Population Pharmacokinetics, Pharmacogenomics, and Adverse Events of Osimertinib and its Two Active Metabolites, AZ5104 and AZ7550, in Japanese Patients with Advanced Non-small Cell Lung Cancer: a Prospective Observational Study.
Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett's Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study.
Disease Markers
Deissova, Tereza T; Cvanova, Michaela M; Kala, Zdenek Z; Jiraskova Zakostelska, Zuzana Z; Dolina, Jiri J; Kunovsky, Lumir L; Kroupa, Radek R; Pavlovsky, Zdenek Z; Lipovy, Bretislav B; Danek, Zdenek Z; Izakovicova Holla, Lydie L; Urban, Ondrej O; Navratil, Vit V; Lischke, Robert R; Harustiak, Tomas T; Grolich, Tomas T; Prochazka, Vladimir V; Slaby, Ondrej O; Borilova Linhartova, Petra P
Validation of Genetic Markers Associated with Survival in Colorectal Cancer Patients Treated with Oxaliplatin-Based Chemotherapy.
Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology
Park, Hanla A HA; Seibold, Petra P; Edelmann, Dominic D; Benner, Axel A; Canzian, Federico F; Alwers, Elizabeth E; Jansen, Lina L; Schneider, Martin M; Hoffmeister, Michael M; Brenner, Hermann H; Chang-Claude, Jenny J
The Investigation of Associations between TP53 rs1042522, BBC3 rs2032809, CCND1 rs9344, EGFR rs2227983 Polymorphisms and Breast Cancer Phenotype and Prognosis.
High-throughput screening and genome-wide analyses of 44 anticancer drugs in the 1000 Genomes cell lines reveals an association of the NQO1 gene with the response of multiple anticancer drugs.
Plos Genetics
Akhtari, Farida S FS; Green, Adrian J AJ; Small, George W GW; Havener, Tammy M TM; House, John S JS; Roell, Kyle R KR; Reif, David M DM; McLeod, Howard L HL; Wiltshire, Timothy T; Motsinger-Reif, Alison A AA
Impact of Angiogenesis- and Hypoxia-Associated Polymorphisms on Tumor Recurrence in Patients with Hepatocellular Carcinoma Undergoing Surgical Resection.
Cancers
Miller, Hannah H; Czigany, Zoltan Z; Lurje, Isabella I; Reichelt, Sophie S; Bednarsch, Jan J; Strnad, Pavel P; Trautwein, Christian C; Roderburg, Christoph C; Tacke, Frank F; Gaisa, Nadine Therese NT; Knüchel-Clarke, Ruth R; Neumann, Ulf Peter UP; Lurje, Georg G
Combining ERBB family and MET inhibitors is an effective therapeutic strategy in cutaneous malignant melanoma independent of BRAF/NRAS mutation status.
Cell Death & Disease
Das, Ishani I; Wilhelm, Margareta M; Höiom, Veronica V; Franco Marquez, Rodolfo R; Costa Svedman, Fernanda F; Hansson, Johan J; Tuominen, Rainer R; Egyhàzi Brage, Suzanne S
Evaluation of the EGFR polymorphism R497K in two cohorts of neoadjuvantly treated breast cancer patients.
Plos One
Sobral-Leite, Marcelo M; Lips, Esther H EH; Vieira-Monteiro, Hayra de Andrade HA; Giacomin, Letícia Carlos LC; Freitas-Alves, Daniely Regina DR; Cornelissen, Sten S; Mulder, Lennart L; Wesseling, Jelle J; Schmidt, Marjanka K MK; Vianna-Jorge, Rosane R
The impact of ERBB-family germline single nucleotide polymorphisms on survival response to adjuvant trastuzumab treatment in HER2-positive breast cancer.
Oncotarget
Toomey, Sinead S; Madden, Stephen F SF; Furney, Simon J SJ; Fan, Yue Y; McCormack, Mark M; Stapleton, Carragh C; Cremona, Mattia M; Cavalleri, Gianpiero L GL; Milewska, Malgorzata M; Elster, Naomi N; Carr, Aoife A; Fay, Joanna J; Kay, Elaine W EW; Kennedy, Susan S; Crown, John J; Gallagher, William M WM; Hennessy, Bryan T BT; Eustace, Alex J AJ
Pharmacogenetics Biomarkers and Their Specific Role in Neoadjuvant Chemoradiotherapy Treatments: An Exploratory Study on Rectal Cancer Patients.
International Journal Of Molecular Sciences
Dreussi, Eva E; Cecchin, Erika E; Polesel, Jerry J; Canzonieri, Vincenzo V; Agostini, Marco M; Boso, Caterina C; Belluco, Claudio C; Buonadonna, Angela A; Lonardi, Sara S; Bergamo, Francesca F; Gagno, Sara S; De Mattia, Elena E; Pucciarelli, Salvatore S; De Paoli, Antonino A; Toffoli, Giuseppe G
Independent Replication of Published Germline Polymorphisms Associated with Urinary Bladder Cancer Prognosis and Treatment Response.
Bladder Cancer (Amsterdam, Netherlands)
Grotenhuis, Anne J AJ; Dudek, Aleksandra M AM; Verhaegh, Gerald W GW; Aben, Katja K KK; Witjes, J Alfred JA; Kiemeney, Lambertus A LA; Vermeulen, Sita H SH
A phase 1 study of cetuximab and lapatinib in patients with advanced solid tumor malignancies.
Cancer
Deeken, John F JF; Wang, Hongkun H; Subramaniam, Deepa D; He, Aiwu Ruth AR; Hwang, Jimmy J; Marshall, John L JL; Urso, Christina E CE; Wang, Yiru Y; Ramos, Corinne C; Steadman, Kenneth K; Pishvaian, Michael J MJ
Pharmacogenetic Analysis of INT 0144 Trial: Association of Polymorphisms with Survival and Toxicity in Rectal Cancer Patients Treated with 5-FU and Radiation.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Bohanes, Pierre P; Rankin, Cathryn J CJ; Blanke, Charles D CD; Winder, Thomas T; Ulrich, Cornelia M CM; Smalley, Stephen R SR; Rich, Tyvin A TA; Martensen, James A JA; Benson, Al B AB; Mayer, Robert J RJ; Cripps, Christine M CM; Danenberg, Kathleen K; Makar, Karen W KW; Zhang, Wu W; Benedetti, Jacqueline K JK; Lenz, Heinz-Josef HJ
New insights into the genetics of glioblastoma multiforme by familial exome sequencing.
Oncotarget
Backes, Christina C; Harz, Christian C; Fischer, Ulrike U; Schmitt, Jana J; Ludwig, Nicole N; Petersen, Britt-Sabina BS; Mueller, Sabine C SC; Kim, Yoo-Jin YJ; Wolf, Nadine M NM; Katus, Hugo A HA; Meder, Benjamin B; Furtwängler, Rhoikos R; Franke, Andre A; Bohle, Rainer R; Henn, Wolfram W; Graf, Norbert N; Keller, Andreas A; Meese, Eckart E
Screening for 392 polymorphisms in 141 pharmacogenes.
Biomedical Reports
Kim, Jason Yongha JY; Cheong, Hyun Sub HS; Park, Tae-Joon TJ; Shin, Hee Jung HJ; Seo, Doo Won DW; Na, Han Sung HS; Chung, Myeon Woo MW; Shin, Hyoung Doo HD
Germline variation in cancer-susceptibility genes in a healthy, ancestrally diverse cohort: implications for individual genome sequencing.
Plos One
Bodian, Dale L DL; McCutcheon, Justine N JN; Kothiyal, Prachi P; Huddleston, Kathi C KC; Iyer, Ramaswamy K RK; Vockley, Joseph G JG; Niederhuber, John E JE
Evaluation of ultra-deep targeted sequencing for personalized breast cancer care.
Breast Cancer Research : Bcr
Harismendy, Olivier O; Schwab, Richard B RB; Alakus, Hakan H; Yost, Shawn E SE; Matsui, Hiroko H; Hasteh, Farnaz F; Wallace, Anne M AM; Park, Hannah L HL; Madlensky, Lisa L; Parker, Barbara B; Carpenter, Philip M PM; Jepsen, Kristen K; Anton-Culver, Hoda H; Frazer, Kelly A KA
Association of epidermal growth factor and epidermal growth factor receptor polymorphisms with the risk of hepatitis B virus-related hepatocellular carcinoma in the population of North China.
Genetic Testing And Molecular Biomarkers
Wu, Jia J; Zhang, Wei W; Xu, Aiqiang A; Zhang, Li L; Yan, Tao T; Li, Zhuo Z; Wu, Xiaopan X; Zhu, Xilin X; Ma, Juan J; Li, Ke K; Li, Hui H; Liu, Ying Y