Publications:

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Cannabinoids Reduce Melanoma Cell Viability and Do Not Interfere with Commonly Used Targeted Therapy in Metastatic Melanoma In Vivo and In Vitro.

Biology

Richtig, Georg G; Kienzl, Melanie M; Rittchen, Sonja S; Roula, David D; Eberle, Jürgen J; Sarif, Zina Z; Pichler, Martin M; Hoefler, Gerald G; Heinemann, Akos A

Publication Date: 2023-05-12

Variant appearance in text: EGFR: A375R

PubMed Link: 37237519

Variant Present in the following documents:

• Main text
• biology-12-00706.pdf

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3-Bromopyruvate Suppresses the Malignant Phenotype of Vemurafenib-Resistant Melanoma Cells.

International Journal Of Molecular Sciences

Vital, Patrik da Silva PDS; Bonatelli, Murilo M; Dias, Marina Pereira MP; de Salis, Larissa Vedovato Vilela LVV; Pinto, Mariana Tomazini MT; Baltazar, Fátima F; Maria-Engler, Silvya Stuchi SS; Pinheiro, Céline C

Publication Date: 2022-12-09

Variant appearance in text: EGFR: A375R

PubMed Link: 36555289

Variant Present in the following documents:

• Main text
• ijms-23-15650.pdf

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Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma.

Life Science Alliance

Romano, David D; García-Gutiérrez, Lucía L; Aboud, Nourhan N; Duffy, David J DJ; Flaherty, Keith T KT; Frederick, Dennie T DT; Kolch, Walter W; Matallanas, David D

Publication Date: 2022-10

Variant appearance in text: EGFR: A375R

PubMed Link: 36038253

Variant Present in the following documents:

• LSA-2022-01445_review_history.pdf

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Norcantharidin overcomes vemurafenib resistance in melanoma by inhibiting pentose phosphate pathway and lipogenesis via downregulating the mTOR pathway.

Frontiers In Pharmacology

Wang, Lei L; Otkur, Wuxiyar W; Wang, Aman A; Wang, Wen W; Lyu, Yitong Y; Fang, Lei L; Shan, Xiu X; Song, Mingzhou M; Feng, Yan Y; Zhao, Yi Y; Piao, Hai-Long HL; Qi, Huan H; Liu, Ji-Wei JW

Publication Date: 2022

Variant appearance in text: EGFR: A375R

PubMed Link: 36034784

Variant Present in the following documents:

• fphar-13-906043.pdf

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CB-RAF600E-1 exerts efficacy in vemurafenib-resistant and non-resistant-melanoma cells via dual inhibition of RAS/RAF/MEK/ERK and PI3K/Akt signaling pathways.

Saudi Journal Of Biological Sciences

Al Shahrani, Mesfer M; Rajagopalan, Prasanna P; Abohassan, Mohammad M; Alshahrani, Mohammad M; Alraey, Yasser Y

Publication Date: 2022-06

Variant appearance in text: EGFR: A375R

PubMed Link: 35592740

Variant Present in the following documents:

• main.pdf

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DUSP4 protects BRAF- and NRAS-mutant melanoma from oncogene overdose through modulation of MITF.

Life Science Alliance

Gutierrez-Prat, Nuria N; Zuberer, Hedwig L HL; Mangano, Luca L; Karimaddini, Zahra Z; Wolf, Luise L; Tyanova, Stefka S; Wellinger, Lisa C LC; Marbach, Daniel D; Griesser, Vera V; Pettazzoni, Piergiorgio P; Bischoff, James R JR; Rohle, Daniel D; Palladino, Chiara C; Vivanco, Igor I

Publication Date: 2022-09

Variant appearance in text: EGFR: A375R

PubMed Link: 35580987

Variant Present in the following documents:

• LSA-2021-01235.pdf

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Overcoming differential tumor penetration of BRAF inhibitors using computationally guided combination therapy.

Science Advances

Ng, Thomas S C TSC; Hu, Huiyu H; Kronister, Stefan S; Lee, Chanseo C; Li, Ran R; Gerosa, Luca L; Stopka, Sylwia A SA; Burgenske, Danielle M DM; Khurana, Ishaan I; Regan, Michael S MS; Vallabhaneni, Sreeram S; Putta, Niharika N; Scott, Ella E; Matvey, Dylan D; Giobbie-Hurder, Anita A; Kohler, Rainer H RH; Sarkaria, Jann N JN; Parangi, Sareh S; Sorger, Peter K PK; Agar, Nathalie Y R NYR; Jacene, Heather A HA; Sullivan, Ryan J RJ; Buchbinder, Elizabeth E; Mikula, Hannes H; Weissleder, Ralph R; Miller, Miles A MA

Publication Date: 2022-04-29

Variant appearance in text: EGFR: A375R

PubMed Link: 35486732

Variant Present in the following documents:

• Main text
• sciadv.abl6339_sm.pdf
• sciadv.abl6339.pdf

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HI-511 overcomes melanoma drug resistance via targeting AURKB and BRAF V600E.

Theranostics

Chang, Xiaoyu X; Zhang, Tianshun T; Wang, Qiushi Q; Rathore, Moeez Ghani MG; Reddy, Kanamata K; Chen, Hanyong H; Shin, Seung Ho SH; Ma, Wei-Ya WY; Bode, Ann M AM; Dong, Zigang Z

Publication Date: 2020

Variant appearance in text: ERBB: A375R

PubMed Link: 32863956

Variant Present in the following documents:

• Main text
• thnov10p9721.pdf
• thnov10p9721s1.pdf

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A novel chalcone derivative suppresses melanoma cell growth through targeting Fyn/Stat3 pathway.

Cancer Cell International

Tang, Ling L; Long, Jing J; Li, Keke K; Zhang, Xu X; Chen, Xiang X; Peng, Cong C

Publication Date: 2020

Variant appearance in text: EGFR: A375R

PubMed Link: 32565740

Variant Present in the following documents:

• Main text
• 12935_2020_Article_1336.pdf

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In Vitro Biophysical and Biological Characterization of Lipid Nanoparticles Co-Encapsulating Oncosuppressors miR-199b-5p and miR-204-5p as Potentiators of Target Therapy in Metastatic Melanoma.

International Journal Of Molecular Sciences

Fattore, Luigi L; Campani, Virginia V; Ruggiero, Ciro Francesco CF; Salvati, Valentina V; Liguoro, Domenico D; Scotti, Lorena L; Botti, Gerardo G; Ascierto, Paolo Antonio PA; Mancini, Rita R; De Rosa, Giuseppe G; Ciliberto, Gennaro G

Publication Date: 2020-03-12

Variant appearance in text: EGFR: A375R

PubMed Link: 32178301

Variant Present in the following documents:

• Main text

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Targeting Cancer Metabolism to Resensitize Chemotherapy: Potential Development of Cancer Chemosensitizers from Traditional Chinese Medicines.

Cancers

Guo, Wei W; Tan, Hor-Yue HY; Chen, Feiyu F; Wang, Ning N; Feng, Yibin Y

Publication Date: 2020-02-10

Variant appearance in text: EGFR: A375R

PubMed Link: 32050640

Variant Present in the following documents:

• Main text

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miR-126-3p down-regulation contributes to dabrafenib acquired resistance in melanoma by up-regulating ADAM9 and VEGF-A.

Journal Of Experimental & Clinical Cancer Research : Cr

Caporali, Simona S; Amaro, Adriana A; Levati, Lauretta L; Alvino, Ester E; Lacal, Pedro Miguel PM; Mastroeni, Simona S; Ruffini, Federica F; Bonmassar, Laura L; Antonini Cappellini, Gian Carlo GC; Felli, Nadia N; Carè, Alessandra A; Pfeffer, Ulrich U; D'Atri, Stefania S

Publication Date: 2019-06-21

Variant appearance in text: EGFR: A375R

PubMed Link: 31227006

Variant Present in the following documents:

• Main text
• 13046_2019_Article_1238.pdf

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BRAF inhibition causes resilience of melanoma cell lines by inducing the secretion of FGF1.

Oncogenesis

Grimm, Johannes J; Hufnagel, Anita A; Wobser, Marion M; Borst, Andreas A; Haferkamp, Sebastian S; Houben, Roland R; Meierjohann, Svenja S

Publication Date: 2018-09-20

Variant appearance in text: EGFR: A375R

PubMed Link: 30237393

Variant Present in the following documents:

• 41389_2018_Article_82.pdf

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Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs.

Genes & Development

Yue, Jingyin J; Lai, Fan F; Beckedorff, Felipe F; Zhang, Anda A; Pastori, Chiara C; Shiekhattar, Ramin R

Publication Date: 2017-09-01

Variant appearance in text: EGFR: A375R

PubMed Link: 28982763

Variant Present in the following documents:

• Main text
• 1809.pdf

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Design and Development of Fluorescent Vemurafenib Analogs for In Vivo Imaging.

Theranostics

Mikula, Hannes H; Stapleton, Shawn S; Kohler, Rainer H RH; Vinegoni, Claudio C; Weissleder, Ralph R

Publication Date: 2017

Variant appearance in text: EGFR: A375R

PubMed Link: 28435463

Variant Present in the following documents:

• thnov07p1257.pdf

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BRAF(V600E) Kinase Domain Duplication Identified in Therapy-Refractory Melanoma Patient-Derived Xenografts.

Cell Reports

Kemper, Kristel K; Krijgsman, Oscar O; Kong, Xiangjun X; Cornelissen-Steijger, Paulien P; Shahrabi, Aida A; Weeber, Fleur F; van der Velden, Daphne L DL; Bleijerveld, Onno B OB; Kuilman, Thomas T; Kluin, Roel J C RJC; Sun, Chong C; Voest, Emile E EE; Ju, Young Seok YS; Schumacher, Ton N M TNM; Altelaar, A F Maarten AFM; McDermott, Ultan U; Adams, David J DJ; Blank, Christian U CU; Haanen, John B JB; Peeper, Daniel S DS

Publication Date: 2016-06-28

Variant appearance in text: EGFR: A375R

PubMed Link: 27320919

Variant Present in the following documents:

• Main text

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Microphthalmia-associated transcription factor suppresses invasion by reducing intracellular GTP pools.

Oncogene

Bianchi-Smiraglia, A A; Bagati, A A; Fink, E E EE; Moparthy, S S; Wawrzyniak, J A JA; Marvin, E K EK; Battaglia, S S; Jowdy, P P; Kolesnikova, M M; Foley, C E CE; Berman, A E AE; Kozlova, N I NI; Lipchick, B C BC; Paul-Rosner, L M LM; Bshara, W W; Ackroyd, J J JJ; Shewach, D S DS; Nikiforov, M A MA

Publication Date: 2017-01-05

Variant appearance in text: EGFR: A375R

PubMed Link: 27181209

Variant Present in the following documents:

• nihms775212.pdf

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Downregulation of the Ubiquitin Ligase RNF125 Underlies Resistance of Melanoma Cells to BRAF Inhibitors via JAK1 Deregulation.

Cell Reports

Kim, Hyungsoo H; Frederick, Dennie T DT; Levesque, Mitchell P MP; Cooper, Zachary A ZA; Feng, Yongmei Y; Krepler, Clemens C; Brill, Laurence L; Samuels, Yardena Y; Hayward, Nicholas K NK; Perlina, Ally A; Piris, Adriano A; Zhang, Tongwu T; Halaban, Ruth R; Herlyn, Meenhard M MM; Brown, Kevin M KM; Wargo, Jennifer A JA; Dummer, Reinhard R; Flaherty, Keith T KT; Ronai, Ze'ev A ZA

Publication Date: 2015-06-09

Variant appearance in text: EGFR: A375R

PubMed Link: 26027934

Variant Present in the following documents:

• Main text

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MITF Modulates Therapeutic Resistance through EGFR Signaling.

The Journal Of Investigative Dermatology

Ji, Zhenyu Z; Erin Chen, Yiyin Y; Kumar, Raj R; Taylor, Michael M; Jenny Njauw, Ching-Ni CN; Miao, Benchun B; Frederick, Dennie T DT; Wargo, Jennifer A JA; Flaherty, Keith T KT; Jönsson, Göran G; Tsao, Hensin H

Publication Date: 2015-07

Variant appearance in text: EGFR: A375R

PubMed Link: 25789707

Variant Present in the following documents:

• Main text
• nihms-670893.pdf
• NIHMS670893-supplement-01.pdf

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Inhibition of HSP90 by AT13387 delays the emergence of resistance to BRAF inhibitors and overcomes resistance to dual BRAF and MEK inhibition in melanoma models.

Molecular Cancer Therapeutics

Smyth, Tomoko T; Paraiso, Kim H T KHT; Hearn, Keisha K; Rodriguez-Lopez, Ana M AM; Munck, Joanne M JM; Haarberg, H Eirik HE; Sondak, Vernon K VK; Thompson, Neil T NT; Azab, Mohammad M; Lyons, John F JF; Smalley, Keiran S M KSM; Wallis, Nicola G NG

Publication Date: 2014-12

Variant appearance in text: EGFR: A375R

PubMed Link: 25349308

Variant Present in the following documents:

• Main text

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