Publications:

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Pharmacological inhibition of LSD1 suppresses growth of hepatocellular carcinoma by inducing GADD45B.

Medcomm

Sang, Na N; Zhong, Xi X; Gou, Kun K; Liu, Huan H; Xu, Jing J; Zhou, Yang Y; Zhou, Xia X; Liu, Yuanzhi Y; Chen, Zhiqian Z; Zhou, Yue Y; Li, Yan Y; Tao, Lei L; Su, Na N; Zhou, Lingyun L; Qiu, Jiahao J; Yang, Xinyu X; Zuo, Zeping Z; Fu, Li L; Zhang, Jingyao J; Li, Dan D; Li, Cong C; Sun, Qingxiang Q; Lei, Jian J; Li, Rui R; Yang, Shengyong S; Cen, Xiaobo X; Zhao, Yinglan Y

Publication Date: 2023-06

Variant appearance in text: EGFR: E545K

PubMed Link: 37250145

Variant Present in the following documents:

• MCO2-4-e269-s001.pdf

View BVdb publication page

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Molecular profiling of colorectal cancer in a genetically admixed Hispanic population.

Cancer Medicine

Montes-Rodríguez, Ingrid M IM; Centeno-Girona, Hilmaris H; Rivera-Lynch, Camila C; Rivera, Noridza N; Cruz-Correa, Marcia M

Publication Date: 2023-04-11

Variant appearance in text: EGFR: E545K

PubMed Link: 37039257

Variant Present in the following documents:

• CAM4-12-11686-s002.xlsx, sheet 1

View BVdb publication page

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Genomic Landscape of Primary Resistance to Osimertinib Among Hispanic Patients with EGFR-Mutant Non-Small Cell Lung Cancer (NSCLC): Results of an Observational Longitudinal Cohort Study.

Targeted Oncology

Chamorro, Diego F DF; Cardona, Andrés F AF; Rodríguez, July J; Ruiz-Patiño, Alejandro A; Arrieta, Oscar O; Moreno-Pérez, Darwin A DA; Rojas, Leonardo L; Zatarain-Barrón, Zyanya Lucia ZL; Ardila, Dora V DV; Viola, Lucia L; Recondo, Gonzalo G; Blaquier, Juan B JB; Martín, Claudio C; Raez, Luis L; Samtani, Suraj S; Ordóñez-Reyes, Camila C; Garcia-Robledo, Juan Esteban JE; Corrales, Luis L; Sotelo, Carolina C; Ricaurte, Luisa L; Cuello, Mauricio M; Mejía, Sergio S; Jaller, Elvira E; Vargas, Carlos C; Carranza, Hernán H; Otero, Jorge J; Archila, Pilar P; Bermudez, Maritza M; Gamez, Tatiana T; Russo, Alessandro A; Malapelle, Umberto U; de Miguel Perez, Diego D; de Lima, Vladmir C Cordeiro VCC; Freitas, Helano H; Saldahna, Erick E; Rolfo, Christian C; Rosell, Rafael R; ,

Publication Date: 2023-04-05

Variant appearance in text: EGFR: E545K

PubMed Link: 37017806

Variant Present in the following documents:

• 11523_2023_955_MOESM1_ESM.pdf

View BVdb publication page

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Plasma ctDNA increases tissue NGS-based detection of therapeutically targetable mutations in lung cancers.

Bmc Cancer

Xie, Jianjiang J; Yao, Weishen W; Chen, Lingxiu L; Zhu, Wenjun W; Liu, Qiang Q; Geng, Geng G; Fang, Jing J; Zhao, Yang Y; Xiao, Li L; Huang, Zhenhua Z; Zhao, Jing J

Publication Date: 2023-03-31

Variant appearance in text: EGFR: Glu545Lys

PubMed Link: 37004022

Variant Present in the following documents:

• 12885_2023_10674_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Frequency-dependent ecological interactions increase the prevalence and shape the distribution of pre-existing drug resistance.

Biorxiv : The Preprint Server For Biology

Maltas, Jeff J; Tadele, Dagim Shiferaw DS; Durmaz, Arda A; McFarland, Christopher D CD; Hinczewski, Michael M; Scott, Jacob G JG

Publication Date: 2023-03-16

Variant appearance in text: EGFR: E545K

PubMed Link: 36993678

Variant Present in the following documents:

• Main text
• nihpp-2023.03.16.533001v1.pdf

View BVdb publication page

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Neoadjuvant chemotherapy plus nivolumab with or without ipilimumab in operable non-small cell lung cancer: the phase 2 platform NEOSTAR trial.

Nature Medicine

Cascone, Tina T; Leung, Cheuk H CH; Weissferdt, Annikka A; Pataer, Apar A; Carter, Brett W BW; Godoy, Myrna C B MCB; Feldman, Hope H; William, William N WN; Xi, Yuanxin Y; Basu, Sreyashi S; Sun, Jing Jing JJ; Yadav, Shalini S SS; Rojas Alvarez, Frank R FR; Lee, Younghee Y; Mishra, Aditya K AK; Chen, Lili L; Pradhan, Monika M; Guo, Haiping H; Sinjab, Ansam A; Zhou, Nicolas N; Negrao, Marcelo V MV; Le, Xiuning X; Gay, Carl M CM; Tsao, Anne S AS; Byers, Lauren Averett LA; Altan, Mehmet M; Glisson, Bonnie S BS; Fossella, Frank V FV; Elamin, Yasir Y YY; Blumenschein, George G; Zhang, Jianjun J; Skoulidis, Ferdinandos F; Wu, Jia J; Mehran, Reza J RJ; Rice, David C DC; Walsh, Garrett L GL; Hofstetter, Wayne L WL; Rajaram, Ravi R; Antonoff, Mara B MB; Fujimoto, Junya J; Solis, Luisa M LM; Parra, Edwin R ER; Haymaker, Cara C; Wistuba, Ignacio I II; Swisher, Stephen G SG; Vaporciyan, Ara A AA; Lin, Heather Y HY; Wang, Jing J; Gibbons, Don L DL; Jack Lee, J J; Ajami, Nadim J NJ; Wargo, Jennifer A JA; Allison, James P JP; Sharma, Padmanee P; Kadara, Humam H; Heymach, John V JV; Sepesi, Boris B

Publication Date: 2023-03-16

Variant appearance in text: EGFR: E545K

PubMed Link: 36928818

Variant Present in the following documents:

• 41591_2022_2189_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Germline pathogenic variants in 786 neuroblastoma patients.

Medrxiv : The Preprint Server For Health Sciences

Kim, Jung J; Vaksman, Zalman Z; Egolf, Laura E LE; Kaufman, Rebecca R; Evans, J Perry JP; Conkrite, Karina L KL; Danesh, Arnavaz A; Lopez, Gonzalo G; Randall, Michael P MP; Dent, Maiah H MH; Farra, Lance M LM; Menghani, Neil N; Dymek, Malwina M; Desai, Heena H; Hausler, Ryan R; , ; , ; , ; Auvil, Jaime Guidry JG; Gerhard, Daniela S DS; Hakonarson, Hakon H; Maxwell, Kara N KN; Cole, Kristina A KA; Pugh, Trevor J TJ; Bosse, Kristopher R KR; Khan, Javed J; Wei, Jun S JS; Maris, John M JM; Stewart, Douglas R DR; Diskin, Sharon J SJ

Publication Date: 2023-01-25

Variant appearance in text: EGFR: 1633G>A; E545K; rs778985185

PubMed Link: 36747619

Variant Present in the following documents:

• media-2.xlsx, sheet 3

View BVdb publication page

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Advanced diagnostic and therapeutic strategies in nanotechnology for lung cancer.

Frontiers In Oncology

Duan, Yujuan Y; Shen, Chen C; Zhang, Yinan Y; Luo, Yao Y

Publication Date: 2022

Variant appearance in text: EGFR: E545K

PubMed Link: 36568152

Variant Present in the following documents:

• Main text

View BVdb publication page

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Analysis of single-nucleotide polymorphisms in genes associated with triple-negative breast cancer.

Frontiers In Genetics

G, Vigneshwaran V; Hasan, Qurratulain Annie QA; Kumar, Rahul R; Eranki, Avinash A

Publication Date: 2022

Variant appearance in text: EGFR: E545K

PubMed Link: 36561320

Variant Present in the following documents:

• Table3.xlsx, sheet 1
• Table2.xlsx, sheet 4

View BVdb publication page

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Molecular characterization of acquired resistance to KRAS G12C-EGFR inhibition in colorectal cancer.

Cancer Discovery

Yaeger, Rona R; Mezzadra, Riccardo R; Sinopoli, Jenna J; Bian, Yu Y; Marasco, Michelangelo M; Kaplun, Esther E; Gao, Yijun Y; Zhao, HuiYong H; Da Cruz Paula, Arnaud A; Zhu, Yingjie Y; Chaves Perez, Almudena A; Chadalavada, Kalyani K; Tse, Edison E; Chowdhry, Sudhir S; Bowker, Sydney S; Chang, Qing Q; Qeriqi, Besnik B; Weigelt, Britta B; Nanjangud, Gouri J GJ; Berger, Michael F MF; Der-Torossian, Hirak H; Anderes, Kenna K; Socci, Nicholas D ND; Shia, Jinru J; Riely, Gregory J GJ; Murciano-Goroff, Yonina R YR; Li, Bob T BT; Christensen, James G JG; Reis-Filho, Jorge S JS; Solit, David B DB; de Stanchina, Elisa E; Lowe, Scott W SW; Rosen, Neal N; Misale, Sandra S

Publication Date: 2022-11-10

Variant appearance in text: EGFR: E545K

PubMed Link: 36355783

Variant Present in the following documents:

• cd-22-0405_supplementary_table_3_suppst3.xlsx, sheet 1

View BVdb publication page

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The Drivers, Mechanisms, and Consequences of Genome Instability in HPV-Driven Cancers.

Cancers

Porter, Vanessa L VL; Marra, Marco A MA

Publication Date: 2022-09-23

Variant appearance in text: EGFR: E545K

PubMed Link: 36230545

Variant Present in the following documents:

• Main text
• cancers-14-04623.pdf

View BVdb publication page

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Utilization of cytologic cell blocks for targeted sequencing of solid tumors.

Cancer Medicine

Vormittag-Nocito, Erica E; Kumar, Ravindra R; Narayan, Kunwar Digvijay KD; Chen, Zhengjia Z; David, Odile O; Behm, Frederick F; Mohapatra, Gayatry G

Publication Date: 2022-09-20

Variant appearance in text: EGFR: E545K

PubMed Link: 36125633

Variant Present in the following documents:

• CAM4-12-4042.pdf

View BVdb publication page

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Novel parameter for cancer chemosensitivity to fibroblast growth factor receptor inhibitors.

Cancer Science

Kitano, Shoichi S; Yamamoto, Takehito T; Taketo, Makoto Mark MM

Publication Date: 2022-11

Variant appearance in text: EGFR: E545K

PubMed Link: 35950366

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma.

Frontiers In Oncology

Yin, Xiang-Qian XQ; Yin, Xue-Hui XH; Yu, Ya-Qin YQ; Xu, Lang L; Zhang, Mao M

Publication Date: 2022

Variant appearance in text: rs778985185

PubMed Link: 35936718

Variant Present in the following documents:

• Table_4.xlsx, sheet 2

View BVdb publication page

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Discovery and Characterization of a Novel Series of Chloropyrimidines as Covalent Inhibitors of the Kinase MSK1.

Acs Medicinal Chemistry Letters

Hall, Adrian A; Abendroth, Jan J; Bolejack, Madison J MJ; Ceska, Tom T; Dell'Aiera, Sylvie S; Ellis, Victoria V; Fox, David D; François, Cyril C; Muruthi, Muigai M MM; Prével, Camille C; Poullennec, Karine K; Romanov, Sergei S; Valade, Anne A; Vanbellinghen, Alain A; Yano, Jason J; Geraerts, Martine M

Publication Date: 2022-07-14

Variant appearance in text: EGFR: E545K

PubMed Link: 35859861

Variant Present in the following documents:

• ml2c00134_si_001.pdf

View BVdb publication page

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Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways.

Nature Communications

Zhang, Yiqun Y; Chen, Fengju F; Chandrashekar, Darshan S DS; Varambally, Sooryanarayana S; Creighton, Chad J CJ

Publication Date: 2022-05-13

Variant appearance in text: EGFR: E545K

PubMed Link: 35562349

Variant Present in the following documents:

• 41467_2022_30342_MOESM4_ESM.xlsx, sheet 1

View BVdb publication page

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Genetic Profiling of Colorectal Carcinomas of Patients with Primary Sclerosing Cholangitis and Inflammatory Bowel Disease.

Inflammatory Bowel Diseases

de Krijger, Manon M; Carvalho, Beatriz B; Rausch, Christian C; Bolijn, Anne S AS; Delis-van Diemen, Pien M PM; Tijssen, Marianne M; van Engeland, Manon M; Mostafavi, Nahid N; Bogie, Roel M M RMM; Dekker, Evelien E; Masclee, Ad A M AAM; Verheij, Joanne J; Meijer, Gerrit A GA; Ponsioen, Cyriel Y CY

Publication Date: 2022-09-01

Variant appearance in text: EGFR: Glu545Lys

PubMed Link: 35554535

Variant Present in the following documents:

• izac087_suppl_supplementary_material.pdf

View BVdb publication page

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Integrated proteomic analysis of low-grade gliomas reveals contributions of 1p-19q co-deletion to oligodendroglioma.

Acta Neuropathologica Communications

Wong, Derek D; Lee, Tae Hoon TH; Lum, Amy A; Tao, Valerie Lan VL; Yip, Stephen S

Publication Date: 2022-05-07

Variant appearance in text: EGFR: 1633G>A; Glu545Lys

PubMed Link: 35526077

Variant Present in the following documents:

• 40478_2022_1372_MOESM18_ESM.xlsx, sheet 1

View BVdb publication page

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Plasma Genotyping at the Time of Diagnostic Tissue Biopsy Decreases Time-to-Treatment in Patients With Advanced NSCLC-Results From a Prospective Pilot Study.

Jto Clinical And Research Reports

Thompson, Jeffrey C JC; Aggarwal, Charu C; Wong, Janeline J; Nimgaonkar, Vivek V; Hwang, Wei-Ting WT; Andronov, Michelle M; Dibardino, David M DM; Hutchinson, Christoph T CT; Ma, Kevin C KC; Lanfranco, Anthony A; Moon, Edmund E; Haas, Andrew R AR; Singh, Aditi P AP; Ciunci, Christine A CA; Marmarelis, Melina M; D'Avella, Christopher C; Cohen, Justine V JV; Bauml, Joshua M JM; Cohen, Roger B RB; Langer, Corey J CJ; Vachani, Anil A; Carpenter, Erica L EL

Publication Date: 2022-04

Variant appearance in text: EGFR: E545K

PubMed Link: 35392653

Variant Present in the following documents:

• mmc3.xlsx, sheet 1

View BVdb publication page

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[Targeted Therapy and Mechanism of Drug Resistance in Non-small Cell Lung Cancer 
with Epidermal Growth Factor Receptor Gene Mutation].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Huang, Junxia J; Wang, Hong H

Publication Date: 2022-03-20

Variant appearance in text: EGFR: E545K

PubMed Link: 35340161

Variant Present in the following documents:

• Main text
• zgfazz-25-3-183.pdf

View BVdb publication page

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PEAC: An Ultrasensitive and Cost-Effective MRD Detection System in Non-small Cell Lung Cancer Using Plasma Specimen.

Frontiers In Medicine

Xu, Jianping J; Pu, Yue Y; Lin, Rui R; Xiao, Shanshan S; Fu, Yingxue Y; Wang, Tao T

Publication Date: 2022

Variant appearance in text: EGFR: E545K

PubMed Link: 35308511

Variant Present in the following documents:

• Table_7.xlsx, sheet 1

View BVdb publication page

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Comparison of sampling methods for next generation sequencing for patients with lung cancer.

Cancer Medicine

Kunimasa, Kei K; Matsumoto, Shingo S; Nishino, Kazumi K; Honma, Keiichiro K; Maeda, Noboru N; Kuhara, Hanako H; Tamiya, Motohiro M; Inoue, Takako T; Kawamura, Takahisa T; Kimura, Toru T; Maniwa, Tomohiro T; Okami, Jiro J; Goto, Koichi K; Kumagai, Toru T

Publication Date: 2022-07

Variant appearance in text: EGFR: E545K

PubMed Link: 35274488

Variant Present in the following documents:

• CAM4-11-2744.pdf

View BVdb publication page

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EGFR Exon 20 Insertion Mutations in Sinonasal Squamous Cell Carcinoma.

Cancers

Pacini, Laura L; Cabal, Virginia N VN; Hermsen, Mario A MA; Huang, Paul H PH

Publication Date: 2022-01-13

Variant appearance in text: EGFR: E545K

PubMed Link: 35053553

Variant Present in the following documents:

• Main text
• cancers-14-00394.pdf

View BVdb publication page

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EGFR Exon 20 Insertion Mutations in Sinonasal Squamous Cell Carcinoma.

Cancers

Pacini, Laura L; Cabal, Virginia N VN; Hermsen, Mario A MA; Huang, Paul H PH

Publication Date: 2022-01-13

Variant appearance in text: EGFR: E545K

PubMed Link: 35053553

Variant Present in the following documents:

• Main text
• cancers-14-00394.pdf

View BVdb publication page

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Oncogenic TYK2P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade.

Haematologica

Woess, Katharina K; Macho-Maschler, Sabine S; Van Ingen Schenau, Dorette S DS; Butler, Miriam M; Lassnig, Caroline C; Valcanover, Daniel D; Poelzl, Andrea A; Meissl, Katrin K; Maurer, Barbara B; Brandstoetter, Tania T; Vogl, Claus C; Koren, Anna A; Kubicek, Stefan S; Orlova, Anna A; Moriggl, Richard R; Strobl, Birgit B; Sexl, Veronika V; Van Leeuwen, Frank N FN; Kuiper, Roland P RP; Mueller, Mathias M

Publication Date: 2022-01-13

Variant appearance in text: EGFR: E545K

PubMed Link: 35021603

Variant Present in the following documents:

• 2021_279848_WOESS_SUPPL.pdf

View BVdb publication page

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Untangling the KRAS mutated lung cancer subsets and its therapeutic implications.

Molecular Biomedicine (Online)

Ritu, Kulshrestha K; Kumar, Pawan P; Singh, Amit A; Nupur, K K; Spalgias, Sonam S; Mrigpuri, Parul P; Rajkumar,

Publication Date: 2021-12-17

Variant appearance in text: EGFR: 1633G>A; E545K

PubMed Link: 34918209

Variant Present in the following documents:

• 43556_2021_Article_61.pdf

View BVdb publication page

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Untangling the KRAS mutated lung cancer subsets and its therapeutic implications.

Molecular Biomedicine

Ritu, Kulshrestha K; Kumar, Pawan P; Singh, Amit A; Nupur, K K; Spalgias, Sonam S; Mrigpuri, Parul P; Rajkumar,

Publication Date: 2021-12-17

Variant appearance in text: EGFR: 1633G>A; E545K

PubMed Link: 34918209

Variant Present in the following documents:

• 43556_2021_Article_61.pdf

View BVdb publication page

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Real-World Approach for Molecular Analysis of Acquired EGFR Tyrosine Kinase Inhibitor Resistance Mechanisms in NSCLC.

Jto Clinical And Research Reports

Hondelink, Liesbeth M LM; Jebbink, Merel M; von der Thüsen, Jan H JH; Cohen, Danielle D; Dubbink, Hendrikus J HJ; Paats, Marthe S MS; Dingemans, Anne-Marie C AC; de Langen, Adrianus J AJ; Boelens, Mirjam C MC; Smit, Egbert F EF; Postmus, Pieter E PE; van Wezel, Tom T; Monkhorst, Kim K

Publication Date: 2021-12

Variant appearance in text: EGFR: E545K

PubMed Link: 34849493

Variant Present in the following documents:

• main.pdf

View BVdb publication page

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Liquid Biopsy-Based Biosensors for MRD Detection and Treatment Monitoring in Non-Small Cell Lung Cancer (NSCLC).

Biosensors

Sardarabadi, Parvaneh P; Kojabad, Amir Asri AA; Jafari, Davod D; Liu, Cheng-Hsien CH

Publication Date: 2021-10-15

Variant appearance in text: EGFR: E545K

PubMed Link: 34677350

Variant Present in the following documents:

• Main text
• biosensors-11-00394.pdf

View BVdb publication page

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Oncogenic signaling inhibits c-FLIPL expression and its non-apoptotic function during ECM-detachment.

Scientific Reports

Tsegaye, Matyas Abel MA; He, Jianping J; McGeehan, Kyle K; Murphy, Ireland M IM; Nemera, Mati M; Schafer, Zachary T ZT

Publication Date: 2021-09-20

Variant appearance in text: EGFR: E545K

PubMed Link: 34545139

Variant Present in the following documents:

• Main text
• 41598_2021_Article_97715.pdf

View BVdb publication page

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Connections between prolactin and ovarian cancer.

Plos One

Alkharusi, Amira A; AlMuslahi, Abdullah A; AlBalushi, Najwa N; AlAjmi, Radiya R; AlRawahi, Sami S; AlFarqani, Asmaa A; Norstedt, Gunnar G; Zadjali, Fahad F

Publication Date: 2021

Variant appearance in text: EGFR: E545K

PubMed Link: 34358244

Variant Present in the following documents:

• Main text
• pone.0255701.pdf

View BVdb publication page

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Dynamic BH3 profiling identifies active BH3 mimetic combinations in non-small cell lung cancer.

Cell Death & Disease

Potter, Danielle S DS; Du, Ruochen R; Bhola, Patrick P; Bueno, Raphael R; Letai, Anthony A

Publication Date: 2021-07-27

Variant appearance in text: EGFR: 1633G>A; E545K

PubMed Link: 34315868

Variant Present in the following documents:

• 41419_2021_4029_MOESM17_ESM.xlsx, sheet 1

View BVdb publication page

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The landscape of driver mutations in cutaneous squamous cell carcinoma.

Npj Genomic Medicine

Chang, Darwin D; Shain, A Hunter AH

Publication Date: 2021-07-16

Variant appearance in text: EGFR: E545K

PubMed Link: 34272401

Variant Present in the following documents:

• 41525_2021_Article_226.pdf

View BVdb publication page

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Engineering an anti-HER2 biparatopic antibody with a multimodal mechanism of action.

Nature Communications

Kast, Florian F; Schwill, Martin M; Stüber, Jakob C JC; Pfundstein, Svende S; Nagy-Davidescu, Gabriela G; Rodríguez, Josep M Monné JMM; Seehusen, Frauke F; Richter, Christian P CP; Honegger, Annemarie A; Hartmann, Karen Patricia KP; Weber, Thomas G TG; Kroener, Felix F; Ernst, Patrick P; Piehler, Jacob J; Plückthun, Andreas A

Publication Date: 2021-06-18

Variant appearance in text: EGFR: E545K

PubMed Link: 34145240

Variant Present in the following documents:

• 41467_2021_Article_23948.pdf

View BVdb publication page

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Organoid models of the tumor microenvironment and their applications.

Journal Of Cellular And Molecular Medicine

Xia, Tao T; Du, Wen-Lin WL; Chen, Xiao-Yi XY; Zhang, You-Ni YN

Publication Date: 2021-05-25

Variant appearance in text: EGFR: E545K

PubMed Link: 34033245

Variant Present in the following documents:

• Main text

View BVdb publication page

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Targeted exome sequencing identifies mutational landscape in a cohort of 1500 Chinese patients with non-small cell lung carcinoma (NSCLC).

Human Genomics

Zhou, Ya-Jun YJ; Zheng, Wei W; Zeng, Qing-Hua QH; Ye, Yang Y; Wang, Ce C; Fang, Cheng C; Liu, Chao-Jun CJ; Niu, Li L; Wu, Li-Ming LM

Publication Date: 2021-04-12

Variant appearance in text: EGFR: E545K

PubMed Link: 33845897

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genomic profiling reveals heterogeneous populations of ductal carcinoma in situ of the breast.

Communications Biology

Nagasawa, Satoi S; Kuze, Yuta Y; Maeda, Ichiro I; Kojima, Yasuyuki Y; Motoyoshi, Ai A; Onishi, Tatsuya T; Iwatani, Tsuguo T; Yokoe, Takamichi T; Koike, Junki J; Chosokabe, Motohiro M; Kubota, Manabu M; Seino, Hibiki H; Suzuki, Ayako A; Seki, Masahide M; Tsuchihara, Katsuya K; Inoue, Eisuke E; Tsugawa, Koichiro K; Ohta, Tomohiko T; Suzuki, Yutaka Y

Publication Date: 2021-04-01

Variant appearance in text: EGFR: E545K

PubMed Link: 33795819

Variant Present in the following documents:

• 42003_2021_1959_MOESM10_ESM.xlsx, sheet 1

View BVdb publication page

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Association of tumor mutation burden and epidermal growth factor receptor inhibitor history with survival in patients with metastatic stage III/IV non-small-cell lung cancer: A retrospective study.

Clinics (Sao Paulo, Brazil)

Lan, Yan Y; Zhou, Shuo S; Feng, Weihong W; Qiao, Ying Y; Du, Xueming X; Li, Fenge F

Publication Date: 2021

Variant appearance in text: EGFR: E545K

PubMed Link: 33787673

Variant Present in the following documents:

• cln-76-2251.pdf

View BVdb publication page

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Targeting FGFR in non-small cell lung cancer: implications from the landscape of clinically actionable aberrations of FGFR kinases.

Cancer Biology & Medicine

Zhou, Zhen Z; Liu, Zichuan Z; Ou, Qiuxiang Q; Wu, Xue X; Wang, Xiaonan X; Shao, Yang Y; Liu, Hongyan H; Yang, Yu Y

Publication Date: 2021-03-12

Variant appearance in text: EGFR: 1633G>A; E545K

PubMed Link: 33710807

Variant Present in the following documents:

• Main text
• cbm-18-490.pdf

View BVdb publication page

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BTK gatekeeper residue variation combined with cysteine 481 substitution causes super-resistance to irreversible inhibitors acalabrutinib, ibrutinib and zanubrutinib.

Leukemia

Estupiñán, H Yesid HY; Wang, Qing Q; Berglöf, Anna A; Schaafsma, Gerard C P GCP; Shi, Yuye Y; Zhou, Litao L; Mohammad, Dara K DK; Yu, Liang L; Vihinen, Mauno M; Zain, Rula R; Smith, C I Edvard CIE

Publication Date: 2021-05

Variant appearance in text: EGFR: E545K

PubMed Link: 33526860

Variant Present in the following documents:

• Main text

View BVdb publication page

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Co-stimulatory and co-inhibitory immune markers in solid tumors with MET alterations.

Future Science Oa

Reckamp, Karen L KL; McQuerry, Jasmine A JA; Mambetsariev, Isa I; Pharaon, Rebecca R; Yost, Susan E SE; Fricke, Jeremy J; Mirzapoiazova, Tamara T; Pillai, Raju K RK; Khan, Ziad Z; Fakih, Marwan M; Yuan, Yuan Y; Koczywas, Marianna M; Massarelli, Erminia E; Kulkarni, Prakash P; Pal, Sumanta K SK; Sattler, Martin M; Bild, Andrea A; Salgia, Ravi R

Publication Date: 2020-11-25

Variant appearance in text: EGFR: E545K

PubMed Link: 33437521

Variant Present in the following documents:

• Main text

View BVdb publication page

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Genomic Landscape and Targeted Treatment of Gallbladder Cancer: Results of a First Ongoing Prospective Study.

South Asian Journal Of Cancer

Patel, Amol A; Soneji, Dharmesh D; Singh, Harinder Pal HP; Kumar, Manish M; Bandyopadhyay, Arnab A; Mathur, Ankit A; Sharma, Anuj A; Gahlot, Gaurav Prakash Singh GPS; Ms, Shivashankara S; Guleria, Bhupesh B; Nair, Rajesh R; Bhuva, Dipen D; Pandalanghat, Suresh S

Publication Date: 2020-06

Variant appearance in text: ERBB: E545K

PubMed Link: 33354548

Variant Present in the following documents:

• Main text

View BVdb publication page

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Case Report: Primary and Acquired Resistance Mechanisms of Nimotuzumab in Advanced Esophageal Squamous Cell Carcinoma Revealed by Targeted Sequencing.

Frontiers In Oncology

Sun, Dantong D; Yan, Weihua W; Zhu, Hua H; Liu, Qiaoling Q; Hou, Helei H

Publication Date: 2020

Variant appearance in text: EGFR: E545K

PubMed Link: 33194681

Variant Present in the following documents:

• Main text

View BVdb publication page

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Cyclin-dependent kinase inhibitors in head and neck cancer and glioblastoma-backbone or add-on in immune-oncology?

Cancer Metastasis Reviews

Riess, Christin C; Irmscher, Nina N; Salewski, Inken I; Strüder, Daniel D; Classen, Carl-Friedrich CF; Große-Thie, Christina C; Junghanss, Christian C; Maletzki, Claudia C

Publication Date: 2021-03

Variant appearance in text: EGFR: E545K

PubMed Link: 33161487

Variant Present in the following documents:

• Main text

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Genetic profiling of somatic alterations by Oncomine Focus Assay in Korean patients with advanced gastric cancer.

Oncology Letters

Park, Joonhong J; Lee, Sang-Il SI; Shin, Soyoung S; Hong, Jang Hee JH; Yoo, Han Mo HM; Kim, Jeong Goo JG

Publication Date: 2020-11

Variant appearance in text: EGFR: 1633G>A; Glu545Lys

PubMed Link: 32934698

Variant Present in the following documents:

• Main text

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USP14 Regulates DNA Damage Response and Is a Target for Radiosensitization in Non-Small Cell Lung Cancer.

International Journal Of Molecular Sciences

Sharma, Arishya A; Almasan, Alexandru A

Publication Date: 2020-09-02

Variant appearance in text: EGFR: 1633G>A; E545K

PubMed Link: 32887472

Variant Present in the following documents:

• ijms-21-06383.pdf

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Molecular profiling of non-small cell lung cancer.

Plos One

Forsythe, Marika L ML; Alwithenani, Akram A; Bethune, Drew D; Castonguay, Mathieu M; Drucker, Arik A; Flowerdew, Gordon G; French, Daniel D; Fris, John J; Greer, Wenda W; Henteleff, Harry H; MacNeil, Mary M; Marignani, Paola P; Morzycki, Wojciech W; Plourde, Madelaine M; Snow, Stephanie S; Xu, Zhaolin Z

Publication Date: 2020

Variant appearance in text: EGFR: 1633G>A

PubMed Link: 32756609

Variant Present in the following documents:

• Main text

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Chemosensitivity of Patient-Derived Cancer Stem Cells Identifies Colorectal Cancer Patients with Potential Benefit from FGFR Inhibitor Therapy.

Cancers

Yamamoto, Takehito T; Miyoshi, Hiroyuki H; Kakizaki, Fumihiko F; Maekawa, Hisatsugu H; Yamaura, Tadayoshi T; Morimoto, Tomonori T; Katayama, Toshiro T; Kawada, Kenji K; Sakai, Yoshiharu Y; Taketo, M Mark MM

Publication Date: 2020-07-22

Variant appearance in text: EGFR: 1633G>A; E545K

PubMed Link: 32708005

Variant Present in the following documents:

• cancers-12-02010-s001.pdf

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Combination therapy of gefitinib and miR-30a-5p may overcome acquired drug resistance through regulating the PI3K/AKT pathway in non-small cell lung cancer.

Therapeutic Advances In Respiratory Disease

Wang, Fengfeng F; Meng, Fei F; Wong, Sze Chuen Cesar SCC; Cho, William C S WCS; Yang, Sijun S; Chan, Lawrence W C LWC

Publication Date: 2020

Variant appearance in text: EGFR: E545K

PubMed Link: 32552611

Variant Present in the following documents:

• Supplementary_materials.pdf

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Clinical Multigene Panel Sequencing Identifies Distinct Mutational Association Patterns in Metastatic Colorectal Cancer.

Frontiers In Oncology

Belardinilli, Francesca F; Capalbo, Carlo C; Malapelle, Umberto U; Pisapia, Pasquale P; Raimondo, Domenico D; Milanetti, Edoardo E; Yasaman, Mahdavian M; Liccardi, Carlotta C; Paci, Paola P; Sibilio, Pasquale P; Pepe, Francesco F; Bonfiglio, Caterina C; Mezi, Silvia S; Magri, Valentina V; Coppa, Anna A; Nicolussi, Arianna A; Gradilone, Angela A; Petroni, Marialaura M; Di Giulio, Stefano S; Fabretti, Francesca F; Infante, Paola P; Coni, Sonia S; Canettieri, Gianluca G; Troncone, Giancarlo G; Giannini, Giuseppe G

Publication Date: 2020

Variant appearance in text: EGFR: E545K

PubMed Link: 32457828

Variant Present in the following documents:

• Table_1.xlsx, sheet 1

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Dual EGFR blockade with cetuximab and erlotinib combined with anti-VEGF antibody bevacizumab in advanced solid tumors: a phase 1 dose escalation triplet combination trial.

Experimental Hematology & Oncology

Subbiah, Vivek V; Dumbrava, Ecaterina Ileana EI; Jiang, Yunfang Y; Thein, Kyaw Z KZ; Naing, Aung A; Hong, David S DS; Fu, Siqing S; Piha-Paul, Sarina A SA; Tsimberidou, Apostolia M AM; Janku, Filip F; Meric-Bernstam, Funda F; Kurzrock, Razelle R; Falchook, Gerald G

Publication Date: 2020

Variant appearance in text: EGFR: E545K

PubMed Link: 32337094

Variant Present in the following documents:

• Main text
• 40164_2020_Article_159.pdf

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An EGFR-Amplified Cervical Squamous Cell Carcinoma Patient with Pulmonary Metastasis Benefits from Afatinib: A Case Report.

Oncotargets And Therapy

Chen, Qian Q; Huang, Yihua Y; Shao, Lin L; Han-Zhang, Han H; Yang, Fan F; Wang, Yang Y; Liu, Jing J; Gan, Jiadi J

Publication Date: 2020

Variant appearance in text: EGFR: Glu545Lys

PubMed Link: 32184619

Variant Present in the following documents:

• Main text

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Comprehensive pharmacogenomic characterization of gastric cancer.

Genome Medicine

Sa, Jason K JK; Hong, Jung Yong JY; Lee, In-Kyoung IK; Kim, Ju-Sun JS; Sim, Moon-Hee MH; Kim, Ha Jung HJ; An, Ji Yeong JY; Sohn, Tae Sung TS; Lee, Joon Ho JH; Bae, Jae Moon JM; Kim, Sung S; Kim, Kyoung-Mee KM; Kim, Seung Tae ST; Park, Se Hoon SH; Park, Joon Oh JO; Lim, Ho Yeong HY; Kang, Won Ki WK; Her, Nam-Gu NG; Lee, Yeri Y; Cho, Hee Jin HJ; Shin, Yong Jae YJ; Kim, Misuk M; Koo, Harim H; Kim, Mirinae M; Seo, Yun Jee YJ; Kim, Ja Yeon JY; Choi, Min-Gew MG; Nam, Do-Hyun DH; Lee, Jeeyun J

Publication Date: 2020-02-18

Variant appearance in text: EGFR: E545K

PubMed Link: 32070411

Variant Present in the following documents:

• 13073_2020_717_MOESM4_ESM.xlsx, sheet 1

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Chaperone mediated detection of small molecule target binding in cells.

Nature Communications

Cho, Kelvin F KF; Ma, Taylur P TP; Rose, Christopher M CM; Kirkpatrick, Donald S DS; Yu, Kebing K; Blake, Robert A RA

Publication Date: 2020-01-23

Variant appearance in text: EGFR: E545K

PubMed Link: 31974362

Variant Present in the following documents:

• Main text

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Expression of myeloid Src-family kinases is associated with poor prognosis in AML and influences Flt3-ITD kinase inhibitor acquired resistance.

Plos One

Patel, Ravi K RK; Weir, Mark C MC; Shen, Kexin K; Snyder, Daniel D; Cooper, Vaughn S VS; Smithgall, Thomas E TE

Publication Date: 2019

Variant appearance in text: EGFR: E545K

PubMed Link: 31790499

Variant Present in the following documents:

• pone.0225887.s012.pdf

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Surface Plasmon Resonance for Biomarker Detection: Advances in Non-invasive Cancer Diagnosis.

Frontiers In Chemistry

Bellassai, Noemi N; D'Agata, Roberta R; Jungbluth, Vanessa V; Spoto, Giuseppe G

Publication Date: 2019

Variant appearance in text: EGFR: E545K

PubMed Link: 31448267

Variant Present in the following documents:

• Main text
• fchem-07-00570.pdf

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Comprehensive validation of liquid-based cytology specimens for next-generation sequencing in cancer genome analysis.

Plos One

Akahane, Toshiaki T; Yamaguchi, Tomomi T; Kato, Yasutaka Y; Yokoyama, Seiya S; Hamada, Taiji T; Nishida, Yukari Y; Higashi, Michiyo M; Nishihara, Hiroshi H; Suzuki, Shinsuke S; Ueno, Shinichi S; Tanimoto, Akihide A

Publication Date: 2019

Variant appearance in text: EGFR: Glu545Lys

PubMed Link: 31199826

Variant Present in the following documents:

• Main text

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PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma.

Acta Neuropathologica Communications

Tanaka, Shota S; Batchelor, Tracy T TT; Iafrate, A John AJ; Dias-Santagata, Dora D; Borger, Darrell R DR; Ellisen, Leif W LW; Yang, Daniel D; Louis, David N DN; Cahill, Daniel P DP; Chi, Andrew S AS

Publication Date: 2019-04-29

Variant appearance in text: EGFR: E545K

PubMed Link: 31036078

Variant Present in the following documents:

• Main text

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miR-125b Upregulates miR-34a and Sequentially Activates Stress Adaption and Cell Death Mechanisms in Multiple Myeloma.

Molecular Therapy. Nucleic Acids

Misso, Gabriella G; Zarone, Mayra Rachele MR; Lombardi, Angela A; Grimaldi, Anna A; Cossu, Alessia Maria AM; Ferri, Carmela C; Russo, Margherita M; Vuoso, Daniela Cristina DC; Luce, Amalia A; Kawasaki, Hiromichi H; Di Martino, Maria Teresa MT; Virgilio, Antonella A; Festa, Agostino A; Galeone, Aldo A; De Rosa, Giuseppe G; Irace, Carlo C; Donadelli, Massimo M; Necas, Alois A; Amler, Evzen E; Tagliaferri, Pierosandro P; Tassone, Pierfrancesco P; Caraglia, Michele M

Publication Date: 2019-06-07

Variant appearance in text: EGFR: 1633G>A; Glu545Lys

PubMed Link: 31009917

Variant Present in the following documents:

• mmc2.pdf

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PI3k and Stat3: Oncogenes that are Required for Gap Junctional, Intercellular Communication.

Cancers

Geletu, Mulu M; Taha, Zaid Z; Gunning, Patrick T PT; Raptis, Leda L

Publication Date: 2019-02-01

Variant appearance in text: EGFR: E545K

PubMed Link: 30717267

Variant Present in the following documents:

• Main text

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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Hillig, Roman C RC; Sautier, Brice B; Schroeder, Jens J; Moosmayer, Dieter D; Hilpmann, André A; Stegmann, Christian M CM; Werbeck, Nicolas D ND; Briem, Hans H; Boemer, Ulf U; Weiske, Joerg J; Badock, Volker V; Mastouri, Julia J; Petersen, Kirstin K; Siemeister, Gerhard G; Kahmann, Jan D JD; Wegener, Dennis D; Böhnke, Niels N; Eis, Knut K; Graham, Keith K; Wortmann, Lars L; von Nussbaum, Franz F; Bader, Benjamin B

Publication Date: 2019-02-12

Variant appearance in text: EGFR: E545K

PubMed Link: 30683722

Variant Present in the following documents:

• pnas.1812963116.sapp.pdf

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