EGFR c.2114G>A ;(p.R705K)

Variant ID: 7-55241666-G-A

NM_005228.3(EGFR):c.2114G>A;(p.R705K)

This variant was identified in 10 publications

View GRCh38 version.




Publications:


Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model.

Oncogene
Ikeuchi, Hiroshi H; Hirose, Takeshi T; Ikegami, Masachika M; Takamochi, Kazuya K; Suzuki, Kenji K; Mano, Hiroyuki H; Kohsaka, Shinji S
Publication Date: 2022-04

Variant appearance in text: EGFR: R705K
PubMed Link: 35304574
Variant Present in the following documents:
  • 41388_2022_Article_2263.pdf
View BVdb publication page



Identification of Immune-Related Gene Signatures in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma.

Frontiers In Immunology
Li, Na N; Wang, Jiahong J; Zhan, Xianquan X
Publication Date: 2021

Variant appearance in text: EGFR: 2114G>A; R705H
PubMed Link: 34887858
Variant Present in the following documents:
  • Table_3.xlsx, sheet 1
View BVdb publication page



Patient specific circulating tumor DNA fingerprints to monitor treatment response across multiple tumors.

Journal Of Translational Medicine
Li, Jiaping J; Jiang, Wei W; Wei, Jinwang J; Zhang, Jianwei J; Cai, Linbo L; Luo, Minjie M; Wang, Zhan Z; Sun, Wending W; Wang, Shengzhou S; Wang, Chen C; Dai, Chun C; Liu, Jun J; Wang, Guan G; Wang, Jiping J; Xu, Qiang Q; Deng, Yanhong Y
Publication Date: 2020-08-01

Variant appearance in text: EGFR: R705K
PubMed Link: 32738923
Variant Present in the following documents:
  • 12967_2020_2449_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Tracking tumour evolution in glioma through liquid biopsies of cerebrospinal fluid.

Nature
Miller, Alexandra M AM; Shah, Ronak H RH; Pentsova, Elena I EI; Pourmaleki, Maryam M; Briggs, Samuel S; Distefano, Natalie N; Zheng, Youyun Y; Skakodub, Anna A; Mehta, Smrutiben A SA; Campos, Carl C; Hsieh, Wan-Ying WY; Selcuklu, S Duygu SD; Ling, Lilan L; Meng, Fanli F; Jing, Xiaohong X; Samoila, Aliaksandra A; Bale, Tejus A TA; Tsui, Dana W Y DWY; Grommes, Christian C; Viale, Agnes A; Souweidane, Mark M MM; Tabar, Viviane V; Brennan, Cameron W CW; Reiner, Anne S AS; Rosenblum, Marc M; Panageas, Katherine S KS; DeAngelis, Lisa M LM; Young, Robert J RJ; Berger, Michael F MF; Mellinghoff, Ingo K IK
Publication Date: 2019-01

Variant appearance in text: EGFR: 2114G>A; R705K
PubMed Link: 30675060
Variant Present in the following documents:
  • NIHMS1516901-supplement-Sup_Table_5.xlsx, sheet 1
View BVdb publication page



DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression.

Ebiomedicine
Mäki-Nevala, Satu S; Valo, Satu S; Ristimäki, Ari A; Sarhadi, Virinder V; Knuutila, Sakari S; Nyström, Minna M; Renkonen-Sinisalo, Laura L; Lepistö, Anna A; Mecklin, Jukka-Pekka JP; Peltomäki, Päivi P
Publication Date: 2019-01

Variant appearance in text: EGFR: Arg705Lys
PubMed Link: 30578081
Variant Present in the following documents:
  • mmc1.pdf
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: EGFR: R705K
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 3
  • pone.0196434.s001.xlsx, sheet 2
View BVdb publication page



Integrative Kinome Profiling Identifies mTORC1/2 Inhibition as Treatment Strategy in Ovarian Clear Cell Carcinoma.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Caumanns, Joseph J JJ; Berns, Katrien K; Wisman, G Bea A GBA; Fehrmann, Rudolf S N RSN; Tomar, Tushar T; Klip, Harry H; Meersma, Gert J GJ; Hijmans, E Marielle EM; Gennissen, Annemiek M C AMC; Duiker, Evelien W EW; Weening, Desiree D; Itamochi, Hiroaki H; Kluin, Roelof J C RJC; Reyners, Anna K L AKL; Birrer, Michael J MJ; Salvesen, Helga B HB; Vergote, Ignace I; van Nieuwenhuysen, Els E; Brenton, James J; Braicu, E Ioana EI; Kupryjanczyk, Jolanta J; Spiewankiewicz, Beata B; Mittempergher, Lorenza L; Bernards, René R; van der Zee, Ate G J AGJ; de Jong, Steven S
Publication Date: 2018-08-15

Variant appearance in text: EGFR: R705K
PubMed Link: 29685880
Variant Present in the following documents:
  • Main text
View BVdb publication page



Routine genetic testing of lung cancer specimens derived from surgery, bronchoscopy and fluid aspiration by next generation sequencing.

International Journal Of Oncology
Yamamoto, Gou G; Kikuchi, Mari M; Kobayashi, Shiho S; Arai, Yoshiko Y; Fujiyoshi, Kenji K; Wakatsuki, Tomokazu T; Kakuta, Miho M; Yamane, Yuki Y; Iijima, Yoshihito Y; Mizutani, Hideaki H; Nakajima, Yuki Y; Sudo, Junko J; Kinoshita, Hiroyasu H; Kurimoto, Futoshi F; Akiyama, Hirohiko H; Uramoto, Hidetaka H; Sakai, Hiroshi H; Akagi, Yoshito Y; Akagi, Kiwamu K
Publication Date: 2017-05

Variant appearance in text: EGFR: R705K
PubMed Link: 28350094
Variant Present in the following documents:
  • Main text
  • ijo-50-05-1579.pdf
View BVdb publication page



Genetic heterogeneity of actionable genes between primary and metastatic tumor in lung adenocarcinoma.

Bmc Cancer
Kim, Eun Young EY; Cho, Eun Na EN; Park, Heae Surng HS; Kim, Arum A; Hong, Ji Young JY; Lim, Seri S; Youn, Jong Pil JP; Hwang, Seung Yong SY; Chang, Yoon Soo YS
Publication Date: 2016-01-18

Variant appearance in text: EGFR: 2114G>A
PubMed Link: 26782967
Variant Present in the following documents:
  • 12885_2016_2049_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



Prognostic value analysis of mutational and clinicopathological factors in non-small cell lung cancer.

Plos One
Li, Chenguang C; Hao, Ligang L; Li, Yue Y; Wang, Shengguang S; Chen, Hui H; Zhang, Lianmin L; Ke, Bin B; Yin, Yuesong Y; Suo, Haijin H; Sun, Bingsheng B; Zhang, Bin B; Wang, Changli C
Publication Date: 2014

Variant appearance in text: EGFR: R705K
PubMed Link: 25198510
Variant Present in the following documents:
  • Main text
  • pone.0107276.pdf
View BVdb publication page