EGFR c.1361A>G ;(p.K454R)

Variant ID: 7-55227894-A-G

NM_005228.3(EGFR):c.1361A>G;(p.K454R)

This variant was identified in 6 publications

View GRCh38 version.




Publications:


N-terminus-independent activation of c-Src via binding to a tetraspan(in) TM4SF5 in hepatocellular carcinoma is abolished by the TM4SF5 C-terminal peptide application.

Theranostics
Song, Haeng Eun HE; Lee, Yoonji Y; Kim, Eunmi E; Cho, Chang Yun CY; Jung, Oisun O; Lee, Doohyung D; Lee, Eun Goo EG; Nam, Seo Hee SH; Kang, Minkyung M; Macalino, Stephani Joy Y SJY; Kim, Ji Eon JE; Jung, Jae Woo JW; Kwon, Sung Won SW; Choi, Sun S; Lee, Jung Weon JW
Publication Date: 2021

Variant appearance in text: EGFR: K454R
PubMed Link: 34335982
Variant Present in the following documents:
  • Main text
  • thnov11p8092.pdf
View BVdb publication page



Pleckstrin homology domain of phospholipase D2 is a negative regulator of focal adhesion kinase.

Bmb Reports
Kim, Mi Kyoung MK; Hwang, Won Chan WC; Min, Do Sik DS
Publication Date: 2021-02

Variant appearance in text: EGFR: K454R
PubMed Link: 32843133
Variant Present in the following documents:
  • Main text
  • bmb-54-2-112.pdf
View BVdb publication page



Oncogenic Receptor Tyrosine Kinases Directly Phosphorylate Focal Adhesion Kinase (FAK) as a Resistance Mechanism to FAK-Kinase Inhibitors.

Molecular Cancer Therapeutics
Marlowe, Timothy A TA; Lenzo, Felicia L FL; Figel, Sheila A SA; Grapes, Abigail T AT; Cance, William G WG
Publication Date: 2016-12

Variant appearance in text: EGFR: K454R
PubMed Link: 27638858
Variant Present in the following documents:
  • Main text
View BVdb publication page



Structural Basis for the Non-catalytic Functions of Protein Kinases.

Structure (London, England : 1993)
Kung, Jennifer E JE; Jura, Natalia N
Publication Date: 2016-01-05

Variant appearance in text: EGFR: K454R
PubMed Link: 26745528
Variant Present in the following documents:
  • Main text
View BVdb publication page



New insights into FAK phosphorylation based on a FAT domain-defective mutation.

Plos One
Fang, Xuqian X; Liu, Xiangfan X; Yao, Ling L; Chen, Changqiang C; Lin, Jiafei J; Ni, Peihua P; Zheng, Xinmin X; Fan, Qishi Q
Publication Date: 2014

Variant appearance in text: EGFR: K454R
PubMed Link: 25226367
Variant Present in the following documents:
  • Main text
  • pone.0107134.pdf
View BVdb publication page



Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling.

The Journal Of Clinical Investigation
Pylayeva, Yuliya Y; Gillen, Kelly M KM; Gerald, William W; Beggs, Hilary E HE; Reichardt, Louis F LF; Giancotti, Filippo G FG
Publication Date: 2009-02

Variant appearance in text: EGFR: K454R
PubMed Link: 19147981
Variant Present in the following documents:
  • Main text
View BVdb publication page