Publications:

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Case Report: Lung adenocarcinoma associated with germline ERCC2 frameshift mutation.

Frontiers In Oncology

Liu, Lili L; Cui, Jia J; Liu, Siye S; Pan, Evenki E; Sun, Limin L

Publication Date: 2023

Variant appearance in text: EGFR: L718Q

PubMed Link: 37223679

Variant Present in the following documents:

• Main text
• fonc-13-1177942.pdf

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Current therapy and development of therapeutic agents for lung cancer.

Cell Insight

Wang, Zilai Z; Kim, Jiyeon J; Zhang, Pin P; Galvan Achi, Jazmin M JM; Jiang, Yuwei Y; Rong, Lijun L

Publication Date: 2022-04

Variant appearance in text: EGFR: L718Q

PubMed Link: 37193130

Variant Present in the following documents:

• Main text
• main.pdf

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Impact of the Recognition Part of Dipeptidyl Nitroalkene Compounds on the Inhibition Mechanism of Cysteine Proteases Cruzain and Cathepsin L.

Acs Catalysis

Arafet, Kemel K; Royo, Santiago S; Schirmeister, Tanja T; Barthels, Fabian F; González, Florenci V FV; Moliner, Vicent V

Publication Date: 2023-05-05

Variant appearance in text: EGFR: L718Q

PubMed Link: 37180968

Variant Present in the following documents:

• cs3c01035.pdf

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Comparison between Three Different Techniques for the Detection of EGFR Mutations in Liquid Biopsies of Patients with Advanced Stage Lung Adenocarcinoma.

International Journal Of Molecular Sciences

Casula, Milena M; Pisano, Marina M; Paliogiannis, Panagiotis P; Colombino, Maria M; Sini, Maria Cristina MC; Zinellu, Angelo A; Santeufemia, Davide D; Manca, Antonella A; Casula, Stefania S; Tore, Silvia S; Lobrano, Renato R; Sardinian Lung Cancer Study Group, ; Cossu, Antonio A; Palmieri, Giuseppe G

Publication Date: 2023-03-29

Variant appearance in text: EGFR: L718Q

PubMed Link: 37047382

Variant Present in the following documents:

• Main text
• ijms-24-06410.pdf

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Toward the next generation EGFR inhibitors: an overview of osimertinib resistance mediated by EGFR mutations in non-small cell lung cancer.

Cell Communication And Signaling : Ccs

Li, Yufeng Y; Mao, Tianyu T; Wang, Jing J; Zheng, Hongrui H; Hu, Ziyi Z; Cao, Pingping P; Yang, Suisui S; Zhu, Lingyun L; Guo, Shunyao S; Zhao, Xinfei X; Tian, Yue Y; Shen, Hua H; Lin, Fan F

Publication Date: 2023-04-11

Variant appearance in text: EGFR: L718Q

PubMed Link: 37041601

Variant Present in the following documents:

• Main text
• 12964_2023_Article_1082.pdf

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Precision targeted therapy for EGFR mutation-positive NSCLC: Dilemmas and coping strategies.

Thoracic Cancer

Meng, Ying Y; Bai, Rilan R; Cui, Jiuwei J

Publication Date: 2023-04-02

Variant appearance in text: EGFR: L718Q

PubMed Link: 37005552

Variant Present in the following documents:

• Main text
• TCA-14-1121.pdf

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Overcoming CEP85L-ROS1, MKRN1-BRAF and MET amplification as rare, acquired resistance mutations to Osimertinib.

Frontiers In Oncology

Kian, Waleed W; Krayim, Bilal B; Alsana, Hadel H; Giles, Betsy B; Purim, Ofer O; Alguayn, Wafeek W; Alguayn, Farouq F; Peled, Nir N; Roisman, Laila C LC

Publication Date: 2023

Variant appearance in text: EGFR: L718Q

PubMed Link: 36923435

Variant Present in the following documents:

• Main text
• fonc-13-1124949.pdf

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[Initial Treatment of Aumolertinib in Combination with Bevacizumab for Advanced NSCLC with Primary EGFR T790M Mutation: A Report of Three Cases and Literature Review].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer

Yang, Xue X; Meng, Fanlu F; Zhong, Diansheng D

Publication Date: 2023-02-20

Variant appearance in text: EGFR: L718Q

PubMed Link: 36872054

Variant Present in the following documents:

• Main text
• zgfazz-26-158.pdf

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Nanotechnology - a robust tool for fighting the challenges of drug resistance in non-small cell lung cancer.

Beilstein Journal Of Nanotechnology

Gorachinov, Filip F; Mraiche, Fatima F; Moustafa, Diala Alhaj DA; Hishari, Ola O; Ismail, Yomna Y; Joseph, Jensa J; Crcarevska, Maja Simonoska MS; Dodov, Marija Glavas MG; Geskovski, Nikola N; Goracinova, Katerina K

Publication Date: 2023

Variant appearance in text: EGFR: L718Q

PubMed Link: 36865093

Variant Present in the following documents:

• Beilstein_J_Nanotechnol-14-240.pdf

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Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancer.

Cancer Discovery

Pradat, Yoann Y; Viot, Julien J; Yurchenko, Andrey A AA; Gunbin, Konstantin K; Cerbone, Luigi L; Deloger, Marc M; Grisay, Guillaume G; Verlingue, Loic L; Scott, Veronique V; Padioleau, Ismael I; Panunzi, Leonardo L; Michiels, Stefan S; Hollebecque, Antoine A; Jules-Clement, Gerome G; Mezquita, Laura L; Laine, Antoine A; Loriot, Yohann Y; Besse, Benjamin B; Friboulet, Luc L; Andre, Fabrice F; Cournede, Paul-Henry PH; Gautheret, Daniel D; Nikolaev, Sergey I SI

Publication Date: 2023-03-02

Variant appearance in text: EGFR: 2153T>A; L718Q

PubMed Link: 36862804

Variant Present in the following documents:

• cd-22-0966_supplementary_tables_s1-s11_suppst1.xlsx, sheet 10
• cd-22-0966_supplementary_tables_s1-s11_suppst1.xlsx, sheet 6

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Analysis of acquired resistance mechanisms to osimertinib in patients with EGFR-mutated advanced non-small cell lung cancer from the AURA3 trial.

Nature Communications

Chmielecki, Juliann J; Mok, Tony T; Wu, Yi-Long YL; Han, Ji-Youn JY; Ahn, Myung-Ju MJ; Ramalingam, Suresh S SS; John, Thomas T; Okamoto, Isamu I; Yang, James Chih-Hsin JC; Shepherd, Frances A FA; Bulusu, Krishna C KC; Laus, Gianluca G; Collins, Barbara B; Barrett, J Carl JC; Hartmaier, Ryan J RJ; Papadimitrakopoulou, Vassiliki V

Publication Date: 2023-02-27

Variant appearance in text: EGFR: L718Q

PubMed Link: 36849516

Variant Present in the following documents:

• 41467_2023_35962_MOESM2_ESM.xlsx, sheet 1

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Candidate mechanisms of acquired resistance to first-line osimertinib in EGFR-mutated advanced non-small cell lung cancer.

Nature Communications

Chmielecki, Juliann J; Gray, Jhanelle E JE; Cheng, Ying Y; Ohe, Yuichiro Y; Imamura, Fumio F; Cho, Byoung Chul BC; Lin, Meng-Chih MC; Majem, Margarita M; Shah, Riyaz R; Rukazenkov, Yuri Y; Todd, Alexander A; Markovets, Aleksandra A; Barrett, J Carl JC; Hartmaier, Ryan J RJ; Ramalingam, Suresh S SS

Publication Date: 2023-02-27

Variant appearance in text: EGFR: L718Q

PubMed Link: 36849494

Variant Present in the following documents:

• 41467_2023_35961_MOESM3_ESM.xlsx, sheet 1
• 41467_2023_35961_MOESM3_ESM.xlsx, sheet 2

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Mechanisms of Acquired Resistance and Tolerance to EGFR Targeted Therapy in Non-Small Cell Lung Cancer.

Cancers

Chhouri, Houssein H; Alexandre, David D; Grumolato, Luca L

Publication Date: 2023-01-13

Variant appearance in text: EGFR: L718Q

PubMed Link: 36672453

Variant Present in the following documents:

• Main text
• cancers-15-00504.pdf

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Long-term survival of a non-small cell lung cancer patient with EGFR-mutated brain metastases: a case report.

Translational Cancer Research

Wan, Yuming Y; Xu, Feng F; Wang, Jin J

Publication Date: 2022-12

Variant appearance in text: EGFR: L718Q

PubMed Link: 36644180

Variant Present in the following documents:

• Main text
• tcr-11-12-4448.pdf

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Landscape and Predictive Significance of the Structural Classification of EGFR Mutations in Chinese NSCLCs: A Real-World Study.

Journal Of Clinical Medicine

Gu, Linping L; Huang, Huayan H; Xu, Zhangwendi Z; Niu, Xiaomin X; Li, Ziming Z; Xia, Liliang L; Yu, Yongfeng Y; Lu, Shun S

Publication Date: 2022-12-28

Variant appearance in text: EGFR: L718Q

PubMed Link: 36615035

Variant Present in the following documents:

• Main text
• jcm-12-00236.pdf

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Short-term dynamics of circulating tumor DNA predicting efficacy of sintilimab plus docetaxel in second-line treatment of advanced NSCLC: biomarker analysis from a single-arm, phase 2 trial.

Journal For Immunotherapy Of Cancer

Han, Xiao X; Tang, Xiaoyong X; Zhu, Hui H; Zhu, Dongyuan D; Zhang, Xiqin X; Meng, Xiangjiao X; Hua, Ying Y; Wang, Zhongtang Z; Zhang, Yan Y; Huang, Wei W; Wang, Linlin L; Yuan, Shuanghu S; Zhang, Pinliang P; Gong, Heyi H; Sun, Yulan Y; Zhang, Yingjie Y; Liu, Zengjun Z; Dong, Xiaomeng X; Gai, Fei F; Huang, Zhan Z; Zhu, Changbin C; Guo, Jun J; Wang, Zhehai Z

Publication Date: 2022-12

Variant appearance in text: EGFR: 2153T>A; L718Q

PubMed Link: 36600554

Variant Present in the following documents:

• jitc-2022-004952supp005.pdf

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Afatinib plus osimertinib in the treatment of osimertinib-resistant non-small cell lung carcinoma: a phase I clinical trial.

Bmc Cancer

Miura, Satoru S; Koh, Yasuhiro Y; Azuma, Koichi K; Yoshioka, Hiroshige H; Koyama, Kenichi K; Teraoka, Shunsuke S; Ishii, Hidenobu H; Kibata, Kayoko K; Ozawa, Yuichi Y; Tokito, Takaaki T; Oyanagi, Jun J; Shimokawa, Toshio T; Kurata, Takayasu T; Yamamoto, Nobuyuki N; Tanaka, Hiroshi H

Publication Date: 2023-01-03

Variant appearance in text: EGFR: L718Q

PubMed Link: 36597021

Variant Present in the following documents:

• Main text
• 12885_2022_Article_10467.pdf

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Combatting acquired resistance to osimertinib in EGFR-mutant lung cancer.

Therapeutic Advances In Medical Oncology

Lee, Jiyun J; Piotrowska, Zofia Z; Soo, Ross R; Cho, Byoung Chul BC; Lim, Sun Min SM

Publication Date: 2022

Variant appearance in text: EGFR: L718Q

PubMed Link: 36544540

Variant Present in the following documents:

• Main text
• 10.1177_17588359221144099.pdf

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Molecular pathways, resistance mechanisms and targeted interventions in non-small-cell lung cancer.

Molecular Biomedicine

Wang, Zixi Z; Xing, Yurou Y; Li, Bingjie B; Li, Xiaoyu X; Liu, Bin B; Wang, Yongsheng Y

Publication Date: 2022-12-12

Variant appearance in text: EGFR: L718Q

PubMed Link: 36508072

Variant Present in the following documents:

• Main text
• 43556_2022_Article_107.pdf

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Therapeutic strategies for EGFR-mutated non-small cell lung cancer patients with osimertinib resistance.

Journal Of Hematology & Oncology

Fu, Kai K; Xie, Fachao F; Wang, Fang F; Fu, Liwu L

Publication Date: 2022-12-08

Variant appearance in text: EGFR: L718Q

PubMed Link: 36482474

Variant Present in the following documents:

• Main text
• 13045_2022_Article_1391.pdf

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Inconsistent clinical outcomes following afatinib treatment in NSCLC patients harboring uncommon epidermal growth factor receptor mutation.

Frontiers In Oncology

Dong, Wei W; Wang, Congjie C; Wang, Chunsheng C; Zhao, Kewei K; Ma, Zhao Z; Hu, Shanliang S

Publication Date: 2022

Variant appearance in text: EGFR: L718Q

PubMed Link: 36425553

Variant Present in the following documents:

• DataSheet_1.pdf

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Michael acceptor molecules in natural products and their mechanism of action.

Frontiers In Pharmacology

Liang, Song-Ting ST; Chen, Chu C; Chen, Rui-Xin RX; Li, Rui R; Chen, Wen-Li WL; Jiang, Gui-Hua GH; Du, Lei-Lei LL

Publication Date: 2022

Variant appearance in text: EGFR: L718Q

PubMed Link: 36408214

Variant Present in the following documents:

• fphar-13-1033003.pdf

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Case Report: A patient with the rare third-generation TKI-resistant mutation EGFR L718Q who responded to afatinib plus cetuximab combination therapy.

Frontiers In Oncology

Zhang, Guoqing G; Yan, Beibei B; Guo, Yanan Y; Yang, Hang H; Li, Xiangnan X; Li, Jindong J

Publication Date: 2022

Variant appearance in text: EGFR: L718Q

PubMed Link: 36387265

Variant Present in the following documents:

• Main text
• fonc-12-995624.pdf

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Afatinib and Dacomitinib Efficacy, Safety, Progression Patterns, and Resistance Mechanisms in Patients with Non-Small Cell Lung Cancer Carrying Uncommon EGFR Mutations: A Comparative Cohort Study in China (AFANDA Study).

Cancers

Li, Hong-Shuai HS; Wang, Shou-Zheng SZ; Xu, Hai-Yan HY; Yan, Xiang X; Zhang, Jin-Yao JY; Lei, Si-Yu SY; Li, Teng T; Hao, Xue-Zhi XZ; Zhang, Tao T; Yang, Guang-Jian GJ; Zhou, Li-Qiang LQ; Liu, Peng P; Wang, Yu-Ying YY; Hu, Xing-Sheng XS; Xing, Pu-Yuan PY; Wang, Yan Y

Publication Date: 2022-10-28

Variant appearance in text: EGFR: L718Q

PubMed Link: 36358728

Variant Present in the following documents:

• cancers-14-05307.pdf

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Aumolertinib challenge as an optional treatment in advanced non small-cell lung cancer after osimertinib failure with epidermal growth factor receptor-sensitive mutation: A case series.

Oncology Letters

Ding, Xinjing X; Ding, Jianghua J; Leng, Zhaohui Z; Song, Yun Y

Publication Date: 2022-11

Variant appearance in text: EGFR: L718Q

PubMed Link: 36276494

Variant Present in the following documents:

• Main text
• ol-24-05-13520.pdf

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Osimertinib+Savolitinib to Overcome Acquired MET-Mediated Resistance in Epidermal Growth Factor Receptor Mutated MET-Amplified Non-Small Cell Lung Cancer: TATTON.

Cancer Discovery

Hartmaier, Ryan J RJ; Markovets, Aleksandra A AA; Ahn, Myung Ju MJ; Sequist, Lecia V LV; Han, Ji-Youn JY; Cho, Byoung Chul BC; Yu, Helena A HA; Kim, Sang-We SW; Yang, James Chih-Hsin JC; Lee, Jong-Seok JS; Su, Wu-Chou WC; Kowalski, Dariusz M DM; Orlov, Sergey S; Ren, Song S; Frewer, Paul P; Ou, Xiaoling X; Cross, Darren Ae DA; Kurian, Nisha N; Cantarini, Mireille M; Janne, Pasi A PA

Publication Date: 2022-10-20

Variant appearance in text: EGFR: L718Q

PubMed Link: 36264123

Variant Present in the following documents:

• Main text
• 98.pdf

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Amivantamab in the Treatment of Metastatic NSCLC: Patient Selection and Special Considerations.

Oncotargets And Therapy

Petrini, Iacopo I; Giaccone, Giuseppe G

Publication Date: 2022

Variant appearance in text: EGFR: L718Q

PubMed Link: 36246734

Variant Present in the following documents:

• Main text
• ott-15-1197.pdf

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Engaging innate immunity for targeting the epidermal growth factor receptor: Therapeutic options leveraging innate immunity versus adaptive immunity versus inhibition of signaling.

Frontiers In Oncology

Hintzen, Gabriele G; Dulat, Holger J HJ; Rajkovic, Erich E

Publication Date: 2022

Variant appearance in text: EGFR: L718Q

PubMed Link: 36185288

Variant Present in the following documents:

• Main text
• fonc-12-892212.pdf

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OPRM1-ROS1 Fusion Detected by Next-Generation Sequencing with Circulating DNA in a Patient with EGFR Mutated Advanced NSCLC: A Case Report.

Case Reports In Oncology

Zhang, Sicai S; Xu, Zhiyong Z; Zhang, Weimin W

Publication Date: 2022

Variant appearance in text: EGFR: L718Q

PubMed Link: 36157687

Variant Present in the following documents:

• Main text
• cro-0015-0700.pdf

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Tumor Heterogeneity and Drug Resistance Mutations Using ctDNA in Metastatic EGFR Mutation-Positive Lung Adenocarcinoma: A Case Report.

Oncotargets And Therapy

Sun, Jinghua J; Sun, Ge G; Lu, KeMou K; Xu, Lingling L; Qu, XiaoNa X; Cheng, Ye Y; Pan, Evenki E; Yang, Peng P; Wu, Tingting T; Zhang, Yang Y; He, HongMei H

Publication Date: 2022

Variant appearance in text: EGFR: L718Q

PubMed Link: 36065405

Variant Present in the following documents:

• Main text
• ott-15-919.pdf

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Molecular Targets in Lung Cancer: Study of the Evolution of Biomarkers Associated with Treatment with Tyrosine Kinase Inhibitors-Has NF1 Tumor Suppressor a Key Role in Acquired Resistance?

Cancers

Alen, Begoña O BO; Estévez-Pérez, Lara S LS; Hermida-Romero, María Teresa MT; Reguera-Arias, Ana A; García-Campelo, Rosario R; de la Torre-Bravos, Mercedes M; Concha, Ángel Á

Publication Date: 2022-07-07

Variant appearance in text: EGFR: L718Q

PubMed Link: 35884384

Variant Present in the following documents:

• Main text
• cancers-14-03323.pdf

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Emerging strategies to overcome resistance to third-generation EGFR inhibitors.

Journal Of Hematology & Oncology

Shi, Kunyu K; Wang, Guan G; Pei, Junping J; Zhang, Jifa J; Wang, Jiaxing J; Ouyang, Liang L; Wang, Yuxi Y; Li, Weimin W

Publication Date: 2022-07-15

Variant appearance in text: EGFR: L718Q

PubMed Link: 35840984

Variant Present in the following documents:

• Main text
• 13045_2022_Article_1311.pdf

View BVdb publication page

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AACR Project GENIE: 100,000 Cases and Beyond.

Cancer Discovery

Pugh, Trevor J TJ; Bell, Jonathan L JL; Bruce, Jeff P JP; Doherty, Gary J GJ; Galvin, Matthew M; Green, Michelle F MF; Hunter-Zinck, Haley H; Kumari, Priti P; Lenoue-Newton, Michele L ML; Li, Marilyn M MM; Lindsay, James J; Mazor, Tali T; Ovalle, Andrea A; Sammut, Stephen-John SJ; Schultz, Nikolaus N; Yu, Thomas V TV; Sweeney, Shawn M SM; Bernard, Brady B; ,

Publication Date: 2022-09-02

Variant appearance in text: EGFR: L718Q

PubMed Link: 35819403

Variant Present in the following documents:

• cd-21-1547_supplementary_table_1_suppst1.xlsx, sheet 1

View BVdb publication page

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Genomic Alterations Identification and Resistance Mechanisms Exploration of NSCLC With Central Nervous System Metastases Using Liquid Biopsy of Cerebrospinal Fluid: A Real-World Study.

Frontiers In Oncology

Shen, Fangfang F; Liang, Naixin N; Fan, Zaiwen Z; Zhao, Min M; Kang, Jing J; Wang, Xifang X; Hu, Qun Q; Mu, Yongping Y; Wang, Kai K; Yuan, Mingming M; Chen, Rongrong R; Guo, Wei W; Dong, Guilan G; Zhao, Jun J; Bai, Jun J

Publication Date: 2022

Variant appearance in text: EGFR: L718Q

PubMed Link: 35814426

Variant Present in the following documents:

• fonc-12-889591.pdf
• DataSheet_1.xlsx, sheet 2

View BVdb publication page

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