EGFR c.2162G>C ;(p.G721A)

Variant ID: 7-55241714-G-C

NM_005228.3(EGFR):c.2162G>C;(p.G721A)

This variant was identified in 13 publications

View GRCh38 version.




Publications:


Rationale and design of a phase II trial of dacomitinib in advanced non-small cell lung cancer patients with uncommon epidermal growth factor receptor mutations: a prospective and single arm study (DANCE study).

Bmc Cancer
Zhang, Bo B; Shi, Chunlei C; Gao, Zhiqiang Z; Zhong, Hua H; Xiong, Liwen L; Gu, Aiqin A; Wang, Weimin W; Chu, Tianqing T; Zhang, Wei W; Wang, Huimin H; Zhang, Xueyan X; Zhong, Runbo R; Han, Baohui B
Publication Date: 2022-03-19

Variant appearance in text: EGFR: G721A
PubMed Link: 35305596
Variant Present in the following documents:
  • Main text
  • 12885_2022_Article_9409.pdf
View BVdb publication page



Durable response to afatinib in an advanced lung adenocarcinoma patient with an EGFR L858R/G729A compound mutation: a case report.

Annals Of Translational Medicine
Wu, Lige L; Fang, Cheng C; Zhao, Weiqing W; Li, Dong D; Tang, Shuxian S; Li, Xi X; Ji, Mei M
Publication Date: 2022-01

Variant appearance in text: EGFR: G721A
PubMed Link: 35282062
Variant Present in the following documents:
  • Main text
  • atm-10-02-116.pdf
View BVdb publication page



Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.

Thoracic Cancer
Asselta, Rosanna R; Di Tommaso, Luca L; Perrino, Matteo M; Destro, Annarita A; Giordano, Laura L; Cardamone, Giulia G; Rubino, Luca L; Santoro, Armando A; Duga, Stefano S; Zucali, Paolo Andrea PA
Publication Date: 2021-05

Variant appearance in text: EGFR: 2162G>C; G721A
PubMed Link: 33704917
Variant Present in the following documents:
  • TCA-12-1271-s003.xls, sheet 1
View BVdb publication page



Association of PARP1-specific polymorphisms and haplotypes with non-small cell lung cancer subtypes.

Plos One
Jin, Jing J; Robeson, Heather H; Fagan, Pebbles P; Orloff, Mohammed S MS
Publication Date: 2020

Variant appearance in text: EGFR: G721A
PubMed Link: 33284833
Variant Present in the following documents:
  • Main text
  • pone.0243509.pdf
View BVdb publication page



Landscape of drug-resistance mutations in kinase regulatory hotspots.

Briefings In Bioinformatics
Kim, Pora P; Li, Hanyang H; Wang, Junmei J; Zhao, Zhongming Z
Publication Date: 2021-05-20

Variant appearance in text: EGFR: G721A
PubMed Link: 32510566
Variant Present in the following documents:
  • Main text
View BVdb publication page



[A Review of EGFR-TKIs Therapy of Non-small Cell Lung Cancer
with Uncommon EGFR Mutations].

Zhongguo Fei Ai Za Zhi = Chinese Journal Of Lung Cancer
Du, Wenxing W; Wo, Yang Y; Lu, Tong T; Wang, Yuanyong Y; Jiao, Wenjie W
Publication Date: 2019-09-20

Variant appearance in text: EGFR: G721A
PubMed Link: 31526464
Variant Present in the following documents:
  • Main text
  • zgfazz-22-9-590.pdf
View BVdb publication page



Heterogeneous Responses to Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors (TKIs) in Patients with Uncommon EGFR Mutations: New Insights and Future Perspectives in this Complex Clinical Scenario.

International Journal Of Molecular Sciences
Russo, Alessandro A; Franchina, Tindara T; Ricciardi, Giuseppina G; Battaglia, Alessandra A; Picciotto, Maria M; Adamo, Vincenzo V
Publication Date: 2019-03-21

Variant appearance in text: EGFR: G721A
PubMed Link: 30901844
Variant Present in the following documents:
  • Main text
  • ijms-20-01431.pdf
View BVdb publication page



Somatic mutations in salivary duct carcinoma and potential therapeutic targets.

Oncotarget
Khoo, Timothy K TK; Yu, Bing B; Smith, Joel A JA; Clarke, Angus J AJ; Luk, Peter P PP; Selinger, Christina I CI; Mahon, Kate L KL; Kraitsek, Spiridoula S; Palme, Carsten C; Boyer, Michael J MJ; Dinger, Marcel E ME; Cowley, Mark J MJ; O'Toole, Sandra A SA; Clark, Jonathan R JR; Gupta, Ruta R
Publication Date: 2017-09-29

Variant appearance in text: EGFR: 2162G>C; G721A
PubMed Link: 29100278
Variant Present in the following documents:
  • Main text
  • oncotarget-08-75893.pdf
View BVdb publication page



Efficacy of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) in targeted therapy of lung squamous cell carcinoma patients with EGFR mutation: a pooled analysis.

Oncotarget
Zhuang, Jingqi J; Yu, Yongfeng Y; Li, Ziming Z; Lu, Shun S
Publication Date: 2017-08-08

Variant appearance in text: EGFR: G721A
PubMed Link: 28881841
Variant Present in the following documents:
  • Main text
  • oncotarget-08-53675.pdf
View BVdb publication page



Targeted sequencing identifies genetic alterations that confer primary resistance to EGFR tyrosine kinase inhibitor (Korean Lung Cancer Consortium).

Oncotarget
Lim, Sun Min SM; Kim, Hye Ryun HR; Cho, Eun Kyung EK; Min, Young Joo YJ; Ahn, Jin Seok JS; Ahn, Myung-Ju MJ; Park, Keunchil K; Cho, Byoung Chul BC; Lee, Ji-Hyun JH; Jeong, Hye Cheol HC; Kim, Eun Kyung EK; Kim, Joo-Hang JH
Publication Date: 2016-06-14

Variant appearance in text: EGFR: G721A
PubMed Link: 27121209
Variant Present in the following documents:
  • Main text
  • oncotarget-07-36311.pdf
View BVdb publication page



Kinome-wide decoding of network-attacking mutations rewiring cancer signaling.

Cell
Creixell, Pau P; Schoof, Erwin M EM; Simpson, Craig D CD; Longden, James J; Miller, Chad J CJ; Lou, Hua Jane HJ; Perryman, Lara L; Cox, Thomas R TR; Zivanovic, Nevena N; Palmeri, Antonio A; Wesolowska-Andersen, Agata A; Helmer-Citterich, Manuela M; Ferkinghoff-Borg, Jesper J; Itamochi, Hiroaki H; Bodenmiller, Bernd B; Erler, Janine T JT; Turk, Benjamin E BE; Linding, Rune R
Publication Date: 2015-09-24

Variant appearance in text: EGFR: G721A
PubMed Link: 26388441
Variant Present in the following documents:
  • mmc4.xlsx, sheet 1
View BVdb publication page



Assessment of computational methods for predicting the effects of missense mutations in human cancers.

Bmc Genomics
Gnad, Florian F; Baucom, Albion A; Mukhyala, Kiran K; Manning, Gerard G; Zhang, Zemin Z
Publication Date: 2013

Variant appearance in text: EGFR: G721A
PubMed Link: 23819521
Variant Present in the following documents:
  • 1471-2164-14-S3-S7-S1.xlsx, sheet 1
View BVdb publication page



Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research
Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C
Publication Date: 2011-09-01

Variant appearance in text: EGFR: G721A
PubMed Link: 21727090
Variant Present in the following documents:
  • supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1
View BVdb publication page