EGFR c.2127_2129del ;(p.E709_T710delinsD)

Variant ID: 7-55241679-AAAC-A

NM_005228.3(EGFR):c.2127_2129del;(p.E709_T710delinsD)

This variant was identified in 41 publications

View GRCh38 version.




Publications:


Plasma ctDNA increases tissue NGS-based detection of therapeutically targetable mutations in lung cancers.

Bmc Cancer
Xie, Jianjiang J; Yao, Weishen W; Chen, Lingxiu L; Zhu, Wenjun W; Liu, Qiang Q; Geng, Geng G; Fang, Jing J; Zhao, Yang Y; Xiao, Li L; Huang, Zhenhua Z; Zhao, Jing J
Publication Date: 2023-03-31

Variant appearance in text: EGFR: Glu709_Thr710delinsAsp
PubMed Link: 37004022
Variant Present in the following documents:
  • Main text
  • 12885_2023_10674_MOESM3_ESM.xlsx, sheet 1
  • 12885_2023_Article_10674.pdf
View BVdb publication page



Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23

Variant appearance in text: EGFR: 2127_2129del; Glu709_Thr710delinsAsp
PubMed Link: 36823319
Variant Present in the following documents:
  • 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Efficacy and clinicogenomic correlates of response to immune checkpoint inhibitors alone or with chemotherapy in non-small cell lung cancer.

Nature Communications
Hong, Lingzhi L; Aminu, Muhammad M; Li, Shenduo S; Lu, Xuetao X; Petranovic, Milena M; Saad, Maliazurina B MB; Chen, Pingjun P; Qin, Kang K; Varghese, Susan S; Rinsurongkawong, Waree W; Rinsurongkawong, Vadeerat V; Spelman, Amy A; Elamin, Yasir Y YY; Negrao, Marcelo V MV; Skoulidis, Ferdinandos F; Gay, Carl M CM; Cascone, Tina T; Gandhi, Saumil J SJ; Lin, Steven H SH; Lee, Percy P PP; Carter, Brett W BW; Wu, Carol C CC; Antonoff, Mara B MB; Sepesi, Boris B; Lewis, Jeff J; Gibbons, Don L DL; Vaporciyan, Ara A AA; Le, Xiuning X; Jack Lee, J J; Roy-Chowdhuri, Sinchita S; Routbort, Mark J MJ; Gainor, Justin F JF; Heymach, John V JV; Lou, Yanyan Y; Wu, Jia J; Zhang, Jianjun J; Vokes, Natalie I NI
Publication Date: 2023-02-08

Variant appearance in text: EGFR: 2127_2129del; E709_T710delinsD
PubMed Link: 36755027
Variant Present in the following documents:
  • 41467_2023_36328_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Short-term dynamics of circulating tumor DNA predicting efficacy of sintilimab plus docetaxel in second-line treatment of advanced NSCLC: biomarker analysis from a single-arm, phase 2 trial.

Journal For Immunotherapy Of Cancer
Han, Xiao X; Tang, Xiaoyong X; Zhu, Hui H; Zhu, Dongyuan D; Zhang, Xiqin X; Meng, Xiangjiao X; Hua, Ying Y; Wang, Zhongtang Z; Zhang, Yan Y; Huang, Wei W; Wang, Linlin L; Yuan, Shuanghu S; Zhang, Pinliang P; Gong, Heyi H; Sun, Yulan Y; Zhang, Yingjie Y; Liu, Zengjun Z; Dong, Xiaomeng X; Gai, Fei F; Huang, Zhan Z; Zhu, Changbin C; Guo, Jun J; Wang, Zhehai Z
Publication Date: 2022-12

Variant appearance in text: EGFR: 2127_2129delAAC; E709_T710delinsD
PubMed Link: 36600554
Variant Present in the following documents:
  • jitc-2022-004952supp005.pdf
View BVdb publication page



An EGFR L858R mutation identified in 1862 Chinese NSCLC patients can be a promising neoantigen vaccine therapeutic strategy.

Frontiers In Immunology
Lin, Jing J; Liu, Jun J; Hao, Shi-Guang SG; Lan, Bin B; Zheng, Xiao-Bin XB; Xiong, Jia-Ni JN; Zhang, Ying-Qian YQ; Gao, Xuan X; Chen, Chuan-Ben CB; Chen, Ling L; Huang, Yu-Fang YF; Luo, Hong H; Yi, Yu-Ting YT; Yi, Xin X; Lu, Jian-Ping JP; Zheng, Xiong-Wei XW; Chen, Gang G; Wang, Xue-Feng XF; Chen, Yu Y
Publication Date: 2022

Variant appearance in text: EGFR: 2127_2129delAAC; E709_T710delinsD
PubMed Link: 36505399
Variant Present in the following documents:
  • Table_2.xlsx, sheet 3
  • Table_2.xlsx, sheet 2
View BVdb publication page



Liquid biopsy using ascitic fluid and pleural effusion supernatants for genomic profiling in gastrointestinal and lung cancers.

Bmc Cancer
Wu, Huita H; Ji, Haonan H; Yang, Wenhui W; Zhang, Min M; Guo, Yifang Y; Li, Bangkai B; Wang, Jiayin J; Chen, Rongrong R; Chen, Yuan Y; Wang, Xin X
Publication Date: 2022-09-27

Variant appearance in text: EGFR: E709_T710delinsD
PubMed Link: 36167530
Variant Present in the following documents:
  • 12885_2022_9922_MOESM5_ESM.xlsx, sheet 1
View BVdb publication page



Landscape of EGFR mutations in lung adenocarcinoma: a single institute experience with comparison of PANAMutyper testing and targeted next-generation sequencing.

Journal Of Pathology And Translational Medicine
Lee, Jeonghyo J; Han, Yeon Bi YB; Kwon, Hyun Jung HJ; Lee, Song Kook SK; Kim, Hyojin H; Chung, Jin-Haeng JH
Publication Date: 2022-09

Variant appearance in text: EGFR: 2127_2129delAAC; E709_T710delinsD
PubMed Link: 36128861
Variant Present in the following documents:
  • jptm-2022-06-11.pdf
View BVdb publication page



Genomic Landscape of RTK/RAS Pathway and Tumor Immune Infiltration as Prognostic Indicator of Lung Adenocarcinoma.

Frontiers In Oncology
Yin, Xiang-Qian XQ; Yin, Xue-Hui XH; Yu, Ya-Qin YQ; Xu, Lang L; Zhang, Mao M
Publication Date: 2022

Variant appearance in text: EGFR: 2127_2129delAAC; E709_T710delinsD; rs397517086
PubMed Link: 35936718
Variant Present in the following documents:
  • Table_4.xlsx, sheet 2
View BVdb publication page



Genomic Alterations Identification and Resistance Mechanisms Exploration of NSCLC With Central Nervous System Metastases Using Liquid Biopsy of Cerebrospinal Fluid: A Real-World Study.

Frontiers In Oncology
Shen, Fangfang F; Liang, Naixin N; Fan, Zaiwen Z; Zhao, Min M; Kang, Jing J; Wang, Xifang X; Hu, Qun Q; Mu, Yongping Y; Wang, Kai K; Yuan, Mingming M; Chen, Rongrong R; Guo, Wei W; Dong, Guilan G; Zhao, Jun J; Bai, Jun J
Publication Date: 2022

Variant appearance in text: EGFR: 2127_2129delAAC; E709_T710delinsD
PubMed Link: 35814426
Variant Present in the following documents:
  • DataSheet_1.xlsx, sheet 2
View BVdb publication page



Unique characteristics of G719X and S768I compound double mutations of epidermal growth factor receptor (EGFR) gene in lung cancer of coal-producing areas of East Yunnan in Southwestern China.

Genes And Environment : The Official Journal Of The Japanese Environmental Mutagen Society
Wang, Jun-Ling JL; Fu, Yu-Dong YD; Gao, Yan-Hong YH; Li, Xiu-Ping XP; Xiong, Qian Q; Li, Rui R; Hou, Bo B; Huang, Ruo-Shan RS; Wang, Jun-Feng JF; Zhang, Jian-Kun JK; Lv, Jia-Ling JL; Zhang, Chao C; Li, Hong-Wei HW
Publication Date: 2022-05-23

Variant appearance in text: EGFR: 2127_2129delAAC; Glu709_Thr710delinsAsp
PubMed Link: 35606799
Variant Present in the following documents:
  • 41021_2022_248_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



Clinical and genomic features of Chinese lung cancer patients with germline mutations.

Nature Communications
Peng, Wenying W; Li, Bin B; Li, Jin J; Chang, Lianpeng L; Bai, Jing J; Yi, Yuting Y; Chen, Rongrong R; Zhang, Yanyan Y; Chen, Chen C; Pu, Xingxiang X; Jiang, Meilin M; Li, Jia J; Zhong, Rui R; Xu, Fang F; Chen, Bolin B; Xu, Li L; Wang, Ning N; Huan, Jiaojiao J; Dai, Pingping P; Guan, Yanfang Y; Yang, Ling L; Xia, Xuefeng X; Yi, Xin X; Wang, Jiayin J; Yu, Fenglei F; Wu, Lin L
Publication Date: 2022-03-10

Variant appearance in text: EGFR: 2127_2129delAAC; E709_T710delinsD
PubMed Link: 35273153
Variant Present in the following documents:
  • 41467_2022_28840_MOESM7_ESM.xlsx, sheet 1
View BVdb publication page



The Molecular Tumor Board Portal supports clinical decisions and automated reporting for precision oncology.

Nature Cancer
Tamborero, David D; Dienstmann, Rodrigo R; Rachid, Maan Haj MH; Boekel, Jorrit J; Lopez-Fernandez, Adria A; Jonsson, Markus M; Razzak, Ali A; Braña, Irene I; De Petris, Luigi L; Yachnin, Jeffrey J; Baird, Richard D RD; Loriot, Yohann Y; Massard, Christophe C; Martin-Romano, Patricia P; Opdam, Frans F; Schlenk, Richard F RF; Vernieri, Claudio C; Masucci, Michele M; Villalobos, Xenia X; Chavarria, Elena E; , ; Balmaña, Judith J; Apolone, Giovanni G; Caldas, Carlos C; Bergh, Jonas J; Ernberg, Ingemar I; Fröhling, Stefan S; Garralda, Elena E; Karlsson, Claes C; Tabernero, Josep J; Voest, Emile E; Rodon, Jordi J; Lehtiö, Janne J
Publication Date: 2022-02

Variant appearance in text: EGFR: Glu709_Thr710delinsAsp
PubMed Link: 35221333
Variant Present in the following documents:
  • 43018_2022_332_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Investigation of PALB2 Mutation and Correlation With Immunotherapy Biomarker in Chinese Non-Small Cell Lung Cancer Patients.

Frontiers In Oncology
Zhang, Jiexia J; Tang, Shuangfeng S; Zhang, Chunning C; Li, Mingyao M; Zheng, Yating Y; Hu, Xue X; Huang, Mengli M; Cheng, Xiangyang X
Publication Date: 2021

Variant appearance in text: EGFR: 2127_2129del; E709_T710delinsD
PubMed Link: 35087742
Variant Present in the following documents:
  • Table_2.xlsx, sheet 1
View BVdb publication page



Real-World Pattern of Treatment and Clinical Outcomes of EGFR-Mutant Non-Small Cell Lung Cancer in a Single Academic Centre in Quebec.

Current Oncology (Toronto, Ont.)
Agulnik, Jason S JS; Kasymjanova, Goulnar G; Pepe, Carmela C; Hurry, Manjusha M; Walton, Ryan N RN; Sakr, Lama L; Cohen, Victor V; Small, David D
Publication Date: 2021-12-07

Variant appearance in text: EGFR: Glu709_Thr710delinsAsp
PubMed Link: 34940073
Variant Present in the following documents:
  • Main text
  • curroncol-28-00434.pdf
View BVdb publication page



Real-World Pattern of Treatment and Clinical Outcomes of EGFR-Mutant Non-Small Cell Lung Cancer in a Single Academic Centre in Quebec.

Current Oncology (Toronto, Ont.)
Agulnik, Jason S JS; Kasymjanova, Goulnar G; Pepe, Carmela C; Hurry, Manjusha M; Walton, Ryan N RN; Sakr, Lama L; Cohen, Victor V; Small, David D
Publication Date: 2021-12-07

Variant appearance in text: EGFR: Glu709_Thr710delinsAsp
PubMed Link: 34940073
Variant Present in the following documents:
  • Main text
  • curroncol-28-00434.pdf
View BVdb publication page



Identification of Immune-Related Gene Signatures in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma.

Frontiers In Immunology
Li, Na N; Wang, Jiahong J; Zhan, Xianquan X
Publication Date: 2021

Variant appearance in text: EGFR: 2127_2129delAAC; E709_T710delinsD
PubMed Link: 34887858
Variant Present in the following documents:
  • Table_3.xlsx, sheet 1
View BVdb publication page



Intertumoural Heterogeneity and Branch Evolution of Synchronous Multiple Primary Lung Adenocarcinomas by Next-Generation Sequencing Analysis.

Frontiers In Oncology
Zhang, Qinleng Q; Jia, Hui H; Wang, Zhendan Z; Hao, Shaoyu S; Huang, Haiyan H; Yang, Airong A; Han, Lu L; Song, Pingping P
Publication Date: 2021

Variant appearance in text: EGFR: 2127_2129delAAC; E709_T710delinsD
PubMed Link: 34804960
Variant Present in the following documents:
  • Table_1.xls, sheet 1
View BVdb publication page



CDKN2A loss-of-function predicts immunotherapy resistance in non-small cell lung cancer.

Scientific Reports
Gutiontov, Stanley I SI; Turchan, William Tyler WT; Spurr, Liam F LF; Rouhani, Sherin J SJ; Chervin, Carolina Soto CS; Steinhardt, George G; Lager, Angela M AM; Wanjari, Pankhuri P; Malik, Renuka R; Connell, Philip P PP; Chmura, Steven J SJ; Juloori, Aditya A; Hoffman, Philip C PC; Ferguson, Mark K MK; Donington, Jessica S JS; Patel, Jyoti D JD; Vokes, Everett E EE; Weichselbaum, Ralph R RR; Bestvina, Christine M CM; Segal, Jeremy P JP; Pitroda, Sean P SP
Publication Date: 2021-10-08

Variant appearance in text: EGFR: 2127_2129del; E709_T710delinsD
PubMed Link: 34625620
Variant Present in the following documents:
  • 41598_2021_99524_MOESM2_ESM.xlsx, sheet 2
View BVdb publication page



Driver gene alterations profiling of Chinese non-small cell lung cancer and the effects of co-occurring alterations on immunotherapy.

Cancer Medicine
Sun, Shengjie S; Du, Wenjuan W; Sun, Qiong Q; Zhao, Xiao X; Qin, Boyu B; Shi, Duozhi D; Wan, Chong C; Wu, Zhiyong Z
Publication Date: 2021-10

Variant appearance in text: EGFR: Glu709_Thr710delinsAsp
PubMed Link: 34599863
Variant Present in the following documents:
  • CAM4-10-7360-s002.xlsx, sheet 2
View BVdb publication page



Driver gene alterations profiling of Chinese non-small cell lung cancer and the effects of co-occurring alterations on immunotherapy.

Cancer Medicine
Sun, Shengjie S; Du, Wenjuan W; Sun, Qiong Q; Zhao, Xiao X; Qin, Boyu B; Shi, Duozhi D; Wan, Chong C; Wu, Zhiyong Z
Publication Date: 2021-10

Variant appearance in text: EGFR: Glu709_Thr710delinsAsp
PubMed Link: 34599863
Variant Present in the following documents:
  • CAM4-10-7360-s002.xlsx, sheet 2
View BVdb publication page



Structure-based classification predicts drug response in EGFR-mutant NSCLC.

Nature
Robichaux, Jacqulyne P JP; Le, Xiuning X; Vijayan, R S K RSK; Hicks, J Kevin JK; Heeke, Simon S; Elamin, Yasir Y YY; Lin, Heather Y HY; Udagawa, Hibiki H; Skoulidis, Ferdinandos F; Tran, Hai H; Varghese, Susan S; He, Junqin J; Zhang, Fahao F; Nilsson, Monique B MB; Hu, Lemei L; Poteete, Alissa A; Rinsurongkawong, Waree W; Zhang, Xiaoshan X; Ren, Chenghui C; Liu, Xiaoke X; Hong, Lingzhi L; Zhang, Jianjun J; Diao, Lixia L; Madison, Russell R; Schrock, Alexa B AB; Saam, Jennifer J; Raymond, Victoria V; Fang, Bingliang B; Wang, Jing J; Ha, Min Jin MJ; Cross, Jason B JB; Gray, Jhanelle E JE; Heymach, John V JV
Publication Date: 2021-09

Variant appearance in text: EGFR: 2127_2129del
PubMed Link: 34526717
Variant Present in the following documents:
  • 41586_2021_3898_MOESM1_ESM.pdf
View BVdb publication page



The immune microenvironment in EGFR- and ERBB2-mutated lung adenocarcinoma.

Esmo Open
Kirchner, M M; Kluck, K K; Brandt, R R; Volckmar, A-L AL; Penzel, R R; Kazdal, D D; Endris, V V; Neumann, O O; Seker-Cin, H H; Goldschmid, H H; Glade, J J; Allgäuer, M M; Kriegsmann, M M; Winter, H H; Muley, T T; Perner, S S; Frost, N N; Reck, M M; Fröhling, S S; Schirmacher, P P; Thomas, M M; Budczies, J J; Christopoulos, P P; Stenzinger, A A
Publication Date: 2021-10

Variant appearance in text: EGFR: Glu709_Thr710delinsAsp
PubMed Link: 34487971
Variant Present in the following documents:
  • mmc1.xlsx, sheet 1
View BVdb publication page



RBM10 Deficiency Is Associated With Increased Immune Activity in Lung Adenocarcinoma.

Frontiers In Oncology
Liu, Bing B; Wang, Yaqi Y; Wang, Han H; Li, Zhongwu Z; Yang, Lujing L; Yan, Shi S; Yang, Xin X; Ma, Yuanyuan Y; Gao, Xuan X; Guan, Yanfang Y; Yi, Xin X; Xia, Xuefeng X; Li, Jingjing J; Wu, Nan N
Publication Date: 2021

Variant appearance in text: EGFR: E709_T710delinsD
PubMed Link: 34367963
Variant Present in the following documents:
  • Table_3.xlsx, sheet 1
View BVdb publication page



A Lung Adenocarcinoma Patient With a Rare EGFR E709_T710delinsD Mutation Showed a Good Response to Afatinib Treatment: A Case Report and Literature Review.

Frontiers In Oncology
Wei, Yu Y; Cui, Yueli Y; Guo, Yao Y; Li, Lei L; Zeng, Liang L
Publication Date: 2021

Variant appearance in text: EGFR: 2127_2129del; E709_T710delinsD
PubMed Link: 34178699
Variant Present in the following documents:
  • Main text
  • fonc-11-700345.pdf
View BVdb publication page



Deciphering the immunosuppressive tumor microenvironment in ALK- and EGFR-positive lung adenocarcinoma.

Cancer Immunology, Immunotherapy : Cii
Budczies, Jan J; Kirchner, Martina M; Kluck, Klaus K; Kazdal, Daniel D; Glade, Julia J; Allgäuer, Michael M; Kriegsmann, Mark M; Heußel, Claus-Peter CP; Herth, Felix J FJ; Winter, Hauke H; Meister, Michael M; Muley, Thomas T; Goldmann, Torsten T; Fröhling, Stefan S; Wermke, Martin M; Waller, Cornelius F CF; Tufman, Amanda A; Reck, Martin M; Peters, Solange S; Schirmacher, Peter P; Thomas, Michael M; Christopoulos, Petros P; Stenzinger, Albrecht A
Publication Date: 2021-06-14

Variant appearance in text: EGFR: Glu709_Thr710delinsAsp
PubMed Link: 34125345
Variant Present in the following documents:
  • 262_2021_2981_MOESM1_ESM.pdf
View BVdb publication page



Deciphering the immunosuppressive tumor microenvironment in ALK- and EGFR-positive lung adenocarcinoma.

Cancer Immunology, Immunotherapy : Cii
Budczies, Jan J; Kirchner, Martina M; Kluck, Klaus K; Kazdal, Daniel D; Glade, Julia J; Allgäuer, Michael M; Kriegsmann, Mark M; Heußel, Claus-Peter CP; Herth, Felix J FJ; Winter, Hauke H; Meister, Michael M; Muley, Thomas T; Goldmann, Torsten T; Fröhling, Stefan S; Wermke, Martin M; Waller, Cornelius F CF; Tufman, Amanda A; Reck, Martin M; Peters, Solange S; Schirmacher, Peter P; Thomas, Michael M; Christopoulos, Petros P; Stenzinger, Albrecht A
Publication Date: 2022-02

Variant appearance in text: EGFR: Glu709_Thr710delinsAsp
PubMed Link: 34125345
Variant Present in the following documents:
  • 262_2021_2981_MOESM1_ESM.pdf
View BVdb publication page



Neutrophil-to-Lymphocyte Ratio Is a Predictive Biomarker in Patients with Epidermal Growth Factor Receptor (EGFR) Mutated Advanced Non-Small Cell Lung Cancer (NSCLC) Treated with Tyrosine Kinase Inhibitor (TKI) Therapy.

Cancers
Yun, Nicole K NK; Rouhani, Sherin J SJ; Bestvina, Christine M CM; Ritz, Ethan M EM; Gilmore, Brendan A BA; Tarhoni, Imad I; Borgia, Jeffrey A JA; Batus, Marta M; Bonomi, Philip D PD; Fidler, Mary Jo MJ
Publication Date: 2021-03-20

Variant appearance in text: EGFR: E709_T710delinsD
PubMed Link: 33804721
Variant Present in the following documents:
  • cancers-13-01426.pdf
View BVdb publication page



Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications
Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q
Publication Date: 2021-01-04

Variant appearance in text: EGFR: 2127_2129delAAC; E709_T710delinsD
PubMed Link: 33397889
Variant Present in the following documents:
  • 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1
  • 41467_2020_20162_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



Validation and clinical application of a targeted next-generation sequencing gene panel for solid and hematologic malignancies.

Peerj
Prieto-Potin, Iván I; Carvajal, Nerea N; Plaza-Sánchez, Jenifer J; Manso, Rebeca R; Aúz-Alexandre, Carmen Laura CL; Chamizo, Cristina C; Zazo, Sandra S; López-Sánchez, Almudena A; Rodríguez-Pinilla, Socorro María SM; Camacho, Laura L; Longarón, Raquel R; Bellosillo, Beatriz B; Somoza, Rosa R; Hernández-Losa, Javier J; Fernández-Soria, Víctor Manuel VM; Ramos-Ruiz, Ricardo R; Cristóbal, Ion I; García-Foncillas, Jesús J; Rojo, Federico F
Publication Date: 2020

Variant appearance in text: EGFR: 2127_2129del; E709_T710delinsD
PubMed Link: 33083132
Variant Present in the following documents:
  • peerj-08-10069-s011.xlsx, sheet 1
View BVdb publication page



Status of 10 targeted genes of non-small cell lung cancer in eastern China: A study of 884 patients based on NGS in a single institution.

Thoracic Cancer
Li, Dan D; Ding, Li L; Ran, Wenwen W; Huang, Yan Y; Li, Guangqi G; Wang, Chengqin C; Xiao, Yujing Y; Wang, Xiaonan X; Lin, Dongliang D; Xing, Xiaoming X
Publication Date: 2020-09

Variant appearance in text: EGFR: Glu709_Thr710delinsAsp
PubMed Link: 32729257
Variant Present in the following documents:
  • Main text
  • TCA-11-2580.pdf
View BVdb publication page



Spectrum of EGFR aberrations and potential clinical implications: insights from integrative pan-cancer analysis.

Cancer Communications (London, England)
Liu, Haijing H; Zhang, Bo B; Sun, Zhifu Z
Publication Date: 2020-01

Variant appearance in text: EGFR: 2127_2129del
PubMed Link: 32067422
Variant Present in the following documents:
  • CAC2-40-43-s001.xlsx, sheet 1
View BVdb publication page



Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes.

Communications Biology
Dong, Xiaobao X; Huang, Dandan D; Yi, Xianfu X; Zhang, Shijie S; Wang, Zhao Z; Yan, Bin B; Chung Sham, Pak P; Chen, Kexin K; Jun Li, Mulin M
Publication Date: 2020-01-07

Variant appearance in text: EGFR: 2127_2129delAAC; E709_T710delinsD
PubMed Link: 31925297
Variant Present in the following documents:
  • 42003_2019_736_MOESM3_ESM.xlsx, sheet 1
  • 42003_2019_736_MOESM10_ESM.xlsx, sheet 1
  • 42003_2019_736_MOESM4_ESM.xlsx, sheet 1
  • 42003_2019_736_MOESM13_ESM.xlsx, sheet 1
View BVdb publication page



Detection of Targetable Genetic Alterations in Korean Lung Cancer Patients: A Comparison Study of Single-Gene Assays and Targeted Next-Generation Sequencing.

Cancer Research And Treatment
Park, Eunhyang E; Shim, Hyo Sup HS
Publication Date: 2020-04

Variant appearance in text: EGFR: E709_T710delinsD
PubMed Link: 31726498
Variant Present in the following documents:
  • Main text
  • crt-2019-305.pdf
View BVdb publication page



Tumor-derived DNA from pleural effusion supernatant as a promising alternative to tumor tissue in genomic profiling of advanced lung cancer.

Theranostics
Tong, Lin L; Ding, Ning N; Tong, Xiaoling X; Li, Jiamin J; Zhang, Yong Y; Wang, Xiaodan X; Xu, Xiaobo X; Ye, Maosong M; Li, Chun C; Wu, Xue X; Bao, Hairong H; Zhang, Xin X; Hong, Qunying Q; Song, Yuanlin Y; Shao, Yang W YW; Bai, Chunxue C; Zhou, Jian J; Hu, Jie J
Publication Date: 2019

Variant appearance in text: EGFR: 2127_2129del
PubMed Link: 31534501
Variant Present in the following documents:
  • thnov09p5532s1.pdf
View BVdb publication page



Next‑generation sequencing‑based detection of EGFR, KRAS, BRAF, NRAS, PIK3CA, Her‑2 and TP53 mutations in patients with non‑small cell lung cancer.

Molecular Medicine Reports
Jing, Changwen C; Mao, Xuhua X; Wang, Zhuo Z; Sun, Kejing K; Ma, Rong R; Wu, Jianzhong J; Cao, Haixia H
Publication Date: 2018-08

Variant appearance in text: EGFR: 2127_2129del; E709_T710delinsD
PubMed Link: 29956783
Variant Present in the following documents:
  • Main text
View BVdb publication page



Detailed overview on the mutations detected by and the sensitivity of the GeneReader NGS sequencing platform.

Data In Brief
Lüsebrink, Jessica J; Pieper, Monika M; Tillmann, Ramona-Liza RL; Brockmann, Michael M; Schildgen, Oliver O; Schildgen, Verena V
Publication Date: 2018-06

Variant appearance in text: EGFR: 2127_2129delAAC; E709_T710delinsD
PubMed Link: 29904702
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas.

Cell Reports
Way, Gregory P GP; Sanchez-Vega, Francisco F; La, Konnor K; Armenia, Joshua J; Chatila, Walid K WK; Luna, Augustin A; Sander, Chris C; Cherniack, Andrew D AD; Mina, Marco M; Ciriello, Giovanni G; Schultz, Nikolaus N; , ; Sanchez, Yolanda Y; Greene, Casey S CS
Publication Date: 2018-04-03

Variant appearance in text: EGFR: Glu709_Thr710delinsAsp
PubMed Link: 29617658
Variant Present in the following documents:
  • NIHMS958974-supplement-5.xlsx, sheet 1
  • NIHMS958974-supplement-6.xlsx, sheet 1
View BVdb publication page



Cancer gene profiling in non-small cell lung cancers reveals activating mutations in JAK2 and JAK3 with therapeutic implications.

Genome Medicine
Li, Shuyu D SD; Ma, Meng M; Li, Hui H; Waluszko, Aneta A; Sidorenko, Tatyana T; Schadt, Eric E EE; Zhang, David Y DY; Chen, Rong R; Ye, Fei F
Publication Date: 2017-10-30

Variant appearance in text: EGFR: 2127_2129delAAC
PubMed Link: 29082853
Variant Present in the following documents:
  • 13073_2017_478_MOESM1_ESM.xlsx, sheet 2
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Pan-urologic cancer genomic subtypes that transcend tissue of origin.

Nature Communications
Chen, Fengju F; Zhang, Yiqun Y; Bossé, Dominick D; Lalani, Aly-Khan A AA; Hakimi, A Ari AA; Hsieh, James J JJ; Choueiri, Toni K TK; Gibbons, Don L DL; Ittmann, Michael M; Creighton, Chad J CJ
Publication Date: 2017-08-04

Variant appearance in text: EGFR: 2127_2129delAAC
PubMed Link: 28775315
Variant Present in the following documents:
  • 41467_2017_289_MOESM7_ESM.xlsx, sheet 1
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Heterogeneity of resistance mutations detectable by nextgeneration sequencing in TKI-treated lung adenocarcinoma.

Oncotarget
Belchis, Deborah A DA; Tseng, Li-Hui LH; Gniadek, Thomas T; Haley, Lisa L; Lokhandwala, Parvez P; Illei, Peter P; Gocke, Christopher D CD; Forde, Patrick P; Brahmer, Julie J; Askin, Frederic B FB; Eshleman, James R JR; Lin, Ming-Tseh MT
Publication Date: 2016-07-19

Variant appearance in text: EGFR: E709_T710delinsD
PubMed Link: 27304188
Variant Present in the following documents:
  • Main text
  • oncotarget-07-45237.pdf
  • oncotarget-07-45237-s001.pdf
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VarDict: a novel and versatile variant caller for next-generation sequencing in cancer research.

Nucleic Acids Research
Lai, Zhongwu Z; Markovets, Aleksandra A; Ahdesmaki, Miika M; Chapman, Brad B; Hofmann, Oliver O; McEwen, Robert R; Johnson, Justin J; Dougherty, Brian B; Barrett, J Carl JC; Dry, Jonathan R JR
Publication Date: 2016-06-20

Variant appearance in text: EGFR: 2127_2129delAAC; rs397517086
PubMed Link: 27060149
Variant Present in the following documents:
  • supp_gkw227_nar-03544-met-k-2015-File003.xls, sheet 2
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Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients.

British Journal Of Cancer
Wong, S Q SQ; Fellowes, A A; Doig, K K; Ellul, J J; Bosma, T J TJ; Irwin, D D; Vedururu, R R; Tan, A Y-C AY; Weiss, J J; Chan, K S KS; Lucas, M M; Thomas, D M DM; Dobrovic, A A; Parisot, J P JP; Fox, S B SB
Publication Date: 2015-04-14

Variant appearance in text: EGFR: 2127_2129delAAC; Glu709_Thr710delinsAsp
PubMed Link: 25742471
Variant Present in the following documents:
  • bjc201580x7.xls, sheet 1
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High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies.

Bmc Cancer
Do, Hongdo H; Krypuy, Michael M; Mitchell, Paul L PL; Fox, Stephen B SB; Dobrovic, Alexander A
Publication Date: 2008-05-21

Variant appearance in text: EGFR: E709_T710delinsD
PubMed Link: 18495026
Variant Present in the following documents:
  • Main text
  • 1471-2407-8-142.pdf
View BVdb publication page