Novel Fab-peptide-HLA-I fusion proteins for redirecting pre-existing anti-CMV T cell immunity to selective eliminate carcinoma cells.
Oncoimmunology
Britsch, Isabel I; van Wijngaarden, Anne P AP; Ke, Xiurong X; Hendriks, Mark A J M MAJM; Samplonius, Douwe F DF; Ploeg, Emily M EM; Helfrich, Wijnand W
Bispecific antibody approach for EGFR-directed blockade of the CD47-SIRPα "don't eat me" immune checkpoint promotes neutrophil-mediated trogoptosis and enhances antigen cross-presentation.
Oncoimmunology
Hendriks, Mark A J M MAJM; Ploeg, Emily M EM; Koopmans, Iris I; Britsch, Isabel I; Ke, Xiurong X; Samplonius, Douwe F DF; Helfrich, Wijnand W
Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies.
Nature Communications
Montero, Joan J; Gstalder, Cécile C; Kim, Daniel J DJ; Sadowicz, Dorota D; Miles, Wayne W; Manos, Michael M; Cidado, Justin R JR; Paul Secrist, J J; Tron, Adriana E AE; Flaherty, Keith K; Stephen Hodi, F F; Yoon, Charles H CH; Letai, Anthony A; Fisher, David E DE; Haq, Rizwan R
Melanoma cells undergo aggressive coalescence in a 3D Matrigel model that is repressed by anti-CD44.
Plos One
Wessels, Deborah D; Lusche, Daniel F DF; Voss, Edward E; Kuhl, Spencer S; Buchele, Emma C EC; Klemme, Michael R MR; Russell, Kanoe B KB; Ambrose, Joseph J; Soll, Benjamin A BA; Bossler, Aaron A; Milhem, Mohammed M; Goldman, Charles C; Soll, David R DR
Hypofractionated radiotherapy for localized prostate cancer.
Strahlentherapie Und Onkologie : Organ Der Deutschen Rontgengesellschaft ... [Et Al]
Höcht, Stefan S; Aebersold, Daniel M DM; Albrecht, Clemens C; Böhmer, Dirk D; Flentje, Michael M; Ganswindt, Ute U; Hölscher, Tobias T; Martin, Thomas T; Sedlmayer, Felix F; Wenz, Frederik F; Zips, Daniel D; Wiegel, Thomas T
A Small Molecule Inhibitor of PDK1/PLCγ1 Interaction Blocks Breast and Melanoma Cancer Cell Invasion.
Scientific Reports
Raimondi, Claudio C; Calleja, Veronique V; Ferro, Riccardo R; Fantin, Alessandro A; Riley, Andrew M AM; Potter, Barry V L BV; Brennan, Caroline H CH; Maffucci, Tania T; Larijani, Banafshé B; Falasca, Marco M