Engaging innate immunity for targeting the epidermal growth factor receptor: Therapeutic options leveraging innate immunity versus adaptive immunity versus inhibition of signaling.
Frontiers In Oncology
Hintzen, Gabriele G; Dulat, Holger J HJ; Rajkovic, Erich E
Pugh, Trevor J TJ; Bell, Jonathan L JL; Bruce, Jeff P JP; Doherty, Gary J GJ; Galvin, Matthew M; Green, Michelle F MF; Hunter-Zinck, Haley H; Kumari, Priti P; Lenoue-Newton, Michele L ML; Li, Marilyn M MM; Lindsay, James J; Mazor, Tali T; Ovalle, Andrea A; Sammut, Stephen-John SJ; Schultz, Nikolaus N; Yu, Thomas V TV; Sweeney, Shawn M SM; Bernard, Brady B; ,
Next-Generation Sequencing on Circulating Tumor DNA in Advanced Solid Cancer: Swiss Army Knife for the Molecular Tumor Board? A Review of the Literature Focused on FDA Approved Test.
Cells
Vasseur, Damien D; Sassi, Hela H; Bayle, Arnaud A; Tagliamento, Marco M; Besse, Benjamin B; Marzac, Christophe C; Arbab, Ahmadreza A; Auger, Nathalie N; Cotteret, Sophie S; Aldea, Mihaela M; Blanc-Durand, Félix F; Géraud, Arthur A; Gazzah, Anas A; Loriot, Yohann Y; Hollebecque, Antoine A; Martín-Romano, Patricia P; Ngo-Camus, Maud M; Nicotra, Claudio C; Ponce, Santiago S; Sakkal, Madona M; Caron, Olivier O; Smolenschi, Cristina C; Micol, Jean-Baptiste JB; Italiano, Antoine A; Rouleau, Etienne E; Lacroix, Ludovic L
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Pharmacogenomics in colorectal cancer: current role in clinical practice and future perspectives.
Journal Of Cancer Metastasis And Treatment
Battaglin, Francesca F; Puccini, Alberto A; Naseem, Madiha M; Schirripa, Marta M; Berger, Martin D MD; Tokunaga, Ryuma R; McSkane, Michelle M; Khoukaz, Taline T; Soni, Shivani S; Zhang, Wu W; Lenz, Heinz-Josef HJ
Esteban-Villarrubia, Jorge J; Soto-Castillo, Juan José JJ; Pozas, Javier J; San Román-Gil, María M; Orejana-Martín, Inmaculada I; Torres-Jiménez, Javier J; Carrato, Alfredo A; Alonso-Gordoa, Teresa T; Molina-Cerrillo, Javier J
Frequency of S492R mutations in the epidermal growth factor receptor: analysis of plasma DNA from patients with metastatic colorectal cancer treated with panitumumab or cetuximab monotherapy.
Cancer Biology & Therapy
Price, Timothy T; Ang, Agnes A; Boedigheimer, Michael M; Kim, Tae Won TW; Li, Jin J; Cascinu, Stefano S; Ruff, Paul P; Satya Suresh, Attili A; Thomas, Anne A; Tjulandin, Sergei S; Peeters, Marc M
Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.
Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Pan-cancer whole-genome analyses of metastatic solid tumours.
Nature
Priestley, Peter P; Baber, Jonathan J; Lolkema, Martijn P MP; Steeghs, Neeltje N; de Bruijn, Ewart E; Shale, Charles C; Duyvesteyn, Korneel K; Haidari, Susan S; van Hoeck, Arne A; Onstenk, Wendy W; Roepman, Paul P; Voda, Mircea M; Bloemendal, Haiko J HJ; Tjan-Heijnen, Vivianne C G VCG; van Herpen, Carla M L CML; Labots, Mariette M; Witteveen, Petronella O PO; Smit, Egbert F EF; Sleijfer, Stefan S; Voest, Emile E EE; Cuppen, Edwin E
RAS and BRAF mutations in cell-free DNA are predictive for outcome of cetuximab monotherapy in patients with tissue-tested RAS wild-type advanced colorectal cancer.
Molecular Oncology
van Helden, Erik J EJ; Angus, Lindsay L; Menke-van der Houven van Oordt, C Willemien CW; Heideman, Daniëlle A M DAM; Boon, Eline E; van Es, Suzanne C SC; Radema, Sandra A SA; van Herpen, Carla M L CML; de Groot, Derk Jan A DJA; de Vries, Elisabeth G E EGE; Jansen, Maurice P H M MPHM; Sleijfer, Stefan S; Verheul, Henk M W HMW
IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer.
Molecular Cell
Colomer, Carlota C; Margalef, Pol P; Villanueva, Alberto A; Vert, Anna A; Pecharroman, Irene I; Solé, Laura L; González-Farré, Mónica M; Alonso, Josune J; Montagut, Clara C; Martinez-Iniesta, Maria M; Bertran, Joan J; Borràs, Eva E; Iglesias, Mar M; Sabidó, Eduard E; Bigas, Anna A; Boulton, Simon J SJ; Espinosa, Lluís L
Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer.
Cancer Cell
Woolston, Andrew A; Khan, Khurum K; Spain, Georgia G; Barber, Louise J LJ; Griffiths, Beatrice B; Gonzalez-Exposito, Reyes R; Hornsteiner, Lisa L; Punta, Marco M; Patil, Yatish Y; Newey, Alice A; Mansukhani, Sonia S; Davies, Matthew N MN; Furness, Andrew A; Sclafani, Francesco F; Peckitt, Clare C; Jiménez, Mirta M; Kouvelakis, Kyriakos K; Ranftl, Romana R; Begum, Ruwaida R; Rana, Isma I; Thomas, Janet J; Bryant, Annette A; Quezada, Sergio S; Wotherspoon, Andrew A; Khan, Nasir N; Fotiadis, Nikolaos N; Marafioti, Teresa T; Powles, Thomas T; Lise, Stefano S; Calvo, Fernando F; Guettler, Sebastian S; von Loga, Katharina K; Rao, Sheela S; Watkins, David D; Starling, Naureen N; Chau, Ian I; Sadanandam, Anguraj A; Cunningham, David D; Gerlinger, Marco M
Detection of ERBB2 (HER2) Gene Amplification Events in Cell-Free DNA and Response to Anti-HER2 Agents in a Large Asian Cancer Patient Cohort.
Frontiers In Oncology
Lee, Jeeyun J; Franovic, Aleksandra A; Shiotsu, Yukimasa Y; Kim, Seung Tae ST; Kim, Kyoung-Mee KM; Banks, Kimberly C KC; Raymond, Victoria M VM; Lanman, Richard B RB
Cell-Free DNA Profiling to Discover Mechanisms of Exceptional Response to Cabozantinib Plus Panitumumab in a Patient With Treatment Refractory Metastatic Colorectal Cancer.
Frontiers In Oncology
Jia, Jingquan J; Morse, Michael A MA; Nagy, Rebecca J RJ; Lanman, Richard B RB; Strickler, John H JH
Integrative omics analyses broaden treatment targets in human cancer.
Genome Medicine
Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L
Efficacy of Sym004 in Patients With Metastatic Colorectal Cancer With Acquired Resistance to Anti-EGFR Therapy and Molecularly Selected by Circulating Tumor DNA Analyses: A Phase 2 Randomized Clinical Trial.
Jama Oncology
Montagut, Clara C; Argilés, Guillem G; Ciardiello, Fortunato F; Poulsen, Thomas T TT; Dienstmann, Rodrigo R; Kragh, Michael M; Kopetz, Scott S; Lindsted, Trine T; Ding, Cliff C; Vidal, Joana J; Clausell-Tormos, Jenifer J; Siravegna, Giulia G; Sánchez-Martín, Francisco J FJ; Koefoed, Klaus K; Pedersen, Mikkel W MW; Grandal, Michael M MM; Dvorkin, Mikhail M; Wyrwicz, Lucjan L; Rovira, Ana A; Cubillo, Antonio A; Salazar, Ramon R; Desseigne, Françoise F; Nadal, Cristina C; Albanell, Joan J; Zagonel, Vittorina V; Siena, Salvatore S; Fumi, Guglielmo G; Rospo, Giuseppe G; Nadler, Paul P; Horak, Ivan D ID; Bardelli, Alberto A; Tabernero, Josep J
Hybrid Capture-Based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Cancers of the Gastrointestinal Tract or Anus.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Schrock, Alexa B AB; Pavlick, Dean D; Klempner, Samuel J SJ; Chung, Jon H JH; Forcier, Brady B; Welsh, Allison A; Young, Lauren L; Leyland-Jones, Bryan B; Bordoni, Rodolfo R; Carvajal, Richard D RD; Chao, Joseph J; Kurzrock, Razelle R; Sicklick, Jason K JK; Ross, Jeffrey S JS; Stephens, Philip J PJ; Devoe, Craig C; Braiteh, Fadi F; Ali, Siraj M SM; Miller, Vincent A VA
Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.
Genome Research
Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U
Liquid biopsy monitoring uncovers acquired RAS-mediated resistance to cetuximab in a substantial proportion of patients with head and neck squamous cell carcinoma.
Oncotarget
Braig, Friederike F; Voigtlaender, Minna M; Schieferdecker, Aneta A; Busch, Chia-Jung CJ; Laban, Simon S; Grob, Tobias T; Kriegs, Malte M; Knecht, Rainald R; Bokemeyer, Carsten C; Binder, Mascha M
Genetic heterogeneity of actionable genes between primary and metastatic tumor in lung adenocarcinoma.
Bmc Cancer
Kim, Eun Young EY; Cho, Eun Na EN; Park, Heae Surng HS; Kim, Arum A; Hong, Ji Young JY; Lim, Seri S; Youn, Jong Pil JP; Hwang, Seung Yong SY; Chang, Yoon Soo YS
Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.
Cell
Creixell, Pau P; Schoof, Erwin M EM; Simpson, Craig D CD; Longden, James J; Miller, Chad J CJ; Lou, Hua Jane HJ; Perryman, Lara L; Cox, Thomas R TR; Zivanovic, Nevena N; Palmeri, Antonio A; Wesolowska-Andersen, Agata A; Helmer-Citterich, Manuela M; Ferkinghoff-Borg, Jesper J; Itamochi, Hiroaki H; Bodenmiller, Bernd B; Erler, Janine T JT; Turk, Benjamin E BE; Linding, Rune R
Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers.
British Journal Of Cancer
Khelwatty, Said A SA; Essapen, Sharadah S; Seddon, Alan M AM; Fan, Zhen Z; Modjtahedi, Helmout H