EGFR c.2125G>C ;(p.E709Q)

Variant ID: 7-55241677-G-C

NM_005228.3(EGFR):c.2125G>C;(p.E709Q)

This variant was identified in 21 publications

View GRCh38 version.




Publications:


Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.

Nature Communications
Gounder, Mrinal M MM; Agaram, Narasimhan P NP; Trabucco, Sally E SE; Robinson, Victoria V; Ferraro, Richard A RA; Millis, Sherri Z SZ; Krishnan, Anita A; Lee, Jessica J; Attia, Steven S; Abida, Wassim W; Drilon, Alexander A; Chi, Ping P; Angelo, Sandra P D' SP; Dickson, Mark A MA; Keohan, Mary Lou ML; Kelly, Ciara M CM; Agulnik, Mark M; Chawla, Sant P SP; Choy, Edwin E; Chugh, Rashmi R; Meyer, Christian F CF; Myer, Parvathi A PA; Moore, Jessica L JL; Okimoto, Ross A RA; Pollock, Raphael E RE; Ravi, Vinod V; Singh, Arun S AS; Somaiah, Neeta N; Wagner, Andrew J AJ; Healey, John H JH; Frampton, Garrett M GM; Venstrom, Jeffrey M JM; Ross, Jeffrey S JS; Ladanyi, Marc M; Singer, Samuel S; Brennan, Murray F MF; Schwartz, Gary K GK; Lazar, Alexander J AJ; Thomas, David M DM; Maki, Robert G RG; Tap, William D WD; Ali, Siraj M SM; Jin, Dexter X DX
Publication Date: 2022-06-15

Variant appearance in text: EGFR: E709Q
PubMed Link: 35705558
Variant Present in the following documents:
  • 41467_2022_30496_MOESM2_ESM.xls, sheet 1
View BVdb publication page



Clinically actionable cancer somatic variants (CACSV): a tumor interpreted dataset for analytical workflows.

Bmc Medical Genomics
Sobahy, Turki M TM; Tashkandi, Ghassan G; Bahussain, Donya D; Al-Harbi, Raneem R
Publication Date: 2022-04-25

Variant appearance in text: EGFR: 2125G>C
PubMed Link: 35468810
Variant Present in the following documents:
  • 12920_2022_1235_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Rationale and design of a phase II trial of dacomitinib in advanced non-small cell lung cancer patients with uncommon epidermal growth factor receptor mutations: a prospective and single arm study (DANCE study).

Bmc Cancer
Zhang, Bo B; Shi, Chunlei C; Gao, Zhiqiang Z; Zhong, Hua H; Xiong, Liwen L; Gu, Aiqin A; Wang, Weimin W; Chu, Tianqing T; Zhang, Wei W; Wang, Huimin H; Zhang, Xueyan X; Zhong, Runbo R; Han, Baohui B
Publication Date: 2022-03-19

Variant appearance in text: EGFR: E709Q
PubMed Link: 35305596
Variant Present in the following documents:
  • Main text
  • 12885_2022_Article_9409.pdf
View BVdb publication page



Durable response to afatinib in an advanced lung adenocarcinoma patient with an EGFR L858R/G729A compound mutation: a case report.

Annals Of Translational Medicine
Wu, Lige L; Fang, Cheng C; Zhao, Weiqing W; Li, Dong D; Tang, Shuxian S; Li, Xi X; Ji, Mei M
Publication Date: 2022-01

Variant appearance in text: EGFR: E709Q
PubMed Link: 35282062
Variant Present in the following documents:
  • Main text
  • atm-10-02-116.pdf
View BVdb publication page



Long term follow-up of EGFR mutated NSCLC cases.

Translational Oncology
Rennert, Gad G; Gottfried, Maya M; Rennert, Hedy S HS; Lejbkowicz, Flavio F; Frank, Meira M; Cohen, Ilana I; Kelt, Shiri S; Agbarya, Abed A; Dudnik, Elizabeta E; Dudnik, Julia J; Katznelson, Rivka R; Mishali, Moshe M; Maimon Rabinovich, Natalie N; Nechushtan, Hovav H; Onn, Amir A; Keren Rosenberg, Shoshana S; Wollner, Mariana M; Zer, Alona A; Bar, Jair J; Gronich, Naomi N
Publication Date: 2021-01

Variant appearance in text: EGFR: E709Q
PubMed Link: 33186889
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan-cancer analysis.

Cancer Communications (London, England)
Liu, Haijing H; Zhang, Bo B; Sun, Zhifu Z
Publication Date: 2020-01

Variant appearance in text: EGFR: 2125G>C; E709Q
PubMed Link: 32067422
Variant Present in the following documents:
  • CAC2-40-43-s001.xlsx, sheet 1
View BVdb publication page



[A Review of EGFR-TKIs Therapy of Non-small Cell Lung Cancer
with Uncommon EGFR Mutations].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Du, Wenxing W; Wo, Yang Y; Lu, Tong T; Wang, Yuanyong Y; Jiao, Wenjie W
Publication Date: 2019-09-20

Variant appearance in text: EGFR: E709Q
PubMed Link: 31526464
Variant Present in the following documents:
  • Main text
  • zgfazz-22-9-590.pdf
View BVdb publication page



Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology
Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR
Publication Date: 2019-04

Variant appearance in text: EGFR: E709Q
PubMed Link: 31034466
Variant Present in the following documents:
  • pcbi.1006981.s010.xlsx, sheet 1
View BVdb publication page



Discrepancies between ALK protein disruption and occurrence of ALK gene rearrangement in Polish NSCLC patients.

Journal Of Thoracic Disease
Grenda, Anna A; Jarosz, Bożena B; Krawczyk, Paweł P; Kucharczyk, Tomasz T; Wojas-Krawczyk, Kamila K; Reszka, Katarzyna K; Krukowska, Kinga K; Nicoś, Marcin M; Pankowski, Juliusz J; Bryl, Maciej M; Ramlau, Rodryg R; Kuźnar-Kamińska, Barbara B; Grodzki, Tomasz T; Szczęsna, Aleksandra A; Siemiątkowska, Krystyna K; Szumiło, Justyna J; Batura-Gabryel, Halina H; Palonka, Michał M; Milanowski, Janusz J
Publication Date: 2018-08

Variant appearance in text: EGFR: 2125G>C; Glu709Gln
PubMed Link: 30233874
Variant Present in the following documents:
  • Main text
View BVdb publication page



Immunohistochemical assays incorporating SP142 and 22C3 monoclonal antibodies for detection of PD-L1 expression in NSCLC patients with known status of EGFR and ALK genes.

Oncotarget
Krawczyk, Paweł P; Jarosz, Bożena B; Kucharczyk, Tomasz T; Grenda, Anna A; Reszka, Katarzyna K; Pankowski, Juliusz J; Wojas-Krawczyk, Kamila K; Nicoś, Marcin M; Szumiło, Justyna J; Trojanowski, Tomasz T; Milanowski, Janusz J
Publication Date: 2017-09-08

Variant appearance in text: EGFR: 2125G>C; Glu709Gln
PubMed Link: 28969070
Variant Present in the following documents:
  • Main text
  • oncotarget-08-64283.pdf
View BVdb publication page



Clinical features and treatment outcome of non-small cell lung cancer (NSCLC) patients with uncommon or complex epidermal growth factor receptor (EGFR) mutations.

Oncotarget
Frega, Stefano S; Lorenzi, Martina M; Fassan, Matteo M; Indraccolo, Stefano S; Calabrese, Fiorella F; Favaretto, Adolfo A; Bonanno, Laura L; Polo, Valentina V; Zago, Giulia G; Lunardi, Francesca F; Attili, Ilaria I; Pavan, Alberto A; Rugge, Massimo M; Guarneri, Valentina V; Conte, PierFranco P; Pasello, Giulia G
Publication Date: 2017-05-16

Variant appearance in text: EGFR: E709Q
PubMed Link: 28427238
Variant Present in the following documents:
  • Main text
  • oncotarget-08-32626.pdf
View BVdb publication page



Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

Genome Research
Brammeld, Jonathan S JS; Petljak, Mia M; Martincorena, Inigo I; Williams, Steven P SP; Alonso, Luz Garcia LG; Dalmases, Alba A; Bellosillo, Beatriz B; Robles-Espinoza, Carla Daniela CD; Price, Stacey S; Barthorpe, Syd S; Tarpey, Patrick P; Alifrangis, Constantine C; Bignell, Graham G; Vidal, Joana J; Young, Jamie J; Stebbings, Lucy L; Beal, Kathryn K; Stratton, Michael R MR; Saez-Rodriguez, Julio J; Garnett, Mathew M; Montagut, Clara C; Iorio, Francesco F; McDermott, Ultan U
Publication Date: 2017-04

Variant appearance in text: EGFR: 2125G>C; E709Q
PubMed Link: 28179366
Variant Present in the following documents:
  • supp_gr.213546.116_Supplemental_Table_S7.xlsx, sheet 1
View BVdb publication page



Effectiveness of tyrosine kinase inhibitors on uncommon E709X epidermal growth factor receptor mutations in non-small-cell lung cancer.

Oncotargets And Therapy
Wu, Jenn-Yu JY; Shih, Jin-Yuan JY
Publication Date: 2016

Variant appearance in text: EGFR: E709Q
PubMed Link: 27785061
Variant Present in the following documents:
  • Main text
  • ott-9-6137.pdf
View BVdb publication page



REGene: a literature-based knowledgebase of animal regeneration that bridge tissue regeneration and cancer.

Scientific Reports
Zhao, Min M; Rotgans, Bronwyn B; Wang, Tianfang T; Cummins, S F SF
Publication Date: 2016-03-15

Variant appearance in text: EGFR: E709Q
PubMed Link: 26975833
Variant Present in the following documents:
  • srep23167-s9.xls, sheet 1
View BVdb publication page



Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Cell
Creixell, Pau P; Schoof, Erwin M EM; Simpson, Craig D CD; Longden, James J; Miller, Chad J CJ; Lou, Hua Jane HJ; Perryman, Lara L; Cox, Thomas R TR; Zivanovic, Nevena N; Palmeri, Antonio A; Wesolowska-Andersen, Agata A; Helmer-Citterich, Manuela M; Ferkinghoff-Borg, Jesper J; Itamochi, Hiroaki H; Bodenmiller, Bernd B; Erler, Janine T JT; Turk, Benjamin E BE; Linding, Rune R
Publication Date: 2015-09-24

Variant appearance in text: EGFR: E709Q
PubMed Link: 26388441
Variant Present in the following documents:
  • mmc4.xlsx, sheet 1
View BVdb publication page



Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype.

Scientific Reports
Fu, Yong Y; Cruz-Monserrate, Zobeida Z; Helen Lin, H H; Chung, Yiyin Y; Ji, Baoan B; Lin, Szu-Min SM; Vonderfecht, Steven S; Logsdon, Craig D CD; Li, Chien-Feng CF; Ann, David K DK
Publication Date: 2015-08-20

Variant appearance in text: EGFR: E709Q
PubMed Link: 26289340
Variant Present in the following documents:
  • srep13347-s1.pdf
View BVdb publication page



Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Publication Date: 2014-10-28

Variant appearance in text: EGFR: E709Q
PubMed Link: 25348012
Variant Present in the following documents:
  • 13059_2014_484_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology.

Journal Of Thoracic Oncology : Official Publication Of The International Association For The Study Of Lung Cancer
Lindeman, Neal I NI; Cagle, Philip T PT; Beasley, Mary Beth MB; Chitale, Dhananjay Arun DA; Dacic, Sanja S; Giaccone, Giuseppe G; Jenkins, Robert Brian RB; Kwiatkowski, David J DJ; Saldivar, Juan-Sebastian JS; Squire, Jeremy J; Thunnissen, Erik E; Ladanyi, Marc M
Publication Date: 2013-07

Variant appearance in text: EGFR: 2125G>C; E709Q
PubMed Link: 23552377
Variant Present in the following documents:
  • Main text
View BVdb publication page



Molecular testing guideline for selection of lung cancer patients for EGFR and ALK tyrosine kinase inhibitors: guideline from the College of American Pathologists, International Association for the Study of Lung Cancer, and Association for Molecular Pathology.

Archives Of Pathology & Laboratory Medicine
Lindeman, Neal I NI; Cagle, Philip T PT; Beasley, Mary Beth MB; Chitale, Dhananjay Arun DA; Dacic, Sanja S; Giaccone, Giuseppe G; Jenkins, Robert Brian RB; Kwiatkowski, David J DJ; Saldivar, Juan-Sebastian JS; Squire, Jeremy J; Thunnissen, Erik E; Ladanyi, Marc M
Publication Date: 2013-06

Variant appearance in text: EGFR: 2125G>C; E709Q
PubMed Link: 23551194
Variant Present in the following documents:
  • Main text
View BVdb publication page



Epidemiology of doublet/multiplet mutations in lung cancers: evidence that a subset arises by chronocoordinate events.

Plos One
Chen, Zhenbin Z; Feng, Jinong J; Buzin, Carolyn H CH; Sommer, Steve S SS
Publication Date: 2008

Variant appearance in text: EGFR: E709Q
PubMed Link: 19005564
Variant Present in the following documents:
  • pone.0003714.s003.xls, sheet 1
View BVdb publication page