Publications:

---

Small-molecule inhibitors, immune checkpoint inhibitors, and more: FDA-approved novel therapeutic drugs for solid tumors from 1991 to 2021.

Journal Of Hematology & Oncology

Wu, Qing Q; Qian, Wei W; Sun, Xiaoli X; Jiang, Shaojie S

Publication Date: 2022-10-08

Variant appearance in text: EGFR: K467T

PubMed Link: 36209184

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Structure-guided and phage-assisted evolution of a therapeutic anti-EGFR antibody to reverse acquired resistance.

Nature Communications

Zhuang, Xinlei X; Wang, Zhe Z; Fan, Jiansheng J; Bai, Xuefei X; Xu, Yingchun Y; Chou, James J JJ; Hou, Tingjun T; Chen, Shuqing S; Pan, Liqiang L

Publication Date: 2022-07-30

Variant appearance in text: EGFR: K467T

PubMed Link: 35907884

Variant Present in the following documents:

• Main text
• 41467_2022_32159_MOESM2_ESM.pdf
• 41467_2022_32159_MOESM1_ESM.pdf
• 41467_2022_Article_32159.pdf

View BVdb publication page

---

Drug Resistance in Colorectal Cancer: From Mechanism to Clinic.

Cancers

Wang, Qianyu Q; Shen, Xiaofei X; Chen, Gang G; Du, Junfeng J

Publication Date: 2022-06-14

Variant appearance in text: EGFR: K467T

PubMed Link: 35740594

Variant Present in the following documents:

• Main text
• cancers-14-02928.pdf

View BVdb publication page

---

Depleting receptor tyrosine kinases EGFR and HER2 overcomes resistance to EGFR inhibitors in colorectal cancer.

Journal Of Experimental & Clinical Cancer Research : Cr

Yang, Lu L; Bhattacharya, Arup A; Li, Yun Y; Sexton, Sandra S; Ling, Xiang X; Li, Fengzhi F; Zhang, Yuesheng Y

Publication Date: 2022-06-02

Variant appearance in text: EGFR: K467T

PubMed Link: 35650607

Variant Present in the following documents:

• Main text
• 13046_2022_Article_2389.pdf

View BVdb publication page

---

The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer

Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J

Publication Date: 2022-02

Variant appearance in text: EGFR: Lys467Thr

PubMed Link: 35221333

Variant Present in the following documents:

• 43018_2022_332_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

---

Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: EGFR: K467T

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

---

Anti-EGFR antibody 528 binds to domain III of EGFR at a site shifted from the cetuximab epitope.

Scientific Reports

Makabe, Koki K; Yokoyama, Takeshi T; Uehara, Shiro S; Uchikubo-Kamo, Tomomi T; Shirouzu, Mikako M; Kimura, Kouki K; Tsumoto, Kouhei K; Asano, Ryutaro R; Tanaka, Yoshikazu Y; Kumagai, Izumi I

Publication Date: 2021-03-11

Variant appearance in text: EGFR: K467T

PubMed Link: 33707468

Variant Present in the following documents:

• Main text
• 41598_2021_Article_84171.pdf

View BVdb publication page

---

Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications

Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q

Publication Date: 2021-01-04

Variant appearance in text: EGFR: 1400A>C; K467T

PubMed Link: 33397889

Variant Present in the following documents:

• 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1

View BVdb publication page

---

Frequency of S492R mutations in the epidermal growth factor receptor: analysis of plasma DNA from patients with metastatic colorectal cancer treated with panitumumab or cetuximab monotherapy.

Cancer Biology & Therapy

Price, Timothy T; Ang, Agnes A; Boedigheimer, Michael M; Kim, Tae Won TW; Li, Jin J; Cascinu, Stefano S; Ruff, Paul P; Satya Suresh, Attili A; Thomas, Anne A; Tjulandin, Sergei S; Peeters, Marc M

Publication Date: 2020-10-02

Variant appearance in text: EGFR: K467T

PubMed Link: 33026965

Variant Present in the following documents:

• Main text
• KCBT_21_1798695.pdf

View BVdb publication page

---

Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine

Li, Jiaping J; Jiang, Wei W; Wei, Jinwang J; Zhang, Jianwei J; Cai, Linbo L; Luo, Minjie M; Wang, Zhan Z; Sun, Wending W; Wang, Shengzhou S; Wang, Chen C; Dai, Chun C; Liu, Jun J; Wang, Guan G; Wang, Jiping J; Xu, Qiang Q; Deng, Yanhong Y

Publication Date: 2020-08-01

Variant appearance in text: EGFR: K467T

PubMed Link: 32738923

Variant Present in the following documents:

• 12967_2020_2449_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

---

Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: EGFR: K467T

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 11

View BVdb publication page

---

Integrative omics analyses broaden treatment targets in human cancer.

Genome Medicine

Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L

Publication Date: 2018-07-27

Variant appearance in text: EGFR: K467T

PubMed Link: 30053901

Variant Present in the following documents:

• 13073_2018_564_MOESM2_ESM.xlsx, sheet 3

View BVdb publication page

---

Clinical Utility of Analyzing Circulating Tumor DNA in Patients with Metastatic Colorectal Cancer.

The Oncologist

Nakamura, Yoshiaki Y; Yoshino, Takayuki T

Publication Date: 2018-11

Variant appearance in text: EGFR: K467T

PubMed Link: 29700206

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Present and future of metastatic colorectal cancer treatment: A review of new candidate targets.

World Journal Of Gastroenterology

Martini, Giulia G; Troiani, Teresa T; Cardone, Claudia C; Vitiello, Pietropaolo P; Sforza, Vincenzo V; Ciardiello, Davide D; Napolitano, Stefania S; Della Corte, Carminia Maria CM; Morgillo, Floriana F; Raucci, Antonio A; Cuomo, Antonio A; Selvaggi, Francesco F; Ciardiello, Fortunato F; Martinelli, Erika E

Publication Date: 2017-07-14

Variant appearance in text: EGFR: K467T

PubMed Link: 28765689

Variant Present in the following documents:

• Main text

View BVdb publication page

---

New frontiers in the treatment of colorectal cancer: Autophagy and the unfolded protein response as promising targets.

Autophagy

Mokarram, Pooneh P; Albokashy, Mohammed M; Zarghooni, Maryam M; Moosavi, Mohammad Amin MA; Sepehri, Zahra Z; Chen, Qi Min QM; Hudecki, Andrzej A; Sargazi, Aliyeh A; Alizadeh, Javad J; Moghadam, Adel Rezaei AR; Hashemi, Mohammad M; Movassagh, Hesam H; Klonisch, Thomas T; Owji, Ali Akbar AA; Łos, Marek J MJ; Ghavami, Saeid S

Publication Date: 2017-05-04

Variant appearance in text: EGFR: K467T

PubMed Link: 28358273

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research

Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U

Publication Date: 2017-04

Variant appearance in text: EGFR: K467T

PubMed Link: 28179366

Variant Present in the following documents:

• supp_gr.213546.116_Supplemental_Table_S1.xlsx, sheet 1

View BVdb publication page

---

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer.

Nature Communications

Van Emburgh, Beth O BO; Arena, Sabrina S; Siravegna, Giulia G; Lazzari, Luca L; Crisafulli, Giovanni G; Corti, Giorgio G; Mussolin, Benedetta B; Baldi, Federica F; Buscarino, Michela M; Bartolini, Alice A; Valtorta, Emanuele E; Vidal, Joana J; Bellosillo, Beatriz B; Germano, Giovanni G; Pietrantonio, Filippo F; Ponzetti, Agostino A; Albanell, Joan J; Siena, Salvatore S; Sartore-Bianchi, Andrea A; Di Nicolantonio, Federica F; Montagut, Clara C; Bardelli, Alberto A

Publication Date: 2016-12-08

Variant appearance in text: EGFR: K467T

PubMed Link: 27929064

Variant Present in the following documents:

• ncomms13665-s1.pdf

View BVdb publication page

---

The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance.

Plos One

Sickmier, E Allen EA; Kurzeja, Robert J M RJ; Michelsen, Klaus K; Vazir, Mukta M; Yang, Evelyn E; Tasker, Andrew S AS

Publication Date: 2016

Variant appearance in text: EGFR: K467T

PubMed Link: 27658254

Variant Present in the following documents:

• Main text
• pone.0163366.pdf

View BVdb publication page

---

Mechanisms of resistance to anti-epidermal growth factor receptor inhibitors in metastatic colorectal cancer.

World Journal Of Gastroenterology

Sforza, Vincenzo V; Martinelli, Erika E; Ciardiello, Fortunato F; Gambardella, Valentina V; Napolitano, Stefania S; Martini, Giulia G; Della Corte, Carminia C; Cardone, Claudia C; Ferrara, Marianna L ML; Reginelli, Alfonso A; Liguori, Giuseppina G; Belli, Giulio G; Troiani, Teresa T

Publication Date: 2016-07-28

Variant appearance in text: EGFR: K467T

PubMed Link: 27605871

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Liquid biopsy monitoring uncovers acquired RAS-mediated resistance to cetuximab in a substantial proportion of patients with head and neck squamous cell carcinoma.

Oncotarget

Braig, Friederike F; Voigtlaender, Minna M; Schieferdecker, Aneta A; Busch, Chia-Jung CJ; Laban, Simon S; Grob, Tobias T; Kriegs, Malte M; Knecht, Rainald R; Bokemeyer, Carsten C; Binder, Mascha M

Publication Date: 2016-07-12

Variant appearance in text: EGFR: K467T

PubMed Link: 27119512

Variant Present in the following documents:

• Main text
• oncotarget-07-42988.pdf

View BVdb publication page

---

Colorectal cancer: Overcoming resistance to anti-EGFR therapy - where do we stand?

Nature Reviews. Gastroenterology & Hepatology

Schirripa, Marta M; Lenz, Heinz-Josef HJ

Publication Date: 2016-05

Variant appearance in text: EGFR: Lys467Thr

PubMed Link: 27006256

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Acquired resistance to anti-EGFR mAb ICR62 in cancer cells is accompanied by an increased EGFR expression, HER-2/HER-3 signalling and sensitivity to pan HER blockers.

British Journal Of Cancer

Khelwatty, Said A SA; Essapen, Sharadah S; Seddon, Alan M AM; Fan, Zhen Z; Modjtahedi, Helmout H

Publication Date: 2015-09-29

Variant appearance in text: EGFR: K467T

PubMed Link: 26372697

Variant Present in the following documents:

• Main text
• bjc2015319a.pdf

View BVdb publication page

---