EGFR c.2156G>C ;(p.G719A)

Variant ID: 7-55241708-G-C

NM_005228.3(EGFR):c.2156G>C;(p.G719A)

This variant was identified in 708 publications

View GRCh38 version.




Publications:


Clinical and prognostic significance of detecting CEA, EGFR, LunX, c-met and EpCAM mRNA-positive cells in the peripheral blood, tumor-draining blood and bone marrow of non-small cell lung cancer patients.

Translational Lung Cancer Research
Rehulkova, Alona A; Chudacek, Josef J; Prokopova, Andrea A; Vidlarova, Monika M; Stranska, Jana J; Drabek, Jiri J; Potockova, Jana J; Trojanec, Radek R; Vrbkova, Jana J; Skarda, Josef J; Bohanes, Tomas T; Szkorupa, Marek M; Tolmaci, Benjamin B; Klein, Jiri J; Srovnal, Josef J; Hajduch, Marian M
Publication Date: 2023-05-31

Variant appearance in text: EGFR: G719A
PubMed Link: 37323172
Variant Present in the following documents:
  • Main text
  • tlcr-12-05-1034.pdf
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Editorial: Case reports in molecular and cellular oncology: 2022.

Frontiers In Oncology
Zheng, Shuhua S; Thomas, Tarita O TO
Publication Date: 2023

Variant appearance in text: EGFR: G719A
PubMed Link: 37260981
Variant Present in the following documents:
  • fonc-13-1209048.pdf
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Heterogeneous distribution of EGFR mutation in NSCLC: Case report.

Respiratory Medicine Case Reports
Boukansa, Sara S; Benbrahim, Zineb Z; Gamrani, Sanaa S; Mouhrach, Ismail I; El Agy, Fatima F; El Bardai, Sanae S; Bouguenouch, Laila L; Serraj, Mounia M; Amara, Bouchra B; Ouadnouni, Yassine Y; Smahi, Mohamed M; Alami, Badreeddine B; Mellas, Nawfel N; El Fatemi, Hinde H
Publication Date: 2023

Variant appearance in text: EGFR: G719A
PubMed Link: 37251359
Variant Present in the following documents:
  • Main text
  • main.pdf
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Overview on Therapeutic Options in Uncommon EGFR Mutant Non-Small Cell Lung Cancer (NSCLC): New Lights for an Unmet Medical Need.

International Journal Of Molecular Sciences
Pretelli, Giulia G; Spagnolo, Calogera Claudia CC; Ciappina, Giuliana G; Santarpia, Mariacarmela M; Pasello, Giulia G
Publication Date: 2023-05-17

Variant appearance in text: EGFR: G719A
PubMed Link: 37240224
Variant Present in the following documents:
  • Main text
  • ijms-24-08878.pdf
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Real world efficacy of osimertinib in second line/beyond in patients with metastatic EGFR+ non-small cell lung cancer and role of paired tumour-plasma T790M testing at tyrosine kinase inhibitor resistance.

Translational Lung Cancer Research
Ma, Jun J; Tan, Sze Huey SH; Yin, Daniel Xing Cheng DXC; Tran, Nguyen Tuan Anh NTA; Tan, Gek San GS; Lai, Gillianne Geet Yi GGY; Ang, Mei-Kim MK; Kanesvaran, Ravindran R; Jain, Amit A; Rajasekaran, Tanujaa T; Tan, Eng-Huat EH; Lim, Tony Kiat Hon TKH; Tan, Daniel Shao-Weng DS; Lim, Darren Wan-Teck DW; Ng, Quan Sing QS; Tan, Wan Ling WL
Publication Date: 2023-04-28

Variant appearance in text: EGFR: G719A
PubMed Link: 37197627
Variant Present in the following documents:
  • Main text
  • tlcr-12-04-742.pdf
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Advanced Non-small Cell Lung Cancer: EGFR Mutation Analysis Using Pyrosequencing and the Fully Automated qPCR-Based IdyllaTM System.

Cancer Control : Journal Of The Moffitt Cancer Center
Boustany, Youssra Y; Laraqui, Abdelilah A; El Zaitouni, Sara S; Ghaouti, Merieme M; Benzekri, Asmae A; Kettani, Fouad F; Oukabli, Mohammed M; Ennibi, Khalid K; Belkadi, Bouchra B; Sekhsokh, Yassine Y
Publication Date: 2023

Variant appearance in text: EGFR: G719A
PubMed Link: 37196225
Variant Present in the following documents:
  • Main text
  • 10.1177_10732748231177538.pdf
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Pan-cancer whole-genome comparison of primary and metastatic solid tumours.

Nature
Martínez-Jiménez, Francisco F; Movasati, Ali A; Brunner, Sascha Remy SR; Nguyen, Luan L; Priestley, Peter P; Cuppen, Edwin E; Van Hoeck, Arne A
Publication Date: 2023-05-10

Variant appearance in text: EGFR: G719A
PubMed Link: 37165194
Variant Present in the following documents:
  • 41586_2023_6054_MOESM12_ESM.xlsx, sheet 5
  • 41586_2023_6054_MOESM1_ESM.pdf
  • 41586_2023_6054_MOESM3_ESM.pdf
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Clinical Outcomes of Afatinib Versus Osimertinib in Patients With Non-Small Cell Lung Cancer With Uncommon EGFR Mutations: A Pooled Analysis.

The Oncologist
Wang, Chunsheng C; Zhao, Kewei K; Hu, Shanliang S; Dong, Wei W; Gong, Yan Y; Xie, Conghua C
Publication Date: 2023-04-28

Variant appearance in text: EGFR: G719A
PubMed Link: 37116899
Variant Present in the following documents:
  • Main text
  • oyad111.pdf
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Practice-Level Variation in Molecular Testing and Use of Targeted Therapy for Patients With Non-Small Cell Lung Cancer and Colorectal Cancer.

Jama Network Open
Roberts, Thomas J TJ; Kehl, Kenneth L KL; Brooks, Gabriel A GA; Sholl, Lynette L; Wright, Alexi A AA; Landrum, Mary Beth MB; Keating, Nancy L NL
Publication Date: 2023-04-03

Variant appearance in text: EGFR: G719A
PubMed Link: 37115543
Variant Present in the following documents:
  • jamanetwopen-e2310809-s001.pdf
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Advances in the Treatment of Rare Epidermal Growth Factor Receptor Mutations in Advanced Nonsmall-Cell Lung Cancer.

Technology In Cancer Research & Treatment
Yu, Limeng L; Wang, Ruilin R; Zhao, Yuhua Y; Wu, Yingxi Y; Wang, Lili L; Chen, Haiyang H; He, Zhen Z; Wang, Qiming Q; Wu, Yufeng Y
Publication Date: 2023

Variant appearance in text: EGFR: G719A
PubMed Link: 37078129
Variant Present in the following documents:
  • Main text
  • 10.1177_15330338231168466.pdf
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Comparison between Three Different Techniques for the Detection of EGFR Mutations in Liquid Biopsies of Patients with Advanced Stage Lung Adenocarcinoma.

International Journal Of Molecular Sciences
Casula, Milena M; Pisano, Marina M; Paliogiannis, Panagiotis P; Colombino, Maria M; Sini, Maria Cristina MC; Zinellu, Angelo A; Santeufemia, Davide D; Manca, Antonella A; Casula, Stefania S; Tore, Silvia S; Lobrano, Renato R; Sardinian Lung Cancer Study Group, ; Cossu, Antonio A; Palmieri, Giuseppe G
Publication Date: 2023-03-29

Variant appearance in text: EGFR: G719A
PubMed Link: 37047382
Variant Present in the following documents:
  • Main text
  • ijms-24-06410.pdf
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Toward the next generation EGFR inhibitors: an overview of osimertinib resistance mediated by EGFR mutations in non-small cell lung cancer.

Cell Communication And Signaling : Ccs
Li, Yufeng Y; Mao, Tianyu T; Wang, Jing J; Zheng, Hongrui H; Hu, Ziyi Z; Cao, Pingping P; Yang, Suisui S; Zhu, Lingyun L; Guo, Shunyao S; Zhao, Xinfei X; Tian, Yue Y; Shen, Hua H; Lin, Fan F
Publication Date: 2023-04-11

Variant appearance in text: EGFR: G719A
PubMed Link: 37041601
Variant Present in the following documents:
  • Main text
  • 12964_2023_Article_1082.pdf
View BVdb publication page



Detection of MET Polysomy by Next-generation Sequencing and Its Clinical Relevance for MET Inhibitors.

Cancer Research Communications
Sun, Boyang B; Qiu, Tian T; Zeng, Xiaoling X; Duan, Jianchun J; Bai, Hua H; Xu, Jiachen J; Li, Jin J; Li, Junling J; Hao, Xuezhi X; Liu, Yutao Y; Lin, Lin L; Wang, Hongyu H; Zhang, Xin X; Zhong, Jia J; Wang, Jie J; Ying, Jianming J; Wang, Zhijie Z
Publication Date: 2023-04

Variant appearance in text: EGFR: G719A
PubMed Link: 37025355
Variant Present in the following documents:
  • Main text
  • crc-22-0438.pdf
View BVdb publication page



Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.

Nature Communications
Abelin, Jennifer G JG; Bergstrom, Erik J EJ; Rivera, Keith D KD; Taylor, Hannah B HB; Klaeger, Susan S; Xu, Charles C; Verzani, Eva K EK; Jackson White, C C; Woldemichael, Hilina B HB; Virshup, Maya M; Olive, Meagan E ME; Maynard, Myranda M; Vartany, Stephanie A SA; Allen, Joseph D JD; Phulphagar, Kshiti K; Harry Kane, M M; Rachimi, Suzanna S; Mani, D R DR; Gillette, Michael A MA; Satpathy, Shankha S; Clauser, Karl R KR; Udeshi, Namrata D ND; Carr, Steven A SA
Publication Date: 2023-04-03

Variant appearance in text: EGFR: G719A
PubMed Link: 37012232
Variant Present in the following documents:
  • 41467_2023_37547_MOESM12_ESM.xlsx, sheet 3
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 4
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 3
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 2
  • 41467_2023_37547_MOESM12_ESM.xlsx, sheet 2
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Plasma ctDNA increases tissue NGS-based detection of therapeutically targetable mutations in lung cancers.

Bmc Cancer
Xie, Jianjiang J; Yao, Weishen W; Chen, Lingxiu L; Zhu, Wenjun W; Liu, Qiang Q; Geng, Geng G; Fang, Jing J; Zhao, Yang Y; Xiao, Li L; Huang, Zhenhua Z; Zhao, Jing J
Publication Date: 2023-03-31

Variant appearance in text: EGFR: Gly719Ala
PubMed Link: 37004022
Variant Present in the following documents:
  • Main text
View BVdb publication page



Impact of Molecular Testing Using Next-Generation Sequencing in the Clinical Management of Patients with Non-Small Cell Lung Cancer in a Public Healthcare Hospital.

Cancers
Simarro, Javier J; Pérez-Simó, Gema G; Mancheño, Nuria N; Ansotegui, Emilio E; Muñoz-Núñez, Carlos Francisco CF; Gómez-Codina, José J; Juan, Óscar Ó; Palanca, Sarai S
Publication Date: 2023-03-10

Variant appearance in text: EGFR: Gly719Ala
PubMed Link: 36980591
Variant Present in the following documents:
  • cancers-15-01705.pdf
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Circulating Tumor DNA Monitoring Reveals Molecular Progression before Radiologic Progression in a Real-life Cohort of Patients with Advanced Non-small Cell Lung Cancer.

Cancer Research Communications
Frank, Malene S MS; Andersen, Christina S A CSA; Ahlborn, Lise B LB; Pallisgaard, Niels N; Bodtger, Uffe U; Gehl, Julie J
Publication Date: 2022-10

Variant appearance in text: EGFR: 2156G>C; G719A
PubMed Link: 36969747
Variant Present in the following documents:
  • crc-22-0258-s07.pdf
  • crc-22-0258-s08.xlsx, sheet 1
View BVdb publication page



Distribution and prognostic impact of EGFR and KRAS mutations according to histological subtype and tumor invasion status in pTis-3N0M0 lung adenocarcinoma.

Bmc Cancer
Ito, Masaoki M; Miyata, Yoshihiro Y; Kushitani, Kei K; Ueda, Daisuke D; Takeshima, Yukio Y; Okada, Morihito M
Publication Date: 2023-03-14

Variant appearance in text: EGFR: G719A
PubMed Link: 36918771
Variant Present in the following documents:
  • Main text
  • 12885_2023_Article_10716.pdf
View BVdb publication page



Development and validation of a mutation-based model to predict immunotherapeutic efficacy in NSCLC.

Frontiers In Oncology
He, Ping P; Liu, Jie J; Xu, Qingyuan Q; Ma, Huaijun H; Niu, Beifang B; Huang, Gang G; Wu, Wei W
Publication Date: 2023

Variant appearance in text: EGFR: 2156G>C; G719A; rs121913428
PubMed Link: 36910641
Variant Present in the following documents:
  • DataSheet_1.xlsx, sheet 8
View BVdb publication page



Case Report: The effective treatment of patients in advanced no-small cell lung cancer patients with EGFR G719X/S768I/L861Q and acquired MET amplification: A case series and literature review.

Frontiers In Oncology
Zhao, Yun Y; Su, Cuiyun C; Shi, Lina L; Luo, Wenqi W; Liu, Zhen Z; Liang, Chuqiao C; Wang, Huilin H; Ning, Ruiling R; Yu, Qitao Q; Jiang, Wei W
Publication Date: 2023

Variant appearance in text: EGFR: 2156G>C; G719A
PubMed Link: 36910616
Variant Present in the following documents:
  • Main text
  • fonc-13-1126325.pdf
View BVdb publication page



A single-arm, multicenter, phase II trial of osimertinib in patients with epidermal growth factor receptor exon 18 G719X, exon 20 S768I, or exon 21 L861Q mutations.

Esmo Open
Villaruz, L C LC; Wang, X X; Bertino, E M EM; Gu, L L; Antonia, S J SJ; Burns, T F TF; Clarke, J J; Crawford, J J; Evans, T L TL; Friedland, D M DM; Otterson, G A GA; Ready, N E NE; Wozniak, A J AJ; Stinchcombe, T E TE
Publication Date: 2023-03-09

Variant appearance in text: EGFR: G719A
PubMed Link: 36905787
Variant Present in the following documents:
  • main.pdf
View BVdb publication page



Osimertinib in NSCLC With Atypical EGFR-Activating Mutations: A Retrospective Multicenter Study.

Jto Clinical And Research Reports
Ji, Jingran J; Aredo, Jacqueline V JV; Piper-Vallillo, Andrew A; Huppert, Laura L; Rotow, Julia K JK; Husain, Hatim H; Stewart, Susan S; Cobb, Rosemary R; Wakelee, Heather A HA; Blakely, Collin M CM; Wong, Melisa L ML; Gubens, Matthew A MA; Madani, Mohammad H MH; Digumarthy, Subba R SR; McCoach, Caroline C; Piotrowska, Zofia Z; Neal, Joel W JW; Riess, Jonathan W JW
Publication Date: 2023-03

Variant appearance in text: EGFR: G719A
PubMed Link: 36879929
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



[Initial Treatment of Aumolertinib in Combination with Bevacizumab for Advanced NSCLC with Primary EGFR T790M Mutation: A Report of Three Cases and Literature Review].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Yang, Xue X; Meng, Fanlu F; Zhong, Diansheng D
Publication Date: 2023-02-20

Variant appearance in text: EGFR: G719A
PubMed Link: 36872054
Variant Present in the following documents:
  • Main text
  • zgfazz-26-158.pdf
View BVdb publication page



Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancer.

Cancer Discovery
Pradat, Yoann Y; Viot, Julien J; Yurchenko, Andrey A AA; Gunbin, Konstantin K; Cerbone, Luigi L; Deloger, Marc M; Grisay, Guillaume G; Verlingue, Loic L; Scott, Veronique V; Padioleau, Ismael I; Panunzi, Leonardo L; Michiels, Stefan S; Hollebecque, Antoine A; Jules-Clement, Gerome G; Mezquita, Laura L; Laine, Antoine A; Loriot, Yohann Y; Besse, Benjamin B; Friboulet, Luc L; Andre, Fabrice F; Cournede, Paul-Henry PH; Gautheret, Daniel D; Nikolaev, Sergey I SI
Publication Date: 2023-03-02

Variant appearance in text: EGFR: G719A
PubMed Link: 36862804
Variant Present in the following documents:
  • 1116.pdf
  • cd-22-0966_supplementary_tables_s1-s11_suppst1.xlsx, sheet 6
View BVdb publication page



Real-world clinical analysis in 190 advanced NSCLC patients with uncommon EGFR mutations: A multi-center study.

Cancer Science
Qin, Yi Y; Long, Yaling Y; Tang, Yuan Y; Tian, Yuke Y; Li, Juan J; Duan, Ping P; Luo, Jieyan J; Yu, Min M; Li, Yanying Y; Zhou, Xiaojuan X; Wang, Ke K; Gong, Youling Y; Peng, Feng F; Zhu, Jiang J; Liu, Yongmei Y; Zhou, Lin L; Lu, You Y; Huang, Meijuan M
Publication Date: 2023-02-27

Variant appearance in text: EGFR: G719A
PubMed Link: 36851884
Variant Present in the following documents:
  • Main text
  • CAS-114-2552.pdf
View BVdb publication page



Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23

Variant appearance in text: EGFR: 2156G>C; Gly719Ala
PubMed Link: 36823319
Variant Present in the following documents:
  • 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Pan-cancer clinical impact of latent drivers from double mutations.

Communications Biology
Yavuz, Bengi Ruken BR; Tsai, Chung-Jung CJ; Nussinov, Ruth R; Tuncbag, Nurcan N
Publication Date: 2023-02-20

Variant appearance in text: EGFR: G719A
PubMed Link: 36808143
Variant Present in the following documents:
  • 42003_2023_4519_MOESM3_ESM.xlsx, sheet 3
View BVdb publication page



Efficacy and clinicogenomic correlates of response to immune checkpoint inhibitors alone or with chemotherapy in non-small cell lung cancer.

Nature Communications
Hong, Lingzhi L; Aminu, Muhammad M; Li, Shenduo S; Lu, Xuetao X; Petranovic, Milena M; Saad, Maliazurina B MB; Chen, Pingjun P; Qin, Kang K; Varghese, Susan S; Rinsurongkawong, Waree W; Rinsurongkawong, Vadeerat V; Spelman, Amy A; Elamin, Yasir Y YY; Negrao, Marcelo V MV; Skoulidis, Ferdinandos F; Gay, Carl M CM; Cascone, Tina T; Gandhi, Saumil J SJ; Lin, Steven H SH; Lee, Percy P PP; Carter, Brett W BW; Wu, Carol C CC; Antonoff, Mara B MB; Sepesi, Boris B; Lewis, Jeff J; Gibbons, Don L DL; Vaporciyan, Ara A AA; Le, Xiuning X; Jack Lee, J J; Roy-Chowdhuri, Sinchita S; Routbort, Mark J MJ; Gainor, Justin F JF; Heymach, John V JV; Lou, Yanyan Y; Wu, Jia J; Zhang, Jianjun J; Vokes, Natalie I NI
Publication Date: 2023-02-08

Variant appearance in text: EGFR: 2156G>C; G719A
PubMed Link: 36755027
Variant Present in the following documents:
  • 41467_2023_36328_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Patient-derived cell-based pharmacogenomic assessment to unveil underlying resistance mechanisms and novel therapeutics for advanced lung cancer.

Journal Of Experimental & Clinical Cancer Research : Cr
Yu, Namhee N; Hwang, Mihwa M; Lee, Youngjoo Y; Song, Bo Ram BR; Kang, Eun Hye EH; Sim, Hanna H; Ahn, Beung-Chul BC; Hwang, Kum Hui KH; Kim, Jihyun J; Hong, Sehwa S; Kim, Sunshin S; Park, Charny C; Han, Ji-Youn JY
Publication Date: 2023-01-30

Variant appearance in text: EGFR: G719A
PubMed Link: 36717865
Variant Present in the following documents:
  • Main text
  • 13046_2023_Article_2606.pdf
View BVdb publication page



A Primary Lung and Breast Cancer Patient with Germline EGFR R776H Mutation: A Case Report and Literature Review.

Oncotargets And Therapy
Li, Dan D; Liu, Xin X; Cui, SaiQiong S; Yang, DaFu D; Zhu, Yue Y; Pan, Evenki E; Yang, Peng P; Dai, ZhaoXia Z
Publication Date: 2023

Variant appearance in text: EGFR: G719A
PubMed Link: 36698436
Variant Present in the following documents:
  • Main text
  • ott-16-17.pdf
View BVdb publication page



Genetic trajectory and clonal evolution of multiple primary lung cancer with lymph node metastasis.

Cancer Gene Therapy
Tian, He H; Wang, Yalong Y; Yang, Zhenlin Z; Chen, Ping P; Xu, Jiachen J; Tian, Yanhua Y; Fan, Tao T; Xiao, Chu C; Bai, Guangyu G; Li, Lin L; Zheng, Bo B; Li, Chunxiang C; He, Jie J
Publication Date: 2023-01-19

Variant appearance in text: EGFR: G719A
PubMed Link: 36653483
Variant Present in the following documents:
  • 41417_2022_572_MOESM2_ESM.xlsx, sheet 1
  • 41417_2022_572_MOESM9_ESM.xlsx, sheet 5
View BVdb publication page



Characterization of driver mutations in Chinese non-small cell lung cancer patients using a novel targeted sequencing panel.

Journal Of Thoracic Disease
Zhao, Jing J; Wu, Yang Y; Chen, Min-Jiang MJ; Xu, Yan Y; Zhong, Wei W; Wang, Meng-Zhao MZ
Publication Date: 2022-12

Variant appearance in text: EGFR: G719A
PubMed Link: 36647494
Variant Present in the following documents:
  • Main text
  • jtd-14-12-4669.pdf
View BVdb publication page