Hamamoto, Junko J; Masuzawa, Keita K; Kobayashi, Keigo K; Manabe, Tadashi T; Arai, Daisuke D; Nakachi, Ichiro I; Kawada, Ichiro I; Ishioka, Kota K; Nakamura, Morio M; Namkoong, Ho H; Naoki, Katsuhiko K; Ono, Fumie F; Araki, Mitsugu M; Kanada, Ryo R; Ma, Biao B; Hayashi, Yuichiro Y; Mimaki, Sachiyo S; Yoh, Kiyotaka K; Kobayashi, Susumu S SS; Kohno, Takashi T; Okuno, Yasushi Y; Goto, Koichi K; Tsuchihara, Katsuya K; Soejima, Kenzo K

Publication Date: 2019-05-14

Variant appearance in text: EGFR: M277E

PubMed Link: 31043566

Variant Present in the following documents:

• pnas.1819430116.sapp.pdf

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The non-small cell lung cancer EGFR extracellular domain mutation, M277E, is oncogenic and drug-sensitive.

Oncotargets And Therapy

Yu, Su S; Zhang, Yang Y; Pan, Yunjian Y; Cheng, Chao C; Sun, Yihua Y; Chen, Haiquan H

Publication Date: 2017

Variant appearance in text: EGFR: M277E

PubMed Link: 28979142

Variant Present in the following documents:

• Main text
• ott-10-4507.pdf

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